DK174416B1 - Oligopeptider, immunogene konjugater heraf med et antigen samt vacciner indeholdende disse konjugater - Google Patents
Oligopeptider, immunogene konjugater heraf med et antigen samt vacciner indeholdende disse konjugater Download PDFInfo
- Publication number
- DK174416B1 DK174416B1 DK199001829A DK182990A DK174416B1 DK 174416 B1 DK174416 B1 DK 174416B1 DK 199001829 A DK199001829 A DK 199001829A DK 182990 A DK182990 A DK 182990A DK 174416 B1 DK174416 B1 DK 174416B1
- Authority
- DK
- Denmark
- Prior art keywords
- conjugates
- oligopeptides
- antigen
- epitopes
- vaccines containing
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 102000015636 Oligopeptides Human genes 0.000 title 1
- 108010038807 Oligopeptides Proteins 0.000 title 1
- 230000002163 immunogen Effects 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 108010060123 Conjugate Vaccines Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000005875 antibody response Effects 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 229940031670 conjugate vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Optical Couplings Of Light Guides (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15068888A | 1988-02-01 | 1988-02-01 | |
| PCT/US1989/000388 WO1989006974A2 (fr) | 1988-02-01 | 1989-01-31 | Epitopes de cellules t a titre de molecules porteuses pour vaccins conjugues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK182990A DK182990A (da) | 1990-07-31 |
| DK182990D0 DK182990D0 (da) | 1990-07-31 |
| DK174416B1 true DK174416B1 (da) | 2003-02-17 |
Family
ID=22535596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK199001829A DK174416B1 (da) | 1988-02-01 | 1990-07-31 | Oligopeptider, immunogene konjugater heraf med et antigen samt vacciner indeholdende disse konjugater |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0399001B1 (fr) |
| JP (1) | JP2921574B2 (fr) |
| AT (1) | ATE109008T1 (fr) |
| AU (1) | AU634153B2 (fr) |
| CA (2) | CA1340956C (fr) |
| DE (1) | DE68917126T2 (fr) |
| DK (1) | DK174416B1 (fr) |
| FI (1) | FI104374B (fr) |
| NO (1) | NO179164C (fr) |
| WO (1) | WO1989006974A2 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE168272T1 (de) * | 1989-10-27 | 1998-08-15 | Arch Dev Corp | Zusammensetzungen und deren verwendung zur förderung der immunopotentiation |
| GB8924438D0 (en) * | 1989-10-31 | 1989-12-20 | Hoffmann La Roche | Vaccine composition |
| CH683101A5 (de) * | 1990-09-18 | 1994-01-14 | Biotech Australia Pty Ltd | T-Zellen-Epitope. |
| WO1993011157A1 (fr) * | 1991-11-27 | 1993-06-10 | The Council Of The Queensland Institute Of Medical Research | VACCIN ET PEPTIDES CONTRE LA MALARIA COMPRENANT UN EPITOPE DE CELLULE T HUMAINE DE PROTEINE CIRCUMSPOROZOITE DE $i(P.VIVAX) |
| IL105503A (en) * | 1992-04-28 | 1999-05-09 | Astra Ab | Carbon peptide couplets capable of eliciting an immune response of T cells |
| MX9304388A (es) * | 1992-07-22 | 1994-03-31 | Proteus Molecular Design | Polopeptido sintetico y proceso para su fabricacion. |
| EP0863211A1 (fr) * | 1992-07-31 | 1998-09-09 | Medeva Holdings B.V. | Expression de protéines recombinantes fusionnées dans des bactéries attenuées |
| HUT71860A (en) | 1992-08-27 | 1996-02-28 | Deakin Res Ltd | Retro-, inverso-, and retro-inverso synthetic peptide analogues |
| DK140992D0 (da) * | 1992-11-24 | 1992-11-24 | Ole Buchardt | Fremgangsmaade til frembringelse af antistoffer mod haptener og andre b-celle-antigener, antistoffer opnaaet ved fremgangsmaaden og anvendelse af disse antistoffer til fremstilling af vacciner, isaer til veterinaermedicinsk brug |
| US5759551A (en) * | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| GB9401787D0 (en) | 1994-01-31 | 1994-03-23 | Medeva Holdings Bv | Vaccine compositions |
| WO1995004151A2 (fr) * | 1993-07-30 | 1995-02-09 | Medeva Holdings B.V. | Compositions vaccinales comprenant des proteines de fusion tetc de recombinaison |
| GB9401795D0 (en) * | 1994-01-31 | 1994-03-23 | Medeva Holdings Bv | Vaccines |
| GB2295394B (en) * | 1994-01-31 | 1997-09-24 | Medeva Holdings Bv | DNA encoding a fusion protein comprising the C fragment of tetanus toxin |
| WO1995024216A1 (fr) * | 1994-03-07 | 1995-09-14 | Auckland Uniservices Limited | Prevention du diabete |
| US5840307A (en) * | 1995-03-31 | 1998-11-24 | Immulogic Pharmacuetical Corp. | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation |
| DK1329226T3 (da) * | 1995-03-31 | 2007-09-24 | Xenova Res Ltd | Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug |
| US5843462A (en) * | 1995-11-30 | 1998-12-01 | Regents Of The University Of Minnesota | Diphtheria toxin epitopes |
| US7709002B1 (en) | 1996-04-19 | 2010-05-04 | The United States Of America As Represented By The Department Of Health And Human Services | Mutated ras peptides for generation of CD8+Cytotoxic T lymphocytes |
| WO1997040156A1 (fr) | 1996-04-19 | 1997-10-30 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Peptides ras ayant subi une mutation et servant a generer des lymphocytes t cytotoxiques cd8?+¿ |
| GB9713156D0 (en) * | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| US6025468A (en) | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
| TWI229679B (en) | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| DE19856052A1 (de) * | 1998-12-04 | 2000-06-08 | Deutsches Krebsforsch | Konjugat zur Anreicherung in neuronalen Zellen |
| WO2002038611A2 (fr) | 2000-11-09 | 2002-05-16 | Immunolex Laboratories | Procede de production d'anticorps par immunisation avec des conjugues de molecules couplees a des proteines a charge modifiee |
| WO2010040847A2 (fr) | 2008-10-10 | 2010-04-15 | Era Biotech, S.A. | Corps de protéines recombinantes en tant qu'adjuvants spécifiques d'immunogènes |
| JP5841044B2 (ja) * | 2009-03-23 | 2016-01-06 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 複合糖質ワクチン |
| EP2418284A1 (fr) | 2010-08-13 | 2012-02-15 | ERA Biotech, S.A. | Séquences de polypeptides induisant le corps protéiques |
| EP2870974A1 (fr) * | 2013-11-08 | 2015-05-13 | Novartis AG | Vaccins conjugués de salmonelle |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| MX2019007910A (es) | 2016-12-30 | 2019-12-05 | Sutrovax Inc | Conjugados de polipeptido-antigeno con aminoacidos no naturales. |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| WO2020009993A1 (fr) | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Améliorations apportées à des conjugués immunogènes |
| WO2020010000A1 (fr) | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Procédés améliorés pour la préparation de conjugués immunogènes |
| WO2020010016A1 (fr) | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Conjugués immunogènes auto-adjuvés |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
| US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
-
1989
- 1989-01-31 AT AT89908669T patent/ATE109008T1/de not_active IP Right Cessation
- 1989-01-31 JP JP1502396A patent/JP2921574B2/ja not_active Expired - Fee Related
- 1989-01-31 WO PCT/US1989/000388 patent/WO1989006974A2/fr active IP Right Grant
- 1989-01-31 DE DE68917126T patent/DE68917126T2/de not_active Expired - Fee Related
- 1989-01-31 EP EP89908669A patent/EP0399001B1/fr not_active Expired - Lifetime
- 1989-01-31 AU AU30654/89A patent/AU634153B2/en not_active Ceased
- 1989-02-01 CA CA000589806A patent/CA1340956C/fr not_active Expired - Fee Related
- 1989-02-01 CA CA000616882A patent/CA1340958C/fr not_active Expired - Fee Related
-
1990
- 1990-06-29 FI FI903292A patent/FI104374B/fi not_active IP Right Cessation
- 1990-06-29 NO NO902909A patent/NO179164C/no not_active IP Right Cessation
- 1990-07-31 DK DK199001829A patent/DK174416B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK182990A (da) | 1990-07-31 |
| WO1989006974A2 (fr) | 1989-08-10 |
| DE68917126D1 (de) | 1994-09-01 |
| NO902909D0 (no) | 1990-06-29 |
| NO179164C (no) | 1996-08-21 |
| FI104374B (fi) | 2000-01-14 |
| JPH03502691A (ja) | 1991-06-20 |
| NO902909L (no) | 1990-08-27 |
| FI903292A0 (fi) | 1990-06-29 |
| CA1340956C (fr) | 2000-04-11 |
| NO179164B (no) | 1996-05-13 |
| ATE109008T1 (de) | 1994-08-15 |
| AU634153B2 (en) | 1993-02-18 |
| DK182990D0 (da) | 1990-07-31 |
| AU3065489A (en) | 1989-08-25 |
| EP0399001A1 (fr) | 1990-11-28 |
| WO1989006974A3 (fr) | 1989-08-24 |
| CA1340958C (fr) | 2000-04-11 |
| JP2921574B2 (ja) | 1999-07-19 |
| DE68917126T2 (de) | 1995-02-02 |
| EP0399001B1 (fr) | 1994-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |
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