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EA201792103A1 - Композиции и способы для ингибирования экспрессии генов hif2альфа - Google Patents

Композиции и способы для ингибирования экспрессии генов hif2альфа

Info

Publication number
EA201792103A1
EA201792103A1 EA201792103A EA201792103A EA201792103A1 EA 201792103 A1 EA201792103 A1 EA 201792103A1 EA 201792103 A EA201792103 A EA 201792103A EA 201792103 A EA201792103 A EA 201792103A EA 201792103 A1 EA201792103 A1 EA 201792103A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hif2α
hif2alph
genes
compositions
methods
Prior art date
Application number
EA201792103A
Other languages
English (en)
Inventor
Со Вон
Дэвид Л. Льюис
Дэвид Б. Розема
Даррен Х. Вэйкфилд
Вэйцзюнь Чэн
Лорен Дж. Альмейда
Андрей В. Блохин
Джеффри С. Карлсон
Энтони Л. Николас
Аарон Альмейда
Стивен Б. Каннер
Джонатан Д. Бенсон
Джастин Вудс
Original Assignee
Эрроухэд Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эрроухэд Фармасьютикалз, Инк. filed Critical Эрроухэд Фармасьютикалз, Инк.
Publication of EA201792103A1 publication Critical patent/EA201792103A1/ru

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Abstract

Описаны триггеры РНК-интерференции (РНКи) и конъюгаты РНКи-триггеров для ингибирования экспрессии гена Hif2α (EPAS1). Также описаны фармацевтические композиции, содержащие один или более РНКи-триггеров Hif2α, необязательно, с одним или более дополнительными терапевтическими средствами. Доставка описанных РНКи-триггеров Hif2α в опухолевые клетки in vivoобеспечивает ингибирование экспрессии генов Hif2α и лечение рака.
EA201792103A 2015-05-29 2016-05-27 Композиции и способы для ингибирования экспрессии генов hif2альфа EA201792103A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562168244P 2015-05-29 2015-05-29
PCT/US2016/034512 WO2016196239A1 (en) 2015-05-29 2016-05-27 Compositions and methods for inhibiting gene expression of hif2alpha

Publications (1)

Publication Number Publication Date
EA201792103A1 true EA201792103A1 (ru) 2018-06-29

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EA201792103A EA201792103A1 (ru) 2015-05-29 2016-05-27 Композиции и способы для ингибирования экспрессии генов hif2альфа

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US (3) US9976141B2 (ru)
EP (1) EP3302503A4 (ru)
JP (3) JP7021076B2 (ru)
KR (1) KR20180011198A (ru)
CN (2) CN114601845A (ru)
AR (1) AR104754A1 (ru)
AU (2) AU2016270593B2 (ru)
BR (1) BR112017025698A2 (ru)
CA (1) CA2984498C (ru)
EA (1) EA201792103A1 (ru)
HK (1) HK1252852A1 (ru)
IL (1) IL255998A (ru)
MX (1) MX2017014641A (ru)
SG (1) SG10202105989WA (ru)
TW (1) TWI761305B (ru)
WO (1) WO2016196239A1 (ru)
ZA (1) ZA201707148B (ru)

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