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EA199901055A1 - Фармацевтическая композиция для лечения и/или профилактики деменции - Google Patents

Фармацевтическая композиция для лечения и/или профилактики деменции

Info

Publication number
EA199901055A1
EA199901055A1 EA199901055A EA199901055A EA199901055A1 EA 199901055 A1 EA199901055 A1 EA 199901055A1 EA 199901055 A EA199901055 A EA 199901055A EA 199901055 A EA199901055 A EA 199901055A EA 199901055 A1 EA199901055 A1 EA 199901055A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dementia
prevention
treatment
pharmaceutical composition
solution
Prior art date
Application number
EA199901055A
Other languages
English (en)
Inventor
Джеймс Альберт Нэппер
Нил Мортимер
Карен Триона О'Браен
Султан Джеймс Манек
Раджиндер Кумар
Майкл Сидней Джордж Кларк
Джулия Мэри Лоудон
Original Assignee
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515624.6A external-priority patent/GB9515624D0/en
Priority claimed from GBGB9606684.0A external-priority patent/GB9606684D0/en
Application filed by Смитклайн Бичам Плс filed Critical Смитклайн Бичам Плс
Publication of EA199901055A1 publication Critical patent/EA199901055A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Способ изготовления лекарственного средства, который включает смешивание частиц носителя с водным раствором лекарственного вещества в количестве 1-3% раствора от общего веса смеси, и способ лечения и/или профилактики деменции, который включает введение пациенту [R-(Z)]-α-(метоксиимино)-α-(1-азабицикло[2.2.2]окт-3-ил)ацетонитрила моногидрохлорида в суточной дозе менее 0,01 мг/кг, а также фармацевтические композиции, используемые в этих способах.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199901055A 1995-07-29 1996-07-29 Фармацевтическая композиция для лечения и/или профилактики деменции EA199901055A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9515624.6A GB9515624D0 (en) 1995-07-29 1995-07-29 Novel process
GBGB9606684.0A GB9606684D0 (en) 1996-03-29 1996-03-29 Novel process
PCT/EP1996/003326 WO1997004750A2 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs

Publications (1)

Publication Number Publication Date
EA199901055A1 true EA199901055A1 (ru) 2000-06-26

Family

ID=26307485

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199901055A EA199901055A1 (ru) 1995-07-29 1996-07-29 Фармацевтическая композиция для лечения и/или профилактики деменции
EA199800179A EA000740B1 (ru) 1995-07-29 1996-07-29 Способ получения твердого терапевтически активного лекарственного средства, содержащего лекарство в малых дозах, и лекарственное средство, полученное этим способом

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA199800179A EA000740B1 (ru) 1995-07-29 1996-07-29 Способ получения твердого терапевтически активного лекарственного средства, содержащего лекарство в малых дозах, и лекарственное средство, полученное этим способом

Country Status (25)

Country Link
EP (1) EP0841902A2 (ru)
JP (1) JPH11510493A (ru)
KR (1) KR19990035972A (ru)
CN (1) CN1196677A (ru)
AP (1) AP858A (ru)
AR (1) AR004178A1 (ru)
AU (1) AU716961B2 (ru)
BG (1) BG102266A (ru)
BR (1) BR9609804A (ru)
CA (1) CA2228048A1 (ru)
CZ (1) CZ24798A3 (ru)
DZ (1) DZ2077A1 (ru)
EA (2) EA199901055A1 (ru)
HU (1) HUP9900521A3 (ru)
IL (1) IL122897A0 (ru)
MA (1) MA23953A1 (ru)
MX (1) MX9800809A (ru)
NO (1) NO980384L (ru)
NZ (1) NZ315632A (ru)
OA (1) OA10659A (ru)
PL (1) PL325242A1 (ru)
SK (1) SK11098A3 (ru)
TR (1) TR199800156T1 (ru)
UY (1) UY24297A1 (ru)
WO (1) WO1997004750A2 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
IL138192A0 (en) * 1998-03-11 2001-11-25 Smithkline Beecham Plc Controlled release oral dosage forms
FR2796840B1 (fr) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques Comprimes faiblement doses et procede de preparation
WO2002047693A2 (en) 2000-12-14 2002-06-20 Ortho-Mcneil Pharmaceutical, Inc. Steroid hormone products comprising a stabilizing agent in non-crystalline form
EP1734930A2 (en) * 2004-04-09 2006-12-27 Smithkline Beecham Corporation Low dose pharmaceutical products

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
JPS5970614A (ja) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd 微量主薬系湿式固形製剤方法
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
EP0392803B1 (en) * 1989-04-13 2004-06-16 Beecham Group p.l.c. Novel compounds
ZA939565B (en) * 1993-12-21 1994-08-11 Applied Analytical Ind Inc Method for preparing low dose pharmaceutical products.

Also Published As

Publication number Publication date
TR199800156T1 (xx) 1998-04-21
EP0841902A2 (en) 1998-05-20
CN1196677A (zh) 1998-10-21
HUP9900521A2 (hu) 1999-06-28
NO980384D0 (no) 1998-01-28
AP858A (en) 2000-07-12
AR004178A1 (es) 1998-11-04
EA000740B1 (ru) 2000-02-28
CZ24798A3 (cs) 1998-06-17
AU716961B2 (en) 2000-03-09
WO1997004750A3 (en) 1997-03-27
KR19990035972A (ko) 1999-05-25
NO980384L (no) 1998-03-26
AU6738496A (en) 1997-02-26
BR9609804A (pt) 1999-07-06
OA10659A (en) 2002-09-18
HUP9900521A3 (en) 2001-04-28
EA199800179A1 (ru) 1998-10-29
PL325242A1 (en) 1998-07-06
AP9801170A0 (en) 1998-01-31
BG102266A (en) 1998-10-30
SK11098A3 (en) 1998-07-08
WO1997004750A2 (en) 1997-02-13
IL122897A0 (en) 1998-08-16
MX9800809A (es) 1998-04-30
JPH11510493A (ja) 1999-09-14
DZ2077A1 (fr) 2002-07-22
UY24297A1 (es) 1997-01-23
NZ315632A (en) 1999-11-29
CA2228048A1 (en) 1997-02-13
MA23953A1 (fr) 1997-04-01

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