EP1007567A4 - Epitope-bearing major histocompatibility complex class ii element/immunoglobulin chimeric molecules - Google Patents

Epitope-bearing major histocompatibility complex class ii element/immunoglobulin chimeric molecules

Info

Publication number: EP1007567A4
Authority: EP; European Patent Office
Prior art keywords: epitope; major histocompatibility; histocompatibility complex; chimeric molecules; complex class
Prior art date: 1997-08-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP97948162A

Other languages

German (de)

French (fr)

Other versions

EP1007567A1 (en

Inventor

Sofia Casares

Teodor Doru Brumeanu

Constantin Bona

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Icahn School of Medicine at Mount Sinai

Original Assignee

Mount Sinai School of Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-19

Filing date

1997-11-04

Publication date

2005-03-16

1997-11-04 Application filed by Mount Sinai School of Medicine filed Critical Mount Sinai School of Medicine

2000-06-14 Publication of EP1007567A1 publication Critical patent/EP1007567A1/en

2005-03-16 Publication of EP1007567A4 publication Critical patent/EP1007567A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Toxicology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Rehabilitation Therapy (AREA)
Diabetes (AREA)
Cell Biology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

EP97948162A 1997-08-19 1997-11-04 Epitope-bearing major histocompatibility complex class ii element/immunoglobulin chimeric molecules Withdrawn EP1007567A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US5618597P	1997-08-19	1997-08-19
US56185P		1997-08-19
PCT/US1997/020023 WO1999009064A1 (en)	1997-08-19	1997-11-04	Epitope-bearing major histocompatibility complex class ii element/immunoglobulin chimeric molecules

Publications (2)

Publication Number	Publication Date
EP1007567A1 EP1007567A1 (en)	2000-06-14
EP1007567A4 true EP1007567A4 (en)	2005-03-16

Family

ID=22002738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP97948162A Withdrawn EP1007567A4 (en)	1997-08-19	1997-11-04	Epitope-bearing major histocompatibility complex class ii element/immunoglobulin chimeric molecules

Country Status (5)

Country	Link
EP (1)	EP1007567A4 (en)
JP (1)	JP2003524369A (en)
AU (1)	AU5428598A (en)
CA (1)	CA2301709C (en)
WO (1)	WO1999009064A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997035991A1 (en)	1996-03-28	1997-10-02	The Johns Hopkins University	Soluble divalent and multivalent heterodimeric analogs of proteins
US6458354B1 (en)	1996-03-28	2002-10-01	The Johns Hopkins University	Molecular complexes which modify immune responses
US6737057B1 (en)	1997-01-07	2004-05-18	The University Of Tennessee Research Corporation	Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors
US6268411B1 (en)	1997-09-11	2001-07-31	The Johns Hopkins University	Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses
US20030007978A1 (en) *	1997-09-16	2003-01-09	Burrows Gregory G.	Recombinant MHC molecules useful for manipulation of antigen-specific T-cells
AU765378B2 (en) *	1998-02-19	2003-09-18	President And Fellows Of Harvard College	Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor
FR2796953B1 (en) *	1999-07-29	2003-10-10	Centre Nat Rech Scient	RECOMBINANT PROTEINS, AND MOLECULAR COMPLEXES DERIVED FROM SUCH PROTEINS, ANALOGS TO MOLECULES INVOLVED IN IMMUNE RESPONSES
CA2403432A1 (en) *	2000-03-22	2001-09-27	Corixa Corporation	Immune mediators and related methods
US6811785B2 (en)	2001-05-07	2004-11-02	Mount Sinai School Of Medicine Of New York University	Multivalent MHC class II—peptide chimeras
ES2559409T3 (en)	2003-09-05	2016-02-12	Oregon Health & Science University	Monomeric recombinant MHC molecules useful for the manipulation of antigen-specific T cells
CA2595462A1 (en) *	2005-01-21	2006-07-27	Nalan Utku	Hla fusion molecules and uses thereof
KR100754667B1 (en)	2005-04-08	2007-09-03	한미약품 주식회사	Immunoglobulin Fc Fragments Modified with Non-Peptide Polymers and Pharmaceutical Compositions Comprising the Same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993010220A1 (en) *	1991-11-19	1993-05-27	Anergen, Inc.	Soluble mhc molecules and their uses
WO1995023814A1 (en) *	1994-03-04	1995-09-08	National Jewish Center For Immunology And Respiratory Medicine	Product and process for t cell regulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5126433A (en) *	1986-08-21	1992-06-30	The Trustees Of Columbia University In The City Of New York	Soluble forms of the t cell surface protein cd4
US5109123A (en) *	1988-06-14	1992-04-28	Dana Farber Cancer Institute	Alteration of ability of soluble CD4 fragments to bind HIV
US5130297A (en) *	1988-06-23	1992-07-14	Anergen, Inc.	Conjugates useful in ameliorating autoimmunity MHC-II-peptide

1997
- 1997-11-04 WO PCT/US1997/020023 patent/WO1999009064A1/en active Application Filing
- 1997-11-04 JP JP2000509741A patent/JP2003524369A/en active Pending
- 1997-11-04 CA CA2301709A patent/CA2301709C/en not_active Expired - Fee Related
- 1997-11-04 EP EP97948162A patent/EP1007567A4/en not_active Withdrawn
- 1997-11-04 AU AU54285/98A patent/AU5428598A/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993010220A1 (en) *	1991-11-19	1993-05-27	Anergen, Inc.	Soluble mhc molecules and their uses
WO1995023814A1 (en) *	1994-03-04	1995-09-08	National Jewish Center For Immunology And Respiratory Medicine	Product and process for t cell regulation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CASARES ET AL: "ENGINEERING AND CHARACTERIZATION OF A MURINE MHC CLASS II-IMMUNOGLOBULIN CHIMERA EXPRESSING AN IMMUNODOMINANT CD4 T VIRAL EPITOPE", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 10, no. 11, 1997, pages 1295 - 1301, XP002097124, ISSN: 0269-2139 *
See also references of WO9909064A1 *

Also Published As

Publication number	Publication date
CA2301709A1 (en)	1999-02-25
JP2003524369A (en)	2003-08-19
WO1999009064A1 (en)	1999-02-25
AU5428598A (en)	1999-03-08
EP1007567A1 (en)	2000-06-14
CA2301709C (en)	2011-03-01

Publication	Publication Date	Title
AU136213S (en)	1999-01-13	Filter element
ZA983656B (en)	1998-11-02	Chimeric opg polypeptides
AUPN560795A0 (en)	1995-10-19	Heating element assembly
GB2324146B (en)	2000-09-27	Heaters
EP1007567A4 (en)	2005-03-16	Epitope-bearing major histocompatibility complex class ii element/immunoglobulin chimeric molecules
GB9727046D0 (en)	1998-02-18	Electrical heater element
AU1864595A (en)	1995-09-11	Catalytic heating element
GB2290577B (en)	1999-01-27	Concealed fixing clip
HUP9800744A3 (en)	2001-04-28	Antibodies against fas-antigene
AU1398297A (en)	1998-08-03	Planar heating element
HU9600370V0 (en)	1997-01-28	Heating element
ATA225694A (en)	2001-01-15	HEATER CARTRIDGE
AU9427298A (en)	1999-05-10	Highly efficient heating element
ZA983810B (en)	1998-11-09	Assembly element
DE69730219D1 (en)	2004-09-16	heating element
ATA177498A (en)	2001-11-15	HEATING ELEMENT
GB9808531D0 (en)	1998-06-17	Immersion heater assembly
GB2316124B (en)	2001-03-21	Spring clips
KR970010406U (en)	1997-03-29	Flanged waterproof heater assembly
GB9718550D0 (en)	1997-11-05	Filter element
KR960003014U (en)	1996-01-22	Slide heater
TW333039U (en)	1998-06-01	Improved spine fixing means
GB9811207D0 (en)	1998-07-22	Modified immunoglobulin e molecules
AU127799S (en)	1996-09-06	Clip case assembly
GB9516436D0 (en)	1995-10-11	Portable heater

Legal Events

Date	Code	Title	Description
2000-04-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2000-06-14	17P	Request for examination filed	Effective date: 20000209
2000-06-14	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2005-03-16	A4	Supplementary search report drawn up and despatched	Effective date: 20050128
2012-02-08	RIC1	Information provided on ipc code assigned before grant	Ipc: C07K 14/47 20060101ALI20111230BHEP Ipc: C07K 14/11 20060101ALI20111230BHEP Ipc: C07K 14/705 20060101AFI20111230BHEP
2012-10-26	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2012-11-28	18D	Application deemed to be withdrawn	Effective date: 20120601