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EP1935392B1 - Raccord pour coupler avec sûreté des seringues de différent types - Google Patents

Raccord pour coupler avec sûreté des seringues de différent types Download PDF

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Publication number
EP1935392B1
EP1935392B1 EP06126404A EP06126404A EP1935392B1 EP 1935392 B1 EP1935392 B1 EP 1935392B1 EP 06126404 A EP06126404 A EP 06126404A EP 06126404 A EP06126404 A EP 06126404A EP 1935392 B1 EP1935392 B1 EP 1935392B1
Authority
EP
European Patent Office
Prior art keywords
syringes
syringe adapter
syringe
adapter
baffles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP06126404A
Other languages
German (de)
English (en)
Other versions
EP1935392A1 (fr
Inventor
Klaus-Dieter Beller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meckel-Spenglersan GmbH
Original Assignee
Meckel-Spenglersan GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE102005030510A priority Critical patent/DE102005030510A1/de
Application filed by Meckel-Spenglersan GmbH filed Critical Meckel-Spenglersan GmbH
Priority to AT06126404T priority patent/ATE439114T1/de
Priority to DE200650004538 priority patent/DE502006004538D1/de
Priority to EP06126404A priority patent/EP1935392B1/fr
Publication of EP1935392A1 publication Critical patent/EP1935392A1/fr
Application granted granted Critical
Publication of EP1935392B1 publication Critical patent/EP1935392B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/431—Straight mixing tubes with baffles or obstructions that do not cause substantial pressure drop; Baffles therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/714—Feed mechanisms for feeding predetermined amounts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7161—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7163—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms

Definitions

  • the invention relates to an adapter for the secure and stable connection of two syringes of unequal design for the preparation of means to be administered by syringe, such as diagnostics, therapeutics and modified autologous blood.
  • Two syringes can be connected together so that the inside of the first and second syringes communicate with each other via the adapter.
  • Echo contrast agents and therapeutics e.g. Lyophilisates
  • autologous blood treatment it is often necessary in the administration of diagnostics, such as e.g. Echo contrast agents and therapeutics, e.g. Lyophilisates and in the autologous blood treatment to achieve a homogenization of the means to produce homogeneous suspensions or emulsions, or in agents such as echo contrast agents containing surfactants to promote the formation of microbubbles.
  • a mixing device for microbubble echo contrast agent in which a syringe is inextricably linked to a mixing chamber, the mixing walls on their inner walls also for the deflection of the flowing through Medium and which is connected to a syringe containing the medium in which the microbubbles are to be generated in order to generate the microbubbles by pumping the medium back and forth through the mixing chamber.
  • the defined volume of the mixing chamber makes it possible to produce a defined number of microbubbles when an equal agitation power, ie back and forth, is present.
  • the present invention seeks to provide an adapter of the type described above with improved properties and thus to eliminate the disadvantages described above.
  • an adapter which, with the use of two syringes of the same or different design, enables the safe and effective introduction of energy for mixing different media.
  • the adapter according to the invention stabilizes the syringes during vigorous pumping of the substances between the syringes and prevents the breakage of the system at the level of the adapter and in the area of the syringe cone.
  • the basic idea of the adapter according to the invention is that not only the cone of the syringe is fixed in the adapter, but also a portion of the syringe barrel is partially enclosed by the adapter and thus stabilized.
  • the hole in the adapter is not round, as expected, but elongated. This allows the stable guidance and fixation to about half the circumference of the syringe plunger of any design.
  • the adapter In order to enable the universal applicability of the adapter according to the invention and thus of the mixing device, it is proposed to design the adapter such that the respective connections are designed as Luer-Lock female-female or Luer-Lock male-female or Luer-Lock male-male. That is, either the free ends are both formed as female terminals, as in the example shown or one end as a male terminal with a corresponding outer cone and the other end as a female terminal. Or both free ends are designed as male connectors. Furthermore, it is preferred that the adapter in the connection area in such a way that it can be mounted on commercial syringes with Luer-Lock-cone according to DIN 13090, especially for syringes sizes 2 ml to 50 ml.
  • adapter can be provided in the manufacture or subsequently with mixing elements.
  • static or flexible resistors, baffles or diaphragms are introduced into the flow channel.
  • the syringe adapter according to the invention has on each side two staggered, merging holes with the purpose to lead and fix not identical syringes when connecting. In the intersection of the merging holes of the flow channel is positioned with a smaller diameter.
  • the walls of the larger holes fix and stabilize the syringes during the mixing process and prevent the breaking or breaking off.
  • the walls of the pilot holes should reach at least the 1 ml mark of the syringes. As the wall height increases, the stability of the system increases.
  • the syringe adapter is characterized in that in the thinner flow channel arbitrarily shaped baffles, obstacles, resistors are installed. These baffles, obstacles, resistors can be insoluble connected to the syringe adapter or be positioned as cuttable replaceable in the flow channel. By specifying the construction volume of the baffles, obstacles, resistors, the gas volume in the flow channel can be defined.
  • the invention provides an adapter for commercial syringes, which allows various substances (liquid, gaseous) under well-defined conditions by means of two syringes effectively and reproducibly mix or energize.
  • the quality of the mixture or energization is easily reproducible and representable by means of variable baffles and resistors.
  • the invention thus also relates to the use of the syringe adapter according to the invention for mixing substances by means of two syringes.
  • the syringe adapter according to the invention enables a reproducible and thus necessarily properly feasible effective mixing of appropriate diagnostics and therapeutics at a defined predetermined docking amount of gas.
  • the syringe adapter according to the invention is not only suitable for a specific therapeutic or diagnostic agent for treatment, but in a universal manner for a variety of means to be administered by injection composed of liquid, pasty or liquid and powdery or liquid, pasty and gaseous media and must be homogenized.
  • the adapter of the first embodiment in FIG. 1 and FIG. 2 has a central channel with bar-like baffles.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (9)

  1. Adaptateur de seringue comprenant de chaque côté deux alésages décalés passants les uns dans les autres formant un alésage allongé contenant dans l'intersection des deux alésages passants les uns dans les autres un canal d'écoulement avec un diamètre plus petit que le diamètre des alésage.
  2. Adaptateur de seringue selon la revendication 1, caractérisé en ce que les raccords respectifs sont conformés en Luer-Lock femelle-femelle ou Luer-Lock mâle-femelle ou Luer-Lock mâle-mâle.
  3. Adaptateur de seringue selon la revendication 1, caractérisé en ce que des cônes Luer-Lock selon DIN 13090 peuvent être raccordés.
  4. Adaptateur de seringue selon l'une des revendications 1 à 3, caractérisé en ce qu'il comprend en outre des résistances, chicanes ou écrans statiques ou flexibles.
  5. Adaptateur de seringue selon la revendication 4, caractérisé en ce que les chicanes, obstacles, résistances sont reliés avec l'adaptateur de seringue d'une manière non amovible ou bien que les chicanes, obstacles, résistances sont positionnés dans le canal d'écoulement en tant qu'éléments mâles interchangeables.
  6. Adaptateur de seringue selon la revendication 5, caractérisé en ce que le volume de gaz dans le canal d'écoulement peut être défini par la spécification du volume de construction des chicanes, des obstacles, des résistances.
  7. Utilisation de l'adaptateur de seringue selon l'une des revendications 1 à 6 pour mélanger des matières au moyen des deux seringues.
  8. Utilisation selon la revendication 7 pour mélanger des diagnostiques et des médications dans le cas d'une quantité de gaz prédéfinie à intégrer.
  9. Utilisation selon la revendication 7 pour composition ou homogénéisation pour des agents différents à administrer par injection comportant des milieux liquides, pâteux ou liquides et poudreux ou liquides, pâteux et gazeux.
EP06126404A 2005-06-30 2006-12-18 Raccord pour coupler avec sûreté des seringues de différent types Active EP1935392B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE102005030510A DE102005030510A1 (de) 2005-06-30 2005-06-30 Spritzenadapter für sichere Verbindung von Spritzen ungleicher Bauart
AT06126404T ATE439114T1 (de) 2005-06-30 2006-12-18 Spritzenadapter für eine sichere verbindung von spritzen ungleicher bauart
DE200650004538 DE502006004538D1 (de) 2006-12-18 2006-12-18 Spritzenadapter für eine sichere Verbindung von Spritzen ungleicher Bauart
EP06126404A EP1935392B1 (fr) 2005-06-30 2006-12-18 Raccord pour coupler avec sûreté des seringues de différent types

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030510A DE102005030510A1 (de) 2005-06-30 2005-06-30 Spritzenadapter für sichere Verbindung von Spritzen ungleicher Bauart
EP06126404A EP1935392B1 (fr) 2005-06-30 2006-12-18 Raccord pour coupler avec sûreté des seringues de différent types

Publications (2)

Publication Number Publication Date
EP1935392A1 EP1935392A1 (fr) 2008-06-25
EP1935392B1 true EP1935392B1 (fr) 2009-08-12

Family

ID=39769352

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06126404A Active EP1935392B1 (fr) 2005-06-30 2006-12-18 Raccord pour coupler avec sûreté des seringues de différent types

Country Status (3)

Country Link
EP (1) EP1935392B1 (fr)
AT (1) ATE439114T1 (fr)
DE (1) DE102005030510A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2762086C (fr) * 2008-08-22 2015-06-02 Matthew R. Kyle Dispositifs de gestion de fluide et procedes afferents
CH700895A1 (de) 2009-04-28 2010-10-29 Medmix Systems Ag Austragvorrichtung mit mischeinrichtung.
US20130105018A1 (en) * 2011-10-28 2013-05-02 Medtronic Xomed, Inc. Turbulence-inducing mixing device
US9707319B2 (en) * 2013-06-20 2017-07-18 Nordson Corporation Device and method for improving hydration of a biomaterial
US10773067B2 (en) 2014-09-08 2020-09-15 Neomed, Inc. Enteral connectors having coupling features
USD825746S1 (en) 2015-06-18 2018-08-14 Neomed, Inc. Syringe-to-syringe coupler
WO2016205626A1 (fr) * 2015-06-18 2016-12-22 Neomed, Inc. Système de couplage seringue-à-seringue avec embout mâle
WO2017147233A2 (fr) 2016-02-24 2017-08-31 Neomed, Inc. Raccord de transfert de fluide
USD833006S1 (en) 2016-11-28 2018-11-06 Neomed, Inc. Fluid transfer connector

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1416305A (en) * 1971-12-06 1975-12-03 Mpl Inc Slidable plunger for liquid dispenser
US4046145A (en) * 1976-06-29 1977-09-06 American Hospital Supply Corporation Syringe connector
US5002538A (en) * 1988-10-25 1991-03-26 Johnson Johnnie M Syringe adapter and method
DE9214935U1 (de) * 1992-11-03 1992-12-24 Körbächer, Petra, 5600 Wuppertal Konnektor für Perfusorspritzen
US6599441B1 (en) * 2000-07-18 2003-07-29 Emerald Biostructures, Inc. Crystallization solutions
JP2002177392A (ja) * 2000-11-08 2002-06-25 West Pharmaceutical Services Inc 注射器安全装置

Also Published As

Publication number Publication date
ATE439114T1 (de) 2009-08-15
EP1935392A1 (fr) 2008-06-25
DE102005030510A1 (de) 2007-01-18

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