DK0536363T3 - Hidtil ukendte heparinderivater og fremgangsmåde til fremstilling deraf - Google Patents
Hidtil ukendte heparinderivater og fremgangsmåde til fremstilling derafInfo
- Publication number
- DK0536363T3 DK0536363T3 DK92908867.2T DK92908867T DK0536363T3 DK 0536363 T3 DK0536363 T3 DK 0536363T3 DK 92908867 T DK92908867 T DK 92908867T DK 0536363 T3 DK0536363 T3 DK 0536363T3
- Authority
- DK
- Denmark
- Prior art keywords
- heparin
- show
- equal
- new
- processes
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 8
- 239000002628 heparin derivative Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229960002897 heparin Drugs 0.000 abstract 5
- 229920000669 heparin Polymers 0.000 abstract 5
- 241000283690 Bos taurus Species 0.000 abstract 2
- 229940064551 bovine heparin Drugs 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229940045627 porcine heparin Drugs 0.000 abstract 2
- 241000282472 Canis lupus familiaris Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9101155A SE9101155D0 (sv) | 1991-04-18 | 1991-04-18 | Novel heparin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0536363T3 true DK0536363T3 (da) | 1998-01-26 |
Family
ID=20382487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92908867.2T DK0536363T3 (da) | 1991-04-18 | 1992-04-14 | Hidtil ukendte heparinderivater og fremgangsmåde til fremstilling deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6150342A (fr) |
| EP (1) | EP0536363B1 (fr) |
| JP (1) | JP3278676B2 (fr) |
| AT (1) | ATE154614T1 (fr) |
| AU (1) | AU642626B2 (fr) |
| CA (1) | CA2084301C (fr) |
| DE (1) | DE69220442T2 (fr) |
| DK (1) | DK0536363T3 (fr) |
| ES (1) | ES2104909T3 (fr) |
| GR (1) | GR3024757T3 (fr) |
| SE (1) | SE9101155D0 (fr) |
| WO (1) | WO1992018545A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696100A (en) * | 1992-12-22 | 1997-12-09 | Glycomed Incorporated | Method for controlling O-desulfation of heparin and compositions produced thereby |
| US5296471A (en) * | 1992-12-22 | 1994-03-22 | Glycomed Incorporated | Method for controlling o-desulfation of heparin and compositions produced thereby |
| JPH09512822A (ja) * | 1994-05-06 | 1997-12-22 | グリコメド・インコーポレイテッド | Ｏ−脱硫酸化ヘパリン誘導体とその製造法および使用 |
| EP0754460B1 (fr) * | 1995-02-07 | 2002-06-05 | Shiseido Company Limited | Agents anti-inflammatoires |
| US6001820A (en) * | 1995-03-31 | 1999-12-14 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
| US6498246B1 (en) * | 1998-02-26 | 2002-12-24 | Seikagaku Corporation | Glycosaminoglycan derivatives and processes for preparing same |
| CN1371391A (zh) * | 1999-06-30 | 2002-09-25 | 汉密尔顿市医院研究发展有限公司 | 抑制凝血相关凝血因子的肝素成分 |
| US7608246B2 (en) * | 2005-09-02 | 2009-10-27 | The Brigham And Women's Hospital, Inc. | Apolipoprotein E as an adjuvant for lipid antigens |
| US8569262B2 (en) | 2007-11-02 | 2013-10-29 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
| US8592393B2 (en) | 2007-11-02 | 2013-11-26 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
| US9351992B2 (en) * | 2007-11-02 | 2016-05-31 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
| US9387256B2 (en) | 2010-04-16 | 2016-07-12 | Momenta Pharmaceuticals, Inc. | Tissue targeting |
| EP2582355A2 (fr) | 2010-06-17 | 2013-04-24 | Momenta Pharmaceuticals, Inc. | Procédés et compositions pour stimuler la croissance capillaire |
| US10016449B2 (en) | 2013-05-28 | 2018-07-10 | Momenta Pharmaceuticals, Inc. | Pharmaceutical compositions |
| GB2515315A (en) * | 2013-06-19 | 2014-12-24 | Dilafor Ab | New Processes |
| WO2022015794A1 (fr) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Procédés de synthèse de sulfate d'héparane non anticoagulant |
| WO2025106117A1 (fr) * | 2023-11-17 | 2025-05-22 | Glycos Biomedical Ltd. | Héparine de poids moléculaire moyen |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1136620A (fr) * | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Fragments d'heparine ayant une activite anticoagulante selective |
| IL61201A (en) * | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
| FR2538404B1 (fr) * | 1982-12-28 | 1985-08-23 | Anic Spa | |
| US4948881A (en) * | 1982-12-28 | 1990-08-14 | Sanofi | Process for the depolymerization and sulfation of polysaccharides |
| US4745098A (en) * | 1984-02-24 | 1988-05-17 | The Regents Of The University Of California | Compositions and method for improving wound healing |
| FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
| FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| SE8702254D0 (sv) * | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
| DE3744119A1 (de) * | 1987-12-24 | 1989-07-06 | Basf Ag | Verwendung von polysulfatierten heparinen |
| IT1237518B (it) * | 1989-11-24 | 1993-06-08 | Renato Conti | Eparine supersolfatate |
-
1991
- 1991-04-18 SE SE9101155A patent/SE9101155D0/xx unknown
-
1992
- 1992-04-14 ES ES92908867T patent/ES2104909T3/es not_active Expired - Lifetime
- 1992-04-14 AU AU16463/92A patent/AU642626B2/en not_active Ceased
- 1992-04-14 WO PCT/SE1992/000243 patent/WO1992018545A1/fr active IP Right Grant
- 1992-04-14 EP EP92908867A patent/EP0536363B1/fr not_active Expired - Lifetime
- 1992-04-14 JP JP50809992A patent/JP3278676B2/ja not_active Expired - Fee Related
- 1992-04-14 CA CA002084301A patent/CA2084301C/fr not_active Expired - Fee Related
- 1992-04-14 DK DK92908867.2T patent/DK0536363T3/da active
- 1992-04-14 US US07/949,551 patent/US6150342A/en not_active Expired - Fee Related
- 1992-04-14 DE DE69220442T patent/DE69220442T2/de not_active Expired - Fee Related
- 1992-04-14 AT AT92908867T patent/ATE154614T1/de not_active IP Right Cessation
-
1995
- 1995-05-10 US US08/438,933 patent/US6326476B1/en not_active Expired - Fee Related
-
1997
- 1997-09-17 GR GR970402402T patent/GR3024757T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1646392A (en) | 1992-11-17 |
| US6150342A (en) | 2000-11-21 |
| ES2104909T3 (es) | 1997-10-16 |
| DE69220442D1 (de) | 1997-07-24 |
| GR3024757T3 (en) | 1997-12-31 |
| CA2084301A1 (fr) | 1992-10-19 |
| CA2084301C (fr) | 2005-10-25 |
| US6326476B1 (en) | 2001-12-04 |
| JPH05508184A (ja) | 1993-11-18 |
| EP0536363A1 (fr) | 1993-04-14 |
| AU642626B2 (en) | 1993-10-21 |
| JP3278676B2 (ja) | 2002-04-30 |
| WO1992018545A1 (fr) | 1992-10-29 |
| SE9101155D0 (sv) | 1991-04-18 |
| ATE154614T1 (de) | 1997-07-15 |
| DE69220442T2 (de) | 1998-01-29 |
| EP0536363B1 (fr) | 1997-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0536363T3 (da) | Hidtil ukendte heparinderivater og fremgangsmåde til fremstilling deraf | |
| DE3688114D1 (de) | Inklusionskomplexe von 7-isopropoxy-isoflavon mit cyclodextrinen, verfahren zu deren herstellung und diese inklusionskomplexe enthaltende pharmazeutische praeparate. | |
| RU93054168A (ru) | Димер молекулярного варианта аро-липопротеина, способ его получения, фармацевтическая композиция на его основе | |
| ATE131176T1 (de) | Sulfatierte polysaccharide, antikoagulierungs- und antikomplementärmittel, hergestellt aus fukanen aus braunen algen, und verfahren zu deren herstellung. | |
| FI833605A0 (fi) | Ny oral mopidamolprodukt | |
| BG101647A (bg) | Бициклени тромбинови инхибитори с ниско молекулно тегло | |
| ATE161273T1 (de) | Polysaccharidderivate von heparin, heparansulfate, ihre fraktionen und fragmente, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, welche diese enthalten | |
| IT8920170A0 (it) | Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. | |
| ES2021905A6 (es) | Procedimiento para la preparacion de fracciones de sulfato de dermatano. | |
| LEE JR et al. | Clinical evaluation of a new plasma expander, hydroxyethyl starch | |
| JPH09510736A (ja) | ヘパリンをベースとした抗血栓性で非出血性の組成物と、その調製方法と、治療への利用 | |
| DK0462194T3 (da) | Fibroblastvækstfaktor-(FGF)-baserede stabiliserede sammensætninger | |
| RU2216548C2 (ru) | Смесь линейных олигосахаридов, полученная из дерматансульфата, фармацевтическая композиция, обладающая антитромботическим действием, и способ лечения | |
| Woods et al. | Antithrombotic therapy in children and adolescents | |
| BR0202439A (pt) | Complexo, método para prolongar o tempo que o ocif ou um seu análogo ou variante fica retido na corrente sang ìnea, composição farmacêutica, uso de um complexo, e, método para a preparação de um complexo | |
| KR930012023A (ko) | 환원된 형태의 비글리코실화 재조합 인체 il2의 안정화된 제약 조성물 및 그의 제조방법 | |
| DE4430204A1 (de) | Arzneimittel, welches als Gegenmittel für Blut-Antikoagulanzien geeignet ist und seine Verwendung | |
| US2976212A (en) | Hyaluronidase with heparin or heparinoids in ointment compositions | |
| JPS63233927A (ja) | ウロキナーゼ阻害剤 | |
| FR2380275A1 (fr) | Nouveaux composes imidazoles et leurs derives sulfoxydes et sulfones correspondants, leur preparation et compositions pharmaceutiques les contenant | |
| SE9003181D0 (sv) | Use of heparin fraction | |
| Borowska et al. | Impairment of primary haemostasis by low molecular weight heparins in rats | |
| RU93000004A (ru) | Вещество для лечения подкожной фибрасаркомы и способ его получения | |
| SU1695929A1 (ru) | Способ лечени инфаркта миокарда | |
| DE60004819T2 (de) | 10-formyltetrahydrofolate dehydrogenase als therapeutischen mittel |