DK0577847T3 - Morphinanderivat og medicinsk anvendelse deraf - Google Patents
Morphinanderivat og medicinsk anvendelse derafInfo
- Publication number
- DK0577847T3 DK0577847T3 DK93902520T DK93902520T DK0577847T3 DK 0577847 T3 DK0577847 T3 DK 0577847T3 DK 93902520 T DK93902520 T DK 93902520T DK 93902520 T DK93902520 T DK 93902520T DK 0577847 T3 DK0577847 T3 DK 0577847T3
- Authority
- DK
- Denmark
- Prior art keywords
- medical use
- nch3
- morphine derivative
- xso2
- alkylene
- Prior art date
Links
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Fertilizers (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1011592 | 1992-01-23 | ||
| JP29430892 | 1992-11-02 | ||
| PCT/JP1993/000080 WO1993015081A1 (fr) | 1992-01-23 | 1993-01-22 | Derive de morphinane et utilisation en medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0577847T3 true DK0577847T3 (da) | 1999-06-23 |
Family
ID=26345314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93902520T DK0577847T3 (da) | 1992-01-23 | 1993-01-22 | Morphinanderivat og medicinsk anvendelse deraf |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6323212B1 (fr) |
| EP (2) | EP0846694A1 (fr) |
| JP (1) | JP2525552B2 (fr) |
| KR (1) | KR970011390B1 (fr) |
| AT (1) | ATE172201T1 (fr) |
| AU (2) | AU666702B2 (fr) |
| CA (1) | CA2105072C (fr) |
| DE (1) | DE69321525T2 (fr) |
| DK (1) | DK0577847T3 (fr) |
| ES (1) | ES2121988T3 (fr) |
| FI (1) | FI106126B (fr) |
| NO (1) | NO302755B1 (fr) |
| NZ (1) | NZ246687A (fr) |
| TW (1) | TW332814B (fr) |
| WO (1) | WO1993015081A1 (fr) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU666702B2 (en) * | 1992-01-23 | 1996-02-22 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
| AU683664B2 (en) * | 1993-06-30 | 1997-11-20 | Toray Industries, Inc. | Antitussive |
| DE69414085T2 (de) * | 1993-07-19 | 1999-03-18 | Toray Industries, Inc., Tokio/Tokyo | Wirkstoff zum schutze von gehirnzellen |
| AU686203B2 (en) * | 1993-07-23 | 1998-02-05 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
| SE9401727D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds I |
| DE19602968A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue Morphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| EP0829481A1 (fr) * | 1996-09-16 | 1998-03-18 | Pfizer Inc. | Dérivés de l'acide morphinane hydroxamique |
| EP1312361A1 (fr) * | 1996-11-25 | 2003-05-21 | Toray Industries, Inc. | Agent antiprurigineux |
| WO1998043978A1 (fr) * | 1997-03-27 | 1998-10-08 | Toray Industries, Inc. | Derives de morphinane et usage medical de ces derniers |
| CN100379419C (zh) * | 1997-07-11 | 2008-04-09 | 东丽株式会社 | 含有4,5-环氧吗啡喃衍生物的稳定的药物组合物 |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| MXPA99011298A (es) * | 1997-07-14 | 2004-10-28 | Adolor Corp | Formulaciones farmaceuticas antiprurito de agonista kappa y metodo para tratar prurito con las mismas. |
| AU6117298A (en) * | 1997-07-25 | 1999-02-16 | Toray Industries, Inc. | Hyponatremia remedies |
| DE69830654T2 (de) * | 1997-09-02 | 2006-05-04 | Toray Industries, Inc. | Heilmittel für die drogenabhängigkeit |
| US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| CN1204139C (zh) * | 1999-08-24 | 2005-06-01 | 东丽株式会社 | 神经性疼痛治疗剂 |
| EP1237462A4 (fr) * | 1999-12-03 | 2005-05-11 | Iouri Malov | Essai de champ par technique d'etalement de spectre |
| WO2001074819A1 (fr) * | 2000-04-03 | 2001-10-11 | Toray Industries, Inc. | Agents analgesiques contenant des derives de n-oxyde de morphinane en tant que principe actif |
| ATE424205T1 (de) * | 2001-03-30 | 2009-03-15 | Toray Industries | Mittel zur behandlung des syndroms der unruhigen beine |
| WO2002080918A1 (fr) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| CN103405431B (zh) | 2002-05-17 | 2016-04-13 | 台湾J药品有限公司 | 阿片和阿片样化合物及其用途 |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7923454B2 (en) * | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| CN100537573C (zh) * | 2002-10-09 | 2009-09-09 | 东丽株式会社 | 尿频或尿失禁的治疗或预防剂以及具有含氮环状取代基的吗啡烷衍生物 |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| AU2004245057B2 (en) * | 2003-06-04 | 2008-07-31 | Alkermes Pharma Ireland Limited | Polymorphic forms of naltrexone |
| ES2623362T3 (es) * | 2004-05-28 | 2017-07-11 | Human Biomolecular Research Institute | Analgésicos metabólicamente estables y medicaciones para el dolor |
| TW200621785A (en) * | 2004-11-04 | 2006-07-01 | Toray Industries | Analgesic |
| CN101155814B (zh) * | 2005-04-06 | 2010-06-16 | 东丽株式会社 | 吗啡喃衍生物的晶体及其制备方法 |
| ES2307352B1 (es) * | 2005-04-12 | 2009-09-18 | Bti, I+D, S.L. | Implante dental y piezas destinadas a ser conectadas a un implante dental, y la conexion interna entre el implante dental y cada pieza. |
| WO2007124114A2 (fr) * | 2006-04-21 | 2007-11-01 | Nektar Therapeutics Al, Corporation | Réduction stéréosélective d'une morphinone |
| US8796301B2 (en) | 2007-04-24 | 2014-08-05 | Toray Industries, Inc. | Therapeutic or prophylactic agent for dyskinesia |
| MX2009011554A (es) | 2007-04-26 | 2010-01-25 | Toray Industries | Preparacion solida estable conteniendo un derivado de 4,5-epoximorfinano. |
| ES2555785T3 (es) | 2007-06-22 | 2016-01-08 | Toray Industries, Inc. | Remedio o preventivo para esquizofrenia |
| WO2009044883A1 (fr) | 2007-10-05 | 2009-04-09 | Toray Industries, Inc. | Remède destiné à soulager des troubles cutanés comprenant un dérivé de morphinane ou l'un de ses sels d'addition d'acide acceptables sur le plan pharmacologique en tant que principe actif |
| TR201809734T4 (tr) * | 2008-02-14 | 2018-07-23 | Alkermes Inc | Seçici opioid bileşikler. |
| US8609682B2 (en) | 2008-07-11 | 2013-12-17 | Regents Of The University Of Minnesota | Analgesic agents |
| PL2356989T3 (pl) | 2008-10-24 | 2018-07-31 | Toray Industries, Inc. | Trwała tabletka zawierająca pochodną 4,5-epoksymorfinanu |
| JP2012518651A (ja) * | 2009-02-23 | 2012-08-16 | マリンクロッド インコーポレイテッド | （＋）−モルフィナニウムｎ−オキシドおよびそれらの生成方法 |
| JP2012518652A (ja) * | 2009-02-23 | 2012-08-16 | マリンクロッド インコーポレイテッド | （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体 |
| EP2398805A1 (fr) * | 2009-02-23 | 2011-12-28 | Mallinckrodt LLC | Sels quaternaires de (+)-morphinane et procédés de préparation |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| CN102803267A (zh) * | 2009-06-11 | 2012-11-28 | 马林克罗特有限公司 | 通过催化氢转移的6-α-氨基N-取代的吗啡喃的制备 |
| EP2440561B1 (fr) * | 2009-06-11 | 2014-04-30 | Mallinckrodt LLC | Amination reductrice de 6-ceto normorphinanes par transfert catalytique d'hydrogene |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| WO2011009020A2 (fr) | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | Composés et compositions pour une utilisation en photothérapie et dans le traitement d'une maladie néovasculaire oculaire et de cancers |
| US10131672B2 (en) | 2010-01-29 | 2018-11-20 | Toray Industries, Inc. | Therapeutic or prophylactic agent for biliary diseases |
| CA2936749C (fr) | 2010-06-11 | 2019-07-09 | Joshua R. Giguere | Procedes catalyses par metal de transition pour la preparation de composes de n-allyle et utilisation de ceux-ci |
| JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| CA2768199C (fr) | 2010-07-16 | 2018-08-28 | Mallinckrodt Llc | (+)-morphinanes en tant qu'antagonistes des recepteurs de type toll-9 et leurs utilisations therapeutiques |
| AU2011317183B2 (en) * | 2010-10-19 | 2016-10-20 | Memorial Sloan-Kettering Cancer Center | 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain |
| US9006262B2 (en) | 2011-01-31 | 2015-04-14 | Toray Industries, Inc. | Therapeutic or prophylactic agent for cachexia |
| US9296699B2 (en) | 2011-06-09 | 2016-03-29 | Mallinckrodt Llc | Reductive amination of 6-keto morphinans by catalytic hydrogen transfer |
| CA2845187A1 (fr) | 2011-09-08 | 2013-03-14 | Peter X. Wang | Production d'alcaloides sans l'isolement d'intermediaires |
| EP2884978B1 (fr) * | 2012-08-16 | 2019-07-17 | The Scripps Research Institute | Nouveaux ligands d'opioïdes kappa |
| TWI449704B (zh) * | 2013-04-26 | 2014-08-21 | Everlight Chem Ind Corp | 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物 |
| ES2784690T3 (es) | 2013-12-05 | 2020-09-29 | Univ Bath | Nuevos compuestos opioides y sus usos |
| JP2015166331A (ja) * | 2014-05-14 | 2015-09-24 | 遼東化学工業株式会社 | ナルフラフィンの結晶およびその製造方法 |
| WO2016152953A1 (fr) * | 2015-03-24 | 2016-09-29 | 東レ株式会社 | Dérivé de morphinane et son usage médical |
| WO2016176657A1 (fr) | 2015-04-30 | 2016-11-03 | Memorial Sloan-Kettering Cancer Center | Analogues de la mitragynine et leurs utilisations |
| AU2016346558A1 (en) | 2015-10-29 | 2018-04-26 | University Of Tsukuba | Morphinan derivative and medical usage thereof |
| WO2017165558A1 (fr) | 2016-03-22 | 2017-09-28 | Regents Of The University Of Minnesota | Combinaison pour traiter la douleur |
| WO2017200970A1 (fr) * | 2016-05-19 | 2017-11-23 | Virginia Commonwealth University | Modulateurs puissants et sélectifs des récepteurs opioïdes mu |
| JP6814470B2 (ja) | 2017-02-10 | 2021-01-20 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| AU2019228497B2 (en) * | 2018-02-27 | 2025-01-16 | Delpor, Inc. | Compositions for small molecule therapeutic agent compounds |
| AU2019229892B2 (en) | 2018-03-08 | 2025-01-30 | University Of Kansas | Treatment of demyelinating diseases |
| WO2020205735A1 (fr) * | 2019-03-29 | 2020-10-08 | Humanwell Pharmaceutical US | Nouveaux morphinanes utiles pour le traitement de troubles médicaux |
| WO2021007366A1 (fr) * | 2019-07-08 | 2021-01-14 | St. Louis College Of Pharmacy | Agonistes/analgésiques au récepteur opioïde à polarisation de protéine g à recrutement d'arrestine réduit |
| JP7678756B2 (ja) | 2019-09-30 | 2025-05-16 | 日本ケミファ株式会社 | アゼパン誘導体 |
| WO2021079978A1 (fr) | 2019-10-24 | 2021-04-29 | 東レ株式会社 | Agent thérapeutique ou prophylactique pour cachexie |
| WO2022004788A1 (fr) | 2020-06-30 | 2022-01-06 | 東レ株式会社 | Agent d'amélioration ou agent prophylactique pour symptôme de faiblesse musculaire dans une maladie ou un syndrome associé à un trouble métabolique |
| CN115181109B (zh) * | 2021-04-02 | 2024-06-04 | 南京正大天晴制药有限公司 | 吗啡喃衍生物的晶体及其制备方法 |
| AU2022260191A1 (en) | 2021-04-23 | 2023-10-26 | Toray Industries, Inc. | Therapeutic or prophylactic agent for cachexia accompanied by ghrelin resistance |
| MA63501B1 (fr) | 2021-06-14 | 2024-07-31 | Scorpion Therapeutics, Inc. | Dérivés d'urée pouvant être utilisés pour traiter le cancer |
| JPWO2023190665A1 (fr) * | 2022-03-29 | 2023-10-05 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3236851A (en) * | 1966-02-22 | Unsaturated morphinan derivatives | ||
| NL290054A (fr) * | ||||
| DE622231C (de) * | 1934-03-09 | 1935-11-23 | Hermann Fischer Dr | Verfahren zur Herstellung von Diacetylmorphin |
| GB864107A (en) * | 1958-09-10 | 1961-03-29 | Albert Boehringer | Morphine derivatives |
| GB919311A (en) * | 1958-10-29 | 1963-02-20 | T & H Smith Ltd | Derivatives of 14-hydroxycodeine and their preparation |
| DE2254298A1 (de) * | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| GB1587831A (en) * | 1977-03-23 | 1981-04-08 | Reckitt & Colmann Prod Ltd | Morphine derivatives |
| GB1593191A (en) | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| US4362870A (en) | 1980-01-16 | 1982-12-07 | Regents Of The University Of Minnesota | Selective opioid receptor alkylating agents |
| JPS574991A (en) | 1980-06-10 | 1982-01-11 | Sankyo Co Ltd | Cyclopropylmethylnormorphine-6-sulfuric ester |
| US4401672A (en) | 1981-10-13 | 1983-08-30 | Regents Of The University Of Minnesota | Non-addictive narcotic antitussive preparation |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| US4767718A (en) * | 1984-06-18 | 1988-08-30 | Southern Illinois University Foundation | Fluorescent opioid reagents and methods of use thereof in the detection of opioid receptors |
| IN163125B (fr) | 1985-01-08 | 1988-08-13 | Alkaloida Vegyeszeti Gyar | |
| DE3617182A1 (de) | 1985-05-23 | 1986-11-27 | Sandoz-Patent-GmbH, 79539 Lörrach | Morphinan-derivate |
| HU196376B (en) * | 1985-05-23 | 1988-11-28 | Sandoz Ag | Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds |
| US4730048A (en) | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4806556A (en) | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
| US4673679A (en) * | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| JPH01149788A (ja) | 1987-12-08 | 1989-06-12 | Chugai Pharmaceut Co Ltd | 新規なモルヒネ誘導体 |
| FR2636330B1 (fr) | 1988-09-13 | 1990-11-30 | Sanofi Sa | Procede de preparation de derives de morphinane |
| EP0374919A1 (fr) * | 1988-12-21 | 1990-06-27 | Chugai Seiyaku Kabushiki Kaisha | Dérivé de morphine |
| US5219861A (en) * | 1988-12-21 | 1993-06-15 | Chugai Seiyaku Kabushiki Kaisha | 6 β-Thiomorphine derivatives |
| US5258386A (en) * | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| AU666702B2 (en) * | 1992-01-23 | 1996-02-22 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
| AU683664B2 (en) * | 1993-06-30 | 1997-11-20 | Toray Industries, Inc. | Antitussive |
-
1993
- 1993-01-22 AU AU33671/93A patent/AU666702B2/en not_active Expired
- 1993-01-22 KR KR1019930702860A patent/KR970011390B1/ko not_active Expired - Lifetime
- 1993-01-22 DK DK93902520T patent/DK0577847T3/da active
- 1993-01-22 WO PCT/JP1993/000080 patent/WO1993015081A1/fr active IP Right Grant
- 1993-01-22 US US08/108,643 patent/US6323212B1/en not_active Expired - Lifetime
- 1993-01-22 DE DE69321525T patent/DE69321525T2/de not_active Expired - Lifetime
- 1993-01-22 EP EP98100805A patent/EP0846694A1/fr not_active Withdrawn
- 1993-01-22 NZ NZ246687A patent/NZ246687A/en not_active IP Right Cessation
- 1993-01-22 AT AT93902520T patent/ATE172201T1/de active
- 1993-01-22 ES ES93902520T patent/ES2121988T3/es not_active Expired - Lifetime
- 1993-01-22 EP EP93902520A patent/EP0577847B1/fr not_active Expired - Lifetime
- 1993-01-22 CA CA002105072A patent/CA2105072C/fr not_active Expired - Lifetime
- 1993-01-22 JP JP5509616A patent/JP2525552B2/ja not_active Expired - Lifetime
- 1993-01-30 TW TW082100590A patent/TW332814B/zh not_active IP Right Cessation
- 1993-09-22 NO NO933376A patent/NO302755B1/no not_active IP Right Cessation
- 1993-09-22 FI FI934144A patent/FI106126B/fi not_active IP Right Cessation
-
1995
- 1995-12-22 AU AU40671/95A patent/AU686483B2/en not_active Expired
-
2000
- 2000-03-31 US US09/541,793 patent/US6277859B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2105072C (fr) | 1998-07-28 |
| NO933376L (no) | 1993-09-23 |
| KR970011390B1 (ko) | 1997-07-10 |
| EP0846694A1 (fr) | 1998-06-10 |
| NZ246687A (en) | 1996-12-20 |
| TW332814B (en) | 1998-06-01 |
| FI934144L (fi) | 1993-09-22 |
| AU666702B2 (en) | 1996-02-22 |
| DE69321525D1 (de) | 1998-11-19 |
| EP0577847A1 (fr) | 1994-01-12 |
| DE69321525T2 (de) | 1999-03-04 |
| WO1993015081A1 (fr) | 1993-08-05 |
| ES2121988T3 (es) | 1998-12-16 |
| US6323212B1 (en) | 2001-11-27 |
| CA2105072A1 (fr) | 1993-07-24 |
| EP0577847B1 (fr) | 1998-10-14 |
| FI934144A0 (fi) | 1993-09-22 |
| US6277859B1 (en) | 2001-08-21 |
| FI106126B (fi) | 2000-11-30 |
| ATE172201T1 (de) | 1998-10-15 |
| JP2525552B2 (ja) | 1996-08-21 |
| AU686483B2 (en) | 1998-02-05 |
| JPH08502275A (ja) | 1996-03-12 |
| NO302755B1 (no) | 1998-04-20 |
| AU4067195A (en) | 1996-03-07 |
| AU3367193A (en) | 1993-09-01 |
| EP0577847A4 (fr) | 1994-12-07 |
| NO933376D0 (no) | 1993-09-22 |
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