EA201590027A1 - Способы детекции заболеваний или состояний - Google Patents
Способы детекции заболеваний или состоянийInfo
- Publication number
- EA201590027A1 EA201590027A1 EA201590027A EA201590027A EA201590027A1 EA 201590027 A1 EA201590027 A1 EA 201590027A1 EA 201590027 A EA201590027 A EA 201590027A EA 201590027 A EA201590027 A EA 201590027A EA 201590027 A1 EA201590027 A1 EA 201590027A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diseases
- conditions
- detection methods
- methods
- relates
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Endocrinology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
Abstract
Настоящее изобретение относится к способам использования образца с множеством аналитических компонентов в диагностике, прогнозе или мониторировании заболеваний или состояний. Изобретение также относится к способам идентификации маркеров заболеваний или состояний.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660427P | 2012-06-15 | 2012-06-15 | |
| PCT/US2013/046020 WO2013188846A1 (en) | 2012-06-15 | 2013-06-14 | Methods of detecting diseases or conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201590027A1 true EA201590027A1 (ru) | 2015-05-29 |
Family
ID=49758768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590027A EA201590027A1 (ru) | 2012-06-15 | 2013-06-14 | Способы детекции заболеваний или состояний |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20140179805A1 (ru) |
| EP (1) | EP2861765B1 (ru) |
| JP (1) | JP2015522260A (ru) |
| KR (1) | KR20150035821A (ru) |
| CN (1) | CN104603289A (ru) |
| AU (1) | AU2013274002A1 (ru) |
| BR (1) | BR112014031365A2 (ru) |
| CA (1) | CA2876731A1 (ru) |
| EA (1) | EA201590027A1 (ru) |
| IL (1) | IL236181A0 (ru) |
| MX (1) | MX2014015425A (ru) |
| SG (2) | SG11201408385TA (ru) |
| WO (1) | WO2013188846A1 (ru) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11585814B2 (en) | 2013-03-09 | 2023-02-21 | Immunis.Ai, Inc. | Methods of detecting prostate cancer |
| WO2014164366A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting cancer |
| US20150260631A1 (en) * | 2014-03-17 | 2015-09-17 | Health Diagnostic Laboratory, Inc. | System and method for assessing quanitites or sizes of lipoprotein particles from lipoprotein particle compositions |
| JP6297676B2 (ja) | 2013-05-06 | 2018-03-20 | 日立化成株式会社 | 標的分子を捕捉するためのデバイス及び方法 |
| US10450620B2 (en) | 2013-11-07 | 2019-10-22 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-free nucleic acids for the analysis of the human microbiome and components thereof |
| WO2015095359A1 (en) * | 2013-12-17 | 2015-06-25 | Harry Stylli | Methods of detecting diseases or conditions |
| EP3161482B1 (en) * | 2014-06-27 | 2020-08-26 | XY Evergreen Technology Company | Method for enriching cns-derived exosomes |
| EP3164506A4 (en) * | 2014-07-01 | 2018-02-28 | Mayo Foundation for Medical Education and Research | Methods and materials for identifying and treating mammals resistant to proteasome inhibitor treatments |
| WO2016040843A1 (en) * | 2014-09-11 | 2016-03-17 | Harry Stylli | Methods of detecting prostate cancer |
| CN105525033A (zh) * | 2014-09-29 | 2016-04-27 | 天津华大基因科技有限公司 | 检测血液中微生物的方法及装置 |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
| JP6631852B2 (ja) * | 2014-11-12 | 2020-01-15 | 日立化成株式会社 | 臓器障害を診断するための方法および装置 |
| US11242559B2 (en) | 2015-01-13 | 2022-02-08 | The Chinese University Of Hong Kong | Method of nuclear DNA and mitochondrial DNA analysis |
| GB2555921B (en) | 2015-03-06 | 2021-09-15 | Micromass Ltd | Endoscopic tissue identification tool |
| CN107646089B (zh) | 2015-03-06 | 2020-12-08 | 英国质谱公司 | 光谱分析 |
| CA2978165A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Improved ionisation of gaseous samples |
| US10026599B2 (en) | 2015-03-06 | 2018-07-17 | Micromass Uk Limited | Rapid evaporative ionisation mass spectrometry (“REIMS”) and desorption electrospray ionisation mass spectrometry (“DESI-MS”) analysis of swabs and biopsy samples |
| EP3726562B1 (en) | 2015-03-06 | 2023-12-20 | Micromass UK Limited | Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue |
| EP3265822B1 (en) | 2015-03-06 | 2021-04-28 | Micromass UK Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| US11342170B2 (en) | 2015-03-06 | 2022-05-24 | Micromass Uk Limited | Collision surface for improved ionisation |
| EP4365928A3 (en) | 2015-03-06 | 2024-07-24 | Micromass UK Limited | Spectrometric analysis of microbes |
| CN108700590B (zh) | 2015-03-06 | 2021-03-02 | 英国质谱公司 | 细胞群体分析 |
| WO2016187234A1 (en) | 2015-05-18 | 2016-11-24 | Karius, Inc. | Compositions and methods for enriching populations of nucleic acids |
| CN105037553B (zh) * | 2015-08-20 | 2018-04-17 | 内蒙古蒙元生物基因科技有限公司 | 一种能够检测癌症的免疫球蛋白 |
| CN106467926A (zh) * | 2015-08-20 | 2017-03-01 | 北京京爱康科技有限公司 | 一种定位目标表型癌细胞中表型基因的方法 |
| DE112016003948T5 (de) | 2015-08-31 | 2018-05-09 | City Of Sapporo | Molekulare verfahren zum beurteilen einer urothelialen erkrankung |
| CN105132575B (zh) * | 2015-09-28 | 2020-03-27 | 固安博健生物技术有限公司 | 骨质疏松症的分子标志物及其应用 |
| GB201517195D0 (en) | 2015-09-29 | 2015-11-11 | Micromass Ltd | Capacitively coupled reims technique and optically transparent counter electrode |
| CN105132429A (zh) * | 2015-10-10 | 2015-12-09 | 华东理工大学 | 靶向人KPNB1基因的siRNA及其应用 |
| WO2017148432A1 (zh) * | 2016-03-04 | 2017-09-08 | 厦门大学 | 用于预测慢性乙肝患者对IFNα治疗的应答的方法和试剂盒 |
| BR112018069557A2 (pt) | 2016-03-25 | 2019-01-29 | Karius Inc | spike-ins de ácido nucléico sintético |
| EP3443354B1 (en) | 2016-04-14 | 2025-08-20 | Micromass UK Limited | Spectrometric analysis of plants |
| IL262794B2 (en) * | 2016-05-10 | 2023-10-01 | Univ Nat Corp Tokyo Medical & Dental | Expression inhibitor of inflammation promoting factor, screening method for active ingredient thereof, expression cassette useful for said method, diagnostic agent and diagnosis method |
| CN106018372B (zh) * | 2016-07-19 | 2018-06-05 | 济南大学 | 双功能复合探针构建荧光/比色双模MiRNA传感器 |
| ES2971214T3 (es) | 2016-09-02 | 2024-06-04 | Univ Texas | Sonda de recolección y métodos para su uso |
| CN106636366A (zh) * | 2016-11-25 | 2017-05-10 | 苏州首度基因科技有限责任公司 | 预测胃癌转移的基因检测试剂盒及其使用方法 |
| US10697008B2 (en) | 2017-04-12 | 2020-06-30 | Karius, Inc. | Sample preparation methods, systems and compositions |
| CN110462064A (zh) * | 2017-04-18 | 2019-11-15 | 深圳华大生命科学研究院 | 基于外泌体核酸进行微生物检测的方法及其应用 |
| CN107475366B (zh) * | 2017-07-03 | 2020-04-28 | 博尔诚(北京)科技有限公司 | 一种用于检测疾病的组合物及其试剂盒和用途 |
| US11685951B2 (en) | 2017-07-18 | 2023-06-27 | The Research Foundation For The State University Of New York | Biomarkers for intracranial aneurysm |
| CN107563069A (zh) * | 2017-09-06 | 2018-01-09 | 国电联合动力技术有限公司 | 一种风力发电机组故障智能诊断方法 |
| JP7376873B2 (ja) | 2017-11-09 | 2023-11-09 | 国立大学法人 東京医科歯科大学 | がん促進因子発現抑制剤、その有効成分のスクリーニング方法、該方法に有用な発現カセット、診断薬、及び診断方法 |
| MX2020005448A (es) | 2017-11-27 | 2020-08-27 | Univ Texas | Sonda de recoleccion minimamente invasiva y metodos para el uso de esta. |
| CN108300716B (zh) * | 2018-01-05 | 2020-06-30 | 武汉康测科技有限公司 | 接头元件、其应用和基于不对称多重pcr进行靶向测序文库构建的方法 |
| CN108384840A (zh) * | 2018-01-24 | 2018-08-10 | 安徽微分基因科技有限公司 | 一种口腔拭子无提取tp53snp基因分型方法 |
| GB201803553D0 (en) * | 2018-03-06 | 2018-04-18 | Univ Newcastle | Detection of pathological protein aggregation |
| JP7469584B2 (ja) | 2018-06-20 | 2024-04-17 | 東ソー株式会社 | 抗体の分離方法および疾患の検査方法 |
| WO2020051530A1 (en) * | 2018-09-07 | 2020-03-12 | Juneau Biosciences, L.L.C. | Methods of using genetic markers associated with endometriosis |
| KR20200048740A (ko) | 2018-10-30 | 2020-05-08 | (주)아모레퍼시픽 | Dnaja1 발현 촉진 물질을 포함하는 피부 장벽기능 강화용 조성물 및 dnaja1 촉진 물질의 스크리닝 방법 |
| EP4428234A3 (en) | 2018-11-21 | 2024-09-25 | Karius, Inc. | Direct-to-library methods, systems, and compositions |
| CN109371123B (zh) * | 2018-12-24 | 2022-06-17 | 中国医学科学院北京协和医院 | 用于检测自身炎症性疾病致病基因的探针组及试剂盒 |
| CN113853443A (zh) * | 2019-03-08 | 2021-12-28 | 株式会社Neogentc | 用于预测淋巴细胞的肿瘤反应性的标志物及其用途 |
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| WO2021041931A1 (en) * | 2019-08-28 | 2021-03-04 | The Regents Of The University Of California | Methods of producing dna methylation profiles |
| KR20220084305A (ko) * | 2019-10-04 | 2022-06-21 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 건선의 치료에서 항-종양 괴사 인자 치료법에 대한 반응성을 결정하는 방법 |
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| CN113913424B (zh) * | 2020-07-09 | 2023-08-08 | 四川大学华西医院 | 一种腺相关病毒及其制备在治疗可卡因成瘾的药物中的用途 |
| KR102400464B1 (ko) * | 2020-07-28 | 2022-05-19 | 부산대학교 산학협력단 | 암 줄기세포 검출용 바이오 마커 조성물 |
| CN111679018B (zh) * | 2020-08-14 | 2020-11-20 | 宝枫生物科技(北京)有限公司 | 用于诊断认知障碍的生物标记物及其应用 |
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| EP2861765A4 (en) | 2016-03-16 |
| EP2861765A1 (en) | 2015-04-22 |
| BR112014031365A2 (pt) | 2017-06-27 |
| IL236181A0 (en) | 2015-01-29 |
| US20150275298A1 (en) | 2015-10-01 |
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