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EA199700452A1 - Новые изоксазолиновые и изоксазольные антагонисты рецептора фибриногена - Google Patents

Новые изоксазолиновые и изоксазольные антагонисты рецептора фибриногена

Info

Publication number
EA199700452A1
EA199700452A1 EA199700452A EA199700452A EA199700452A1 EA 199700452 A1 EA199700452 A1 EA 199700452A1 EA 199700452 A EA199700452 A EA 199700452A EA 199700452 A EA199700452 A EA 199700452A EA 199700452 A1 EA199700452 A1 EA 199700452A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
new
compounds
fibrinogen receptor
isoxasoline
Prior art date
Application number
EA199700452A
Other languages
English (en)
Other versions
EA000924B1 (ru
Inventor
Джон Витьяк
Гари Авонн Кайн
Дуглас Гай Батт
Дональд Пинто
Минур Алван Хуссейн
Чу-Биао Ксу
Таис Мотриа Силеки-Дзурдз
Ричард Эрик Олсон
Уильям Фрэнк Деградо
Шакер Ахмед Моуса
Original Assignee
Дзе Дюпон Мерк Фармасьютикал Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Дюпон Мерк Фармасьютикал Компани filed Critical Дзе Дюпон Мерк Фармасьютикал Компани
Publication of EA199700452A1 publication Critical patent/EA199700452A1/ru
Publication of EA000924B1 publication Critical patent/EA000924B1/ru

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P35/00—Antineoplastic agents
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    • A61P37/08—Antiallergic agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Данное изобретение относится к новым изоксазолинам и изоксазолам, которые являются полезными в качестве антагонистов комплекса гликопротеин тромбоцитов IIb/IIIa рецептора фибриногена или рецептора витронектина, к фармацевтическим композициям, содержащим такие соединения, способам получения этих соединений и к способам использования этих соединений, одних или в сочетании с другими терапевтическими агентами, для ингибирования агрегации тромбоцитов, в качестве тромболитических средств и/или для лечения тромбоэмболических осложнений.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700452A 1995-05-31 1996-05-30 Изоксазолиновые антагонисты рецептора фибриногена EA000924B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/455,436 US5849736A (en) 1993-11-24 1995-05-31 Isoxazoline and isoxazole fibrinogen receptor antagonists
PCT/US1996/007692 WO1996038426A1 (en) 1995-05-31 1996-05-30 Novel isoxazoline and isoxazole fibrinogen receptor antagonists

Publications (2)

Publication Number Publication Date
EA199700452A1 true EA199700452A1 (ru) 1998-10-29
EA000924B1 EA000924B1 (ru) 2000-06-26

Family

ID=23808800

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700452A EA000924B1 (ru) 1995-05-31 1996-05-30 Изоксазолиновые антагонисты рецептора фибриногена

Country Status (26)

Country Link
US (2) US5849736A (ru)
EP (1) EP0832076B1 (ru)
JP (1) JPH11504651A (ru)
KR (1) KR19990022198A (ru)
CN (1) CN1202893A (ru)
AT (1) ATE245150T1 (ru)
AU (1) AU723577B2 (ru)
BR (1) BR9609151A (ru)
CA (1) CA2222147A1 (ru)
CZ (1) CZ374397A3 (ru)
DE (1) DE69629116T2 (ru)
EA (1) EA000924B1 (ru)
EE (1) EE9700312A (ru)
ES (1) ES2198483T3 (ru)
HU (1) HUP9900102A3 (ru)
IL (1) IL118262A (ru)
LT (1) LT4416B (ru)
LV (1) LV12046B (ru)
NZ (1) NZ309944A (ru)
PL (1) PL323835A1 (ru)
RO (1) RO117324B1 (ru)
SI (1) SI9620071A (ru)
SK (1) SK162097A3 (ru)
TW (1) TW454007B (ru)
WO (1) WO1996038426A1 (ru)
ZA (1) ZA964486B (ru)

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AU6024396A (en) 1996-12-18
WO1996038426A1 (en) 1996-12-05
LV12046B (en) 1998-09-20
ATE245150T1 (de) 2003-08-15
CZ374397A3 (cs) 1998-12-16
RO117324B1 (ro) 2002-01-30
TW454007B (en) 2001-09-11
BR9609151A (pt) 1999-06-29
LV12046A (lv) 1998-05-20
CA2222147A1 (en) 1996-12-05
LT4416B (lt) 1998-12-28
NZ309944A (en) 1999-10-28
JPH11504651A (ja) 1999-04-27
US6114328A (en) 2000-09-05
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PL323835A1 (en) 1998-04-27
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DE69629116D1 (de) 2003-08-21
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CN1202893A (zh) 1998-12-23
IL118262A (en) 2003-02-12
EP0832076B1 (en) 2003-07-16
LT97182A (en) 1998-07-27
DE69629116T2 (de) 2004-04-08
EP0832076A1 (en) 1998-04-01
HUP9900102A2 (hu) 1999-05-28
US5849736A (en) 1998-12-15
AU723577B2 (en) 2000-08-31
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