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DE69233656D1 - Kokain-Rezeptor Bindungsliganden - Google Patents

Kokain-Rezeptor Bindungsliganden

Info

Publication number
DE69233656D1
DE69233656D1 DE69233656T DE69233656T DE69233656D1 DE 69233656 D1 DE69233656 D1 DE 69233656D1 DE 69233656 T DE69233656 T DE 69233656T DE 69233656 T DE69233656 T DE 69233656T DE 69233656 D1 DE69233656 D1 DE 69233656D1
Authority
DE
Germany
Prior art keywords
sub
alkyl
cycloalkyl
alkoxy
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233656T
Other languages
English (en)
Inventor
Michael J Kuhar
John W Boja
Frank Ivy Carrol
Anita H Lewin
Philip Abraham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institutes of Health NIH
RTI International Inc
Original Assignee
National Institutes of Health NIH
RTI International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25157598&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69233656(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by National Institutes of Health NIH, RTI International Inc filed Critical National Institutes of Health NIH
Application granted granted Critical
Publication of DE69233656D1 publication Critical patent/DE69233656D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69233656T 1991-11-15 1992-11-13 Kokain-Rezeptor Bindungsliganden Expired - Lifetime DE69233656D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79264891A 1991-11-15 1991-11-15

Publications (1)

Publication Number Publication Date
DE69233656D1 true DE69233656D1 (de) 2006-10-19

Family

ID=25157598

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69229744T Expired - Lifetime DE69229744T2 (de) 1991-11-15 1992-11-13 Kokainrezeptor bindende Liganden
DE69233656T Expired - Lifetime DE69233656D1 (de) 1991-11-15 1992-11-13 Kokain-Rezeptor Bindungsliganden
DE69233536T Expired - Lifetime DE69233536D1 (de) 1991-11-15 1992-11-13 Kokainrezeptor bindende Liganden

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69229744T Expired - Lifetime DE69229744T2 (de) 1991-11-15 1992-11-13 Kokainrezeptor bindende Liganden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69233536T Expired - Lifetime DE69233536D1 (de) 1991-11-15 1992-11-13 Kokainrezeptor bindende Liganden

Country Status (13)

Country Link
EP (3) EP0897922B1 (de)
JP (1) JP2852467B2 (de)
KR (1) KR100251339B1 (de)
AT (3) ATE182794T1 (de)
AU (1) AU668371B2 (de)
CA (1) CA2123570C (de)
DE (3) DE69229744T2 (de)
DK (1) DK0644775T3 (de)
ES (1) ES2138601T3 (de)
FI (1) FI942231A0 (de)
GR (1) GR3031579T3 (de)
NO (1) NO313097B1 (de)
WO (1) WO1993009814A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935953A (en) * 1990-08-09 1999-08-10 Research Triangle Institute Methods for controlling invertebrate pests using cocaine receptor binding ligands
US6531483B1 (en) 1990-08-09 2003-03-11 Research Triangle Institute Cocaine receptor binding ligands
US7011813B2 (en) 1990-08-09 2006-03-14 Research Triangle Institute Cocaine receptor binding ligands
US7189737B2 (en) 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US6329520B1 (en) * 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
DK154192D0 (da) * 1992-12-23 1992-12-23 Neurosearch As Heterocycliske forbindelser
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
US5554626A (en) * 1992-12-23 1996-09-10 Neurosearch A/S Substituted heterocyclic compounds as dopamine-reuptake inhibitors
FI96603C (fi) * 1994-12-30 1996-07-25 Joergen Bergman Uusi radioisotoopilla leimattu yhdiste, yhdistettä sisältävä seos sekä menetelmä niiden valmistamiseksi
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
ZA971525B (en) * 1996-02-22 1997-10-21 Neurosearch As Tropane derivatives, their preparation and use.
ZA99681B (en) * 1998-01-28 1999-09-27 Neurosearch As 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled or unlabelled form in diagnostic methods.
CA2285516C (en) 1999-05-12 2010-12-07 President And Fellows Of Harvard College Dopamine transporter imaging agents
DE20120708U1 (de) 2001-10-09 2002-08-01 Blundell, Paul, Sommerville, Mass. Tropan-Analoga zur Inhibierung des Monoamin-Transports
JP2007519646A (ja) * 2004-01-22 2007-07-19 ノイロサーチ アクティーゼルスカブ 体重の持続的低減のための化合物
US20080200498A1 (en) * 2005-07-12 2008-08-21 Angelo Ceci Pharmaceutical Composition For The Treatment Of Disorders Of Sexual Desire
EP1779851A1 (de) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Behandlung von Diabetes
GB0922304D0 (en) * 2009-12-22 2010-02-03 Ge Healthcare Ltd Radioiodinated compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US4179567A (en) * 1978-04-10 1979-12-18 Sterling Drug Inc. 2-Aryltropane compounds
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands

Also Published As

Publication number Publication date
ATE182794T1 (de) 1999-08-15
EP0644775A4 (de) 1994-10-19
EP0905135A2 (de) 1999-03-31
EP0905135B1 (de) 2006-09-06
EP0644775B1 (de) 1999-08-04
FI942231A7 (fi) 1994-05-13
NO941753L (no) 1994-05-10
EP0897922A2 (de) 1999-02-24
NO313097B1 (no) 2002-08-12
JP2852467B2 (ja) 1999-02-03
DE69233536D1 (de) 2005-08-25
EP0644775A1 (de) 1995-03-29
CA2123570A1 (en) 1993-05-27
DE69229744D1 (de) 1999-09-09
AU668371B2 (en) 1996-05-02
FI942231L (fi) 1994-05-13
ES2138601T3 (es) 2000-01-16
FI942231A0 (fi) 1994-05-13
NO941753D0 (no) 1994-05-10
ATE338755T1 (de) 2006-09-15
WO1993009814A1 (en) 1993-05-27
EP0905135A3 (de) 1999-04-14
CA2123570C (en) 2003-11-04
GR3031579T3 (en) 2000-01-31
DK0644775T3 (da) 2000-03-06
DE69229744T2 (de) 2000-04-27
ATE299879T1 (de) 2005-08-15
KR100251339B1 (ko) 2000-09-01
JPH07501074A (ja) 1995-02-02
EP0897922A3 (de) 1999-04-07
EP0897922B1 (de) 2005-07-20
AU3064592A (en) 1993-06-15

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Legal Events

Date Code Title Description
8332 No legal effect for de