DK10189D0 - Fremgangsmaade til indvinding af renset, oxideret, renatureret interleukin-2 fra mikroorganismer - Google Patents
Fremgangsmaade til indvinding af renset, oxideret, renatureret interleukin-2 fra mikroorganismerInfo
- Publication number
- DK10189D0 DK10189D0 DK010189A DK10189A DK10189D0 DK 10189 D0 DK10189 D0 DK 10189D0 DK 010189 A DK010189 A DK 010189A DK 10189 A DK10189 A DK 10189A DK 10189 D0 DK10189 D0 DK 10189D0
- Authority
- DK
- Denmark
- Prior art keywords
- oxidized
- guanidine hydrochloride
- renated
- oxidated
- interleukin
- Prior art date
Links
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 2
- 244000005700 microbiome Species 0.000 title abstract 2
- 102000000588 Interleukin-2 Human genes 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- 229960000789 guanidine hydrochloride Drugs 0.000 abstract 3
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 abstract 3
- 238000004255 ion exchange chromatography Methods 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4840887A | 1987-05-11 | 1987-05-11 | |
| US16714488A | 1988-03-25 | 1988-03-25 | |
| PCT/US1988/001043 WO1988008849A1 (fr) | 1987-05-11 | 1988-03-31 | Procede de recuperation, a partir de microorganismes, d'interleukine-2 recombinante, purifiee, oxydee et renaturee |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK10189A DK10189A (da) | 1989-01-11 |
| DK10189D0 true DK10189D0 (da) | 1989-01-11 |
Family
ID=26726091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK010189A DK10189D0 (da) | 1987-05-11 | 1989-01-11 | Fremgangsmaade til indvinding af renset, oxideret, renatureret interleukin-2 fra mikroorganismer |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0368857B1 (fr) |
| JP (1) | JP2955294B2 (fr) |
| AT (1) | ATE156491T1 (fr) |
| AU (1) | AU622860B2 (fr) |
| DE (1) | DE3855986T2 (fr) |
| DK (1) | DK10189D0 (fr) |
| IL (1) | IL86326A (fr) |
| NO (1) | NO176797C (fr) |
| WO (1) | WO1988008849A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
| CA1339757C (fr) | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Methode de production bacteriologique de csf-1 humain recombinant biologiquement actif pur |
| US4931543A (en) * | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
| EP0337243A1 (fr) * | 1988-04-14 | 1989-10-18 | F. Hoffmann-La Roche Ag | Procédé pour purifier de l'interleukine-2 recombinante |
| DK580789D0 (da) * | 1989-11-20 | 1989-11-20 | Novo Nordisk As | Fremgangsmaade til oprensning af polypeptider |
| GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
| US5258496A (en) * | 1990-07-10 | 1993-11-02 | Scios Nova Inc. | Isolation and purification of lung surfactant protein |
| CA2077906A1 (fr) * | 1991-01-10 | 1992-07-11 | Kimihiko Matsuzawa | Methode tres sensible permettant de mesurer un facteur tissulaire et trousse de mesure |
| US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| CA2144523A1 (fr) * | 1993-08-04 | 1995-02-16 | Hugo Grossenbacher | Desulfatohirudine de masse moleculaire elevee |
| US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| TW517059B (en) | 1994-07-25 | 2003-01-11 | Ciba Geigy Ag | New process for the production of biologically active protein |
| AU707719B2 (en) * | 1995-07-21 | 1999-07-15 | Amgen, Inc. | Process for protein refolding by means of buffer exchange using a continuous stationary phase capable of separating proteins from salt |
| AU2003223936A1 (en) * | 2002-05-17 | 2003-12-02 | Kobenhavns Universitet | Method for purifying denatured proteins having a desired disulfide bond configuration |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR79124B (fr) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
| US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
| US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
| JPH0640832B2 (ja) * | 1985-05-10 | 1994-06-01 | 味の素株式会社 | インタ−ロイキン２ポリペプチドの回収方法 |
| US4748234A (en) * | 1985-06-26 | 1988-05-31 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
| US4656255A (en) * | 1985-09-09 | 1987-04-07 | International Minerals & Chemical Corp. | Protein recovery |
| US4801686A (en) * | 1986-09-04 | 1989-01-31 | Immunex Corporation | Purification of recombinant interleukin-1 |
| US4931543A (en) * | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
-
1988
- 1988-03-31 AU AU16279/88A patent/AU622860B2/en not_active Expired
- 1988-03-31 EP EP88903676A patent/EP0368857B1/fr not_active Expired - Lifetime
- 1988-03-31 JP JP63503562A patent/JP2955294B2/ja not_active Expired - Lifetime
- 1988-03-31 AT AT88903676T patent/ATE156491T1/de not_active IP Right Cessation
- 1988-03-31 DE DE3855986T patent/DE3855986T2/de not_active Expired - Lifetime
- 1988-03-31 WO PCT/US1988/001043 patent/WO1988008849A1/fr active IP Right Grant
- 1988-05-10 IL IL8632688A patent/IL86326A/xx not_active IP Right Cessation
- 1988-12-21 NO NO885678A patent/NO176797C/no not_active IP Right Cessation
-
1989
- 1989-01-11 DK DK010189A patent/DK10189D0/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO885678L (no) | 1988-12-21 |
| DE3855986T2 (de) | 1998-02-05 |
| WO1988008849A1 (fr) | 1988-11-17 |
| JPH02503384A (ja) | 1990-10-18 |
| DE3855986D1 (de) | 1997-09-11 |
| AU622860B2 (en) | 1992-04-30 |
| ATE156491T1 (de) | 1997-08-15 |
| EP0368857A1 (fr) | 1990-05-23 |
| NO176797C (no) | 1995-05-31 |
| NO176797B (no) | 1995-02-20 |
| DK10189A (da) | 1989-01-11 |
| IL86326A (en) | 1997-02-18 |
| JP2955294B2 (ja) | 1999-10-04 |
| EP0368857B1 (fr) | 1997-08-06 |
| NO885678D0 (no) | 1988-12-21 |
| AU1627988A (en) | 1988-12-06 |
| IL86326A0 (en) | 1988-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |