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EA201390821A1 - Антагонисты рецепторов лизофосфатидной кислоты и их применение - Google Patents

Антагонисты рецепторов лизофосфатидной кислоты и их применение

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Publication number
EA201390821A1
EA201390821A1 EA201390821A EA201390821A EA201390821A1 EA 201390821 A1 EA201390821 A1 EA 201390821A1 EA 201390821 A EA201390821 A EA 201390821A EA 201390821 A EA201390821 A EA 201390821A EA 201390821 A1 EA201390821 A1 EA 201390821A1
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EA
Eurasian Patent Office
Prior art keywords
antagonists
lysophpatidic
application
acid receptors
compounds
Prior art date
Application number
EA201390821A
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English (en)
Inventor
Томас Джон Сеидерс
Боуи Ванг
Николас Саймон Сток
Дебора Волкотс
Джон Говард Хатчинсон
Original Assignee
Амира Фармасьютикалс, Инк.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45418800&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201390821(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Амира Фармасьютикалс, Инк. filed Critical Амира Фармасьютикалс, Инк.
Publication of EA201390821A1 publication Critical patent/EA201390821A1/ru

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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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Abstract

В изобретении описаны соединения, которые являются антагонистами рецептора(ов) лизофосфатидной кислоты. Также описаны фармацевтические композиции и лекарственные средства, которые включают соединения, описанные в настоящем изобретении, а также способы применения таких антагонистов, отдельно и в сочетании с другими соединениями для лечения LPA-зависимых или LPA-опосредованных состояний или заболеваний.
EA201390821A 2010-12-07 2011-12-06 Антагонисты рецепторов лизофосфатидной кислоты и их применение EA201390821A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42071610P 2010-12-07 2010-12-07
PCT/US2011/063465 WO2012078593A2 (en) 2010-12-07 2011-12-06 Lysophosphatidic acid receptor antagonists and uses thereof

Publications (1)

Publication Number Publication Date
EA201390821A1 true EA201390821A1 (ru) 2013-10-30

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ID=45418800

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EA201390821A EA201390821A1 (ru) 2010-12-07 2011-12-06 Антагонисты рецепторов лизофосфатидной кислоты и их применение

Country Status (19)

Country Link
US (1) US9272990B2 (ru)
EP (1) EP2648714B1 (ru)
JP (1) JP2014508111A (ru)
KR (1) KR20130126659A (ru)
CN (1) CN103347510B (ru)
AU (1) AU2011338561A1 (ru)
BR (1) BR112013014019A2 (ru)
CA (1) CA2820817A1 (ru)
CL (1) CL2013001655A1 (ru)
CO (1) CO6771417A2 (ru)
EA (1) EA201390821A1 (ru)
IL (1) IL226491A0 (ru)
MA (1) MA34765B1 (ru)
MX (1) MX2013006040A (ru)
PE (1) PE20140879A1 (ru)
PH (1) PH12013501136A1 (ru)
SG (1) SG190417A1 (ru)
WO (1) WO2012078593A2 (ru)
ZA (1) ZA201304159B (ru)

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RU2641916C2 (ru) 2012-10-02 2018-01-23 Байер Кропсайенс Аг Гетероциклические соединения в качестве пестицидов
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JP2014231508A (ja) * 2013-05-02 2014-12-11 宇部興産株式会社 ハロゲン置換へテロ環化合物
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KR102726939B1 (ko) 2017-12-19 2024-11-05 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 피라졸 아졸
EP3728196B1 (en) 2017-12-19 2023-04-05 Bristol-Myers Squibb Company Pyrazole o-linked carbamoyl cyclohexyl acids as lpa antagonists
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