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EA200802415A1 - REPLACED PHENYLACETIC ACIDS AS A DP-2-ANTAGONIST - Google Patents

REPLACED PHENYLACETIC ACIDS AS A DP-2-ANTAGONIST

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Publication number
EA200802415A1
EA200802415A1 EA200802415A EA200802415A EA200802415A1 EA 200802415 A1 EA200802415 A1 EA 200802415A1 EA 200802415 A EA200802415 A EA 200802415A EA 200802415 A EA200802415 A EA 200802415A EA 200802415 A1 EA200802415 A1 EA 200802415A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonist
replaced
phenylacetic acids
methods
conditions
Prior art date
Application number
EA200802415A
Other languages
Russian (ru)
Inventor
Томас Дадлер
Франсьен Фаруз
Керри Фаулер
Натали Хоторн
Данвен Хуанг
Анжела Джадкинс
Мусон Ким
Джошуа Одинго
Эми Оливер
Марк Рид
Фуцян Руан
Юджин Торсет
Original Assignee
Икос Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Икос Корпорейшн filed Critical Икос Корпорейшн
Publication of EA200802415A1 publication Critical patent/EA200802415A1/en

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Изобретение относится к замещенным фенилуксусным производным формулы (I), фармацевтическим композициям, способам их получения и способам, которые являются полезными в лечении и предупреждении нарушений или состояний, чувствительных к модуляции DP-2-рецептора, в частности воспалительных и связанных с иммунитетом нарушений и состояний, таких как астма, аллергический ринит и атопический дерматит.The invention relates to substituted phenylacetic derivatives of formula (I), pharmaceutical compositions, methods for their preparation and methods that are useful in the treatment and prevention of disorders or conditions sensitive to modulation of the DP-2 receptor, in particular inflammatory and immune related disorders and conditions such as asthma, allergic rhinitis and atopic dermatitis.

EA200802415A 2006-06-09 2007-06-08 REPLACED PHENYLACETIC ACIDS AS A DP-2-ANTAGONIST EA200802415A1 (en)

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PCT/US2007/070803 WO2007143745A2 (en) 2006-06-09 2007-06-08 Substituted phenyl acetic acids as dp-2 antagonists

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KR20150027827A (en) 2012-07-05 2015-03-12 액테리온 파마슈티칼 리미티드 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
CN102757339A (en) * 2012-08-01 2012-10-31 北京联本医药化学技术有限公司 Improved preparation method of 4-(2-carboxybenzyloxy) phenylacetic acid
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CN112300120B (en) * 2019-07-31 2023-04-14 北京四环制药有限公司 Compound for preparing balsalavir or derivatives thereof, preparation method and application thereof
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US8492437B2 (en) 2006-08-21 2013-07-23 Array Biopharma Inc. 4-substituted phenoxyphenylacetic acid derivatives

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CA2654784A1 (en) 2007-12-13
BRPI0712301A2 (en) 2012-01-17
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