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DE69231586D1 - Pharmazeutische anwendungen auf der basis von peptid-metall-ionen - Google Patents

Pharmazeutische anwendungen auf der basis von peptid-metall-ionen

Info

Publication number
DE69231586D1
DE69231586D1 DE69231586T DE69231586T DE69231586D1 DE 69231586 D1 DE69231586 D1 DE 69231586D1 DE 69231586 T DE69231586 T DE 69231586T DE 69231586 T DE69231586 T DE 69231586T DE 69231586 D1 DE69231586 D1 DE 69231586D1
Authority
DE
Germany
Prior art keywords
metal ions
useful metal
medically useful
applications based
pharmaceutical applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69231586T
Other languages
English (en)
Other versions
DE69231586T2 (de
Inventor
Buck A Rhodes
Paul O Zamora
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhomed Inc
Original Assignee
Rhomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27542230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69231586(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/816,476 external-priority patent/US5346687A/en
Priority claimed from US07/816,477 external-priority patent/US5460785A/en
Priority claimed from US07/840,077 external-priority patent/US5443816A/en
Priority claimed from US07/998,820 external-priority patent/US5738838A/en
Priority claimed from US07/998,910 external-priority patent/US5556609A/en
Application filed by Rhomed Inc filed Critical Rhomed Inc
Publication of DE69231586D1 publication Critical patent/DE69231586D1/de
Application granted granted Critical
Publication of DE69231586T2 publication Critical patent/DE69231586T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/14Peptides, e.g. proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/655Somatostatins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69231586T 1992-01-03 1992-12-31 Pharmazeutische anwendungen auf der basis von peptid-metall-ionen Revoked DE69231586T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US07/816,476 US5346687A (en) 1989-08-09 1992-01-03 Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging
US07/816,477 US5460785A (en) 1989-08-09 1992-01-03 Direct labeling of antibodies and other protein with metal ions
US07/840,077 US5443816A (en) 1990-08-08 1992-02-20 Peptide-metal ion pharmaceutical preparation and method
US07/998,820 US5738838A (en) 1992-02-20 1992-12-30 IKVAV peptide radiopharmaceutical applications
US07/998,910 US5556609A (en) 1992-02-20 1992-12-30 YIGSR peptide radiopharmaceutical applications
PCT/US1992/011334 WO1993012819A1 (en) 1992-01-03 1992-12-31 Protein- and peptide-metal ion pharmaceutical applications

Publications (2)

Publication Number Publication Date
DE69231586D1 true DE69231586D1 (de) 2001-01-04
DE69231586T2 DE69231586T2 (de) 2001-07-19

Family

ID=27542230

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231586T Revoked DE69231586T2 (de) 1992-01-03 1992-12-31 Pharmazeutische anwendungen auf der basis von peptid-metall-ionen

Country Status (8)

Country Link
EP (1) EP0629133B1 (de)
AT (1) ATE197767T1 (de)
AU (1) AU683833B2 (de)
CA (1) CA2127284C (de)
DE (1) DE69231586T2 (de)
DK (1) DK0629133T3 (de)
ES (1) ES2155447T3 (de)
WO (1) WO1993012819A1 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792444A (en) * 1989-05-09 1998-08-11 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5440015A (en) * 1992-07-21 1995-08-08 Glycomed Incorporated Selectin peptide medicaments for treating disease
DE4301871A1 (de) * 1993-01-13 1994-07-14 Diagnostikforschung Inst Neue Mittel zur Diagnose von Gefäßerkrankungen
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
SG48977A1 (en) * 1993-06-23 1998-05-18 Diatide Inc Radiolabeled peptides
EP0772459B1 (de) * 1994-05-02 2003-03-19 Diatide, Inc. Technetium-99m markierte bildformungsmittel
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
DE4425778A1 (de) * 1994-07-13 1996-01-18 Diagnostikforschung Inst Komplexverbindungen zur Diagnose von Gefäßerkrankungen
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
US6027711A (en) * 1995-06-07 2000-02-22 Rhomed Incorporated Structurally determined metallo-constructs and applications
AU709219B2 (en) * 1995-06-07 1999-08-26 Immunomedics Inc. Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
US8038994B2 (en) 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
PT910407E (pt) 1996-05-15 2003-07-31 Altarex Inc Metodo e composicao para modificar a conformacao de antigenios multi-epitopicos de modo a iniciar uma resposta imunitaria
US6106804A (en) * 1997-06-13 2000-08-22 The University Of New Mexico Arsenic-72 labeled compounds for tissue specific medical imaging
US7060251B1 (en) 1997-09-08 2006-06-13 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
AU9307498A (en) * 1997-09-08 1999-03-29 General Hospital Corporation, The Imaging agents for early detection and monitoring of cardiovascular plaque
ATE384075T1 (de) * 1998-05-15 2008-02-15 Ge Healthcare Ltd Markierte glutamin- und lysinanaloge
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
EP1404371B1 (de) 2001-07-10 2019-03-13 GE Healthcare UK Limited Peptidverbindingen zur zielrichtung von interginrezeptoren
IL160126A0 (en) * 2001-07-31 2004-06-20 Immunomedics Inc A kit for targeting a target site containing a polymer conjugate
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7371364B2 (en) 2003-08-15 2008-05-13 Board Of Regents, The University Of Texas System Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy
US9186644B2 (en) 2003-09-08 2015-11-17 Proportional Technologies, Inc. Miniaturized 62zn/62cu generator for high concentration clinical delivery of 62cu kit formulation for the facile preparation of radiolabeled cu-bis(thiosemicarbazone)compounds
JP2007526300A (ja) 2004-03-04 2007-09-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ 医薬化合物
WO2007001339A2 (en) 2004-08-17 2007-01-04 Wake Forest University Health Sciences Ambient stored blood plasma expanders
US8920827B2 (en) 2005-10-21 2014-12-30 Wake Forest University Health Sciences Keratin bioceramic compositions
US7892573B2 (en) 2006-02-10 2011-02-22 Wake Forest University Health Sciences Nerve regeneration employing keratin biomaterials
US8273702B2 (en) 2006-02-17 2012-09-25 Wake Forest University Health Sciences Wound healing compositions containing keratin biomaterials
WO2007098053A2 (en) 2006-02-17 2007-08-30 Wake Forest University Health Sciences Coatings and biomedical implants formed from keratin biomaterials
BRPI0907294A2 (pt) 2008-12-19 2013-05-07 Oreal processo de clareamento ou de coloraÇço das fibras queratÍnicas e dispositivo com vÁrios compartimentos
EP2198831B1 (de) 2008-12-19 2017-05-10 L'Oréal Verfahren zur Aufhellung, aufhellenden Direktfärbung oder Oxidationsfärbung in Gegenwart von organischen Aminen und Mineralbasen, sowie Kit
EP2198834B1 (de) 2008-12-19 2015-03-18 L'Oréal Aufhellungsverfahren für menschliche Keratinfasern durch Einsatz einer wasserfreien Zusammensetzung und einer basischen Mischung aus Monoethanolamin und Aminsäure, sowie geeignete Vorrichtung
FR2940077B1 (fr) 2008-12-19 2012-07-20 Oreal Procede de coloration eclaircissante de matieres keratiniques mettant en oeuvre une composition anhydre colorante comprenant un agent alcalin et une composition oxydante.
US7947089B2 (en) 2008-12-19 2011-05-24 L'oreal S.A. Method of coloring or lightening in the presence of an inorganic base and kit
CN101843564A (zh) 2008-12-19 2010-09-29 莱雅公司 使蛋白纤维色泽变淡和染色的无水组合物、及其装置
FR2940103B1 (fr) 2008-12-19 2011-06-10 Oreal Procede de coloration eclaircissante de matieres keratiniques mettant en oeuvre une emulsion comprenant un colorant et un agent alcalin et une composition oxydante
US7927381B2 (en) 2008-12-19 2011-04-19 L'oreal S.A. Process for lightening or lightening direct dyeing or oxidation dyeing in the presence of an aqueous composition comprising at least one fatty substance, and device
WO2010093882A1 (en) 2009-02-13 2010-08-19 Wake Forest University Health Sciences Keratin biomaterials for cell culture and methods of use
FR2942704B1 (fr) 2009-03-04 2011-09-02 Oreal Dispositif de distribution d'une composition tinctoriale pour les fibres keratiniques et procede associe.
FR2949971B1 (fr) 2009-09-17 2012-08-17 Oreal Procede d'eclaircissement ou de coloration en presence d'une composition anhydre particuliere et dispositif
FR2951080B1 (fr) 2009-10-13 2012-01-20 Oreal Composition comprenant un corps gras et un acide organophosphonique ou l'un de ses sels, procede de coloration ou d'eclaircissement la mettant en oeuvre et dispositifs
WO2011076646A2 (en) 2009-12-22 2011-06-30 L'oreal Agent for dyeing and/or bleaching keratin fibres, comprising an inverse emulsion comprising an oxidizing agent
FR2954101B1 (fr) 2009-12-22 2012-05-11 Oreal Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties ou plus, comprenant une composition alcaline en emulsion inverse.
FR2954121B1 (fr) 2009-12-22 2016-03-25 Oreal Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties, comprenant un corps gras particulier et une reductone.
FR2954113B1 (fr) 2009-12-22 2013-03-08 Oreal Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties ou plus, sous forme d'emulsion.
FR2954160B1 (fr) 2009-12-22 2012-03-30 Oreal Composition de coloration ou d'eclaircissement comprenant un corps gras et un polymere amphotere
EP2515831A2 (de) 2009-12-22 2012-10-31 L'Oréal Invertierte emulsion zur haarbehandlung mit einem bestimmten fettigen stoff und einem alkalinmittel
FR2954127B1 (fr) 2009-12-22 2015-10-30 Oreal Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties, comprenant un corps gras et un agent sequestrant.
FR2954161B1 (fr) 2009-12-23 2012-03-02 Oreal Procede de coloration ou d'eclaircissement de fibres keratiniques en presence d'alcane(s) lineaire(s) volatil(s) et dispositif
JP2013521313A (ja) 2010-03-05 2013-06-10 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 制御送達系
WO2011112575A1 (en) 2010-03-08 2011-09-15 Wake Forest University Health Sciences Keratin biomaterials for treatment of ischemia
FR2958161B1 (fr) 2010-04-02 2012-04-27 Oreal Procede de traitement des cheveux mettant en oeuvre une emulsion directe comprenant un agent oxydant et une emulsion directe contenant un agent alcalin
FR2959127B1 (fr) 2010-04-22 2016-01-01 Oreal Emulsion inverse pour le traitement des cheveux comprenant un solvant particulier
FR2960773B1 (fr) 2010-06-03 2015-12-11 Oreal Procedes de traitement cosmetique utilisant un revetement a base d'un polymere polyamide-polyether
AU2011329839B2 (en) 2010-11-17 2016-12-08 Wake Forest University Health Sciences Keratin compositions for treatment of bone deficiency or injury
WO2014015181A2 (en) * 2012-07-18 2014-01-23 University Of Kansas Metal abstraction peptide with release of metal

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO167124C (no) * 1985-04-03 1991-10-09 Du Pont Merck Pharma Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl.
EP0210684A1 (de) * 1985-07-31 1987-02-04 MALLINCKRODT, INC.(a Missouri corporation) Ein eine radioaktive Metallzusammensetzung enthaltendes Präparat für Radiodiagnostika
ES2017088B3 (es) * 1986-05-28 1991-01-01 Mallinckrodt Inc (A Missouri Corporation) Quelatos de tecnecio a utilizar para determinar la funcion renal.
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
WO1988007382A2 (en) * 1987-04-02 1988-10-06 Centocor Cardiovascular Imaging Partners, L.P. Method for labelling antibodies with a metal ion
US5128119A (en) * 1989-06-12 1992-07-07 Immunomedics, Inc. Methods for technetium/rhenium labeling of f(ab1)2 fragments
US4917878A (en) * 1988-05-02 1990-04-17 Thomas Jefferson University Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals
JPH03505094A (ja) * 1988-05-02 1991-11-07 ニュー イングランド ディーコネス ホスピタル コーポレイション 動脈映像のための合成ペプチド
US5135736A (en) * 1988-08-15 1992-08-04 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
CA2016235C (en) * 1989-05-09 2002-03-12 Alan J. Fischman Labeled chemotactic peptides to image focal sites of infection or inflammation
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
HU219336B (en) * 1989-07-20 2001-03-28 Novartis Ag Process for producing peptide derivatives and pharmaceutical compositions comprising such compounds and diagnostic unit containing such compounds
DK0486622T3 (da) * 1989-08-09 1999-07-19 Rhomed Inc Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium
US5277892A (en) * 1990-08-08 1994-01-11 Rhomed Incorporated In vivo lymphocyte tagging
CA2101942C (en) * 1991-02-08 2001-01-30 Richard T. Dean Technetium-99m labeled polypeptides for imaging

Also Published As

Publication number Publication date
EP0629133A1 (de) 1994-12-21
ATE197767T1 (de) 2000-12-15
DK0629133T3 (da) 2001-04-02
EP0629133A4 (de) 1995-02-01
CA2127284A1 (en) 1993-07-08
AU683833B2 (en) 1997-11-27
ES2155447T3 (es) 2001-05-16
DE69231586T2 (de) 2001-07-19
WO1993012819A1 (en) 1993-07-08
AU3427293A (en) 1993-07-28
CA2127284C (en) 2002-02-05
EP0629133B1 (de) 2000-11-29

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