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EP0632893A4 - Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding. - Google Patents

Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding.

Info

Publication number
EP0632893A4
EP0632893A4 EP93908390A EP93908390A EP0632893A4 EP 0632893 A4 EP0632893 A4 EP 0632893A4 EP 93908390 A EP93908390 A EP 93908390A EP 93908390 A EP93908390 A EP 93908390A EP 0632893 A4 EP0632893 A4 EP 0632893A4
Authority
EP
European Patent Office
Prior art keywords
aggregation
fluorescent dyes
serum binding
fluorescence immunoassays
dyes free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP93908390A
Other languages
German (de)
French (fr)
Other versions
EP0632893A1 (en
Inventor
Robert Francis Devlin
Walter Dandliker
Peter Olof Gustaf Arrhenius
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyperion Inc
Original Assignee
Diatron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatron Corp filed Critical Diatron Corp
Publication of EP0632893A1 publication Critical patent/EP0632893A1/en
Publication of EP0632893A4 publication Critical patent/EP0632893A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0838—Compounds with one or more Si-O-Si sequences
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G01N2333/19—Rubella virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP93908390A 1992-03-23 1993-03-23 Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding. Ceased EP0632893A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85617692A 1992-03-23 1992-03-23
US856176 1992-03-23
PCT/US1993/002470 WO1993019366A1 (en) 1992-03-23 1993-03-23 Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding

Publications (2)

Publication Number Publication Date
EP0632893A1 EP0632893A1 (en) 1995-01-11
EP0632893A4 true EP0632893A4 (en) 1997-01-02

Family

ID=25323005

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93908390A Ceased EP0632893A4 (en) 1992-03-23 1993-03-23 Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding.

Country Status (3)

Country Link
EP (1) EP0632893A4 (en)
CA (1) CA2132708C (en)
WO (1) WO1993019366A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919922A (en) * 1990-05-15 1999-07-06 Hyperion, Inc. Fluorescent dyes free of aggregation and serum binding
US5880287A (en) * 1990-05-15 1999-03-09 Hyperion, Inc. Polyoxyhydrocarbyl related products and methods for fluorescence assays
US6060598A (en) * 1990-05-15 2000-05-09 Hyperion, Inc. Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
US7083984B2 (en) 1993-09-24 2006-08-01 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US6238931B1 (en) 1993-09-24 2001-05-29 Biosite Diagnostics, Inc. Fluorescence energy transfer in particles
US7322927B2 (en) 1993-09-24 2008-01-29 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US5824799A (en) * 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
CA2215727C (en) * 1995-03-23 2003-12-30 Kenneth F. Buechler Hybrid phthalocyanine derivatives and their uses
US5876935A (en) * 1997-01-08 1999-03-02 Dade Behring Inc. Luminescent specific binding assay
JP2002530662A (en) * 1998-11-25 2002-09-17 ハイペリオン，インコーポレイテッド Water-soluble fluorescent dyes without aggregation and serum binding and related products and methods
EP1780213A1 (en) * 2005-10-27 2007-05-02 3M Innovative Properties Company Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups
EP2343974A4 (en) * 2008-08-15 2015-07-15 Univ Georgetown SODIUM CHANNELS, DISEASE, AND ASSAYS AND RELATED COMPOSITIONS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0502723A2 (en) * 1991-03-05 1992-09-09 Hitachi Chemical Co., Ltd. Water-soluble tetraazaporphins and fluorochrome for labeling

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0645681B2 (en) * 1986-02-05 1994-06-15 美浜 久春 Modified hem
ATE98020T1 (en) * 1986-12-15 1993-12-15 British Tech Group Usa MONOMERIC PHTHALOCYANINE REAGENTS.
DE69132750T2 (en) * 1990-05-15 2002-06-20 Hyperion, Inc. FLUORESCENT PORPHYRIN AND FLUORESCENT PHTHALOCYANIN-POLYETHYLENE GLYCOL, POLYOL AND SACCHARID DERIVATIVES AS FLUORESCENT PROBE
DE69132744T2 (en) * 1990-05-15 2002-10-10 Hyperion, Inc. Detectably labeled marker compound with a fluorophore residue, a fluorescence sample with the marker compound and uses thereof.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0502723A2 (en) * 1991-03-05 1992-09-09 Hitachi Chemical Co., Ltd. Water-soluble tetraazaporphins and fluorochrome for labeling

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9319366A1 *

Also Published As

Publication number Publication date
CA2132708A1 (en) 1993-09-30
CA2132708C (en) 2005-05-10
EP0632893A1 (en) 1995-01-11
WO1993019366A1 (en) 1993-09-30

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19941007

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19961118

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 19970214

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: HYPERION, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20030209