EA201991944A1 - BACILLUS SUBTILIS STRAINS IMPROVING ANIMAL PRODUCTIVITY INDICATORS - Google Patents
BACILLUS SUBTILIS STRAINS IMPROVING ANIMAL PRODUCTIVITY INDICATORSInfo
- Publication number
- EA201991944A1 EA201991944A1 EA201991944A EA201991944A EA201991944A1 EA 201991944 A1 EA201991944 A1 EA 201991944A1 EA 201991944 A EA201991944 A EA 201991944A EA 201991944 A EA201991944 A EA 201991944A EA 201991944 A1 EA201991944 A1 EA 201991944A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bacillus subtilis
- strain
- reduced
- animal
- subtilis strain
- Prior art date
Links
- 244000063299 Bacillus subtilis Species 0.000 title abstract 5
- 235000014469 Bacillus subtilis Nutrition 0.000 title abstract 5
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000037931 necrotizing enteritis Diseases 0.000 abstract 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 abstract 2
- 230000004584 weight gain Effects 0.000 abstract 2
- 235000019786 weight gain Nutrition 0.000 abstract 2
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 241000193468 Clostridium perfringens Species 0.000 abstract 1
- 208000004232 Enteritis Diseases 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 229930182566 Gentamicin Natural products 0.000 abstract 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 108010059993 Vancomycin Proteins 0.000 abstract 1
- 229960000723 ampicillin Drugs 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- 235000019730 animal feed additive Nutrition 0.000 abstract 1
- 229960005091 chloramphenicol Drugs 0.000 abstract 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 abstract 1
- 229960002227 clindamycin Drugs 0.000 abstract 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229960000318 kanamycin Drugs 0.000 abstract 1
- 229930027917 kanamycin Natural products 0.000 abstract 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
- 229930182823 kanamycin A Natural products 0.000 abstract 1
- 230000001338 necrotic effect Effects 0.000 abstract 1
- 239000006041 probiotic Substances 0.000 abstract 1
- 230000000529 probiotic effect Effects 0.000 abstract 1
- 235000018291 probiotics Nutrition 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 229960005322 streptomycin Drugs 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 abstract 1
- 229960003165 vancomycin Drugs 0.000 abstract 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
- C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Physiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Fodder In General (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
В настоящем изобретении предложен штамм Bacillus subtilis, выбранный из группы, состоящей из а) штамма, депонированного как DSM32324, б) штамма, депонированного как DSM32325, и в) мутантного штамма по (а) или (б), обладающий чувствительностью к ампициллину, ванкомицину, гентамицину, канамицину, стрептомицину, эритромицину, клиндамицину, тетрациклину и хлорамфениколу и обладающий ингибирующей активностью в отношении Е. coli и Clostridium perfringens. Кроме того, изобретение относится к композициям Bacillus, содержащим по меньшей мере один штамм Bacillus subtilis по изобретению, предпочтительно штамм Bacillus subtilis DSM32324 и/или штамм Bacillus subtilis DSM32325, в качестве пробиотика (DFM), премикса, кормовой добавки для животных или корма для животных. В изобретении предложен способ улучшения одного или более показателей продуктивности животного, выбранных из группы, состоящей из 1) увеличенного прироста массы (WG), 2) пониженного коэффициента кормоотдачи (FCR), 3) пониженной балльной оценки поражения от некротического энтерита, 4) пониженной частоты некротического энтерита, 5) пониженной смертности от некротического энтерита, 6) повышенного Европейского фактора эффективности производства (EPEF) и 7) пониженной смертности, путем кормления животного штаммом или композицией по настоящему изобретению.The present invention provides a Bacillus subtilis strain selected from the group consisting of a) a strain deposited as DSM32324, b) a strain deposited as DSM32325, and c) a mutant strain according to (a) or (b) having sensitivity to ampicillin, vancomycin , gentamycin, kanamycin, streptomycin, erythromycin, clindamycin, tetracycline and chloramphenicol, and has inhibitory activity against E. coli and Clostridium perfringens. In addition, the invention relates to Bacillus compositions containing at least one Bacillus subtilis strain according to the invention, preferably Bacillus subtilis strain DSM32324 and / or Bacillus subtilis strain DSM32325, as probiotic (DFM), premix, animal feed additive or animal feed ... The invention provides a method for improving one or more performance indicators of an animal selected from the group consisting of 1) increased weight gain (WG), 2) reduced feed-return ratio (FCR), 3) reduced scores for necrotic enteritis damage, 4) reduced frequency necrotizing enteritis, 5) reduced mortality from necrotizing enteritis, 6) increased European production efficiency factor (EPEF), and 7) reduced mortality, by feeding the animal with the strain or composition of the present invention.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18154862 | 2018-02-02 | ||
| PCT/EP2018/056442 WO2018167171A1 (en) | 2017-03-14 | 2018-03-14 | Bacillus subtilis strains improving animal performance parameters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201991944A1 true EA201991944A1 (en) | 2020-02-21 |
Family
ID=61157069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201991944A EA201991944A1 (en) | 2018-02-02 | 2018-03-14 | BACILLUS SUBTILIS STRAINS IMPROVING ANIMAL PRODUCTIVITY INDICATORS |
Country Status (1)
| Country | Link |
|---|---|
| EA (1) | EA201991944A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117461725A (en) * | 2023-12-13 | 2024-01-30 | 广东省农业科学院动物科学研究所 | Composition, feed and application for reducing emission of poultry odor substances |
-
2018
- 2018-03-14 EA EA201991944A patent/EA201991944A1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117461725A (en) * | 2023-12-13 | 2024-01-30 | 广东省农业科学院动物科学研究所 | Composition, feed and application for reducing emission of poultry odor substances |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12019502073A1 (en) | Bacillus subtilis strains improving animal performance parameters | |
| MX2021015894A (en) | Peptide acetals for stabilising enzymes. | |
| EA201792544A1 (en) | GENETICALLY DESIGNED MICROORGANISMS FOR OBTAINING PRODUCTS DESIRING FROM HORIZMAT | |
| MX2023012907A (en) | Nlrp3 inhibitors. | |
| MX2023004157A (en) | Oligosaccharide compositions for use animal feed and methods of producing thereof. | |
| MX382837B (en) | COMPOSITION AND METHOD FOR HAIR GROWTH. | |
| PH12019502853A1 (en) | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis | |
| MX2023001200A (en) | Metschnikowia species for biosynthesis of compounds. | |
| CO2019010062A2 (en) | Novel clostridium perfringens bacteriophage clo-pep-2 and its use to inhibit the proliferation of clostridium perfringens | |
| PH12020551223A1 (en) | Management of pathogenic lawsonia | |
| MX384834B (en) | NOVEL BACTERIOPHAGE ESC-COP-1 OF SHIGA TOXIN-PRODUCING E. COLI TYPE F18 AND ITS USE TO INHIBIT THE PROLIFERATION OF SHIGA TOXIN-PRODUCING E. COLI TYPE F18 | |
| MY200724A (en) | Method and use | |
| EP4424806A3 (en) | Particles including bacterial endospores | |
| EA201991944A1 (en) | BACILLUS SUBTILIS STRAINS IMPROVING ANIMAL PRODUCTIVITY INDICATORS | |
| SA520411974B1 (en) | Polycarbonate Compositions | |
| MX2022001694A (en) | METHODS AND COMPOSITIONS TO IMPROVE THE YIELD OF SOYBEAN. | |
| TN2017000318A1 (en) | Multi-stage enzymatic hydrolysis of lignocellulosic biomass | |
| MX2021001904A (en) | Solid forms of substituted benzoxaborole and compositions thereof. | |
| EA202091280A1 (en) | METHOD FOR OBTAINING FOOD PRODUCTS CONTAINING RYE | |
| MX2020007364A (en) | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators. | |
| AU2020394241A8 (en) | Composition for inhibiting HMF production comprising allulose disaccharide | |
| MX2025004910A (en) | Ahr agonists | |
| WO2023192286A3 (en) | Alkenyl succinimide compounds and their use | |
| MX2021015572A (en) | PYRAZOLOPYRIMIDINE COMPOUND, PREPARATION METHOD FOR THE SAME AND ITS APPLICATIONS. | |
| WO2019027224A3 (en) | Peptide targeting mycobacterium tuberculosis toxin-antitoxin system and use thereof |