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DE69104727D1 - Biologisch aktives material, das kovalent auf azlacton-funktionalisierten polymertraegern immobilisiert ist, und verfahren zu seiner herstellung. - Google Patents

Biologisch aktives material, das kovalent auf azlacton-funktionalisierten polymertraegern immobilisiert ist, und verfahren zu seiner herstellung.

Info

Publication number
DE69104727D1
DE69104727D1 DE69104727T DE69104727T DE69104727D1 DE 69104727 D1 DE69104727 D1 DE 69104727D1 DE 69104727 T DE69104727 T DE 69104727T DE 69104727 T DE69104727 T DE 69104727T DE 69104727 D1 DE69104727 D1 DE 69104727D1
Authority
DE
Germany
Prior art keywords
azlactone
covalent
production
active material
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69104727T
Other languages
English (en)
Other versions
DE69104727T2 (de
Inventor
Patrick Coleman
Dean Milbrath
Margaret Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Co
Original Assignee
Minnesota Mining and Manufacturing Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining and Manufacturing Co filed Critical Minnesota Mining and Manufacturing Co
Publication of DE69104727D1 publication Critical patent/DE69104727D1/de
Application granted granted Critical
Publication of DE69104727T2 publication Critical patent/DE69104727T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087Acrylic polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE69104727T 1990-11-05 1991-10-22 Biologisch aktives material, das kovalent auf azlacton-funktionalisierten polymertraegern immobilisiert ist, und verfahren zu seiner herstellung. Expired - Fee Related DE69104727T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/609,436 US5200471A (en) 1990-11-05 1990-11-05 Biomolecules covalently immobilized with a high bound specific biological activity and method of preparing same
PCT/US1991/007800 WO1992007879A1 (en) 1990-11-05 1991-10-22 Biological active material covalently immobilized on to azlactone-functional polymeric supports and method for preparing it

Publications (2)

Publication Number Publication Date
DE69104727D1 true DE69104727D1 (de) 1994-11-24
DE69104727T2 DE69104727T2 (de) 1995-03-23

Family

ID=24440795

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69104727T Expired - Fee Related DE69104727T2 (de) 1990-11-05 1991-10-22 Biologisch aktives material, das kovalent auf azlacton-funktionalisierten polymertraegern immobilisiert ist, und verfahren zu seiner herstellung.

Country Status (9)

Country Link
US (1) US5200471A (de)
EP (1) EP0556271B1 (de)
JP (1) JP3269554B2 (de)
CA (1) CA2093641A1 (de)
CZ (1) CZ77393A3 (de)
DE (1) DE69104727T2 (de)
DK (1) DK0556271T3 (de)
NO (1) NO931622L (de)
WO (1) WO1992007879A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279558A (en) * 1989-06-16 1994-01-18 Science Incorporated Fluid delivery apparatus with an additive
JPH07508518A (ja) * 1992-06-23 1995-09-21 ミネソタ マイニング アンド マニュファクチャリング カンパニー アズラクトン官能支持体による脱タンパク質
US5385546A (en) * 1992-06-24 1995-01-31 Science Incorporated Mixing and delivering system
US5292514A (en) * 1992-06-24 1994-03-08 Minnesota Mining And Manufacturing Company Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof
US5705585A (en) 1993-06-30 1998-01-06 Arqule, Inc. Aminimide-containing molecules and materials as molecular recognition agents
US6436635B1 (en) 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5236418A (en) * 1992-12-07 1993-08-17 Science Incorporated Fluid mixing and delivery apparatus
CZ4294A3 (en) * 1993-01-21 1994-11-16 Minnesota Mining & Mfg Crosslinkable polymer carrier with isocyanate functional groups, process of its preparation, a supported catalyst based thereon and method of its use
US5321095A (en) * 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
WO1994022918A1 (en) * 1993-03-29 1994-10-13 Minnesota Mining And Manufacturing Company Method of coupling ligands within porous supports (p.e. azlactone) and uses thereof
DE4333213A1 (de) * 1993-09-29 1995-03-30 Merck Patent Gmbh Immobilisierte Proteinase K
GB9310241D0 (en) * 1993-05-18 1993-06-30 Unilever Plc Cosmetic treatment of substrates
JP3708542B2 (ja) * 1993-08-13 2005-10-19 ミネソタ マイニング アンド マニュファクチャリング カンパニー その上に不溶性酵素粒子を含有するカートリッジ・フィルター
US5408002A (en) * 1993-09-09 1995-04-18 Minnesota Mining And Manufacturing Company Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both
US5670480A (en) 1994-01-05 1997-09-23 Arqule, Inc. Method of making polymers having specific properties
US7034110B2 (en) * 1994-01-05 2006-04-25 Arqule, Inc. Method of identifying chemical compounds having selected properties for a particular application
JP3014262B2 (ja) * 1994-01-11 2000-02-28 三菱レイヨン株式会社 生体触媒固定化用担体および固定化生体触媒
US5639843A (en) * 1994-01-12 1997-06-17 Minnesota Mining And Manufacturing Company Organometallic acrylamide compositions and methods for making same, including antifouling agents and usage thereof
US5468847A (en) * 1994-03-10 1995-11-21 Minnesota Mining And Manufacturing Company Method of isolating and purifying a biomacromolecule
US5476665A (en) * 1994-04-13 1995-12-19 Minnesota Mining And Manufacturing Company Azlactone functional particles incorporated in a membrane formed by solvent phase inversion
US5561097A (en) * 1994-04-28 1996-10-01 Minnesota Mining And Manufacturing Company Method of controlling density of ligand coupled onto supports and products produced therefrom
US5510421A (en) * 1994-05-26 1996-04-23 Minnesota Mining And Manufacturing Company Azlactone-functional membranes and methods of preparing and using same
GB9415911D0 (en) * 1994-08-05 1994-09-28 Unilever Plc Hair styling composition and method
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5734082A (en) 1994-10-20 1998-03-31 Arqule Inc. Hydroxyethyl aminimides
GB9423356D0 (en) * 1994-11-17 1995-01-11 Unilever Plc Oral treatment
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
JPH08256773A (ja) * 1995-03-27 1996-10-08 Bio Material:Kk 微生物固定化用担体及びその微生物固定化用担体を用いた液体中の窒素化合物の変換方法
AU5438796A (en) 1995-04-06 1996-10-23 Arqule, Inc. Method for rapid purification, analysis and characterization of collections of chemical compounds
US5962412A (en) 1996-06-10 1999-10-05 Arqule, Inc. Method of making polymers having specific properties
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
CA2702219C (en) * 1996-11-06 2013-01-08 Sequenom, Inc. High density immobilization of nucleic acids
AU735416B2 (en) 1996-11-06 2001-07-05 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US6133436A (en) * 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US7285422B1 (en) 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
PT1864999E (pt) * 1996-11-27 2009-06-25 Genentech Inc Purificação por afinidade de um polipéptido numa matriz de proteína a
US6376619B1 (en) 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6156478A (en) * 1998-10-30 2000-12-05 3M Innovative Properties Company Photocurable and photopatternable hydrogel matrix based on azlactone copolymers
US6379952B1 (en) 1999-02-01 2002-04-30 3M Innovative Properties Company Method for cell selection utilizing azlactone-functional supports
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6482638B1 (en) * 1999-12-09 2002-11-19 3M Innovative Properties Company Heat-relaxable substrates and arrays
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
US20020142483A1 (en) 2000-10-30 2002-10-03 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
US6787635B2 (en) * 2001-04-05 2004-09-07 3M Innovative Properties Company Solid phase synthesis supports and methods
US20030040125A1 (en) * 2001-08-21 2003-02-27 3M Innovative Properties Company Methods for performing immunological assays
US7368296B2 (en) * 2002-01-17 2008-05-06 Applied Biosystems Solid phases optimized for chemiluminescent detection
WO2005007819A2 (en) 2003-07-09 2005-01-27 Wisconsin Alumni Research Foundation Charge-dynamic polymers and delivery of anionic compounds
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7939249B2 (en) * 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7727710B2 (en) * 2003-12-24 2010-06-01 3M Innovative Properties Company Materials, methods, and kits for reducing nonspecific binding of molecules to a surface
EP1807171A1 (de) * 2004-10-15 2007-07-18 Cuno Incorporated Gefaltete mehrlagige filtermedien und patrone
US20100129878A1 (en) * 2007-04-25 2010-05-27 Parthasarathy Ranjani V Methods for nucleic acid amplification
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
US20090105375A1 (en) * 2007-10-09 2009-04-23 Lynn David M Ultrathin Multilayered Films for Controlled Release of Anionic Reagents
US9116150B2 (en) 2007-11-19 2015-08-25 Emd Millipore Corporation Method of and device for packing a chromatography column
JP2011523965A (ja) 2008-05-30 2011-08-25 スリーエム イノベイティブ プロパティズ カンパニー リガンド官能化基材
US8652582B2 (en) 2008-05-30 2014-02-18 3M Innovative Properties Company Method of making ligand functionalized substrates
WO2009154849A1 (en) * 2008-06-20 2009-12-23 3M Innovative Properties Company Molded microstructured articles and method of making same
US8377672B2 (en) 2010-02-18 2013-02-19 3M Innovative Properties Company Ligand functionalized polymers
CN102844662B (zh) * 2010-03-03 2015-04-29 3M创新有限公司 配体胍基官能化聚合物
US10131899B2 (en) * 2014-03-17 2018-11-20 Ut-Battelle, Llc Bioactive compositions for high avidity cell capture
KR102582192B1 (ko) 2014-12-05 2023-09-25 후지필름 가부시키가이샤 Tim 단백질 결합 담체, 당해 담체를 사용한 세포외막소포 및 바이러스의 취득 방법, 제거 방법, 검출 방법 그리고 당해 담체를 포함하는 키트
EP4083624A4 (de) 2019-12-27 2023-06-21 FUJIFILM Corporation Verfahren zur unterstützung der diagnose von metastasierendem kastrationsresistentem prostatakrebs
JP7461382B2 (ja) 2020-01-15 2024-04-03 富士フイルム株式会社 抗炎症剤、及び抗炎症作用を有する細胞外小胞の製造方法
WO2021145396A1 (ja) 2020-01-15 2021-07-22 富士フイルム和光純薬株式会社 血管新生剤、及び血管新生作用を有する細胞外小胞の製造方法
EP4091617A4 (de) 2020-01-15 2023-08-09 FUJIFILM Corporation Antifibrotisches mittel und verfahren zum produzieren extrazellulärer vesikel, die eine antifibrotische wirkung aufweisen
JPWO2024143438A1 (de) 2022-12-28 2024-07-04

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS176421B1 (de) * 1972-11-06 1977-06-30
US4070348A (en) * 1973-07-25 1978-01-24 Rohm Gmbh Water-swellable, bead copolymer
CS179184B1 (en) * 1975-07-25 1977-10-31 Stanislav Vozka Method for preparation of precisely spherical particles of silica gel with controlled size and controled size pores.
DE2722751C2 (de) * 1977-05-20 1990-06-21 Röhm GmbH, 6100 Darmstadt Perlpolymerisat mit einem Teilchendurchmesser von 5 bis 1000 μm und innerem Hohlraum
US4440903A (en) * 1978-06-30 1984-04-03 Ramot University Authority For Applied Research And Industrial Development Ltd. Dihaloisocyanide derivatives of polymers for coupling nucleophiles
CS216992B1 (en) * 1980-07-21 1982-12-31 Miroslav Stol Composite polymere material for the biological and medicinal utilitation and method of preparation thereof
DE3106456A1 (de) * 1981-02-21 1982-10-07 Röhm GmbH, 6100 Darmstadt Verfahren zur herstellung von perlfoermigen, hydrophilen, gegenueber proteinen bindungsaktiven traegerpolymeren
DE3116995A1 (de) * 1981-04-29 1982-11-25 Röhm GmbH, 6100 Darmstadt Latex zur immobilisierung von biologisch wirksamen substanzen
US4582860A (en) * 1983-12-15 1986-04-15 Rohm And Haas Company Oxirane resins for enzyme immobilization
US4704366A (en) * 1984-06-22 1987-11-03 Bio-Rad Laboratories, Inc. Process for binding IgG to protein A
CS253971B1 (en) * 1984-12-11 1987-12-17 Peter Hermann Production method of high active biological effective compounds immobilized on carrier
DE3515252C2 (de) * 1985-04-27 1994-02-24 Roehm Gmbh Verfahren zur Immobilisierung gelöster Eiweißstoffe
US4929556A (en) * 1986-02-06 1990-05-29 The Dow Chemical Company Enzyme immobilization with polysulfonium salts
US4871824A (en) * 1987-03-13 1989-10-03 Minnesota Mining And Manufacturing Company Variably crosslinked polymeric supports
US4737560A (en) * 1987-03-13 1988-04-12 Minnesota Mining And Manufacturing Company Polymer beads
US5292840A (en) * 1987-03-13 1994-03-08 Minnesota Mining And Manufacturing Company Polymeric supports
US4933435A (en) * 1989-04-05 1990-06-12 Bioprobe International Antibody purification process
US5013795A (en) * 1989-04-10 1991-05-07 Minnesota Mining And Manufacturing Company Azlactone graft copolymers
US4981933A (en) * 1989-06-23 1991-01-01 Polaroid Corporation Azlactone copolymers
JPH03185000A (ja) * 1989-12-15 1991-08-12 Tosoh Corp プロテインAと免疫グロブリンG(IgG)との結合方法

Also Published As

Publication number Publication date
NO931622D0 (no) 1993-05-04
JPH06501394A (ja) 1994-02-17
JP3269554B2 (ja) 2002-03-25
US5200471A (en) 1993-04-06
WO1992007879A1 (en) 1992-05-14
CA2093641A1 (en) 1992-05-06
EP0556271B1 (de) 1994-10-19
DK0556271T3 (da) 1995-03-06
CZ77393A3 (en) 1994-01-19
NO931622L (no) 1993-05-04
EP0556271A1 (de) 1993-08-25
DE69104727T2 (de) 1995-03-23

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