DE69314613D1 - Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten - Google Patents

Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten

Info

Publication number: DE69314613D1
Authority: DE; Germany
Prior art keywords: agent; compounds; metal atoms; diagnostic agents; agents containing
Prior art date: 1992-07-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69314613T

Other languages

English (en)

Other versions

DE69314613T2 (de

DE69314613T3 (de

Inventor

Fumio Mori

Tadashi Okano

Kazuki Murakami

Masakazu Shintome

Hiromichi Mukai

Ikuko Miyagi

Takashi Imagawa

Shogen Kindaichi

Taro Marukawa

Takahiro Kozuka

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mitsubishi Tanabe Pharma Corp

Original Assignee

Green Cross Corp Japan

Green Cross Corp Korea

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-03

Filing date

1993-03-22

Publication date

1997-11-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16423568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69314613(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-07-03 Priority claimed from JP4200392A external-priority patent/JP2807852B2/ja

1993-03-22 Application filed by Green Cross Corp Japan, Green Cross Corp Korea filed Critical Green Cross Corp Japan

1997-11-20 Application granted granted Critical

1997-11-20 Publication of DE69314613D1 publication Critical patent/DE69314613D1/de

1998-05-14 Publication of DE69314613T2 publication Critical patent/DE69314613T2/de

2002-07-04 Publication of DE69314613T3 publication Critical patent/DE69314613T3/de

2013-03-23 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Radiology & Medical Imaging (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69314613T 1992-07-03 1993-03-22 Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten Expired - Fee Related DE69314613T3 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP4200392A JP2807852B2 (ja)	1991-07-18	1992-07-03	新規キレート化剤、該キレート化剤と金属原子との錯化合物及びそれを含む診断剤
PCT/JP1993/000331 WO1994001393A1 (fr)	1992-07-03	1993-03-22	Nouveau chelateur, complexe compose dudit chelateur et d'un atome metallique, et agent diagnostique renfermant ledit complexe

Publications (3)

Publication Number	Publication Date
DE69314613D1 true DE69314613D1 (de)	1997-11-20
DE69314613T2 DE69314613T2 (de)	1998-05-14
DE69314613T3 DE69314613T3 (de)	2002-07-04

Family

ID=16423568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69314613T Expired - Fee Related DE69314613T3 (de)	1992-07-03	1993-03-22	Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten

Country Status (7)

Country	Link
US (2)	US5453264A (de)
EP (1)	EP0603403B2 (de)
CA (1)	CA2116867C (de)
DE (1)	DE69314613T3 (de)
DK (1)	DK0603403T4 (de)
ES (1)	ES2108269T5 (de)
WO (1)	WO1994001393A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5843399A (en) *	1990-04-06	1998-12-01	Schering Aktiengesellschaft	DTPA monoamides for MRI
DE4011684A1 (de) *	1990-04-06	1991-10-10	Schering Ag	Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5807535A (en) *	1992-07-31	1998-09-15	Australian Nuclear Science & Technology Organisation	Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
EP0664713B1 (de) *	1992-10-14	2000-01-19	Nycomed Imaging As	Therapeutische und diagnostische bilderzeugungzusammensetzung und verfahren zur herstellung
DE19507820A1 (de) *	1995-02-21	1996-08-22	Schering Ag	Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
US5660815A (en) *	1995-04-28	1997-08-26	Molecular Biosystems, Inc.	Water soluble fluorinated fatty acid sulfonate derivatives useful as magnetic resonance imaging agents
JP2759627B2 (ja) *	1995-07-21	1998-05-28	東北大学長	非エステル結合性ｄｔｐａ誘導体およびその製造方法
US6403055B1 (en)	1996-08-02	2002-06-11	Dibra S.P.A.	Diagnostic imaging contrast agent with improved in serum relaxivity
US6458337B1 (en)	1996-08-02	2002-10-01	Dibra S.P.A	Diagnostic imaging contrast agent with improved in serum relaxivity
IT1290417B1 (it) *	1996-08-02	1998-12-03	Bracco Spa	Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed
US5888476A (en) *	1996-11-13	1999-03-30	Mallinckrodt Medical, Inc.	Magnetic resonance blood pool agents
US6005083A (en) *	1997-03-28	1999-12-21	Neorx Corporation	Bridged aromatic substituted amine ligands with donor atoms
DE19744004C1 (de) *	1997-09-26	1999-07-22	Schering Ag	Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en)	1997-09-26	2002-12-17	Schering Aktiengesellschaft	Lipophilic metal complexes for necrosis and infarction imaging
US6462034B1 (en)	1998-04-03	2002-10-08	Theravance, Inc.	Local anesthetic compounds and uses
PE20000354A1 (es)	1998-04-03	2000-05-20	Advanced Medicine Inc	Nuevos compuestos y usos anestesicos locales
DE10105014C2 (de) *	2001-01-26	2003-03-27	Schering Ag	Neues Verfahren zur Herstellung von Monoamiden der DTPA
US6677483B2 (en) *	2001-01-26	2004-01-13	Schering Ag	Process for the production of monoamides of DTPA
US7674902B2 (en) *	2004-08-26	2010-03-09	Mallinckrodt Inc.	Luminescent metal complexes for monitoring renal function
CN100439468C (zh) *	2005-12-16	2008-12-03	湖州星星研磨有限公司	一种抛磨块

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH569405A5 (en) †	1972-07-11	1975-11-28	Ciba Geigy Ag	Combatting metal deficiency in biological systems - with metal chelates of ethylene diamine tetraacetic acid diamide derivs
DE2511891A1 (de) †	1975-03-19	1976-10-07	Gruenenthal Chemie	Neue derivate des 2,6-dioxopiperazins, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel sowie verfahren zu deren herstellung
DE3927444A1 (de) *	1989-08-16	1991-02-28	Schering Ag	Verwendung von amid-komplexverbindungen
DE4011684A1 (de) *	1990-04-06	1991-10-10	Schering Ag	Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
JP2776953B2 (ja) *	1990-04-10	1998-07-16	日本メジフィジックス株式会社	多官能性金属キレート化合物とその用途
GB9027922D0 (en) †	1990-12-21	1991-02-13	Nycomed As	Compounds
JP2807852B2 (ja) *	1991-07-18	1998-10-08	株式会社ミドリ十字	新規キレート化剤、該キレート化剤と金属原子との錯化合物及びそれを含む診断剤
JPH05186372A (ja) *	1991-07-18	1993-07-27	Green Cross Corp:The	脂肪乳剤及びｍｒｉ診断用造影剤
EP0598837A4 (en) *	1991-08-09	1994-07-13	Univ California	Amino acid, ester and/or catechol contrast agents for mri.
JPH09211232A (ja) *	1996-02-06	1997-08-15	Fine Rubber Kenkyusho:Kk	導光板および照明装置
JPH09303351A (ja) *	1996-05-13	1997-11-25	Toa Corp	機器取付装置

1993
- 1993-03-22 EP EP93906798A patent/EP0603403B2/de not_active Expired - Lifetime
- 1993-03-22 ES ES93906798T patent/ES2108269T5/es not_active Expired - Lifetime
- 1993-03-22 DE DE69314613T patent/DE69314613T3/de not_active Expired - Fee Related
- 1993-03-22 DK DK93906798T patent/DK0603403T4/da active
- 1993-03-22 WO PCT/JP1993/000331 patent/WO1994001393A1/ja not_active Ceased
- 1993-03-22 CA CA002116867A patent/CA2116867C/en not_active Expired - Fee Related
1994
- 1994-03-03 US US08/204,164 patent/US5453264A/en not_active Expired - Fee Related
1995
- 1995-04-19 US US08/423,451 patent/US5575986A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK0603403T4 (da)	2002-12-16
EP0603403B1 (de)	1997-10-15
EP0603403B2 (de)	2001-06-27
US5453264A (en)	1995-09-26
CA2116867C (en)	2004-04-27
CA2116867A1 (en)	1994-01-20
WO1994001393A1 (fr)	1994-01-20
DE69314613T2 (de)	1998-05-14
ES2108269T3 (es)	1997-12-16
DE69314613T3 (de)	2002-07-04
EP0603403A4 (en)	1994-08-24
EP0603403A1 (de)	1994-06-29
DK0603403T3 (da)	1998-03-16
US5575986A (en)	1996-11-19
ES2108269T5 (es)	2001-09-01

Publication	Publication Date	Title
DE69314613D1 (de)	1997-11-20	Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten
DE69424173D1 (de)	2000-05-31	Carbodiimide-Verbindungen und dauerhafte wasserabweisende Zusammensetzungen, die diese Verbindungen enthalten
DE69307869D1 (de)	1997-03-13	Wärmehärtende pulverlackzusammensetzungen, die fliessmodifizierer enthalten
DE69711640D1 (de)	2002-05-08	Naphthopyrane, zusammensetzungen und artikel die diese enthalten
DE3852229D1 (de)	1995-01-12	Metalle der Platingruppe enthaltende Mikrokapsel und Zusammensetzungen, die diese enthalten.
DE3869114D1 (de)	1992-04-16	Fluessigkristallverbindung und gemische, die diese verbindung enthalten.
ATE272608T1 (de)	2004-08-15	Bicyclo (2.2.1) heptane und verwandte verbindungen
ATE225844T1 (de)	2002-10-15	Metall-ligand enthaltende bleichmittelzusammensetzungen
ATE267161T1 (de)	2004-06-15	Phenoxyessigsäure-verbindungen und medizinische zusammensetzungen, die diese enthalten
DE69007960D1 (de)	1994-05-11	Mischungen von aus Curcuma SPP isolierten Verbindungen als entzündungshemmende Mittel.
DE69815842D1 (de)	2003-07-31	Riechstofffixiermittel die polyvinylpyrrolidon und hydroxylcellulose enthalten
ATE252883T1 (de)	2003-11-15	Schweisshemmende mittel und zusammensetzungen die diese enthalten
DE69714213D1 (de)	2002-08-29	Synergistische Organomolybdänumzusammensetzungen und Schmiermittelzusammensetzungen die diese enthalten
DE69818516D1 (de)	2003-10-30	Phenylaminoalkylcarbonsäure-derivate und medizinische zusammensetzungen, die diese enthalten
ATE70973T1 (de)	1992-01-15	Heterocyclische sulfide, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten.
DE69400752D1 (de)	1996-11-21	Zusammensetzungen die hexafluorpropan enthalten
DE69401151D1 (de)	1997-01-30	Indenderivate und antimikrobe Mittel, die diese Indenderivate als Aktivkomponente enthalten
IT1167113B (it)	1987-05-13	Composizione farmaceutica contenente un composto di 1,4-benzochinone e suo impiego come agente antifibrotico
DE69630156D1 (de)	2003-10-30	Naphtholverbindung sowie Flüssigkristallzusammensetzung und Flüssigkristallelement, die diese Verbindung enthalten
ATE289595T1 (de)	2005-03-15	Neue pyrimidin-2,4,6-trion-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel die diese enthalten
DE69535697D1 (de)	2008-03-20	Dihydrobenzofurane und verwandte verbindungen als entzündungshemmende mittel
DE4393754T1 (de)	1995-07-20	Ladungskontrollmittel-Zusammensetzung und Toner, welcher diese enthält
DE69713763D1 (de)	2002-08-08	Binukleare platinkomplexe, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese komplexe enthalten
DE69004188D1 (de)	1993-12-02	Carboxylatverbindungen, diese Verbindungen enthaltende flüssigkristalline Zusammensetzungen und flüssigkristalliner Bauteil.
DE69512409D1 (de)	1999-10-28	Multigrad schmiermittelzusammensetzungen, die keine viskositätsmodifizierungsmittel enthalten

Legal Events

Date	Code	Title	Description
1998-10-01	8363	Opposition against the patent
2000-06-21	8327	Change in the person/name/address of the patent owner	Owner name: YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD., OSAKA,
2001-05-31	8327	Change in the person/name/address of the patent owner	Owner name: WELFIDE CORP., OSAKA, JP
2001-08-30	8366	Restricted maintained after opposition proceedings
2002-01-31	8332	No legal effect for de
2003-02-06	8327	Change in the person/name/address of the patent owner	Owner name: MITSUBISHI PHARMA CORP., OSAKA, JP
2006-01-05	8339	Ceased/non-payment of the annual fee