DOP2015000289A - Compuestos de 3,4-dihidroisoquinolin-2(1h)-ilo - Google Patents
Compuestos de 3,4-dihidroisoquinolin-2(1h)-iloInfo
- Publication number
- DOP2015000289A DOP2015000289A DO2015000289A DO2015000289A DOP2015000289A DO P2015000289 A DOP2015000289 A DO P2015000289A DO 2015000289 A DO2015000289 A DO 2015000289A DO 2015000289 A DO2015000289 A DO 2015000289A DO P2015000289 A DOP2015000289 A DO P2015000289A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- compounds
- dihydroisoquinolin
- ilo
- formula
- schizophrenia
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 3,4-dihydroisoquinolin-2 (1H) -yl compounds Chemical class 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a ciertos compuestos de 3,4-dihidroisoquinolin-2(1H)-ilo, particularmente compuestos de fórmula I, y composiciones farmacéuticas de los mismos. La invención además proporciona métodos para usar un compuesto de fórmula I para tratar el deterioro cognitivo asociado con la enfermedad de Parkinson o esquizofrenia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361828740P | 2013-05-30 | 2013-05-30 | |
| US201361905329P | 2013-11-18 | 2013-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2015000289A true DOP2015000289A (es) | 2015-12-31 |
Family
ID=50983199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2015000289A DOP2015000289A (es) | 2013-05-30 | 2015-11-27 | Compuestos de 3,4-dihidroisoquinolin-2(1h)-ilo |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8962654B2 (es) |
| EP (1) | EP3004061B8 (es) |
| JP (2) | JP6130590B2 (es) |
| KR (1) | KR101808933B1 (es) |
| CN (1) | CN105228985B (es) |
| AP (1) | AP2015008867A0 (es) |
| AU (2) | AU2014274435B2 (es) |
| BR (1) | BR112015029090B1 (es) |
| CA (1) | CA2912849C (es) |
| CL (1) | CL2015003444A1 (es) |
| CR (1) | CR20150622A (es) |
| CY (1) | CY1119361T1 (es) |
| DK (1) | DK3004061T3 (es) |
| DO (1) | DOP2015000289A (es) |
| EA (1) | EA029220B1 (es) |
| ES (1) | ES2647086T3 (es) |
| GT (1) | GT201500334A (es) |
| HR (1) | HRP20171696T1 (es) |
| HU (1) | HUE034607T2 (es) |
| JO (1) | JO3316B1 (es) |
| LT (1) | LT3004061T (es) |
| ME (1) | ME02838B (es) |
| MX (1) | MX373843B (es) |
| MY (1) | MY180751A (es) |
| NZ (1) | NZ713809A (es) |
| PE (1) | PE20152032A1 (es) |
| PH (1) | PH12015502658B1 (es) |
| PL (1) | PL3004061T3 (es) |
| PT (1) | PT3004061T (es) |
| RS (1) | RS56294B1 (es) |
| SG (1) | SG11201509310QA (es) |
| SI (1) | SI3004061T1 (es) |
| TN (1) | TN2015000514A1 (es) |
| TW (2) | TWI691489B (es) |
| UA (1) | UA118759C2 (es) |
| WO (1) | WO2014193781A1 (es) |
| ZA (1) | ZA201508213B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12015502514B1 (en) | 2009-11-27 | 2022-07-29 | Genzyme Corp | An amorphous and crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| JO3316B1 (ar) * | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
| AR106332A1 (es) * | 2015-10-23 | 2018-01-03 | Lilly Co Eli | Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanona |
| BR112018070363A2 (pt) | 2016-04-13 | 2019-01-29 | Ucb Biopharma Sprl | derivados de tetraidroisoquinolina |
| AU2018225556A1 (en) | 2017-02-21 | 2019-10-03 | Emory University | Chemokine CXCR4 receptor modulators and uses related thereto |
| EP3418270A1 (en) | 2017-06-19 | 2018-12-26 | Universidad Complutense De Madrid | Novel biphenylsulfoximines as allosteric modulators of the dopamine d1 receptor |
| CN111432847A (zh) * | 2017-12-01 | 2020-07-17 | Ucb生物制药有限责任公司 | 显像剂 |
| TWI725408B (zh) | 2018-04-20 | 2021-04-21 | 美商美國禮來大藥廠 | 多巴胺d1受體正向異位調節劑 |
| WO2020131671A1 (en) | 2018-12-18 | 2020-06-25 | Eli Lilly And Company | Dose regimens for use of ly3154207 in the treatment of dopaminergic cns disorders |
| TWI843678B (zh) * | 2019-06-18 | 2024-05-21 | 美商美國禮來大藥廠 | 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物 |
| US20220259179A1 (en) * | 2019-07-01 | 2022-08-18 | UCB Biopharma SRL | A Substituted Tetrahydroisoquinoiline Derivative as a D1 Positive Allosteric Modulator |
| MX2021015872A (es) * | 2019-07-01 | 2022-02-03 | UCB Biopharma SRL | Un derivado de tetrahidroisoquinolina sustituido como modulador alosterico positivo de d1. |
| WO2022076418A1 (en) * | 2020-10-07 | 2022-04-14 | Eli Lilly And Company | Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1 receptor positive allosteric modulators |
| CA3198635A1 (en) * | 2020-12-03 | 2022-06-09 | UCB Biopharma SRL | Octahydroisoquinolinyl derivatives |
| CA3202106A1 (en) * | 2020-12-18 | 2022-06-23 | Adrian Hall | Dihydroisoquinolinyl derivatives |
| KR20230121849A (ko) | 2020-12-18 | 2023-08-21 | 유씨비 바이오파마 에스알엘 | D1 포지티브 알로스테릭 모듈레이터로서 치환된 테트라하이드로이소퀴놀린유도체 |
| US20240000769A1 (en) * | 2020-12-18 | 2024-01-04 | UCB Biopharma SRL | Amorphous solid dispersions |
| ES3004257T3 (en) * | 2020-12-18 | 2025-03-12 | UCB Biopharma SRL | Prodrugs of 2-(3,5-dichloro-1-methyl-indazol-4-yl)-1-[(1s,3r)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1h-isoquinolin-2-yl]ethanone |
| WO2022192231A1 (en) | 2021-03-08 | 2022-09-15 | Eli Lilly And Company | Use of mevidalen and other d1 positive allosteric modulators in the treatment of hallucinations and dementia-related psychosis |
| AU2022234226B2 (en) * | 2021-03-09 | 2025-08-14 | Eli Lilly And Company | Use of mevidalen and other d1 positive allosteric modulators for slowing of parkinson's disease progression |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE97893T1 (de) | 1988-02-19 | 1993-12-15 | Smithkline Beecham Farma | 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten. |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| US5236934A (en) | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
| US5932590A (en) | 1996-12-05 | 1999-08-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| TR200002427T2 (tr) | 1998-02-18 | 2001-01-22 | Neurosearch A/S | Yeni bileşikler ve bunların pozitif ampa reseptör modülatörleri olarak kullanımı. |
| JP2004507456A (ja) | 2000-05-11 | 2004-03-11 | ブリストル−マイヤーズ スクイブ カンパニー | 成長ホルモン分泌促進薬として有用なテトラヒドロイソキノリン類縁体 |
| US7601739B2 (en) | 2003-08-08 | 2009-10-13 | Virgina Commonwealth University | Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases |
| US7541466B2 (en) | 2003-12-23 | 2009-06-02 | Genzyme Corporation | Tetrahydroisoquinoline derivatives for treating protein trafficking diseases |
| CA2679735A1 (en) * | 2007-03-01 | 2008-09-12 | Janssen Pharmaceutica N.V. | Tetrahydroisoquinoline compounds as modulators of the histamine h3 receptor |
| US20120252853A1 (en) * | 2011-04-01 | 2012-10-04 | H. Lundbeck A/S | Positive allosteric modulators of nicotinic acetylcholine receptor |
| BR112014015081A2 (pt) | 2011-12-21 | 2017-06-13 | Actelion Pharmaceuticals Ltd | derivados heterocíclicos e seu uso como moduladores do receptor d2 de prostaglandina |
| JO3316B1 (ar) * | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
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2014
- 2014-05-15 JO JOP/2014/0163A patent/JO3316B1/ar active
- 2014-05-16 TW TW108104751A patent/TWI691489B/zh active
- 2014-05-16 TW TW103117402A patent/TWI691488B/zh active
- 2014-05-27 HU HUE14732756A patent/HUE034607T2/en unknown
- 2014-05-27 CA CA2912849A patent/CA2912849C/en active Active
- 2014-05-27 RS RS20170896A patent/RS56294B1/sr unknown
- 2014-05-27 PE PE2015002534A patent/PE20152032A1/es unknown
- 2014-05-27 MY MYPI2015704341A patent/MY180751A/en unknown
- 2014-05-27 JP JP2016516713A patent/JP6130590B2/ja active Active
- 2014-05-27 EP EP14732756.3A patent/EP3004061B8/en active Active
- 2014-05-27 CN CN201480031030.7A patent/CN105228985B/zh active Active
- 2014-05-27 AU AU2014274435A patent/AU2014274435B2/en active Active
- 2014-05-27 MX MX2015016495A patent/MX373843B/es active IP Right Grant
- 2014-05-27 SG SG11201509310QA patent/SG11201509310QA/en unknown
- 2014-05-27 LT LTEP14732756.3T patent/LT3004061T/lt unknown
- 2014-05-27 TN TN2015000514A patent/TN2015000514A1/en unknown
- 2014-05-27 SI SI201430377T patent/SI3004061T1/sl unknown
- 2014-05-27 WO PCT/US2014/039494 patent/WO2014193781A1/en active Application Filing
- 2014-05-27 HR HRP20171696TT patent/HRP20171696T1/hr unknown
- 2014-05-27 PT PT147327563T patent/PT3004061T/pt unknown
- 2014-05-27 ME MEP-2017-221A patent/ME02838B/me unknown
- 2014-05-27 AP AP2015008867A patent/AP2015008867A0/xx unknown
- 2014-05-27 EA EA201592082A patent/EA029220B1/ru not_active IP Right Cessation
- 2014-05-27 NZ NZ71380914A patent/NZ713809A/en unknown
- 2014-05-27 DK DK14732756.3T patent/DK3004061T3/en active
- 2014-05-27 UA UAA201511029A patent/UA118759C2/uk unknown
- 2014-05-27 US US14/287,239 patent/US8962654B2/en active Active
- 2014-05-27 ES ES14732756.3T patent/ES2647086T3/es active Active
- 2014-05-27 BR BR112015029090-6A patent/BR112015029090B1/pt active IP Right Grant
- 2014-05-27 KR KR1020157033616A patent/KR101808933B1/ko active Active
- 2014-05-27 PL PL14732756T patent/PL3004061T3/pl unknown
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2015
- 2015-11-06 ZA ZA2015/08213A patent/ZA201508213B/en unknown
- 2015-11-23 CR CR20150622A patent/CR20150622A/es unknown
- 2015-11-24 CL CL2015003444A patent/CL2015003444A1/es unknown
- 2015-11-26 GT GT201500334A patent/GT201500334A/es unknown
- 2015-11-27 PH PH12015502658A patent/PH12015502658B1/en unknown
- 2015-11-27 DO DO2015000289A patent/DOP2015000289A/es unknown
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2016
- 2016-10-07 AU AU2016238934A patent/AU2016238934B2/en active Active
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2017
- 2017-04-13 JP JP2017079775A patent/JP6387433B2/ja active Active
- 2017-10-05 CY CY20171101039T patent/CY1119361T1/el unknown
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