DK0467954T3 - Fremstilling af liposom- og lipidkomplekssammensætninger - Google Patents
Fremstilling af liposom- og lipidkomplekssammensætningerInfo
- Publication number
- DK0467954T3 DK0467954T3 DK90906530.2T DK90906530T DK0467954T3 DK 0467954 T3 DK0467954 T3 DK 0467954T3 DK 90906530 T DK90906530 T DK 90906530T DK 0467954 T3 DK0467954 T3 DK 0467954T3
- Authority
- DK
- Denmark
- Prior art keywords
- liposome
- compounds
- aprotic solvent
- preparation
- lipid complex
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 150000002632 lipids Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 3
- 239000000010 aprotic solvent Substances 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33260989A | 1989-03-31 | 1989-03-31 | |
| US33405589A | 1989-04-05 | 1989-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0467954T3 true DK0467954T3 (da) | 1996-05-28 |
Family
ID=26988293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90906530.2T DK0467954T3 (da) | 1989-03-31 | 1990-03-28 | Fremstilling af liposom- og lipidkomplekssammensætninger |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0467954B1 (fr) |
| JP (1) | JP2798302B2 (fr) |
| AT (1) | ATE137403T1 (fr) |
| AU (1) | AU638245B2 (fr) |
| CA (1) | CA2050679C (fr) |
| DE (1) | DE69026820T2 (fr) |
| DK (1) | DK0467954T3 (fr) |
| ES (1) | ES2087151T3 (fr) |
| HK (1) | HK1000912A1 (fr) |
| HU (1) | HU208070B (fr) |
| NO (1) | NO303205B1 (fr) |
| WO (1) | WO1990011780A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5178875A (en) * | 1991-01-14 | 1993-01-12 | The Board Of Regents, The University Of Texas System | Liposomal-polyene preliposomal powder and method for its preparation |
| JPH0363298A (ja) * | 1989-07-31 | 1991-03-19 | Green Cross Corp:The | コロニー形成刺激因子・脂質複合体 |
| FR2653015B1 (fr) * | 1989-10-12 | 1993-10-29 | Oreal | Composition cosmetique ou pharmaceutique pour application topique contenant au moins un derive retinouide et au moins un derive de pyrimidine, son utilisation comme medicament et procede de traitement correspondant. |
| US5776904A (en) | 1990-11-16 | 1998-07-07 | Nippon Shinyaku Co., Ltd. | Dispersion preparation |
| DE4238779A1 (de) * | 1992-11-12 | 1994-05-19 | Max Delbrueck Centrum | Lyotrophe Mesophasen und ihre Anwendung in der Pharmazie, der Kosmetik und der Dermatologie |
| WO1995001777A1 (fr) | 1993-07-08 | 1995-01-19 | The Liposome Company, Inc. | Procede de maitrise de la taille des liposomes |
| ATE311748T1 (de) * | 1993-09-29 | 2005-12-15 | Dsm Ip Assets Bv | Modifizierte formen des natamycins, verfahren zu ihrer herstellung und sie enthaltende antifungale zusammensetzungen |
| CA2223179A1 (fr) * | 1995-06-07 | 1996-12-19 | Bob Dale Brown | Nouveaux lipides cationiques a base d'acide phosphonique |
| DE69924004T2 (de) * | 1998-12-22 | 2006-02-09 | United States Of America Represented By The Secretary, Department Of Health & Human Services | Verabreichungssystem für wasserunlösliche arzneistoffe |
| US6511676B1 (en) * | 1999-11-05 | 2003-01-28 | Teni Boulikas | Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes |
| WO2002034252A1 (fr) * | 2000-10-26 | 2002-05-02 | Senju Pharmaceutical Co., Ltd. | Composition medicamenteuse contenant un compose dipeptidyl aldehyde |
| AU2002219998B2 (en) * | 2000-12-01 | 2006-03-02 | Biomira, Inc. | Preparation of large liposomes by infusion into peg |
| IS6389A (is) * | 2001-08-31 | 2003-03-03 | Heraeus Kulzer Gmbh & Co. Kg | Reynsla af sýklalyfjahúðun skrokka, sem í eru örholrými, og einnig af þannig húðuðum skrokkum og notkun þeirra |
| CA2681302C (fr) * | 2007-03-19 | 2013-07-23 | Dhiraj Khattar | Compositions proliposomales et liposimale de composes faiblement hydrosolubles |
| US20110177156A1 (en) * | 2007-11-14 | 2011-07-21 | Szoka Jr Francis C | Sterol-Modified Amphiphilic Lipids |
| CA2737025C (fr) | 2008-09-27 | 2012-09-04 | Jina Pharmaceuticals, Inc. | Preparations pharmaceutiques a base de lipide(s) a usage oral et topique, leurs compositions, procedes et utilisations |
| JP6051157B2 (ja) * | 2010-07-14 | 2016-12-27 | 中国医学科学院▲薬▼物研究所 | 一種インスリンの脂質複合物及び作製方法や製剤 |
| CN106999419A (zh) | 2014-08-04 | 2017-08-01 | 佐尼奥尼制药股份有限公司 | 远程装载略微水溶性药物至脂质膜泡 |
| CN113616798A (zh) * | 2021-09-06 | 2021-11-09 | 天津农学院 | 一种甲苯咪唑脂质复合物、制备方法和应用 |
| CN115177590A (zh) * | 2022-04-20 | 2022-10-14 | 南昌大学抚州医学院 | 一种甲苯达唑类脂质体的制备方法及应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588578A (en) * | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
| JPS60240634A (ja) | 1984-05-08 | 1985-11-29 | 関 則雄 | 飲み干し容易なコツプ |
| US4619913A (en) * | 1984-05-29 | 1986-10-28 | Matrix Pharmaceuticals, Inc. | Treatments employing drug-containing matrices for introduction into cellular lesion areas |
| AU598002B2 (en) * | 1986-07-15 | 1990-06-14 | Cilag Ltd. | Method of preparing single bilayered liposomes |
| US4804539A (en) | 1986-07-28 | 1989-02-14 | Liposome Technology, Inc. | Ophthalmic liposomes |
| US4839175A (en) * | 1986-07-28 | 1989-06-13 | Liposome Technology, Inc. | Liposomes with enhanced retention on mucosal tissue |
| US4812312A (en) * | 1987-03-03 | 1989-03-14 | Board Of Regents Of The University Of Texas System | Liposome-incorporated nystatin |
| NZ223660A (en) * | 1987-03-05 | 1990-11-27 | Liposome Co Inc | Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity |
-
1990
- 1990-03-28 WO PCT/US1990/001646 patent/WO1990011780A1/fr active IP Right Grant
- 1990-03-28 HU HU903559A patent/HU208070B/hu not_active IP Right Cessation
- 1990-03-28 CA CA002050679A patent/CA2050679C/fr not_active Expired - Fee Related
- 1990-03-28 DK DK90906530.2T patent/DK0467954T3/da active
- 1990-03-28 AU AU54345/90A patent/AU638245B2/en not_active Ceased
- 1990-03-28 AT AT90906530T patent/ATE137403T1/de not_active IP Right Cessation
- 1990-03-28 JP JP2506114A patent/JP2798302B2/ja not_active Expired - Fee Related
- 1990-03-28 ES ES90906530T patent/ES2087151T3/es not_active Expired - Lifetime
- 1990-03-28 DE DE69026820T patent/DE69026820T2/de not_active Expired - Fee Related
- 1990-03-28 EP EP90906530A patent/EP0467954B1/fr not_active Expired - Lifetime
- 1990-03-28 HK HK97102512A patent/HK1000912A1/en not_active IP Right Cessation
-
1991
- 1991-09-27 NO NO913816A patent/NO303205B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE137403T1 (de) | 1996-05-15 |
| NO913816L (no) | 1991-11-26 |
| ES2087151T3 (es) | 1996-07-16 |
| CA2050679C (fr) | 1998-09-22 |
| AU638245B2 (en) | 1993-06-24 |
| EP0467954B1 (fr) | 1996-05-01 |
| WO1990011780A1 (fr) | 1990-10-18 |
| NO303205B1 (no) | 1998-06-15 |
| DE69026820T2 (de) | 1996-11-28 |
| DE69026820D1 (de) | 1996-06-05 |
| JPH04506207A (ja) | 1992-10-29 |
| CA2050679A1 (fr) | 1990-10-01 |
| HU903559D0 (en) | 1991-12-30 |
| HUT59818A (en) | 1992-07-28 |
| HU208070B (en) | 1993-08-30 |
| EP0467954A1 (fr) | 1992-01-29 |
| EP0467954A4 (en) | 1992-06-03 |
| HK1000912A1 (en) | 1998-05-08 |
| NO913816D0 (no) | 1991-09-27 |
| AU5434590A (en) | 1990-11-05 |
| JP2798302B2 (ja) | 1998-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0467954T3 (da) | Fremstilling af liposom- og lipidkomplekssammensætninger | |
| CA1262093C (fr) | Liposomes steroidiens | |
| ATE71834T1 (de) | Liposomzubereitung und ihre herstellung. | |
| ES2107668T3 (es) | Liposomas, procedimiento para su preparacion y su uso en la elaboracion de un medicamento. | |
| GR3020068T3 (en) | Preparation of lipidic microparticles | |
| PT877602E (pt) | Processo para o fabrico de composicoes de surfactantes pulmonares em po | |
| DE3855265D1 (de) | Liposomen-Formulierungen mit hohem antineoplastischem Wirkstoff/Lipid-Verhältnis | |
| NO172729C (no) | Fremgangsmaate for fremstilling av en suspensjon av fosfolipidvesikler. | |
| IE780464L (en) | Liposome compositions | |
| RU2000124317A (ru) | Эритропоэтиновая липосомальная дисперсия | |
| GR3017118T3 (en) | Liposomal-polyene preliposomal powder and method for its preparation. | |
| DK544883A (da) | Stabile plurilamellare vesikler | |
| NO20003471D0 (no) | Fremstilling av en lipidblanding og en fosfolipidsuspensjon som inneholder lipidblandingen | |
| EA200501285A1 (ru) | Способ получения липосомальных препаратов | |
| CO4480019A1 (es) | Liposomas de cetoprofeno | |
| WO2003041682A3 (fr) | Compositions a vecteurs lipidiques garantissant une meilleure retention medicamenteuse | |
| FI103178B (fi) | Menetelmä vaikuttavaa ainetta sisältävien vesipohjaisten liposomisuspe nsioiden valmistamiseksi | |
| DE69738416T2 (de) | Liposomale zubereitungen von indolocarbazol-derivaten | |
| ES2060050T3 (es) | Beta-tioacrilamidas s-sustituidas y su uso como microbicidas. | |
| DE3851842D1 (de) | Wässrige bereitung von liposomenzusammensetzungen. | |
| ATE270093T1 (de) | Schaumförmige zubereitungen mit einem gehalt an grenzflächenaktiven substanzen und elektrolyten | |
| AU617123B2 (en) | Method of manufacturing unilamellar lipid vesicles | |
| JPS6431720A (en) | Antihyperlipemic agent consisting of pyrimido(2,1-b)benzothiazole derivative | |
| KR900012934A (ko) | 피리도 피리미딘 유도체, 이들을 함유하는 약학적 조성물 및 이들을 제조하는 제조방법 |