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EA200601591A1 - Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций - Google Patents

Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций

Info

Publication number
EA200601591A1
EA200601591A1 EA200601591A EA200601591A EA200601591A1 EA 200601591 A1 EA200601591 A1 EA 200601591A1 EA 200601591 A EA200601591 A EA 200601591A EA 200601591 A EA200601591 A EA 200601591A EA 200601591 A1 EA200601591 A1 EA 200601591A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
ribonousalic
application
flavivirus
pestivirus
Prior art date
Application number
EA200601591A
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English (en)
Inventor
Жан-Пьер Соммадосси
Паоло Лаколла
Original Assignee
Айденикс (Кайман) Лимитед
Университа Дельи Студи Ди Кальяри
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26902464&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200601591(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Айденикс (Кайман) Лимитед, Университа Дельи Студи Ди Кальяри filed Critical Айденикс (Кайман) Лимитед
Publication of EA200601591A1 publication Critical patent/EA200601591A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
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    • C07—ORGANIC CHEMISTRY
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

Настоящее изобретение относится к применению рибонуклеозидных соединений для лечения хозяина, инфицированного флавивирусом или пестивирусом, которое включает введение эффективного для уничтожения флавивируса или пестивируса количества описанного 1'-, 2'- или 3'-модифицированного нуклеозида, его фармацевтически приемлемой соли или пролекарства.
EA200601591A 2000-05-26 2001-05-23 Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций EA200601591A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20767400P 2000-05-26 2000-05-26
US28327601P 2001-04-11 2001-04-11

Publications (1)

Publication Number Publication Date
EA200601591A1 true EA200601591A1 (ru) 2007-02-27

Family

ID=26902464

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200201262A EA007867B1 (ru) 2000-05-26 2001-05-23 Композиции для лечения флавивирусных и пестивирусных инфекций и способы их применения
EA200601591A EA200601591A1 (ru) 2000-05-26 2001-05-23 Применение рибонуклеозидных соединений для лечения флавивирусных и пестивирусных инфекций

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200201262A EA007867B1 (ru) 2000-05-26 2001-05-23 Композиции для лечения флавивирусных и пестивирусных инфекций и способы их применения

Country Status (24)

Country Link
US (9) US6812219B2 (ru)
EP (2) EP1736478B1 (ru)
JP (2) JP5230052B2 (ru)
KR (2) KR20030036189A (ru)
CN (2) CN101099745A (ru)
AP (2) AP1727A (ru)
AR (1) AR032883A1 (ru)
AU (2) AU2001272923A1 (ru)
BR (1) BR0111196A (ru)
CA (1) CA2410579C (ru)
CZ (1) CZ301182B6 (ru)
EA (2) EA007867B1 (ru)
IL (1) IL153020A0 (ru)
MA (1) MA26916A1 (ru)
MX (1) MXPA02011691A (ru)
NO (1) NO327249B1 (ru)
NZ (2) NZ547204A (ru)
OA (1) OA12382A (ru)
PE (1) PE20020051A1 (ru)
PL (1) PL359169A1 (ru)
TW (1) TW200425898A (ru)
WO (1) WO2001092282A2 (ru)
YU (1) YU92202A (ru)
ZA (2) ZA200210112B (ru)

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