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DE69333358D1 - Erhöhte Produktion von Taxol und Taxanen mittels Taxus-Spezies-Zellkulturen - Google Patents

Erhöhte Produktion von Taxol und Taxanen mittels Taxus-Spezies-Zellkulturen

Info

Publication number
DE69333358D1
DE69333358D1 DE69333358T DE69333358T DE69333358D1 DE 69333358 D1 DE69333358 D1 DE 69333358D1 DE 69333358 T DE69333358 T DE 69333358T DE 69333358 T DE69333358 T DE 69333358T DE 69333358 D1 DE69333358 D1 DE 69333358D1
Authority
DE
Germany
Prior art keywords
taxus species
cell cultures
taxol
species cell
taxane production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333358T
Other languages
English (en)
Other versions
DE69333358T2 (de
Inventor
Christopher L Prince
Barry F Schubmehl
Eugene J Kane
Braden Roach
Venkataraman Bringi
Prakash G Kadkade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phyton Inc
Original Assignee
Phyton Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27126086&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69333358(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phyton Inc filed Critical Phyton Inc
Application granted granted Critical
Publication of DE69333358D1 publication Critical patent/DE69333358D1/de
Publication of DE69333358T2 publication Critical patent/DE69333358T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69333358T 1992-02-20 1993-02-22 Erhöhte Produktion von Taxol und Taxanen mittels Taxus-Spezies-Zellkulturen Expired - Lifetime DE69333358T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83914492A 1992-02-20 1992-02-20
US839144 1992-02-20
US07/874,344 US5407816A (en) 1992-02-20 1992-04-24 Enhanced production of taxol and taxanes by cell cultures of taxus species
US874344 1992-04-24

Publications (2)

Publication Number Publication Date
DE69333358D1 true DE69333358D1 (de) 2004-01-22
DE69333358T2 DE69333358T2 (de) 2004-08-19

Family

ID=27126086

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69333358T Expired - Lifetime DE69333358T2 (de) 1992-02-20 1993-02-22 Erhöhte Produktion von Taxol und Taxanen mittels Taxus-Spezies-Zellkulturen
DE69329154T Revoked DE69329154T2 (de) 1992-02-20 1993-02-22 Erhöhte produktion von taxol und taxanen mittels -taxus-spezifische zellkulturen
DE69334352T Expired - Lifetime DE69334352D1 (de) 1992-02-20 1993-02-22 Erhöhte Produktion von Taxol und Taxanen mittels Taxus-Spezies-Zellkulturen

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69329154T Revoked DE69329154T2 (de) 1992-02-20 1993-02-22 Erhöhte produktion von taxol und taxanen mittels -taxus-spezifische zellkulturen
DE69334352T Expired - Lifetime DE69334352D1 (de) 1992-02-20 1993-02-22 Erhöhte Produktion von Taxol und Taxanen mittels Taxus-Spezies-Zellkulturen

Country Status (15)

Country Link
US (1) US5407816A (de)
EP (3) EP0960944B1 (de)
JP (5) JP3513151B2 (de)
KR (6) KR100392036B1 (de)
AT (3) ATE195146T1 (de)
AU (1) AU672194B2 (de)
CA (1) CA2130745C (de)
DE (3) DE69333358T2 (de)
DK (2) DK0672162T3 (de)
ES (3) ES2361150T3 (de)
GR (1) GR3034722T3 (de)
NZ (1) NZ249734A (de)
PT (2) PT672162E (de)
SG (1) SG46427A1 (de)
WO (1) WO1993017121A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
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US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
US7264951B1 (en) 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
US5850032A (en) * 1992-04-01 1998-12-15 Union Camp Corporation Method for production of plant biological products in precocious neomorphic embryoids
CA2434692A1 (en) * 1992-04-07 1993-10-08 Paul M. Cino Callus cell induction and the preparation of taxanes
WO1993023555A1 (en) * 1992-05-21 1993-11-25 The Penn State Research Foundation Cultured taxus tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
JP2967532B2 (ja) * 1992-06-11 1999-10-25 日石三菱株式会社 タキサン類化合物の製造方法
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
KR950005081B1 (ko) * 1993-07-06 1995-05-18 산림청임목육종연구소 주목 종자의 씨눈 유래의 체세포배 및 체세포배성세포 혹은 그 배양배지로부터 택솔(Taxol) 및 그 유도체를 생산하는 방법
EP1063300B1 (de) * 1993-11-15 2003-09-03 Mitsui Chemicals, Inc. Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen
IL113447A (en) * 1994-04-22 1999-01-26 Us Agriculture Attractant for controlling insects and apparatus containing the same
CA2163614C (en) * 1994-11-25 2002-12-31 Yukihito Yukimune Method of producing a taxane-type diterpene
US6248572B1 (en) * 1995-04-27 2001-06-19 Samyang, Genex, Corporation Production of taxol from taxus plant cell culture adding silver nitrate
KR960037826A (ko) * 1995-04-27 1996-11-19 김경환 택서스속 식물세포의 반연속식 배양방법
US5900367A (en) * 1995-04-29 1999-05-04 Samyang Genex Co., Ltd. Method for purifying taxol from taxus biomass
WO1996034522A1 (en) * 1995-05-05 1996-11-07 Union Camp Corporation Method for production of plant biological products in precocious neomorphic embryoids
WO1996036693A1 (en) * 1995-05-19 1996-11-21 Phytera, Inc. Manipulation of plant cell and tissue cultures
EP1398384A1 (de) * 1996-05-24 2004-03-17 Phyton Inc. Erhöhte Produktion von Taxanen durch Zellkulturen von Taxus-Arten
ES2388248T3 (es) 1997-03-31 2012-10-11 Boston Scientific Scimed Limited Forma de dosificación que comprende taxol en forma cristalina
US5801193A (en) * 1997-04-15 1998-09-01 Immune Modulation, Inc. Compositions and methods for immunosuppressing
KR100287465B1 (ko) 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
KR100266448B1 (ko) * 1997-06-26 2000-09-15 박종헌 식물세포 배양 중의 온도변화에 의한 택솔의 대량생산 방법
WO1999036413A1 (en) 1998-01-14 1999-07-22 Bristol-Myers Squibb Company Novel crystalline complexes of baccatin iii with imidazole, 2-methylimidazole or isopropanol
US6093422A (en) 1998-01-23 2000-07-25 Zodiac Pool Care, Inc. Biocidal compositions for treating water
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
FR2800740B1 (fr) * 1999-11-08 2002-10-11 Lorraine Inst Nat Polytech Procede de production de metabolites a partir de vegetaux en culture hors sol
JP2004501143A (ja) 2000-06-22 2004-01-15 ニトロメド　インコーポレーテッド ニトロソ化およびニトロシル化タキサン、組成物および使用方法
AU2002225693A1 (en) * 2000-11-14 2002-05-27 Regents Of The University Of California Optimized antitrypsin expression in rice cell culture
US6365407B1 (en) * 2001-03-05 2002-04-02 Council Of Scientific & Industrial Research Culture medium composition useful for induction and proliferation of Taxus calli
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US20030091659A1 (en) * 2001-11-09 2003-05-15 Avon Products, Inc. Topical composition having undifferentiated plant seed cells and method for using same
US20030124205A1 (en) * 2001-12-28 2003-07-03 Avon Products, Inc. Topical cosmetic composition having a natural plant active ingredient and method of using same
TW200304947A (en) * 2002-02-08 2003-10-16 Bristol Myers Squibb Co Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
WO2005079355A2 (en) * 2004-02-13 2005-09-01 Phyton Biotech, Inc. Use of indanoyl amide to stimulate secondary metabolism in taxus sp.
EP1891206B1 (de) * 2005-06-03 2013-07-24 Samyang Genexbio Corporation Massenproduktion eines sekundären metaboliten in einer pflanzenzellkultur durch benützung eines saccharidgemischs in kulturmedium
RU2398874C2 (ru) * 2005-10-31 2010-09-10 Юнхва Клеточные клоны камбия, способ их выделения и консервации
US8053238B2 (en) * 2005-10-31 2011-11-08 Unhwa Corporation Isolated population of plant single cells and method of preparing the same
GB0605900D0 (en) * 2006-03-23 2006-05-03 Lipigen As Modulators of nuclear receptors
CN101652381B (zh) 2007-01-30 2014-04-09 维莱尼姆公司 用于处理木质纤维素的酶、编码它们的核酸及其制备和应用方法
KR101064518B1 (ko) * 2007-09-21 2011-09-19 주식회사 운화 저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법
AU2008202078B2 (en) * 2007-10-10 2012-05-31 Wellkey Holdings Limited Stability of secondary metabolite mass production through synchronized plant cell cultures
KR101100867B1 (ko) * 2008-05-14 2012-01-02 주식회사 운화 주목의 형성층 또는 전형성층 유래 식물줄기세포주를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물
US8713329B2 (en) * 2009-02-26 2014-04-29 Red Hat, Inc. Authenticated secret sharing
US8568798B2 (en) 2009-04-03 2013-10-29 Dianaplantsciences, S.A.S. Production and extraction of procyanidins from plant cell cultures
KR101212032B1 (ko) * 2009-05-26 2012-12-12 주식회사 운화 국화과의 형성층 유래 식물줄기세포 및 이의 분리배양방법
KR20100127727A (ko) * 2009-05-26 2010-12-06 주식회사 운화 버드나무과의 형성층 유래 식물줄기세포 및 이의 분리배양방법
RU2011153268A (ru) * 2009-05-28 2013-07-10 Юнхва Корпорейшн Растительная стволовая клетка, происходящая из камбия семейства solanaceae, способ ее выделения и культивирования
CN101671319B (zh) * 2009-09-18 2012-02-29 应成杰 红豆杉无毒提取物的提取工艺
BR112013008175A2 (pt) 2010-10-04 2016-06-21 Dianaplantsciences Sas produção e extração de procianidinas de culturas celulares vegetais
JP2012217441A (ja) * 2011-04-14 2012-11-12 Housetec Inc タキサン類の生産方法、およびカルス誘導方法
CN102715086B (zh) * 2012-06-19 2014-04-16 湖南农业大学 一种红豆杉试管苗诱导获得愈伤组织和悬浮细胞的方法
CN102715085B (zh) * 2012-06-19 2014-04-16 湖南农业大学 一种诱导红豆杉种子种胚获得愈伤组织和悬浮细胞的方法
CN103058961B (zh) * 2013-01-28 2015-04-29 普洱市红宝生物科技有限公司 从云南红豆杉中提取紫杉醇的方法
CN103570647A (zh) * 2013-11-06 2014-02-12 湖南农业大学 从红豆杉细胞培养液中制备高纯度紫杉醇的方法
KR101603539B1 (ko) * 2014-08-11 2016-03-15 영남대학교 산학협력단 택솔을 생산하는 콜레토트리쿰 데마티움 균주 및 그 용도
KR101786448B1 (ko) 2015-08-24 2017-10-18 영남대학교 산학협력단 택솔을 생산하는 트라이코더마 비리데슨스 tx1 균주 및 이의 용도
CN109022510A (zh) * 2018-08-23 2018-12-18 吉首大学 一种利用南方红豆杉菌根菌与活组织细胞共培养生产紫杉醇及10-dabⅲ的方法
CN110441439B (zh) * 2019-07-01 2022-03-01 杭州师范大学 区分密叶红豆杉和云南红豆杉的代谢标志物及其检测方法
EP4284939A1 (de) * 2021-01-28 2023-12-06 Phyto-Technics BV Herstellung von taxol aus taxus schneiden

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Publication number Priority date Publication date Assignee Title
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
JPH03216123A (ja) * 1990-01-17 1991-09-24 Nitsusen Kagaku Kogyo Kk 培養植物体の増殖促進方法
WO1992013961A1 (en) * 1991-02-12 1992-08-20 Nippon Steel Corporation Process for producing taxol by cell culture of taxus species
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species

Also Published As

Publication number Publication date
KR100392036B1 (ko) 2003-07-16
EP0672162B1 (de) 2000-08-02
EP0672162A4 (de) 1995-11-29
JP3513151B2 (ja) 2004-03-31
ES2361150T3 (es) 2011-06-14
EP0960944A1 (de) 1999-12-01
JP2005348751A (ja) 2005-12-22
DE69333358T2 (de) 2004-08-19
CA2130745C (en) 2008-01-22
PT672162E (pt) 2001-01-31
AU3729193A (en) 1993-09-13
DE69329154D1 (de) 2000-09-07
KR20090116792A (ko) 2009-11-11
JPH07506721A (ja) 1995-07-27
JP2009183305A (ja) 2009-08-20
KR100285788B1 (ko) 2001-05-02
WO1993017121A1 (en) 1993-09-02
HK1024936A1 (en) 2000-10-27
JP2004000285A (ja) 2004-01-08
PT960944E (pt) 2004-04-30
EP1378574B1 (de) 2011-04-06
ES2150938T3 (es) 2000-12-16
AU672194B2 (en) 1996-09-26
KR20070104684A (ko) 2007-10-26
SG46427A1 (en) 1998-02-20
DK0672162T3 (da) 2000-12-18
ATE195146T1 (de) 2000-08-15
JP2008131955A (ja) 2008-06-12
EP0672162A1 (de) 1995-09-20
EP1378574A1 (de) 2004-01-07
KR950700996A (ko) 1995-02-20
DK0960944T3 (da) 2004-04-05
KR20110079863A (ko) 2011-07-08
ES2213328T3 (es) 2004-08-16
HK1003718A1 (en) 1998-11-06
GR3034722T3 (en) 2001-01-31
KR20040000390A (ko) 2004-01-03
ATE256197T1 (de) 2003-12-15
ATE504659T1 (de) 2011-04-15
NZ249734A (en) 1996-08-27
DE69329154T2 (de) 2001-06-07
DE69334352D1 (de) 2011-05-19
EP0960944B1 (de) 2003-12-10
US5407816A (en) 1995-04-18
CA2130745A1 (en) 1993-09-02

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