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EA015805B9 - Пиперидиновые агонисты gpcr - Google Patents

Пиперидиновые агонисты gpcr

Info

Publication number
EA015805B9
EA015805B9 EA200900796A EA200900796A EA015805B9 EA 015805 B9 EA015805 B9 EA 015805B9 EA 200900796 A EA200900796 A EA 200900796A EA 200900796 A EA200900796 A EA 200900796A EA 015805 B9 EA015805 B9 EA 015805B9
Authority
EA
Eurasian Patent Office
Prior art keywords
gpcr agonists
piperidine
agonists
piperidine gpcr
gpcr
Prior art date
Application number
EA200900796A
Other languages
English (en)
Other versions
EA015805B1 (ru
EA200900796A1 (ru
Inventor
Лайза Сара Бертрам
Мэттью Колин Тор Файф
Ревати Перпетуа Дживаратнам
Джон Кейли
Саймон Эндрю Суэйн
Original Assignee
Прозидион Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0700124A external-priority patent/GB0700124D0/en
Priority claimed from GB0708740A external-priority patent/GB0708740D0/en
Priority claimed from GB0719762A external-priority patent/GB0719762D0/en
Application filed by Прозидион Лимитед filed Critical Прозидион Лимитед
Publication of EA200900796A1 publication Critical patent/EA200900796A1/ru
Publication of EA015805B1 publication Critical patent/EA015805B1/ru
Publication of EA015805B9 publication Critical patent/EA015805B9/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

В изобретении соединения формулы (I) или их фармацевтически приемлемые соли являются агонистами GPCR (G-белок-сопряженных рецепторов) и полезны для лечения ожирения и диабета
EA200900796A 2007-01-04 2008-01-04 Пиперидиновые агонисты gpcr EA015805B9 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0700124A GB0700124D0 (en) 2007-01-04 2007-01-04 GPCR agonists
GB0708740A GB0708740D0 (en) 2007-05-08 2007-05-08 Gpcr agonists
GB0719762A GB0719762D0 (en) 2007-10-10 2007-10-10 GPCR agonists
PCT/GB2008/050011 WO2008081205A1 (en) 2007-01-04 2008-01-04 Piperidine gpcr agonists

Publications (3)

Publication Number Publication Date
EA200900796A1 EA200900796A1 (ru) 2010-02-26
EA015805B1 EA015805B1 (ru) 2011-12-30
EA015805B9 true EA015805B9 (ru) 2012-03-30

Family

ID=39203222

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900796A EA015805B9 (ru) 2007-01-04 2008-01-04 Пиперидиновые агонисты gpcr

Country Status (27)

Country Link
US (1) US20100022591A1 (ru)
EP (2) EP2114931B1 (ru)
JP (1) JP2010514829A (ru)
KR (1) KR20090104092A (ru)
CN (1) CN101627036A (ru)
AR (1) AR064736A1 (ru)
AT (1) ATE531710T1 (ru)
AU (1) AU2008203673A1 (ru)
BR (1) BRPI0806468A2 (ru)
CA (1) CA2674093A1 (ru)
CL (1) CL2008000017A1 (ru)
DK (1) DK2114931T3 (ru)
EA (1) EA015805B9 (ru)
ES (1) ES2376015T3 (ru)
HR (1) HRP20110964T1 (ru)
IL (1) IL199680A0 (ru)
MA (1) MA31084B1 (ru)
MX (1) MX2009007180A (ru)
NZ (1) NZ578144A (ru)
PE (1) PE20081849A1 (ru)
PL (1) PL2114931T3 (ru)
PT (1) PT2114931E (ru)
RS (1) RS52168B (ru)
SA (1) SA08280756B1 (ru)
SI (1) SI2114931T1 (ru)
TW (1) TWI380818B (ru)
WO (1) WO2008081205A1 (ru)

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