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EA200800430A1 - Замещённые тетрагидро-1н-пиридо[4,3,b] индолы как агонисты и антагонисты серотониновых рецепторов - Google Patents

Замещённые тетрагидро-1н-пиридо[4,3,b] индолы как агонисты и антагонисты серотониновых рецепторов

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Publication number
EA200800430A1
EA200800430A1 EA200800430A EA200800430A EA200800430A1 EA 200800430 A1 EA200800430 A1 EA 200800430A1 EA 200800430 A EA200800430 A EA 200800430A EA 200800430 A EA200800430 A EA 200800430A EA 200800430 A1 EA200800430 A1 EA 200800430A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
serotonin receptors
diseases
indols
pyrido
Prior art date
Application number
EA200800430A
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English (en)
Inventor
Тэкиу Ли
Original Assignee
Бристол-Маерс Сквибб Компани
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Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA200800430A1 publication Critical patent/EA200800430A1/ru

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Abstract

В настоящей заявке описываются соединения формулы I, включая все их фармацевтически приемлемые соли, пролекарства, сольваты и стереоизомеры, фармацевтические композиции, содержащие по меньшей мере одно соединение формулы I и, необязательно, по меньшей мере один дополнительный терапевтический агент, и способы лечения различных заболеваний, состояний и нарушений, ассоциированных с модуляцией серотониновых рецепторов, например таких, как метаболические заболевания, включающие, но без ограничения, ожирение, диабет, диабетические осложнения, атеросклероз, нарушение толерантности к глюкозе и дислипидемию; заболевания центральной нервной системы, которые включают, но без ограничения, страх, депрессию, обсессивно-компульсивное расстройство, паническое расстройство, психоз; шизофрению, расстройства сна, сексуальные расстройства и социофобии; головную боль; мигрень; и желудочно-кишечные расстройства, с помощью соединений формулы I.
EA200800430A 2005-07-28 2006-07-27 Замещённые тетрагидро-1н-пиридо[4,3,b] индолы как агонисты и антагонисты серотониновых рецепторов EA200800430A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70309105P 2005-07-28 2005-07-28
PCT/US2006/029436 WO2007016353A2 (en) 2005-07-28 2006-07-27 Substituted tetrahydro-1h-pyrido[4,3,b]indoles as serotonin receptor agonists and antagonists

Publications (1)

Publication Number Publication Date
EA200800430A1 true EA200800430A1 (ru) 2008-06-30

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EA200800430A EA200800430A1 (ru) 2005-07-28 2006-07-27 Замещённые тетрагидро-1н-пиридо[4,3,b] индолы как агонисты и антагонисты серотониновых рецепторов

Country Status (14)

Country Link
US (1) US20070027178A1 (ru)
EP (1) EP1910361A2 (ru)
JP (1) JP2009502959A (ru)
KR (1) KR20080034171A (ru)
CN (1) CN101268075A (ru)
AU (1) AU2006275694A1 (ru)
BR (1) BRPI0614485A2 (ru)
CA (1) CA2617102A1 (ru)
EA (1) EA200800430A1 (ru)
IL (1) IL188799A0 (ru)
MX (1) MX2008000811A (ru)
NO (1) NO20080317L (ru)
WO (1) WO2007016353A2 (ru)
ZA (1) ZA200800512B (ru)

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RU2007139634A (ru) 2007-10-25 2009-04-27 Сергей Олегович Бачурин (RU) Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
CA2727055C (en) 2008-01-11 2016-12-20 Albany Molecular Research, Inc. (1-azinone) -substituted pyridoindoles as mch antagonists
RU2544856C2 (ru) * 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
TWI498328B (zh) * 2008-01-25 2015-09-01 Medivation Technologies Inc 新穎之２，３，４，５－四氫－１ｈ－吡啶并〔４，３－ｂ〕吲哚化合物及其使用方法
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MX2008000811A (es) 2008-03-18
CA2617102A1 (en) 2007-02-08
BRPI0614485A2 (pt) 2011-03-29
JP2009502959A (ja) 2009-01-29
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CN101268075A (zh) 2008-09-17
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