DE69301311D1 - Selbst-agglomerierendes diketopiperazin-arzneistoffabgabesystem - Google Patents

Selbst-agglomerierendes diketopiperazin-arzneistoffabgabesystem

Info

Publication number: DE69301311D1
Authority: DE; Germany
Prior art keywords: microparticles; drug delivery; diketopiperazine; stable; agglomerating
Prior art date: 1992-03-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69301311T

Other languages

English (en)

Other versions

DE69301311T2 (de

Inventor

Robert Feldstein

John Glass

Solomon S Steiner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mannkind Corp

Original Assignee

Pharmaceutical Discovery Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-11

Filing date

1993-03-11

Publication date

1996-02-22

1993-03-11 Application filed by Pharmaceutical Discovery Corp filed Critical Pharmaceutical Discovery Corp

1996-02-22 Application granted granted Critical

1996-02-22 Publication of DE69301311D1 publication Critical patent/DE69301311D1/de

1996-08-22 Publication of DE69301311T2 publication Critical patent/DE69301311T2/de

2013-03-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title abstract 4
238000012377 drug delivery Methods 0.000 title abstract 3
239000011859 microparticle Substances 0.000 abstract 5
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
230000007935 neutral effect Effects 0.000 abstract 2
102000055006 Calcitonin Human genes 0.000 abstract 1
108060001064 Calcitonin Proteins 0.000 abstract 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
229960004015 calcitonin Drugs 0.000 abstract 1
238000006074 cyclodimerization reaction Methods 0.000 abstract 1
WKGXYQFOCVYPAC-UHFFFAOYSA-N felbamate Chemical compound NC(=O)OCC(COC(N)=O)C1=CC=CC=C1 WKGXYQFOCVYPAC-UHFFFAOYSA-N 0.000 abstract 1
229960003472 felbamate Drugs 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229940126701 oral medication Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Cephalosporin Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

DE69301311T 1992-03-11 1993-03-11 Selbst-agglomerierendes diketopiperazin-arzneistoffabgabesystem Expired - Lifetime DE69301311T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/849,186 US5352461A (en)	1992-03-11	1992-03-11	Self assembling diketopiperazine drug delivery system
PCT/US1993/002245 WO1993018754A1 (en)	1992-03-11	1993-03-11	Self-assembling diketopiperazine drug delivery system

Publications (2)

Publication Number	Publication Date
DE69301311D1 true DE69301311D1 (de)	1996-02-22
DE69301311T2 DE69301311T2 (de)	1996-08-22

Family

ID=25305266

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69301311T Expired - Lifetime DE69301311T2 (de)	1992-03-11	1993-03-11	Selbst-agglomerierendes diketopiperazin-arzneistoffabgabesystem

Country Status (11)

Country	Link
US (2)	US5352461A (de)
EP (1)	EP0630236B1 (de)
JP (1)	JP2617273B2 (de)
AT (1)	ATE132744T1 (de)
AU (1)	AU680408B2 (de)
CA (1)	CA2131366C (de)
DE (1)	DE69301311T2 (de)
DK (1)	DK0630236T3 (de)
ES (1)	ES2089844T3 (de)
GR (1)	GR3019622T3 (de)
WO (1)	WO1993018754A1 (de)

Families Citing this family (209)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5578323A (en)	1992-06-15	1996-11-26	Emisphere Technologies, Inc.	Proteinoid carriers and methods for preparation and use thereof
US6221367B1 (en)	1992-06-15	2001-04-24	Emisphere Technologies, Inc.	Active agent transport systems
US5693338A (en)	1994-09-29	1997-12-02	Emisphere Technologies, Inc.	Diketopiperazine-based delivery systems
US6099856A (en)	1992-06-15	2000-08-08	Emisphere Technologies, Inc.	Active agent transport systems
US5714167A (en)	1992-06-15	1998-02-03	Emisphere Technologies, Inc.	Active agent transport systems
US5629020A (en) *	1994-04-22	1997-05-13	Emisphere Technologies, Inc.	Modified amino acids for drug delivery
US5541155A (en) *	1994-04-22	1996-07-30	Emisphere Technologies, Inc.	Acids and acid salts and their use in delivery systems
US5443841A (en)	1992-06-15	1995-08-22	Emisphere Technologies, Inc.	Proteinoid microspheres and methods for preparation and use thereof
US6331318B1 (en)	1994-09-30	2001-12-18	Emisphere Technologies Inc.	Carbon-substituted diketopiperazine delivery systems
US5352461A (en) *	1992-03-11	1994-10-04	Pharmaceutical Discovery Corporation	Self assembling diketopiperazine drug delivery system
US5811127A (en)	1992-06-15	1998-09-22	Emisphere Technologies, Inc.	Desferrioxamine oral delivery system
US6916489B2 (en) *	1992-06-15	2005-07-12	Emisphere Technologies, Inc.	Active agent transport systems
US5792451A (en)	1994-03-02	1998-08-11	Emisphere Technologies, Inc.	Oral drug delivery compositions and methods
US5401516A (en)	1992-12-21	1995-03-28	Emisphere Technologies, Inc.	Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5709861A (en)	1993-04-22	1998-01-20	Emisphere Technologies, Inc.	Compositions for the delivery of antigens
US20010003001A1 (en) *	1993-04-22	2001-06-07	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
EP0696208B1 (de)	1993-04-22	2001-08-22	Emisphere Technologies, Inc.	Orale darreichungsform
US5643957A (en)	1993-04-22	1997-07-01	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US6461643B2 (en)	1993-04-22	2002-10-08	Emisphere Technologies, Inc.	Oral drug delivery compositions and methods
US5958457A (en)	1993-04-22	1999-09-28	Emisphere Technologies, Inc.	Compositions for the delivery of antigens
US6632456B1 (en)	1993-06-24	2003-10-14	Astrazeneca Ab	Compositions for inhalation
US6794357B1 (en)	1993-06-24	2004-09-21	Astrazeneca Ab	Compositions for inhalation
US20010003739A1 (en) *	1993-06-24	2001-06-14	Astrazeneca Ab	Systemic administration of a therapeutic preparation
US5830853A (en)	1994-06-23	1998-11-03	Astra Aktiebolag	Systemic administration of a therapeutic preparation
US5466259A (en) *	1994-03-07	1995-11-14	Durette; Jean-Francois	Orbital implant and method
US6165976A (en)	1994-06-23	2000-12-26	Astra Aktiebolag	Therapeutic preparation for inhalation
US6524557B1 (en) *	1994-12-22	2003-02-25	Astrazeneca Ab	Aerosol formulations of peptides and proteins
CN1088580C (zh)	1994-12-22	2002-08-07	阿斯特拉公司	气溶胶药物制剂
US5650386A (en)	1995-03-31	1997-07-22	Emisphere Technologies, Inc.	Compositions for oral delivery of active agents
US6090958A (en)	1995-03-31	2000-07-18	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US5989539A (en)	1995-03-31	1999-11-23	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US5965121A (en)	1995-03-31	1999-10-12	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US6001347A (en)	1995-03-31	1999-12-14	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US5866536A (en)	1995-03-31	1999-02-02	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
BR9604880A (pt)	1995-03-31	1998-05-19	Emisphere Tech Inc	Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US5820881A (en)	1995-04-28	1998-10-13	Emisphere Technologies, Inc.	Microspheres of diamide-dicarboxylic acids
US6428771B1 (en) *	1995-05-15	2002-08-06	Pharmaceutical Discovery Corporation	Method for drug delivery to the pulmonary system
US5667806A (en)	1995-06-07	1997-09-16	Emisphere Technologies, Inc.	Spray drying method and apparatus
US6051258A (en)	1995-06-07	2000-04-18	Emisphere Technologies, Inc.	Proteinoid emulsions and methods for preparation and use thereof
US5750147A (en)	1995-06-07	1998-05-12	Emisphere Technologies, Inc.	Method of solubilizing and encapsulating itraconazole
US5824345A (en)	1995-06-07	1998-10-20	Emisphere Technologies, Inc.	Fragrances and flavorants
WO1997010197A1 (en)	1995-09-11	1997-03-20	Emisphere Technologies, Inc.	METHOD FOR PREPARING φ-AMINOALKANOIC ACID DERIVATIVES FROM CYCLOALKANONES
EP0874638A4 (de) *	1995-11-13	1999-07-21	Smithkline Beecham Corp	Hämoregulatorische verbindungen
SI9720025A (sl)	1996-03-29	1999-08-31	Emishphere Technologies, Inc.	Spojine in sestavki za prenos aktivne snovi
CA2258264A1 (en)	1996-06-14	1997-12-18	Emisphere Technologies, Inc.	Microencapsulated fragrances and method for preparation
WO1998021951A1 (en)	1996-11-18	1998-05-28	Emisphere Technologies, Inc.	Methods and compositions for inducing oral tolerance in mammals
US5804688A (en)	1997-02-07	1998-09-08	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US5876710A (en)	1997-02-07	1999-03-02	Emisphere Technologies Inc.	Compounds and compositions for delivering active agents
US6313088B1 (en)	1997-02-07	2001-11-06	Emisphere Technologies, Inc.	8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US6358504B1 (en)	1997-02-07	2002-03-19	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US6060513A (en)	1997-02-07	2000-05-09	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US5879681A (en)	1997-02-07	1999-03-09	Emisphere Technolgies Inc.	Compounds and compositions for delivering active agents
US5990166A (en)	1997-02-07	1999-11-23	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US5939381A (en)	1997-02-07	1999-08-17	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US5863944A (en)	1997-04-30	1999-01-26	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US5962710A (en)	1997-05-09	1999-10-05	Emisphere Technologies, Inc.	Method of preparing salicyloylamino acids
US5891237A (en) *	1997-10-08	1999-04-06	Millennium Inorganic Chemicals, Ltd.	Production of free flowing spheres using partially neutralized fatty acid
WO2000006534A1 (en)	1998-07-27	2000-02-10	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
US6440929B1 (en)	1998-07-27	2002-08-27	Emisphere Technologies, Inc.	Pulmonary delivery of active agents
US6991798B1 (en)	1998-08-07	2006-01-31	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
NZ509410A (en) *	1998-08-07	2003-08-29	Emisphere Tech Inc	Compounds and compositions for delivering active agents
JP2002534363A (ja)	1999-01-08	2002-10-15	エミスフェアー・テクノロジーズ・インク	ポリマー性デリバリー剤及びデリバリー剤化合物
WO2000050050A1 (en) *	1999-02-23	2000-08-31	Isis Pharmaceuticals, Inc.	Multiparticulate formulation
JP4637365B2 (ja)	1999-02-26	2011-02-23	エミスフェアー・テクノロジーズ・インク	活性剤デリバリーのための化合物及び組成物
ATE288415T1 (de) *	1999-04-05	2005-02-15	Emisphere Tech Inc	Dinatrium-salze, monohydrate und ethanol-solvate
US9006175B2 (en) *	1999-06-29	2015-04-14	Mannkind Corporation	Potentiation of glucose elimination
AU2012201760B2 (en) *	1999-06-29	2015-04-16	Mannkind Corporation	Purification and stabilization of peptide and protein pharmaceutical agents
JP4713798B2 (ja) *	1999-06-29	2011-06-29	マンカインドコーポレイション	ペプチドおよびタンパク質の薬学的因子の精製および安定化
US7129274B1 (en)	1999-11-05	2006-10-31	Emisphere Technologies Inc.	Phenoxy carboxylic acid compounds and compositions for delivering active agents
US7279597B1 (en)	1999-11-05	2007-10-09	Emisphere Technologies, Inc.	Phenyl amine carboxylic acid compounds and compositions for delivering active agents
EP1231905B1 (de)	1999-11-15	2009-04-08	BioCure, Inc.	Auf äussere bedingungen ansprechende polymere hohle partikel
EP1237872B1 (de) *	1999-12-16	2008-02-27	Emisphere Technologies, Inc.	Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe
US7833549B2 (en) *	2000-01-19	2010-11-16	Mannkind Corporation	Dry powder formulations of antihistamine for nasal administration
US6808707B2 (en) *	2000-02-04	2004-10-26	Matrix Design	Wound healing compositions and methods using tropoelastin and lysyl oxidase
DE10019879A1 (de) *	2000-04-20	2001-10-25	Degussa	Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
US6537968B1 (en) *	2000-07-24	2003-03-25	Alphamed Pharmaceuticals Corp	Treatment of lupus erythematosus
US6555543B2 (en)	2000-08-04	2003-04-29	Dmi Biosciences, Inc.	Method of using diketopiperazines and composition containing them
WO2002062797A2 (en) *	2000-12-29	2002-08-15	Celltech R & D, Inc.	Pharmaceutical uses and synthesis of diketopiperazines
US20030225300A1 (en) *	2001-04-19	2003-12-04	Emisphere Technologies Inc.	Compounds and compositions for delivering active agents
WO2003061578A2 (en) *	2002-01-18	2003-07-31	Mannkind Corporation	Compositions for treatment or prevention of bioterrorism
JP4681231B2 (ja) *	2002-03-20	2011-05-11	マンカインドコーポレイション	吸入装置
US7053034B2 (en) *	2002-04-10	2006-05-30	Salvona, Llc	Targeted controlled delivery compositions activated by changes in pH or salt concentration
ATE357217T1 (de) *	2002-04-23	2007-04-15	Teva Pharma	Pharmazeutische zusammensetzung enthaltend lamotrigine-partikel mit definierter morphologie
DE60326709D1 (de) *	2002-04-29	2009-04-30	Supernus Pharmaceuticals Inc	Pharmazeutische formulierungen mit verbesserter bioverfügbarkeit
US20080260838A1 (en) *	2003-08-01	2008-10-23	Mannkind Corporation	Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
WO2004012672A2 (en) *	2002-08-01	2004-02-12	Mannkind Corporation	Cell transport compositions and uses thereof
US8377869B2 (en)	2007-10-24	2013-02-19	Mannkind Corporation	Method of preventing adverse effects by GLP-1
US20040038865A1 (en) *	2002-08-01	2004-02-26	Mannkind Corporation	Cell transport compositions and uses thereof
US20040171518A1 (en) *	2003-02-27	2004-09-02	Medtronic Minimed, Inc.	Compounds for protein stabilization and methods for their use
US20040224024A1 (en) *	2003-04-23	2004-11-11	Massachusetts Institute Of Technology	Controlled drug release formulations containing polyion complexes
KR20120101164A (ko)	2003-05-15	2012-09-12	디엠아이 바이오사이언시스, 인크	Ｔ-세포 매개성 질환의 치료 방법
EP1651035A2 (de) *	2003-07-31	2006-05-03	3M Innovative Properties Company	Verkapselungs- und kontrollierte-freisetzungs-zusammensetzungen
US8921311B2 (en)	2003-08-01	2014-12-30	Mannkind Corporation	Method for treating hyperglycemia
US8133680B2 (en) *	2003-09-23	2012-03-13	Wisconsin Alumni Research Foundation	Using liquid crystals to detect affinity microcontact printed biomolecules
US7795007B2 (en)	2003-09-23	2010-09-14	Wisconsin Alumni Research Foundation	Detection of post-translationally modified peptides with liquid crystals
US7338171B2 (en) *	2003-10-27	2008-03-04	Jen-Chuen Hsieh	Method and apparatus for visual drive control
EP1708738B1 (de)	2004-01-12	2016-05-04	MannKind Corporation	Verfahren zur verringerung des proinsulinspiegels im serum bei zuckerkranken mit type 2 diabetes
US20070027063A1 (en) *	2004-01-12	2007-02-01	Mannkind Corporation	Method of preserving the function of insulin-producing cells
JP2005209106A (ja) *	2004-01-26	2005-08-04	Nec Corp	携帯通信端末、受信メール管理方法、プログラムおよび記録媒体
US20080096800A1 (en) *	2004-03-12	2008-04-24	Biodel, Inc.	Rapid mucosal gel or film insulin compositions
US7279457B2 (en) *	2004-03-12	2007-10-09	Biodel, Inc.	Rapid acting drug delivery compositions
US20080090753A1 (en)	2004-03-12	2008-04-17	Biodel, Inc.	Rapid Acting Injectable Insulin Compositions
US20080085298A1 (en) *	2004-03-12	2008-04-10	Biodel, Inc.	Rapid Mucosal Gel or Film Insulin Compositions
US20080248999A1 (en) *	2007-04-04	2008-10-09	Biodel Inc.	Amylin formulations
DE602005024413D1 (de)	2004-08-20	2010-12-09	Mannkind Corp	Katalyse der diketopiperazinsynthese
ES2543007T3 (es) *	2004-08-23	2015-08-13	Mannkind Corporation	Micropartículas que comprenden sales de dicetopiperazina para la administración de fármacos
WO2006023944A2 (en) *	2004-08-23	2006-03-02	Mannkind Corporation	Pulmonary delivery of inhibitors of phosphodiesterase type 5
WO2006086107A2 (en) *	2005-01-10	2006-08-17	Mannkind Corporation	Methods and compositions for minimizing accrual of inhalable insulin in the lungs
AU2006259415B2 (en)	2005-06-15	2012-08-30	Massachusetts Institute Of Technology	Amine-containing lipids and uses thereof
US20070004036A1 (en) *	2005-07-01	2007-01-04	Rodolfo Faudoa	Methods and compositions for keratinocyte culture
US20070003541A1 (en) *	2005-07-01	2007-01-04	Rodolfo Faudoa	Methods and compositions for therapeutics
US20070128685A1 (en) *	2005-07-01	2007-06-07	Rodolfo Faudoa	Methods and compositions for cell culture
ES2640282T3 (es) *	2005-09-14	2017-11-02	Mannkind Corporation	Método de formulación de fármacos basado en el aumento de la afinidad de superficies de micropartículas cristalinas para agentes activos
US20070086952A1 (en) *	2005-09-29	2007-04-19	Biodel, Inc.	Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
US8084420B2 (en)	2005-09-29	2011-12-27	Biodel Inc.	Rapid acting and long acting insulin combination formulations
US7713929B2 (en)	2006-04-12	2010-05-11	Biodel Inc.	Rapid acting and long acting insulin combination formulations
ATE457006T1 (de)	2005-11-21	2010-02-15	Mannkind Corp	Gerät und verfahren zur pulverausgabe und messung
EP1986679B1 (de)	2006-02-22	2017-10-25	MannKind Corporation	Verfahren zur verbesserung der pharmazeutischen eigenschaften von mikropartikeln mit diketopiperazin und einem wirkstoff
CA2649109A1 (en)	2006-04-12	2007-10-25	Biodel, Inc.	Rapid acting and long acting insulin combination formulations
AU2007238000B2 (en) *	2006-04-14	2013-01-17	Mannkind Corporation	Glucagon-like peptide 1(GLP-1) pharmaceutical formulations
WO2008014613A1 (en) *	2006-08-04	2008-02-07	Manus Pharmaceuticals (Canada) Ltd.	Multifunctional bioactive compounds
US10669383B2 (en)	2006-10-31	2020-06-02	Evonik Corporation	Spheronized polymer particles
US8785396B2 (en)	2007-10-24	2014-07-22	Mannkind Corporation	Method and composition for treating migraines
RU2467741C2 (ru) *	2007-10-24	2012-11-27	Маннкайнд Корпорейшн	Доставка активных веществ
WO2009089181A1 (en) *	2008-01-04	2009-07-16	Blodel, Inc.	Insulin formulations for insulin release as a function of tissue glucose levels
EP2300011A4 (de)	2008-05-27	2012-06-20	Dmi Life Sciences Inc	Therapeutische verfahren und verbindungen
US8485180B2 (en)	2008-06-13	2013-07-16	Mannkind Corporation	Dry powder drug delivery system
CN106039494B (zh)	2008-06-13	2019-12-24	曼金德公司	干粉吸入器和用于药物输送的系统
CN102065942B (zh)	2008-06-20	2013-12-11	曼金德公司	用于对吸入工作进行实时描绘的交互式设备和方法
CN102143890B (zh)	2008-08-05	2013-08-28	曼康公司	改进的粉末分配器模块及粉末分配器组件
TWI532497B (zh) *	2008-08-11	2016-05-11	曼凱公司	超快起作用胰島素之用途
CA2742954C (en)	2008-11-07	2018-07-10	Massachusetts Institute Of Technology	Aminoalcohol lipidoids and uses thereof
CA2748490C (en)	2008-12-29	2016-10-04	Mannkind Corporation	Substituted diketopiperazine analogs for use as drug delivery agents
US8314106B2 (en)	2008-12-29	2012-11-20	Mannkind Corporation	Substituted diketopiperazine analogs for use as drug delivery agents
EP2853268A1 (de)	2009-01-08	2015-04-01	Mannkind Corporation	Behandlung von Hyperglykämie mit GLP-1
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
MX2011009251A (es)	2009-03-04	2011-11-18	Mannkind Corp	Sistema mejorado de suministro de farmaco en polvo seco.
MX2011009512A (es)	2009-03-11	2011-11-29	Mannkind Corp	Aparato, sistema y metodo para medir la resistencia de un inhalador.
JP5859432B2 (ja) *	2009-06-12	2016-02-10	マンカインドコーポレイション	規定された含量の異性体を有するジケトピペラジン微粒子
MY157166A (en) *	2009-06-12	2016-05-13	Mankind Corp	Diketopiperazine microparticles with defined specific surface areas
EP2482840A4 (de)	2009-08-07	2013-06-26	Mannkind Corp	Val (8) glp-1-zusammensetzung und verfahren zur behandlung von reizmagen und/oder reizdarmsyndrom
CA2979182C (en) *	2009-11-02	2021-03-02	Mannkind Corporation	Reactor for producing pharmaceutical particles in a precipitation process
SG10201406835XA (en)	2009-11-02	2014-11-27	Mannkind Corp	Apparatus And Method For Cryogranulating A Pharmaceutical Composition
US9016147B2 (en)	2009-11-03	2015-04-28	Mannkind Corporation	Apparatus and method for simulating inhalation efforts
ES2713852T3 (es)	2009-12-01	2019-05-24	Translate Bio Inc	Derivado de esteroides para la administración de ARNm en enfermedades genéticas humanas
US9140651B2 (en)	2010-05-07	2015-09-22	Mannkind Corporation	Determining percent solids in suspension using raman spectroscopy
AU2011271097B2 (en)	2010-06-21	2014-11-27	Mannkind Corporation	Dry powder drug delivery system and methods
US9193827B2 (en)	2010-08-26	2015-11-24	Massachusetts Institute Of Technology	Poly(beta-amino alcohols), their preparation, and uses thereof
US8507496B2 (en)	2010-09-07	2013-08-13	Dmi Acquisition Corp.	Treatment of diseases
EP2637657B1 (de)	2010-11-09	2019-05-22	MannKind Corporation	Zusammensetzung mit einem serotoninrezeptoragonist und einem diketopiperazin zur behandlung von migräne
WO2012109256A2 (en)	2011-02-10	2012-08-16	Mannkind, Corp	Formation of n-protected bis-3,6-(4-aminoalkyl) -2,5,diketopiperazine
EP2691443B1 (de)	2011-03-28	2021-02-17	Massachusetts Institute of Technology	Konjugierte lipomers und ihre verwendung
SG194034A1 (en)	2011-04-01	2013-11-29	Mannkind Corp	Blister package for pharmaceutical cartridges
US9642888B2 (en)	2011-04-12	2017-05-09	Moerae Matrix, Inc.	Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
US9890200B2 (en)	2011-04-12	2018-02-13	Moerae Matrix, Inc.	Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
US20140120162A1 (en) *	2011-06-06	2014-05-01	Perosphere Inc.	Bioadhesive Drug Delivery Compositions
KR102128248B1 (ko)	2011-06-08	2020-07-01	샤이어 휴먼 지네틱 테라피즈 인크.	Mrna 전달을 위한 지질 나노입자 조성물 및 방법
WO2012174472A1 (en)	2011-06-17	2012-12-20	Mannkind Corporation	High capacity diketopiperazine microparticles
SG10201608087WA (en)	2011-10-10	2016-11-29	Ampio Pharmaceuticals Inc	Implantable medical devices with increased immune tolerance, and methods for making and implanting
PL2766029T3 (pl)	2011-10-10	2020-08-24	Ampio Pharmaceuticals, Inc.	Leczenie choroby zwyrodnieniowej stawów
KR20140095483A (ko)	2011-10-24	2014-08-01	맨카인드 코포레이션	통증을 치료하기 위한 방법 및 조성물
KR102272498B1 (ko)	2011-10-27	2021-07-06	메사추세츠 인스티튜트 오브 테크놀로지	약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체
EP2771007B1 (de)	2011-10-28	2018-04-04	Ampio Pharmaceuticals, Inc.	Behandlung von rhinitis
WO2013114373A1 (en)	2012-02-01	2013-08-08	Protalix Ltd.	Inhalable liquid formulations of dnase i
AU2013216832B2 (en)	2012-02-09	2016-09-22	Novus International Inc.	Heteroatom containing cyclic dimers
WO2013142969A1 (en) *	2012-03-28	2013-10-03	Jian Ping Gao	Urethanes and ureas and processes
IN2014DN09774A (de) *	2012-04-27	2015-07-31	Mannkind Corp
EP3536787A1 (de)	2012-06-08	2019-09-11	Translate Bio, Inc.	Nukleaseresistente polynukleotide und verwendungen davon
CA2878457C (en)	2012-07-12	2021-01-19	Mannkind Corporation	Dry powder drug delivery systems and methods
CN104754956B (zh)	2012-07-12	2017-11-17	诺华丝国际股份有限公司	用于保护生物活性剂的基质和层组合物
WO2014028487A1 (en)	2012-08-13	2014-02-20	Massachusetts Institute Of Technology	Amine-containing lipidoids and uses thereof
EP2911690A1 (de)	2012-10-26	2015-09-02	MannKind Corporation	Inhalierbare influenza-impfstoffzusammensetzungen und verfahren
US9957499B2 (en)	2013-03-14	2018-05-01	Translate Bio, Inc.	Methods for purification of messenger RNA
UA117008C2 (uk)	2013-03-14	2018-06-11	Шир Хьюман Дженетік Терапіс, Інк.	IN VITRO ТРАНСКРИБОВАНА мРНК ТА КОМПОЗИЦІЯ, ЩО ЇЇ МІСТИТЬ, ДЛЯ ЗАСТОСУВАННЯ В ЛІКУВАННІ МУКОВІСЦИДОЗУ В ССАВЦЯ
NZ712630A (en)	2013-03-15	2021-07-30	Ampio Pharmaceuticals Inc	Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
SG10201708090TA (en)	2013-03-15	2017-11-29	Mannkind Corp	Microcrystalline diketopiperazine compositions and methods
WO2014179562A1 (en)	2013-05-01	2014-11-06	Massachusetts Institute Of Technology	1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
CA2918369C (en)	2013-07-18	2021-06-29	Mannkind Corporation	Heat-stable dry powder pharmaceutical compositions and methods
WO2015021064A1 (en)	2013-08-05	2015-02-12	Mannkind Corporation	Insufflation apparatus and methods
EP3060257B1 (de)	2013-10-22	2021-02-24	Translate Bio, Inc.	Lipidzusammensetzungen zur verabreichung von mrna
CN106413811A (zh)	2013-10-22	2017-02-15	夏尔人类遗传性治疗公司	精氨基琥珀酸合成酶缺乏症的mrna疗法
EA034103B1 (ru)	2013-10-22	2019-12-27	Транслейт Био, Инк.	СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
WO2015148905A1 (en)	2014-03-28	2015-10-01	Mannkind Corporation	Use of ultrarapid acting insulin
US10336788B2 (en)	2014-04-17	2019-07-02	Moerae Matrix, Inc.	Inhibition of cardiac fibrosis in myocardial infarction
WO2015164773A1 (en)	2014-04-25	2015-10-29	Shire Human Genetic Therapies, Inc.	Methods for purification of messenger rna
CN106659731A (zh)	2014-05-30	2017-05-10	夏尔人类遗传性治疗公司	用于递送核酸的可生物降解脂质
EA033966B1 (ru)	2014-06-24	2019-12-13	Транслейт Био, Инк.	Стереохимически обогащенные композиции для доставки нуклеиновых кислот
EP3164379A1 (de)	2014-07-02	2017-05-10	Massachusetts Institute of Technology	Lipidoide aus polyaminfettsäure und verwendungen davon
CN106604915A (zh)	2014-08-18	2017-04-26	安皮奥制药股份有限公司	关节病症的治疗
US10561806B2 (en)	2014-10-02	2020-02-18	Mannkind Corporation	Mouthpiece cover for an inhaler
US20170304459A1 (en)	2014-10-10	2017-10-26	Alnylam Pharmaceuticals, Inc.	Methods and compositions for inhalation delivery of conjugated oligonucleotide
JP2018501201A (ja)	2014-11-17	2018-01-18	モイライマトリックスインコーポレイテッド	異常な線維芽細胞増殖および細胞外マトリックス沈着を特徴とする疾患、状態、またはプロセスを予防または処置するための組成物および方法
US9999655B2 (en)	2015-03-12	2018-06-19	Moerae Matrix, Inc.	Use of MKS inhibitor peptide-containing compositions for treating non-small cell lung cancer with same
CN104961687B (zh) *	2015-06-03	2017-07-25	苏州维泰生物技术有限公司	1,2‑二嗪衍生物及其制剂、用途
CN113968823A (zh)	2015-06-19	2022-01-25	麻省理工学院	烯基取代的2,5-哌嗪二酮和其在组合物中用于向个体或细胞递送药剂的用途
HK1246669A1 (zh)	2015-06-22	2018-09-14	Ampio Pharmaceuticals, Inc.	人血清白蛋白低分子量组分在疾病治疗中的应用
CA3199504A1 (en) *	2016-01-29	2017-08-03	Mannkind Corporation	Dry powder inhaler
TW201809049A (zh)	2016-03-31	2018-03-16	盧伯利索先進材料有限公司	生物可分解及／或生物可吸收的熱塑性聚胺甲酸酯
AU2018224326B2 (en)	2017-02-27	2024-01-04	Translate Bio, Inc.	Novel codon-optimized CFTR mRNA
EP3624824B1 (de)	2017-05-16	2024-07-10	Translate Bio, Inc.	Codonoptimierter mrna, die cftr codiert, zur verwendung in der behandlung von zystischer fibrose
US10584306B2 (en)	2017-08-11	2020-03-10	Board Of Regents Of The University Of Oklahoma	Surfactant microemulsions
US20200230066A1 (en) *	2017-10-06	2020-07-23	The Regents Of The University Of California	Self-Assembled Microcapsules for Optically Controlled Cargo Encapsulation and Release
CA3102967A1 (en) *	2018-06-07	2019-12-12	Mannkind Corporation	Composition and method for inhalation
AU2019325702A1 (en)	2018-08-24	2021-02-25	Translate Bio, Inc.	Methods for purification of messenger RNA
WO2020106946A1 (en)	2018-11-21	2020-05-28	Translate Bio, Inc.	TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR
EP4031111A2 (de) *	2019-09-17	2022-07-27	Cass Pharmaceuticals, Inc.	Subkutan injizierbare insulinformulierungen und verfahren zur verabreichung
CN113527217B (zh) *	2020-04-21	2025-05-23	上海惠永药物研究有限公司	一种二酮基哌嗪类化合物及其应用
CN115991678B (zh) *	2021-10-20	2025-05-23	上海惠永药物研究有限公司	一种二酮基哌嗪类化合物、制备方法及其应用
CN118978722B (zh) *	2024-10-22	2025-02-18	上海昊海生物科技股份有限公司	一种高黏弹性交联生物多糖凝胶及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1155036A (en) *	1966-07-08	1969-06-11	Ethan Allan Brown	Injectionable Substance
GB1255805A (en) *	1967-12-16	1971-12-01	Albert Ag Chem Werke	Improvements in delayed release pharmaceutical preparations and stabilisation of vitamins
GB1377074A (en) *	1971-07-13	1974-12-11	Beecham Group Ltd	Process for preparing injectable compositions
US4400330A (en) *	1982-07-29	1983-08-23	Stauffer Chemical Company	Method for preparation of N-phosphonomethylglycine
US4694082A (en) *	1985-09-23	1987-09-15	Monsanto Company	Compound 1,4-diisopropyl-2,5-diketopiperazine
NL8720442A (nl) *	1986-08-18	1989-04-03	Clinical Technologies Ass	Afgeefsystemen voor farmacologische agentia.
US5075109A (en) *	1986-10-24	1991-12-24	Southern Research Institute	Method of potentiating an immune response
US5057317A (en) *	1987-03-24	1991-10-15	Chugai Seiyaku Kabushiki Kaisha	Slow-release pharmaceutical agent
JP2827287B2 (ja) *	1988-07-05	1998-11-25	武田薬品工業株式会社	水溶性薬物含有徐放型マイクロカプセル
US4976968A (en) *	1989-02-24	1990-12-11	Clinical Technologies Associates, Inc.	Anhydrous delivery systems for pharmacological agents
US4983402A (en) *	1989-02-24	1991-01-08	Clinical Technologies Associates, Inc.	Orally administerable ANF
JP2571874B2 (ja) *	1989-11-06	1997-01-16	アルカーメスコントロールドセラピューティクス，インコーポレイテッド	タンパク質マイクロスフェア組成物
US5352461A (en) *	1992-03-11	1994-10-04	Pharmaceutical Discovery Corporation	Self assembling diketopiperazine drug delivery system

1992
- 1992-03-11 US US07/849,186 patent/US5352461A/en not_active Expired - Lifetime
1993
- 1993-03-11 CA CA002131366A patent/CA2131366C/en not_active Expired - Lifetime
- 1993-03-11 DK DK93920574.6T patent/DK0630236T3/da active
- 1993-03-11 WO PCT/US1993/002245 patent/WO1993018754A1/en active IP Right Grant
- 1993-03-11 DE DE69301311T patent/DE69301311T2/de not_active Expired - Lifetime
- 1993-03-11 AU AU38044/93A patent/AU680408B2/en not_active Expired
- 1993-03-11 EP EP93920574A patent/EP0630236B1/de not_active Expired - Lifetime
- 1993-03-11 ES ES93920574T patent/ES2089844T3/es not_active Expired - Lifetime
- 1993-03-11 JP JP5516624A patent/JP2617273B2/ja not_active Expired - Lifetime
- 1993-03-11 AT AT93920574T patent/ATE132744T1/de active
1994
- 1994-09-01 US US08/299,842 patent/US5503852A/en not_active Expired - Lifetime
1996
- 1996-04-10 GR GR960401019T patent/GR3019622T3/el unknown

Also Published As

Publication number	Publication date
ES2089844T3 (es)	1996-10-01
WO1993018754A1 (en)	1993-09-30
EP0630236B1 (de)	1996-01-10
DE69301311T2 (de)	1996-08-22
GR3019622T3 (en)	1996-07-31
JP2617273B2 (ja)	1997-06-04
AU3804493A (en)	1993-10-21
US5503852A (en)	1996-04-02
DK0630236T3 (da)	1996-06-03
CA2131366A1 (en)	1993-09-30
JPH07506818A (ja)	1995-07-27
ATE132744T1 (de)	1996-01-15
EP0630236A1 (de)	1994-12-28
US5352461A (en)	1994-10-04
CA2131366C (en)	2003-09-23
AU680408B2 (en)	1997-07-31

Publication	Publication Date	Title
ATE132744T1 (de)	1996-01-15	Selbst-agglomerierendes diketopiperazin- arzneistoffabgabesystem
ID28160A (id)	2001-05-10	Sistem pengobatan untuk pemberian fenilasetilglutamina, fenilasetilisoglutamina dan/atau fenilasetat.
ES2137948T3 (es)	2000-01-01	Sistema avanzado de administracion de medicamentos y metodo de tratamiento de trastornos psiquiatricos, neurologicos y otros con carbamacepina.
DE69721489D1 (de)	2003-06-05	Herstellungsverfahren von löslichen verabreichungssystemen unter verwendung von flüchtigen salzen
ATE150469T1 (de)	1997-04-15	Mitogenfreie substanz, deren herstellung sowie verwendung
DE69519670D1 (de)	2001-01-25	Mikropartikel mit abgabesystem
BR9910251A (pt)	2001-01-02	Estimulação hematopoiética
DK0814782T3 (da)	2002-12-16	Farmaceutisk præparat stabiliseret med et basisk middel
NO20001042D0 (no)	2000-03-01	Oftalmiske preparater med forsinket frigivelse inneholdende vannoppløselige medikamenter
IT1200589B (it)	1989-01-27	Derivati naturali attivita farmagologica
ATE83383T1 (de)	1993-01-15	Hochmolekulare prodrogenderivate von entzuendungshemmenden arzneimitteln.
EP0414007A3 (en)	1991-03-20	A novel arginine deiminase, its manufacturing method and an anti-cancer agent containing this enzyme as an effective ingredient
MY115211A (en)	2003-04-30	Novel amino acid derivatives, their preparation and use
YU48420B (sh)	1998-07-10	Postupak za dobijanje biološki razgradljivih mikročestica sa dugotrajnim delovanjem
KR910001041A (ko)	1991-01-30	지효성의 히루딘 유도체
KR850005271A (ko)	1985-08-24	폴리카프로락톤 매트릭스로 이루어진 경구용 약제의 제조방법
EP0998941A4 (de)	2004-05-12	Arzneimittel, die als wirksubstanz midkin oder dessen inhibitoren enthalten
ES2153842T3 (es)	2001-03-16	Derivados de 3-oxo-pirido(1,2-a-)bencimidazol-4-carboxilo y de 4-oxo-azepino(1,2-a)bencimidazol-5-carboxilo utiles en el tratamiento de enfermedades del sistema nervioso central.
HUP9701284A2 (hu)	1999-03-29	2,3-Benzodiazepin-származékok felhasználása az endogén opioid rendszerrel összefüggő betegségek és állapotok kezelésére, és megelőzésére alkalmas gyógyászati készítmények előállítására
DE69016087D1 (de)	1995-03-02	Stabile Lösungen von Rebeccamycinderivaten sowie deren Herstellung.
MD586C2 (ro)	1997-03-31	Substanţă medicamentoasă cu acţiune antihipotensivă "Difetur"
ES2118248T3 (es)	1998-09-16	Esteres y amidas de 9-cloro-prostaglandina y su empleo para preparar medicamentos.
HRP20020332B1 (hr)	2011-02-28	Oralne otopine koje sadrže galantamin i sladilo
ES2146200T3 (es)	2000-08-01	Medicamentos inducidos peritonealmente.
ES2017935B3 (es)	1991-03-16	Derivado del acido 4-metoxi-isoftalico que tiene una actividad farmacologica en las afecciones tromboembolicas, y un procedimiento para su preparacion.

Legal Events

Date	Code	Title	Description
1997-02-13	8364	No opposition during term of opposition
2004-12-23	8327	Change in the person/name/address of the patent owner	Owner name: MANNKIND CORP. (N.D.GES.D. STAATES DELAWARE), DANB
2006-11-09	8327	Change in the person/name/address of the patent owner	Owner name: MANNKIND CORP., VALENCIA, CALIF., US