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DE69233188D1 - Hormonanaloge mit mehreren ctp-erweiterungen - Google Patents

Hormonanaloge mit mehreren ctp-erweiterungen

Info

Publication number
DE69233188D1
DE69233188D1 DE69233188T DE69233188T DE69233188D1 DE 69233188 D1 DE69233188 D1 DE 69233188D1 DE 69233188 T DE69233188 T DE 69233188T DE 69233188 T DE69233188 T DE 69233188T DE 69233188 D1 DE69233188 D1 DE 69233188D1
Authority
DE
Germany
Prior art keywords
amino acid
ctp units
ctp
several
hormone analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233188T
Other languages
English (en)
Other versions
DE69233188T2 (de
Inventor
Irving Boime
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
St Louis University
Washington University in St Louis WUSTL
Original Assignee
St Louis University
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Louis University, Washington University in St Louis WUSTL filed Critical St Louis University
Publication of DE69233188D1 publication Critical patent/DE69233188D1/de
Application granted granted Critical
Publication of DE69233188T2 publication Critical patent/DE69233188T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69233188T 1991-10-04 1992-10-02 Hormonanaloge mit mehreren ctp-erweiterungen Expired - Lifetime DE69233188T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/771,262 US6225449B1 (en) 1991-10-04 1991-10-04 Hormone analogs with multiple CTP extensions
US771262 1991-10-04
PCT/US1992/008424 WO1993006844A1 (en) 1991-10-04 1992-10-02 Hormone analogs with multiple ctp extensions

Publications (2)

Publication Number Publication Date
DE69233188D1 true DE69233188D1 (de) 2003-10-09
DE69233188T2 DE69233188T2 (de) 2004-05-27

Family

ID=25091246

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69233188T Expired - Lifetime DE69233188T2 (de) 1991-10-04 1992-10-02 Hormonanaloge mit mehreren ctp-erweiterungen

Country Status (11)

Country Link
US (2) US6225449B1 (de)
EP (1) EP0607297B1 (de)
JP (2) JP4081137B2 (de)
KR (1) KR100281811B1 (de)
AT (1) ATE248922T1 (de)
CA (1) CA2120358A1 (de)
DE (1) DE69233188T2 (de)
ES (1) ES2204893T3 (de)
FI (1) FI941500L (de)
NO (1) NO941186D0 (de)
WO (1) WO1993006844A1 (de)

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ES2098261T3 (es) 1989-02-21 1997-05-01 Univ Washington Formas modificadas de hormonas reproductoras.
US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
FR2710845B1 (fr) * 1993-10-08 1996-03-29 Lafon Labor Composition destinée à l'immunothérapie d'un cancer sécrétant l'hCG ou des fragments d'hCG.
NZ265529A (en) * 1993-04-20 1998-01-26 Univ Washington Peptide/protein modified with insertion of complete or partial carboxy terminal peptide unit into a non critical region
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US5657411A (en) * 1995-12-15 1997-08-12 Honeywell Inc. Negative trimming of fiber optic winding
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AU750244B2 (en) 1997-09-04 2002-07-11 Gryphon Sciences Modular protein libraries and methods of preparation
JO2291B1 (en) * 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythropoietin derivatives
US20030036181A1 (en) * 2000-06-30 2003-02-20 Okkels Jens Sigurd Peptide extended glycosylated polypeptides
KR101229995B1 (ko) * 2000-12-11 2013-02-06 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
EP1342730B1 (de) * 2000-12-11 2006-03-15 Cheil Jedang Corporation Fusionsprotein mit verbesserter in vivo erythropoietinwirkung
US6987172B2 (en) * 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
ATE329930T1 (de) * 2001-10-22 2006-07-15 Applied Research Systems Fsh-zusammensetzungen mit hohem sialylierungsgrad und deren verwendung zur herstellung von arzneimitteln
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JP6392123B2 (ja) * 2011-12-20 2018-09-19 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ 糖尿病治療のためのｃｔｐ系インスリンアナローグ
CN109535245A (zh) * 2012-02-14 2019-03-29 奥普科生物制品有限公司 长效凝血因子和生产它们的方法
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US10457713B2 (en) 2012-07-30 2019-10-29 Trophogen, Inc. Glycoprotein hormone long-acting superagonists
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Also Published As

Publication number Publication date
FI941500A7 (fi) 1994-05-23
ES2204893T3 (es) 2004-05-01
EP0607297A1 (de) 1994-07-27
JP4081137B2 (ja) 2008-04-23
EP0607297A4 (en) 1995-10-25
EP0607297B1 (de) 2003-09-03
KR100281811B1 (ko) 2001-02-15
JPH07502166A (ja) 1995-03-09
NO941186L (no) 1994-03-30
WO1993006844A1 (en) 1993-04-15
AU2864892A (en) 1993-05-03
AU667489B2 (en) 1996-03-28
NO941186D0 (no) 1994-03-30
DE69233188T2 (de) 2004-05-27
ATE248922T1 (de) 2003-09-15
US5759818A (en) 1998-06-02
CA2120358A1 (en) 1993-04-15
FI941500A0 (fi) 1994-03-30
FI941500L (fi) 1994-05-23
US6225449B1 (en) 2001-05-01
JP2008073057A (ja) 2008-04-03

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