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EE03605B1 - Protsess amorfse [R-(R*,R*)]-2-(4-fluorofenüül)-ß,š-dihüdroksü-5-(1-metüületüül)-3-fenüül-4-[(fenüülamino) -karbonüül]-1H-pürrool-1-heptaanhappe kaltsiumsoola (2:1) tootmiseks - Google Patents

Protsess amorfse [R-(R*,R*)]-2-(4-fluorofenüül)-ß,š-dihüdroksü-5-(1-metüületüül)-3-fenüül-4-[(fenüülamino) -karbonüül]-1H-pürrool-1-heptaanhappe kaltsiumsoola (2:1) tootmiseks

Info

Publication number
EE03605B1
EE03605B1 EE9700369A EE9700369A EE03605B1 EE 03605 B1 EE03605 B1 EE 03605B1 EE 9700369 A EE9700369 A EE 9700369A EE 9700369 A EE9700369 A EE 9700369A EE 03605 B1 EE03605 B1 EE 03605B1
Authority
EE
Estonia
Prior art keywords
phenylamino
methylethyl
fluorophenyl
pyrrole
dihydroxy
Prior art date
Application number
EE9700369A
Other languages
English (en)
Estonian (et)
Other versions
EE9700369A (et
Inventor
Lin Min
Schweiss Dieter
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696097&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03605(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE9700369A publication Critical patent/EE9700369A/xx
Publication of EE03605B1 publication Critical patent/EE03605B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
EE9700369A 1995-07-17 1996-07-16 Protsess amorfse [R-(R*,R*)]-2-(4-fluorofenüül)-ß,š-dihüdroksü-5-(1-metüületüül)-3-fenüül-4-[(fenüülamino) -karbonüül]-1H-pürrool-1-heptaanhappe kaltsiumsoola (2:1) tootmiseks EE03605B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US145395P 1995-07-17 1995-07-17
PCT/US1996/011807 WO1997003960A1 (en) 1995-07-17 1996-07-16 NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS [R-(R*,R*)]-2-(4-FLUOROPHENYL)-β,δ-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1)

Publications (2)

Publication Number Publication Date
EE9700369A EE9700369A (et) 1998-06-15
EE03605B1 true EE03605B1 (et) 2002-02-15

Family

ID=21696097

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700369A EE03605B1 (et) 1995-07-17 1996-07-16 Protsess amorfse [R-(R*,R*)]-2-(4-fluorofenüül)-ß,š-dihüdroksü-5-(1-metüületüül)-3-fenüül-4-[(fenüülamino) -karbonüül]-1H-pürrool-1-heptaanhappe kaltsiumsoola (2:1) tootmiseks

Country Status (37)

Country Link
US (1) US6274740B1 (xx)
EP (1) EP0839132B1 (xx)
JP (1) JP4064459B2 (xx)
KR (1) KR100400805B1 (xx)
CN (1) CN1087289C (xx)
AR (1) AR002849A1 (xx)
AT (1) ATE199542T1 (xx)
AU (1) AU700794B2 (xx)
BG (1) BG63631B1 (xx)
BR (1) BR9609714A (xx)
CA (1) CA2220455C (xx)
CO (1) CO4700441A1 (xx)
CZ (1) CZ289421B6 (xx)
DE (1) DE69611999T2 (xx)
DK (1) DK0839132T5 (xx)
EA (1) EA000625B1 (xx)
EE (1) EE03605B1 (xx)
ES (1) ES2156997T3 (xx)
GE (1) GEP20002027B (xx)
GR (1) GR3035859T3 (xx)
HR (1) HRP960312B1 (xx)
HU (1) HU220343B (xx)
IL (1) IL122161A (xx)
IN (1) IN185276B (xx)
MX (1) MX9708959A (xx)
NO (1) NO309322B1 (xx)
NZ (1) NZ313008A (xx)
PE (1) PE1698A1 (xx)
PL (1) PL191017B1 (xx)
PT (1) PT839132E (xx)
RO (1) RO120069B1 (xx)
SI (1) SI0839132T1 (xx)
SK (1) SK283204B6 (xx)
UA (1) UA50743C2 (xx)
UY (1) UY24286A1 (xx)
WO (1) WO1997003960A1 (xx)
ZA (1) ZA966043B (xx)

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* Cited by examiner, † Cited by third party
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FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
IN191236B (xx) 1999-05-25 2003-10-11 Ranbaxy Lab Ltd
HU226640B1 (en) * 1999-10-18 2009-05-28 Egis Gyogyszergyar Nyilvanosan Process for producing amorphous atorvastatin calcium salt
US6646133B1 (en) 2000-10-17 2003-11-11 Egis Gyogyszergyar Rt. Process for the preparation of amorphous atorvastatin calcium
US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
SI20425A (sl) * 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
CA2427255A1 (en) 2000-11-16 2002-06-06 Teva Pharmaceutical Industries Ltd. Hydrolysis of [r(r*,r*)]-2-(4-fluorophenyl)-.beta.,.delta. -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
SK9532003A3 (en) 2000-12-27 2004-04-06 Ciba Sc Holding Ag Crystalline forms of atorvastatin calcium
WO2002057228A1 (en) * 2001-01-17 2002-07-25 Biocon India Limited Atorvastatin calcium
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
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US7361772B2 (en) 2001-08-16 2008-04-22 Biocon Limited Process for the production of atorvastatin calcium
WO2003018547A2 (en) 2001-08-31 2003-03-06 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
HUP0500074A3 (en) 2002-03-18 2005-07-28 Biocon Ltd Bangalore Amorphous hmg-coa reductase inhibitors of desired particle size and process for producing them
RU2309141C2 (ru) * 2002-03-18 2007-10-27 Байокон Лимитид АМОРФНЫЕ ИНГИБИТОРЫ ГМГ-КоА-РЕДУКТАЗЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
AU2002356423A1 (en) * 2002-05-28 2003-12-12 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
US7179942B2 (en) 2002-07-05 2007-02-20 Bicon Limited Halo-substituted active methylene compounds
AU2002330735A1 (en) * 2002-09-03 2004-03-29 Morepen Laboratories Limited Atorvastatin calcium form vi or hydrates thereof
EA013500B1 (ru) * 2003-04-11 2010-06-30 Лек Фармасьютиклз Д.Д. Способ получения аморфной кальциевой соли аторвастатина
DE60326654D1 (de) 2003-04-22 2009-04-23 Biocon Ltd Neues verfahren zur stereoselektiven reduktion von beta-ketoestern
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US7655692B2 (en) 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
WO2005026107A1 (en) 2003-09-18 2005-03-24 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CZ298382B6 (cs) * 2004-03-10 2007-09-12 Zentiva, A. S. Zpusob prípravy amorfní formy hemivápenaté soli atorvastatinu a její stabilizace
CA2627940A1 (en) 2004-03-17 2005-10-06 Ranbaxy Laboratories Limited Process for the production of atorvastatin calcium in amorphous form
WO2005105738A2 (en) 2004-05-05 2005-11-10 Pfizer Products Inc. Salt forms of atorvastatin
CN1997651B (zh) * 2004-07-16 2012-06-06 力奇制药公司 阿托伐他汀钙的氧化降解产物
WO2006021969A1 (en) 2004-08-27 2006-03-02 Biocon Limited Process for atorvastatin calcium amorphous
KR20070106680A (ko) * 2004-09-30 2007-11-05 닥터 레디스 레보러터리즈 리미티드 비정질 아토르바스타틴 칼슘
KR20070054730A (ko) * 2004-10-18 2007-05-29 테바 파마슈티컬 인더스트리즈 리미티드 알콜 및 케톤 및/또는 에스테르의 혼합물인 유기 용매에아토르바스타틴 헤미-칼슘 염을 용해시키고 용매를제거하여 비결정형 아토르바스타틴 헤미-칼슘을 제조하는방법
CN101048141A (zh) 2004-10-28 2007-10-03 沃尼尔·朗伯有限责任公司 形成非晶形的阿托伐他汀的方法
EP1814541A4 (en) 2004-11-22 2009-10-28 Dexcel Pharma Technologies Ltd STABLE ATORVASTATIN FORMULATIONS
JP2008521878A (ja) * 2004-12-02 2008-06-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 非晶質アトルバスタチンの医薬組成物及びその製造のための方法
US20080108664A1 (en) * 2005-12-23 2008-05-08 Liu Belle B Solid-state form of AMG 706 and pharmaceutical compositions thereof
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
KR20070116963A (ko) * 2006-03-01 2007-12-11 테바 파마슈티컬 인더스트리즈 리미티드 아토르바스타틴 헤미 칼슘 결정형의 제조 방법
WO2008053312A2 (en) * 2006-11-02 2008-05-08 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate
US7834195B2 (en) 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
WO2009007856A2 (en) * 2007-07-11 2009-01-15 Actavis Group Ptc Ehf Novel polymorph of atorvastatin calcium and use thereof for the preparation of amorphous atorvastatin calcium
US20090124817A1 (en) * 2007-11-09 2009-05-14 The Industry & Academic Cooperation In Chungnam National University Process for Preparing Amorphous Atorvastatin Calcium Nanoparticles
EP2075246A1 (en) 2007-12-27 2009-07-01 M. J. Institute of Research A process for preparation of amorphous form of atorvastatin hemi-calcium salt
WO2010066846A2 (en) * 2008-12-11 2010-06-17 Dsm Ip Assets B.V. Method for the isolation of atorvastatin
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
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FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
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US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
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Also Published As

Publication number Publication date
BR9609714A (pt) 1999-02-23
PE1698A1 (es) 1998-02-19
CZ289421B6 (cs) 2002-01-16
WO1997003960A1 (en) 1997-02-06
AU700794B2 (en) 1999-01-14
BG63631B1 (bg) 2002-07-31
AU6497896A (en) 1997-02-18
UY24286A1 (es) 1997-01-17
DE69611999D1 (de) 2001-04-12
DE69611999T2 (de) 2001-07-26
KR100400805B1 (ko) 2003-12-24
HRP960312A2 (en) 1998-02-28
ATE199542T1 (de) 2001-03-15
GEP20002027B (en) 2000-04-10
SK283204B6 (sk) 2003-03-04
NZ313008A (en) 2000-01-28
IL122161A (en) 1999-07-14
HUP9903017A3 (en) 2001-01-29
NO309322B1 (no) 2001-01-15
BG102188A (en) 1998-08-31
JPH11510486A (ja) 1999-09-14
EE9700369A (et) 1998-06-15
DK0839132T3 (da) 2001-04-09
CA2220455C (en) 2002-09-24
NO980209D0 (no) 1998-01-16
SK5898A3 (en) 1998-08-05
PL191017B1 (pl) 2006-03-31
EA000625B1 (ru) 1999-12-29
ZA966043B (en) 1997-02-03
CN1087289C (zh) 2002-07-10
JP4064459B2 (ja) 2008-03-19
SI0839132T1 (xx) 2001-06-30
EA199800128A1 (ru) 1998-08-27
CN1190956A (zh) 1998-08-19
KR19990029045A (ko) 1999-04-15
HU220343B (hu) 2001-12-28
CO4700441A1 (es) 1998-12-29
NO980209L (no) 1998-01-16
US6274740B1 (en) 2001-08-14
EP0839132B1 (en) 2001-03-07
GR3035859T3 (en) 2001-08-31
CA2220455A1 (en) 1997-02-06
HRP960312B1 (en) 2001-10-31
RO120069B1 (ro) 2005-08-30
UA50743C2 (uk) 2002-11-15
DK0839132T5 (da) 2006-03-20
IL122161A0 (en) 1998-04-05
ES2156997T3 (es) 2001-08-01
IN185276B (xx) 2000-12-16
MX9708959A (es) 1998-03-31
EP0839132A1 (en) 1998-05-06
CZ12298A3 (cs) 1998-12-16
PL324463A1 (en) 1998-05-25
AR002849A1 (es) 1998-04-29
PT839132E (pt) 2001-06-29
HK1018054A1 (en) 1999-12-10

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