DE69231586D1 - Pharmazeutische anwendungen auf der basis von peptid-metall-ionen - Google Patents
Pharmazeutische anwendungen auf der basis von peptid-metall-ionenInfo
- Publication number
- DE69231586D1 DE69231586D1 DE69231586T DE69231586T DE69231586D1 DE 69231586 D1 DE69231586 D1 DE 69231586D1 DE 69231586 T DE69231586 T DE 69231586T DE 69231586 T DE69231586 T DE 69231586T DE 69231586 D1 DE69231586 D1 DE 69231586D1
- Authority
- DE
- Germany
- Prior art keywords
- metal ions
- useful metal
- medically useful
- applications based
- pharmaceutical applications
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/816,476 US5346687A (en) | 1989-08-09 | 1992-01-03 | Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging |
| US07/816,477 US5460785A (en) | 1989-08-09 | 1992-01-03 | Direct labeling of antibodies and other protein with metal ions |
| US07/840,077 US5443816A (en) | 1990-08-08 | 1992-02-20 | Peptide-metal ion pharmaceutical preparation and method |
| US07/998,820 US5738838A (en) | 1992-02-20 | 1992-12-30 | IKVAV peptide radiopharmaceutical applications |
| US07/998,910 US5556609A (en) | 1992-02-20 | 1992-12-30 | YIGSR peptide radiopharmaceutical applications |
| PCT/US1992/011334 WO1993012819A1 (en) | 1992-01-03 | 1992-12-31 | Protein- and peptide-metal ion pharmaceutical applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69231586D1 true DE69231586D1 (de) | 2001-01-04 |
| DE69231586T2 DE69231586T2 (de) | 2001-07-19 |
Family
ID=27542230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69231586T Revoked DE69231586T2 (de) | 1992-01-03 | 1992-12-31 | Pharmazeutische anwendungen auf der basis von peptid-metall-ionen |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0629133B1 (de) |
| AT (1) | ATE197767T1 (de) |
| AU (1) | AU683833B2 (de) |
| CA (1) | CA2127284C (de) |
| DE (1) | DE69231586T2 (de) |
| DK (1) | DK0629133T3 (de) |
| ES (1) | ES2155447T3 (de) |
| WO (1) | WO1993012819A1 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
| US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
| US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
| US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US5440015A (en) * | 1992-07-21 | 1995-08-08 | Glycomed Incorporated | Selectin peptide medicaments for treating disease |
| DE4301871A1 (de) * | 1993-01-13 | 1994-07-14 | Diagnostikforschung Inst | Neue Mittel zur Diagnose von Gefäßerkrankungen |
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| SG48977A1 (en) * | 1993-06-23 | 1998-05-18 | Diatide Inc | Radiolabeled peptides |
| EP0772459B1 (de) * | 1994-05-02 | 2003-03-19 | Diatide, Inc. | Technetium-99m markierte bildformungsmittel |
| US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
| DE4425778A1 (de) * | 1994-07-13 | 1996-01-18 | Diagnostikforschung Inst | Komplexverbindungen zur Diagnose von Gefäßerkrankungen |
| US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
| US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
| AU709219B2 (en) * | 1995-06-07 | 1999-08-26 | Immunomedics Inc. | Thiolation of peptides for radionuclide-based radiodetection and radiotherapy |
| US8038994B2 (en) | 1996-05-15 | 2011-10-18 | Quest Pharmatech Inc. | Combination therapy for treating disease |
| PT910407E (pt) | 1996-05-15 | 2003-07-31 | Altarex Inc | Metodo e composicao para modificar a conformacao de antigenios multi-epitopicos de modo a iniciar uma resposta imunitaria |
| US6106804A (en) * | 1997-06-13 | 2000-08-22 | The University Of New Mexico | Arsenic-72 labeled compounds for tissue specific medical imaging |
| US7060251B1 (en) | 1997-09-08 | 2006-06-13 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
| AU9307498A (en) * | 1997-09-08 | 1999-03-29 | General Hospital Corporation, The | Imaging agents for early detection and monitoring of cardiovascular plaque |
| ATE384075T1 (de) * | 1998-05-15 | 2008-02-15 | Ge Healthcare Ltd | Markierte glutamin- und lysinanaloge |
| US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
| US6685914B1 (en) | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
| EP1404371B1 (de) | 2001-07-10 | 2019-03-13 | GE Healthcare UK Limited | Peptidverbindingen zur zielrichtung von interginrezeptoren |
| IL160126A0 (en) * | 2001-07-31 | 2004-06-20 | Immunomedics Inc | A kit for targeting a target site containing a polymer conjugate |
| US7319149B2 (en) | 2003-06-13 | 2008-01-15 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
| US7317104B2 (en) | 2003-06-13 | 2008-01-08 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
| US7371364B2 (en) | 2003-08-15 | 2008-05-13 | Board Of Regents, The University Of Texas System | Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy |
| US9186644B2 (en) | 2003-09-08 | 2015-11-17 | Proportional Technologies, Inc. | Miniaturized 62zn/62cu generator for high concentration clinical delivery of 62cu kit formulation for the facile preparation of radiolabeled cu-bis(thiosemicarbazone)compounds |
| JP2007526300A (ja) | 2004-03-04 | 2007-09-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 医薬化合物 |
| WO2007001339A2 (en) | 2004-08-17 | 2007-01-04 | Wake Forest University Health Sciences | Ambient stored blood plasma expanders |
| US8920827B2 (en) | 2005-10-21 | 2014-12-30 | Wake Forest University Health Sciences | Keratin bioceramic compositions |
| US7892573B2 (en) | 2006-02-10 | 2011-02-22 | Wake Forest University Health Sciences | Nerve regeneration employing keratin biomaterials |
| US8273702B2 (en) | 2006-02-17 | 2012-09-25 | Wake Forest University Health Sciences | Wound healing compositions containing keratin biomaterials |
| WO2007098053A2 (en) | 2006-02-17 | 2007-08-30 | Wake Forest University Health Sciences | Coatings and biomedical implants formed from keratin biomaterials |
| BRPI0907294A2 (pt) | 2008-12-19 | 2013-05-07 | Oreal | processo de clareamento ou de coloraÇço das fibras queratÍnicas e dispositivo com vÁrios compartimentos |
| EP2198831B1 (de) | 2008-12-19 | 2017-05-10 | L'Oréal | Verfahren zur Aufhellung, aufhellenden Direktfärbung oder Oxidationsfärbung in Gegenwart von organischen Aminen und Mineralbasen, sowie Kit |
| EP2198834B1 (de) | 2008-12-19 | 2015-03-18 | L'Oréal | Aufhellungsverfahren für menschliche Keratinfasern durch Einsatz einer wasserfreien Zusammensetzung und einer basischen Mischung aus Monoethanolamin und Aminsäure, sowie geeignete Vorrichtung |
| FR2940077B1 (fr) | 2008-12-19 | 2012-07-20 | Oreal | Procede de coloration eclaircissante de matieres keratiniques mettant en oeuvre une composition anhydre colorante comprenant un agent alcalin et une composition oxydante. |
| US7947089B2 (en) | 2008-12-19 | 2011-05-24 | L'oreal S.A. | Method of coloring or lightening in the presence of an inorganic base and kit |
| CN101843564A (zh) | 2008-12-19 | 2010-09-29 | 莱雅公司 | 使蛋白纤维色泽变淡和染色的无水组合物、及其装置 |
| FR2940103B1 (fr) | 2008-12-19 | 2011-06-10 | Oreal | Procede de coloration eclaircissante de matieres keratiniques mettant en oeuvre une emulsion comprenant un colorant et un agent alcalin et une composition oxydante |
| US7927381B2 (en) | 2008-12-19 | 2011-04-19 | L'oreal S.A. | Process for lightening or lightening direct dyeing or oxidation dyeing in the presence of an aqueous composition comprising at least one fatty substance, and device |
| WO2010093882A1 (en) | 2009-02-13 | 2010-08-19 | Wake Forest University Health Sciences | Keratin biomaterials for cell culture and methods of use |
| FR2942704B1 (fr) | 2009-03-04 | 2011-09-02 | Oreal | Dispositif de distribution d'une composition tinctoriale pour les fibres keratiniques et procede associe. |
| FR2949971B1 (fr) | 2009-09-17 | 2012-08-17 | Oreal | Procede d'eclaircissement ou de coloration en presence d'une composition anhydre particuliere et dispositif |
| FR2951080B1 (fr) | 2009-10-13 | 2012-01-20 | Oreal | Composition comprenant un corps gras et un acide organophosphonique ou l'un de ses sels, procede de coloration ou d'eclaircissement la mettant en oeuvre et dispositifs |
| WO2011076646A2 (en) | 2009-12-22 | 2011-06-30 | L'oreal | Agent for dyeing and/or bleaching keratin fibres, comprising an inverse emulsion comprising an oxidizing agent |
| FR2954101B1 (fr) | 2009-12-22 | 2012-05-11 | Oreal | Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties ou plus, comprenant une composition alcaline en emulsion inverse. |
| FR2954121B1 (fr) | 2009-12-22 | 2016-03-25 | Oreal | Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties, comprenant un corps gras particulier et une reductone. |
| FR2954113B1 (fr) | 2009-12-22 | 2013-03-08 | Oreal | Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties ou plus, sous forme d'emulsion. |
| FR2954160B1 (fr) | 2009-12-22 | 2012-03-30 | Oreal | Composition de coloration ou d'eclaircissement comprenant un corps gras et un polymere amphotere |
| EP2515831A2 (de) | 2009-12-22 | 2012-10-31 | L'Oréal | Invertierte emulsion zur haarbehandlung mit einem bestimmten fettigen stoff und einem alkalinmittel |
| FR2954127B1 (fr) | 2009-12-22 | 2015-10-30 | Oreal | Agent de coloration et/ou de decoloration des fibres keratiniques en deux parties, comprenant un corps gras et un agent sequestrant. |
| FR2954161B1 (fr) | 2009-12-23 | 2012-03-02 | Oreal | Procede de coloration ou d'eclaircissement de fibres keratiniques en presence d'alcane(s) lineaire(s) volatil(s) et dispositif |
| JP2013521313A (ja) | 2010-03-05 | 2013-06-10 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | 制御送達系 |
| WO2011112575A1 (en) | 2010-03-08 | 2011-09-15 | Wake Forest University Health Sciences | Keratin biomaterials for treatment of ischemia |
| FR2958161B1 (fr) | 2010-04-02 | 2012-04-27 | Oreal | Procede de traitement des cheveux mettant en oeuvre une emulsion directe comprenant un agent oxydant et une emulsion directe contenant un agent alcalin |
| FR2959127B1 (fr) | 2010-04-22 | 2016-01-01 | Oreal | Emulsion inverse pour le traitement des cheveux comprenant un solvant particulier |
| FR2960773B1 (fr) | 2010-06-03 | 2015-12-11 | Oreal | Procedes de traitement cosmetique utilisant un revetement a base d'un polymere polyamide-polyether |
| AU2011329839B2 (en) | 2010-11-17 | 2016-12-08 | Wake Forest University Health Sciences | Keratin compositions for treatment of bone deficiency or injury |
| WO2014015181A2 (en) * | 2012-07-18 | 2014-01-23 | University Of Kansas | Metal abstraction peptide with release of metal |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO167124C (no) * | 1985-04-03 | 1991-10-09 | Du Pont Merck Pharma | Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl. |
| EP0210684A1 (de) * | 1985-07-31 | 1987-02-04 | MALLINCKRODT, INC.(a Missouri corporation) | Ein eine radioaktive Metallzusammensetzung enthaltendes Präparat für Radiodiagnostika |
| ES2017088B3 (es) * | 1986-05-28 | 1991-01-01 | Mallinckrodt Inc (A Missouri Corporation) | Quelatos de tecnecio a utilizar para determinar la funcion renal. |
| DE3728599A1 (de) * | 1986-12-10 | 1988-06-23 | Hoechst Ag | Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz |
| WO1988007382A2 (en) * | 1987-04-02 | 1988-10-06 | Centocor Cardiovascular Imaging Partners, L.P. | Method for labelling antibodies with a metal ion |
| US5128119A (en) * | 1989-06-12 | 1992-07-07 | Immunomedics, Inc. | Methods for technetium/rhenium labeling of f(ab1)2 fragments |
| US4917878A (en) * | 1988-05-02 | 1990-04-17 | Thomas Jefferson University | Novel use of a radiolabelled antibody against stage specific embryonic antigen for the detection of occult abscesses in mammals |
| JPH03505094A (ja) * | 1988-05-02 | 1991-11-07 | ニュー イングランド ディーコネス ホスピタル コーポレイション | 動脈映像のための合成ペプチド |
| US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| MY106120A (en) * | 1988-12-05 | 1995-03-31 | Novartis Ag | Peptide derivatives. |
| US5196510A (en) * | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
| CA2016235C (en) * | 1989-05-09 | 2002-03-12 | Alan J. Fischman | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
| HU219336B (en) * | 1989-07-20 | 2001-03-28 | Novartis Ag | Process for producing peptide derivatives and pharmaceutical compositions comprising such compounds and diagnostic unit containing such compounds |
| DK0486622T3 (da) * | 1989-08-09 | 1999-07-19 | Rhomed Inc | Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium |
| US5277892A (en) * | 1990-08-08 | 1994-01-11 | Rhomed Incorporated | In vivo lymphocyte tagging |
| CA2101942C (en) * | 1991-02-08 | 2001-01-30 | Richard T. Dean | Technetium-99m labeled polypeptides for imaging |
-
1992
- 1992-12-31 DE DE69231586T patent/DE69231586T2/de not_active Revoked
- 1992-12-31 AT AT93902846T patent/ATE197767T1/de not_active IP Right Cessation
- 1992-12-31 AU AU34272/93A patent/AU683833B2/en not_active Ceased
- 1992-12-31 DK DK93902846T patent/DK0629133T3/da active
- 1992-12-31 CA CA002127284A patent/CA2127284C/en not_active Expired - Fee Related
- 1992-12-31 EP EP93902846A patent/EP0629133B1/de not_active Revoked
- 1992-12-31 ES ES93902846T patent/ES2155447T3/es not_active Expired - Lifetime
- 1992-12-31 WO PCT/US1992/011334 patent/WO1993012819A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP0629133A1 (de) | 1994-12-21 |
| ATE197767T1 (de) | 2000-12-15 |
| DK0629133T3 (da) | 2001-04-02 |
| EP0629133A4 (de) | 1995-02-01 |
| CA2127284A1 (en) | 1993-07-08 |
| AU683833B2 (en) | 1997-11-27 |
| ES2155447T3 (es) | 2001-05-16 |
| DE69231586T2 (de) | 2001-07-19 |
| WO1993012819A1 (en) | 1993-07-08 |
| AU3427293A (en) | 1993-07-28 |
| CA2127284C (en) | 2002-02-05 |
| EP0629133B1 (de) | 2000-11-29 |
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