Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
  • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
  • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
  • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
  • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
  • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Definitions

• the invention relates to a novel process for the preparation of piperazine derivatives and salts thereof.
• the invention relates to the preparation of piperazine derivatives of the formula (I), wherein R stands for a hydrogen atom or a methyl group, and salts thereof.
• the compounds of the formula (I) influence the calcium-ion intake and can advantageously be used for the treatment of cardiovascular diseases such as myocardial infarction, congestive heart diseases, angina and arrhythmia.
• a further drawback of these processes is the necessity of using the piperazine in big excess in order to avoid the side-reaction on the other nitrogen atom of the ring.
• the object of the invention is to provide a process for eliminating the above drawbacks and preparing the end products with high yields.
• the invention is based on the recognition that if the compounds of the formulae (II) and (III) are prepared independently from each other by methods known per se and the piperazine ring is formed from these compounds as a closing step of the process, a pure and high quality end product is obtained with favourable yields.
• the present invention relates to a process for the preparation of piperazine derivatives of the formula (I) and salts thereof - in the formula R stands for a hydrogen atom or a methyl group - by reacting an amine compound of the formula (II) with a compound of the formula (III), in which R is as defined above, or with an acid addition salt thereof.
• reaction is carried out in a water-miscible organic solvent, such as acetone. It is especially preferred to use as reaction medium a 30 to 60% by volume mixture of acetone and water.
• the compound of the formula (II) is known and can be prepared e.g. from an appropriate oxirane derivative as described in J. Med. Chem. 9 , 155 (1966).
• the compound of the formula (III), in which R stands for hydrogen, is also known and can be prepared as described in Can. J. Chem. 45 , 155 (1967) from N,N-bis(2-chloroethyl)amine-hydrochloride, or by reacting a corresponding bis(2-hydroxyethyl)-amino derivative with thionyl chloride.
• the compound of the formula (III), in which R stands for a methyl group is novel. It can be prepared in an analoguous manner.
• water and a water-miscible organic solvent are used as a solvent in the form of mixtures of different composition, preferably acetone containing 30 to 60% of water, at the boiling point.
• an acid binding agent it is suitable to use different organic bases, preferably triethylamine, or an inorganic base, e.g. an aqueous solution of sodium hydroxyde.
• the compound of the formula (III) or a hydrochloride salt thereof and the compound of the formula (II)used as starting materials are boiled in equimolar ratio, in the presence of triethylamine in an amount high enough for binding the acid formed, in a 50% aqueous acetone for 1 to 3 hours; then the acetone is removed by distillation and the product is extracted from the aqueous phase with an organic solvent. If desired, the product is subjected to chromatography, or it is purified by salt formation.
• the mixture is boiled for 2 hours, then cooled to room temperature and the acetone is distilled off in vacuo.
• the residual aqueous phase is extracted twice with 10 cm3 of chloroform each.
• the organic phase is dried and evaporated.
• the residual oil is dissolved in 2 cm3 of methanol and made acidic till pH 2 by adding methanolic hydrochloric acid.
• the precipitated crystalline title product is filtered and dried. Yield: 0.85 g (60.0%), melting point: 207-211°C.

Landscapes

• Organic Chemistry (AREA)
• Chemical & Material Sciences (AREA)
• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Public Health (AREA)
• General Chemical & Material Sciences (AREA)
• Heart & Thoracic Surgery (AREA)
• Medicinal Chemistry (AREA)
• Life Sciences & Earth Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Animal Behavior & Ethology (AREA)
• Pharmacology & Pharmacy (AREA)
• General Health & Medical Sciences (AREA)
• Cardiology (AREA)
• Veterinary Medicine (AREA)
• Urology & Nephrology (AREA)
• Vascular Medicine (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Applications Claiming Priority (2)

Publications (1)

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Cited By (14)

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Citations (2)

• 1990
  • 1990-10-31 HU HU906953A patent/HU209723B/hu not_active IP Right Cessation
• 1991
  • 1991-10-29 PT PT99368A patent/PT99368A/pt not_active Application Discontinuation
  • 1991-10-30 NO NO91914250A patent/NO914250L/no unknown
  • 1991-10-30 KR KR1019910019180A patent/KR920008018A/ko not_active Withdrawn
  • 1991-10-30 ZA ZA918636A patent/ZA918636B/xx unknown
  • 1991-10-30 CS CS913294A patent/CS329491A3/cs unknown
  • 1991-10-30 AU AU86830/91A patent/AU8683091A/en not_active Abandoned
  • 1991-10-30 CA CA002054544A patent/CA2054544A1/fr not_active Abandoned
  • 1991-10-30 JP JP3285053A patent/JPH04264078A/ja active Pending
  • 1991-10-30 PL PL29222791A patent/PL292227A1/xx unknown
  • 1991-10-31 EP EP91202836A patent/EP0483932A1/fr not_active Withdrawn

Patent Citations (2)

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