|
US6136311A
(en)
|
1996-05-06 |
2000-10-24 |
Cornell Research Foundation, Inc. |
Treatment and diagnosis of cancer
|
|
DK1472275T3
(da)
*
|
2002-02-05 |
2009-04-14 |
Genentech Inc |
Proteinoprensning
|
|
US20160279239A1
(en)
|
2011-05-02 |
2016-09-29 |
Immunomedics, Inc. |
Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
|
|
JP5416338B2
(ja)
*
|
2003-05-09 |
2014-02-12 |
デューク ユニバーシティ |
Cd20特異的抗体およびその使用方法
|
|
HUE050171T2
(hu)
*
|
2003-07-28 |
2020-11-30 |
Genentech Inc |
Protein-A kioldódásának csökkentése protein-A affinitáskromatográfia során
|
|
SE0400501D0
(sv)
*
|
2004-02-27 |
2004-02-27 |
Amersham Biosciences Ab |
Antibody purification
|
|
ZA200608572B
(en)
*
|
2004-04-16 |
2008-06-25 |
Genentech Inc |
Assay for antibodies
|
|
US20160355591A1
(en)
|
2011-05-02 |
2016-12-08 |
Immunomedics, Inc. |
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
|
|
WO2006138737A2
(en)
*
|
2005-06-17 |
2006-12-28 |
Elan Pharma International Limited |
Methods of purifying anti a beta antibodies
|
|
US20070021591A1
(en)
*
|
2005-07-25 |
2007-01-25 |
Trubion Pharmaceuticals, Inc. |
Compositions and methods for protein deaggregation
|
|
US7834162B2
(en)
*
|
2006-01-06 |
2010-11-16 |
Amgen Inc. |
Methods and systems for isolating target molecules from complex solutions by column-chromatography using eluants containing organic solvents
|
|
WO2007109163A2
(en)
*
|
2006-03-16 |
2007-09-27 |
Amgen Inc |
Wash buffer and method of using
|
|
EP1996716B1
(en)
|
2006-03-20 |
2011-05-11 |
The Regents of the University of California |
Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
|
|
WO2007108955A1
(en)
*
|
2006-03-20 |
2007-09-27 |
Medarex, Inc. |
Protein purification
|
|
SG10201406358SA
(en)
|
2006-04-05 |
2014-12-30 |
Abbvie Biotechnology Ltd |
Antibody purification
|
|
BRPI0716597A2
(pt)
*
|
2006-09-08 |
2013-10-08 |
Wyeth Corp |
Método para o isolamento de um produto; produto preparado pelo método; método para o isolamento de um anticorpo; método para reduzir a turvação de um eluído compreendendo em produto; e método para reduzir a turvação e impurezas de um eluído compreendendo um produto
|
|
CA2842966A1
(en)
|
2006-09-13 |
2008-03-20 |
Abbvie Inc. |
Cell culture improvements
|
|
US8911964B2
(en)
|
2006-09-13 |
2014-12-16 |
Abbvie Inc. |
Fed-batch method of making human anti-TNF-alpha antibody
|
|
US8853371B2
(en)
*
|
2006-10-19 |
2014-10-07 |
Janssen Biotech, Inc. |
Process for preparing unaggregated antibody Fc domains
|
|
NZ576262A
(en)
*
|
2006-11-01 |
2012-05-25 |
Biogen Idec Inc |
Method of isolating biomacromolecules using low ph and divalent cations
|
|
US7691980B2
(en)
|
2007-01-09 |
2010-04-06 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
|
DE102007001370A1
(de)
*
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
|
US7999085B2
(en)
*
|
2007-01-09 |
2011-08-16 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
|
CA2673851C
(en)
|
2007-01-22 |
2016-05-03 |
Genentech, Inc. |
Polyelectrolyte precipitation and purification of proteins
|
|
ATE509107T1
(de)
*
|
2007-01-26 |
2011-05-15 |
Merck Serono Sa |
Aufreinigung von fc-tact-fusionsproteinen unter verwendung der ölkörper-technik
|
|
CA2698343C
(en)
|
2007-09-04 |
2018-06-12 |
The Regents Of The University Of California |
High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection
|
|
WO2009046294A2
(en)
*
|
2007-10-03 |
2009-04-09 |
Cornell University |
Treatment of proliferative disorders using antibodies to psma
|
|
BRPI0910482A2
(pt)
*
|
2008-04-29 |
2019-09-24 |
Abbott Lab |
imunoglobinas de domínio variável duplo e usos das mesmas
|
|
RU2010153578A
(ru)
|
2008-06-03 |
2012-07-20 |
Эбботт Лэборетриз (Us) |
Иммуноглобулины с двойными вариабельными доменами и их применение
|
|
MX2010013239A
(es)
|
2008-06-03 |
2011-02-24 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
|
NZ603698A
(en)
|
2008-07-08 |
2014-03-28 |
Abbvie Inc |
Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
|
|
US20100069616A1
(en)
*
|
2008-08-06 |
2010-03-18 |
The Regents Of The University Of California |
Engineered antibody-nanoparticle conjugates
|
|
US8895709B2
(en)
*
|
2008-10-20 |
2014-11-25 |
Abbvie Inc. |
Isolation and purification of antibodies using protein A affinity chromatography
|
|
WO2010048192A2
(en)
|
2008-10-20 |
2010-04-29 |
Abbott Laboratories |
Viral inactivation during purification of antibodies
|
|
KR101093717B1
(ko)
*
|
2008-11-26 |
2011-12-19 |
한국생명공학연구원 |
Vegf―특이적인 인간항체
|
|
WO2010096486A1
(en)
*
|
2009-02-17 |
2010-08-26 |
Cornell Research Foundation, Inc. |
Methods and kits for diagnosis of cancer and prediction of therapeutic value
|
|
AU2010289527C1
(en)
*
|
2009-09-01 |
2014-10-30 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
CN103980346A
(zh)
|
2009-10-01 |
2014-08-13 |
弗·哈夫曼-拉罗切有限公司 |
多步骤的最终过滤
|
|
WO2011038894A1
(en)
|
2009-10-01 |
2011-04-07 |
F. Hoffmann-La Roche Ag |
Protein a chromatography
|
|
MX2012004415A
(es)
|
2009-10-15 |
2012-05-08 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
MX354143B
(es)
|
2009-12-02 |
2018-02-14 |
Imaginab Inc |
Minicuerpos j591 y diacuerpos-cys para apuntar con especificidad de objetivo a un antígeno de membrana específico para próstata de humano (psma) y métodos para su uso.
|
|
WO2011084496A1
(en)
|
2009-12-16 |
2011-07-14 |
Abbott Biotherapeutics Corp. |
Anti-her2 antibodies and their uses
|
|
PT2513134T
(pt)
|
2009-12-18 |
2017-12-14 |
Novartis Ag |
Solução de lavagem e método para cromatografia de afinidade
|
|
JP5567691B2
(ja)
|
2010-01-22 |
2014-08-06 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Fc含有タンパク質を精製するためのクロマトグラフィー法
|
|
US20120034207A1
(en)
*
|
2010-06-16 |
2012-02-09 |
Mclean Michael D |
Production of her receptor antibodies in plant
|
|
EP3252072A3
(en)
|
2010-08-03 |
2018-03-14 |
AbbVie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
|
EP3578205A1
(en)
|
2010-08-06 |
2019-12-11 |
ModernaTX, Inc. |
A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
|
|
CN103260639A
(zh)
|
2010-08-26 |
2013-08-21 |
Abbvie公司 |
双重可变结构域免疫球蛋白及其用途
|
|
FI4108671T3
(fi)
|
2010-10-01 |
2024-12-27 |
Modernatx Inc |
Muokattuja nukleosideja, nukleotideja ja nukleiinihappoja sekä niiden käyttötapoja
|
|
US8962804B2
(en)
|
2010-10-08 |
2015-02-24 |
City Of Hope |
Meditopes and meditope-binding antibodies and uses thereof
|
|
JP5838221B2
(ja)
|
2010-12-21 |
2016-01-06 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
アイソフォーム濃縮抗体調製物及びこれを得る方法
|
|
AU2012236486B2
(en)
*
|
2011-03-29 |
2016-06-23 |
Glaxosmithkline Llc |
Buffer system for protein purification
|
|
US8710200B2
(en)
|
2011-03-31 |
2014-04-29 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids encoding a modified erythropoietin and their expression
|
|
WO2012149197A2
(en)
|
2011-04-27 |
2012-11-01 |
Abbott Laboratories |
Methods for controlling the galactosylation profile of recombinantly-expressed proteins
|
|
CN107115526A
(zh)
|
2011-05-02 |
2017-09-01 |
免疫医疗公司 |
用于小体积施用的同种异型选择的抗体的超滤浓缩
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
AU2012318752B2
(en)
|
2011-10-03 |
2017-08-31 |
Modernatx, Inc. |
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
|
|
IL296507A
(en)
|
2011-10-10 |
2022-11-01 |
Hope City |
Meditopes and meditope-binding antibodies and uses thereof
|
|
EP2797957B1
(en)
|
2011-11-23 |
2019-06-19 |
MedImmune, LLC |
Binding molecules specific for her3 and uses thereof
|
|
MX2014007233A
(es)
|
2011-12-16 |
2015-02-04 |
Moderna Therapeutics Inc |
Composiciones de nucleosidos, nucleotidos y acidos nucleicos modificados.
|
|
EP2797955A2
(en)
|
2011-12-30 |
2014-11-05 |
AbbVie Inc. |
Dual variable domain immunoglobulins against il-13 and/or il-17
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
|
EP3520821A1
(en)
|
2012-04-02 |
2019-08-07 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of biologics and proteins associated with human disease
|
|
US10317376B2
(en)
*
|
2012-04-11 |
2019-06-11 |
Bioverativ Therapeutics Inc. |
Methods of detecting glycosaminoglycans
|
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
|
US9150645B2
(en)
|
2012-04-20 |
2015-10-06 |
Abbvie, Inc. |
Cell culture methods to reduce acidic species
|
|
WO2013158273A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Methods to modulate c-terminal lysine variant distribution
|
|
US9249182B2
(en)
|
2012-05-24 |
2016-02-02 |
Abbvie, Inc. |
Purification of antibodies using hydrophobic interaction chromatography
|
|
EP2682168A1
(en)
|
2012-07-02 |
2014-01-08 |
Millipore Corporation |
Purification of biological molecules
|
|
EP2889617B1
(en)
|
2012-08-27 |
2017-10-11 |
Asahi Kasei Medical Co., Ltd. |
Antibody purification method by means of temperature-responsive chromatography
|
|
EP2890782A1
(en)
|
2012-09-02 |
2015-07-08 |
AbbVie Inc. |
Methods to control protein heterogeneity
|
|
US9512214B2
(en)
|
2012-09-02 |
2016-12-06 |
Abbvie, Inc. |
Methods to control protein heterogeneity
|
|
TW202014439A
(zh)
|
2012-11-01 |
2020-04-16 |
美商艾伯維有限公司 |
抗-vegf/dll4雙重可變區域免疫球蛋白及其用途
|
|
WO2014081507A1
(en)
|
2012-11-26 |
2014-05-30 |
Moderna Therapeutics, Inc. |
Terminally modified rna
|
|
WO2014099577A1
(en)
*
|
2012-12-17 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
Process for purifying insulin and analogues thereof
|
|
WO2014137903A2
(en)
|
2013-03-08 |
2014-09-12 |
Genzyme Corporation |
Integrated continuous manufacturing of therapeutic protein drug substances
|
|
SG11201507230PA
(en)
|
2013-03-12 |
2015-10-29 |
Abbvie Inc |
Human antibodies that bind human tnf-alpha and methods of preparing the same
|
|
US10023608B1
(en)
|
2013-03-13 |
2018-07-17 |
Amgen Inc. |
Protein purification methods to remove impurities
|
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
|
US8921526B2
(en)
|
2013-03-14 |
2014-12-30 |
Abbvie, Inc. |
Mutated anti-TNFα antibodies and methods of their use
|
|
WO2014151878A2
(en)
|
2013-03-14 |
2014-09-25 |
Abbvie Inc. |
Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
WO2014144280A2
(en)
|
2013-03-15 |
2014-09-18 |
Abbvie Inc. |
DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17
|
|
AU2014255285B2
(en)
|
2013-04-18 |
2019-07-11 |
Institut National De La Sante Et De La Recherche Medicale |
Composition with reduced immunogenicity
|
|
TW201509432A
(zh)
|
2013-07-05 |
2015-03-16 |
Lab Francais Du Fractionnement |
親和層析基質
|
|
JP6751344B2
(ja)
|
2013-09-13 |
2020-09-02 |
ジェネンテック, インコーポレイテッド |
精製された組み換えポリペプチドを含む方法及び組成物
|
|
RU2016107435A
(ru)
|
2013-09-13 |
2017-10-18 |
Дженентек, Инк. |
Композиции и способы обнаружения и количественного определения белка клеток-хозяев в клеточных линиях и рекомбинантные полипептидные продукты
|
|
WO2015048008A2
(en)
|
2013-09-24 |
2015-04-02 |
Medimmune, Llc |
Binding molecules specific for her3 and uses thereof
|
|
CA2926218A1
(en)
|
2013-10-03 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
|
EP3052640A2
(en)
|
2013-10-04 |
2016-08-10 |
AbbVie Inc. |
Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
|
|
US8946395B1
(en)
|
2013-10-18 |
2015-02-03 |
Abbvie Inc. |
Purification of proteins using hydrophobic interaction chromatography
|
|
US9181337B2
(en)
|
2013-10-18 |
2015-11-10 |
Abbvie, Inc. |
Modulated lysine variant species compositions and methods for producing and using the same
|
|
US9085618B2
(en)
|
2013-10-18 |
2015-07-21 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same
|
|
US20150139988A1
(en)
|
2013-11-15 |
2015-05-21 |
Abbvie, Inc. |
Glycoengineered binding protein compositions
|
|
WO2015103545A1
(en)
|
2014-01-03 |
2015-07-09 |
Bio-Rad Laboratories, Inc. |
Removal of impurities from protein a eluates
|
|
TWI709569B
(zh)
|
2014-01-17 |
2020-11-11 |
美商健臻公司 |
無菌層析樹脂及其用於製造方法的用途
|
|
TWI671312B
(zh)
|
2014-01-17 |
2019-09-11 |
美商健臻公司 |
無菌層析法及製法
|
|
WO2015157634A1
(en)
|
2014-04-11 |
2015-10-15 |
Kolltan Pharmaceuticals, Inc. |
Anti-erbb antibodies and methods of use thereof
|
|
TWI535784B
(zh)
|
2014-08-26 |
2016-06-01 |
財團法人工業技術研究院 |
剪切增稠配方、及包含其之複合材料
|
|
EA201790558A1
(ru)
|
2014-10-15 |
2017-08-31 |
Ксенотера |
Композиция с пониженной иммуногенностью
|
|
US11566082B2
(en)
|
2014-11-17 |
2023-01-31 |
Cytiva Bioprocess R&D Ab |
Mutated immunoglobulin-binding polypeptides
|
|
US10093733B2
(en)
|
2014-12-11 |
2018-10-09 |
Abbvie Inc. |
LRP-8 binding dual variable domain immunoglobulin proteins
|
|
US12428483B2
(en)
|
2014-12-22 |
2025-09-30 |
Systimmune, Inc. |
Bispecific tetravalent antibodies and methods of making and using thereof
|
|
DK3237005T3
(en)
*
|
2014-12-22 |
2024-11-18 |
Systimmune Inc |
Bispecific tetravalent antibodies and methods of making and using thereof
|
|
JPWO2016121701A1
(ja)
|
2015-01-26 |
2017-11-09 |
株式会社カネカ |
免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス
|
|
JP6663360B2
(ja)
|
2015-01-26 |
2020-03-11 |
株式会社カネカ |
変異型免疫グロブリンκ鎖可変領域結合性ペプチド
|
|
CN107636005B
(zh)
|
2015-03-13 |
2021-07-16 |
百时美施贵宝公司 |
在色谱过程中利用碱洗涤去除杂质
|
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
|
SG10201913625XA
(en)
|
2015-08-07 |
2020-03-30 |
Imaginab Inc |
Antigen binding constructs to target molecules
|
|
WO2017195638A1
(ja)
|
2016-05-09 |
2017-11-16 |
株式会社カネカ |
抗体またはκ鎖可変領域含有抗体断片の精製方法
|
|
US10889615B2
(en)
|
2016-05-11 |
2021-01-12 |
Cytiva Bioprocess R&D Ab |
Mutated immunoglobulin-binding polypeptides
|
|
JP7106187B2
(ja)
|
2016-05-11 |
2022-07-26 |
サイティバ・バイオプロセス・アールアンドディ・アクチボラグ |
分離マトリックスを保存する方法
|
|
US10513537B2
(en)
|
2016-05-11 |
2019-12-24 |
Ge Healthcare Bioprocess R&D Ab |
Separation matrix
|
|
US10703774B2
(en)
|
2016-09-30 |
2020-07-07 |
Ge Healthcare Bioprocess R&D Ab |
Separation method
|
|
JP7031934B2
(ja)
|
2016-05-11 |
2022-03-08 |
サイティバ・バイオプロセス・アールアンドディ・アクチボラグ |
分離マトリックス
|
|
US10730908B2
(en)
|
2016-05-11 |
2020-08-04 |
Ge Healthcare Bioprocess R&D Ab |
Separation method
|
|
WO2017194593A1
(en)
|
2016-05-11 |
2017-11-16 |
Ge Healthcare Bioprocess R&D Ab |
Method of cleaning and/or sanitizing a separation matrix
|
|
US10654887B2
(en)
|
2016-05-11 |
2020-05-19 |
Ge Healthcare Bio-Process R&D Ab |
Separation matrix
|
|
CN117736281A
(zh)
*
|
2016-08-11 |
2024-03-22 |
瑞普利金公司 |
用于亲和色谱的碱性稳定性fc结合蛋白
|
|
CN107964044B
(zh)
*
|
2016-10-19 |
2021-11-19 |
无锡科捷诺生物科技有限责任公司 |
从乳样中纯化抗cd20单克隆抗体的方法
|
|
WO2018147960A1
(en)
|
2017-02-08 |
2018-08-16 |
Imaginab, Inc. |
Extension sequences for diabodies
|
|
CN110352201A
(zh)
|
2017-04-03 |
2019-10-18 |
免疫医疗公司 |
用于癌症疗法的抗体药物缀合物的皮下施用
|
|
CA3066893A1
(en)
*
|
2017-06-21 |
2018-12-27 |
Cephalon, Inc. |
Cation exchange chromatography wash buffer
|
|
AU2018314651B2
(en)
|
2017-08-07 |
2022-12-15 |
Repligen Corporation |
Fc binding proteins with Cysteine in the C-terminal helical region
|
|
CN111344410B
(zh)
|
2017-08-17 |
2023-09-15 |
济世易为生物有限公司 |
从宿主细胞半乳糖凝集素和其他污染物中纯化糖基化蛋白的方法
|
|
EP4249097A3
(en)
|
2018-02-01 |
2024-01-10 |
Repligen Corporation |
Fc binding proteins with cysteine in the c-terminal helical region
|
|
EP3560945A1
(en)
*
|
2018-04-27 |
2019-10-30 |
F. Hoffmann-La Roche AG |
Methods for purification of polypeptides using polysorbates
|
|
WO2020046602A1
(en)
|
2018-08-31 |
2020-03-05 |
Genzyme Corporation |
Sterile chromatography resin and use thereof in manufacturing processes
|
|
US11034774B2
(en)
|
2018-10-30 |
2021-06-15 |
The Regents Of The University Of California |
Engineered antibodies for the detection of phosphorylated tyrosine
|
|
WO2020125757A1
(en)
*
|
2018-12-21 |
2020-06-25 |
Wuxi Biologics (Shanghai) Co., Ltd. |
A method for improving aggregate removal by protein a chromatography
|
|
WO2020200944A1
(en)
|
2019-03-29 |
2020-10-08 |
F. Hoffmann-La Roche Ag |
Method for generating avid-binding multispecific antibodies
|
|
EP3962957A1
(en)
|
2019-04-30 |
2022-03-09 |
Xenothera |
Association of polyclonal antibodies and anti-pd1 or anti-pdl1 antibodies for the treatment of cancer
|
|
UY38700A
(es)
|
2019-05-20 |
2020-12-31 |
Novartis Ag |
Conjugados de anticuerpo-fármaco inhibidores de mcl-1 y sus métodos de uso
|
|
IL303048A
(en)
|
2020-11-24 |
2023-07-01 |
Novartis Ag |
Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
|
|
AR129380A1
(es)
|
2022-05-20 |
2024-08-21 |
Novartis Ag |
Conjugados de anticuerpo-fármaco de compuestos antineoplásicos y métodos de uso de los mismos
|
|
JP2025517332A
(ja)
|
2022-05-20 |
2025-06-05 |
ノバルティス アーゲー |
抗体薬物コンジュゲート
|