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EA201891589A1 - Условно активные гетеродимерные полипептиды и способы их применения - Google Patents

Условно активные гетеродимерные полипептиды и способы их применения

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Publication number
EA201891589A1
EA201891589A1 EA201891589A EA201891589A EA201891589A1 EA 201891589 A1 EA201891589 A1 EA 201891589A1 EA 201891589 A EA201891589 A EA 201891589A EA 201891589 A EA201891589 A EA 201891589A EA 201891589 A1 EA201891589 A1 EA 201891589A1
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EA
Eurasian Patent Office
Prior art keywords
conditionally active
methods
application
active heterodimeric
polypeptides
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Application number
EA201891589A
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English (en)
Inventor
Джон В. Тонтон
Венделл А. Лим
Чиа-Юнг Ву
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Те Риджентс Оф Те Юниверсити Оф Калифорния
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Publication of EA201891589A1 publication Critical patent/EA201891589A1/ru

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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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Abstract

Данное изобретение предлагает условно активные гетеродимерные полипептиды. Условно активные гетеродимерные полипептиды активны в присутствии димеризующего агента, который индуцирует димеризацию полипептидов гетеродимера. Условно активный гетеродимерный полипептид по данному изобретению пригоден для использования в различных способах исследований и лечения, которые также предлагаются.
EA201891589A 2016-01-08 2017-01-06 Условно активные гетеродимерные полипептиды и способы их применения EA201891589A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662276725P 2016-01-08 2016-01-08
PCT/US2017/012634 WO2017120546A1 (en) 2016-01-08 2017-01-06 Conditionally active heterodimeric polypeptides and methods of use thereof

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EA201891589A1 true EA201891589A1 (ru) 2019-01-31

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US (2) US11136562B2 (ru)
EP (1) EP3399991A4 (ru)
JP (2) JP7068169B2 (ru)
KR (1) KR20180096788A (ru)
CN (2) CN109310727B (ru)
AU (3) AU2017205197B2 (ru)
BR (1) BR112018013914A2 (ru)
CA (1) CA3004491A1 (ru)
EA (1) EA201891589A1 (ru)
IL (2) IL299616A (ru)
MX (1) MX2018008416A (ru)
SG (2) SG11201804038VA (ru)
WO (1) WO2017120546A1 (ru)

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