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EA200971041A1 - Новые пептидные ингибиторы репликации вируса гепатита с - Google Patents

Новые пептидные ингибиторы репликации вируса гепатита с

Info

Publication number
EA200971041A1
EA200971041A1 EA200971041A EA200971041A EA200971041A1 EA 200971041 A1 EA200971041 A1 EA 200971041A1 EA 200971041 A EA200971041 A EA 200971041A EA 200971041 A EA200971041 A EA 200971041A EA 200971041 A1 EA200971041 A1 EA 200971041A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
virus replication
compound
new peptide
replication inhibitors
Prior art date
Application number
EA200971041A
Other languages
English (en)
Inventor
Стивен В. Эндрюс
Скотт Сейверт
Леонид Бейгельман
Лоренс Блат
Брэд Бакмэн
Ютонг Цзянг
Роберт Дж. Каус
Эйприл Л. Кеннеди
Тимоти С. Керчер
Майкл А. Лион
Бин Ванг
Кевин Р. Кондроски
Original Assignee
Интермьюн, Инк.
Эрей Биофарма, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39743068&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200971041(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Интермьюн, Инк., Эрей Биофарма, Инк. filed Critical Интермьюн, Инк.
Publication of EA200971041A1 publication Critical patent/EA200971041A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение раскрывает соединения общей формулы I, также композиции, включающие фармацевтические композиции, содержащие соединение по изобретению. Настоящее изобретение раскрывает соединения общей формулы II, также композиции, включающие фармацевтические композиции, содержащие соединение по изобретению. Представленное изобретение раскрывает также способы лечения, включая способы лечения вирусной инфекции гепатита С и способы лечения фиброза печени, способы обычно включают введение пациенту, который нуждается в лечении, эффективного количества соединения или композиции по изобретению.
EA200971041A 2007-05-10 2008-05-09 Новые пептидные ингибиторы репликации вируса гепатита с EA200971041A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91730007P 2007-05-10 2007-05-10
US2304108P 2008-01-23 2008-01-23
PCT/US2008/063304 WO2008141227A1 (en) 2007-05-10 2008-05-09 Novel peptide inhibitors of hepatitis c virus replication

Publications (1)

Publication Number Publication Date
EA200971041A1 true EA200971041A1 (ru) 2010-08-30

Family

ID=39743068

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200971041A EA200971041A1 (ru) 2007-05-10 2008-05-09 Новые пептидные ингибиторы репликации вируса гепатита с

Country Status (22)

Country Link
US (1) US7932277B2 (ru)
EP (1) EP2185524A1 (ru)
JP (1) JP2010526834A (ru)
KR (1) KR20100027134A (ru)
CN (1) CN101679277A (ru)
AP (1) AP2009005057A0 (ru)
AR (1) AR066528A1 (ru)
AU (1) AU2008251425A1 (ru)
BR (1) BRPI0811447A2 (ru)
CA (1) CA2686546A1 (ru)
CL (1) CL2008001381A1 (ru)
CO (1) CO6241100A2 (ru)
EA (1) EA200971041A1 (ru)
EC (1) ECSP099792A (ru)
IL (1) IL201842A0 (ru)
MA (1) MA31497B1 (ru)
MX (1) MX2009012093A (ru)
NI (1) NI200900205A (ru)
TN (1) TN2009000481A1 (ru)
TW (1) TW200902520A (ru)
WO (1) WO2008141227A1 (ru)
ZA (1) ZA200907858B (ru)

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