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EP2046314A4 - Dianthraquinones polycycliques comme inhibiteurs de cytokines inflammatoires - Google Patents

Dianthraquinones polycycliques comme inhibiteurs de cytokines inflammatoires

Info

Publication number
EP2046314A4
EP2046314A4 EP07790022A EP07790022A EP2046314A4 EP 2046314 A4 EP2046314 A4 EP 2046314A4 EP 07790022 A EP07790022 A EP 07790022A EP 07790022 A EP07790022 A EP 07790022A EP 2046314 A4 EP2046314 A4 EP 2046314A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
inflammatory cytokines
dianthraquinones
polycyclic
polycyclic dianthraquinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07790022A
Other languages
German (de)
English (en)
Other versions
EP2046314A2 (fr
Inventor
Zadik Hazan
Ruth Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HY BIOPHARMA Inc
Original Assignee
HY BIOPHARMA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HY BIOPHARMA Inc filed Critical HY BIOPHARMA Inc
Publication of EP2046314A2 publication Critical patent/EP2046314A2/fr
Publication of EP2046314A4 publication Critical patent/EP2046314A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP07790022A 2006-08-03 2007-08-02 Dianthraquinones polycycliques comme inhibiteurs de cytokines inflammatoires Withdrawn EP2046314A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83509806P 2006-08-03 2006-08-03
PCT/IL2007/000967 WO2008015680A2 (fr) 2006-08-03 2007-08-02 Dianthraquinones polycycliques comme inhibiteurs de cytokines inflammatoires

Publications (2)

Publication Number Publication Date
EP2046314A2 EP2046314A2 (fr) 2009-04-15
EP2046314A4 true EP2046314A4 (fr) 2009-12-30

Family

ID=38997569

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07790022A Withdrawn EP2046314A4 (fr) 2006-08-03 2007-08-02 Dianthraquinones polycycliques comme inhibiteurs de cytokines inflammatoires

Country Status (4)

Country Link
US (1) US20100048728A1 (fr)
EP (1) EP2046314A4 (fr)
CA (1) CA2659800A1 (fr)
WO (1) WO2008015680A2 (fr)

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0256452A2 (fr) * 1986-08-08 1988-02-24 Yeda Research And Development Company Limited Compositions pharmaceutiques antivirales contenant de l'hypericine ou du pseudohypericine
US4898891A (en) * 1987-08-07 1990-02-06 Yeda Research And Development Company Ltd. Antiviral compositions
EP0432496A2 (fr) * 1989-11-15 1991-06-19 Yeda Research And Development Company Limited Préparation d'hypéricine
WO1993008797A1 (fr) * 1991-11-01 1993-05-13 New York University Compositions a base d'hypercine destinees a traiter les maladies induites par des lymphocytes t
US5514714A (en) * 1990-08-23 1996-05-07 New York University Methods and polycyclic aromatic compound containing compositions for treating T-cell-mediated diseases
WO1999006347A1 (fr) * 1997-07-31 1999-02-11 Yeda Research And Development Company Ltd. Utilisation de 1,3,4,6-tetrahydroxy-helianthrone et de ses derives dans le traitement photodynamique et certains nouveaux derives
WO2000002455A1 (fr) * 1998-07-09 2000-01-20 Cv Technologies Inc. Hypericine et extrait d'hypericum: agents bloquant les canaux de calcium de type c et leur utilisation comme agents therapeutiques diriges contre le canal de calcium de type t
WO2000057707A1 (fr) * 1999-03-15 2000-10-05 Proteotech, Inc. Methodes de traitement de la maladie d'alzheimer et d'autres amyloses avec l'hypericum perforatum et ses derives
US6159986A (en) * 1999-11-02 2000-12-12 Altman; David A. Compounds and therapy for resisting memory loss in humans
WO2004047821A1 (fr) * 2002-11-25 2004-06-10 New York University Procedes de prevention d'endommagement ph ototoxique de tissus lors de la therapie photodynamique
WO2005009423A1 (fr) * 2003-07-25 2005-02-03 K.U.Leuven Research And Development Agent traceur presentant une avidite pour la necrose
WO2007106884A2 (fr) * 2006-03-15 2007-09-20 Theralogics, Inc. Méthodes de traitement des maladies d'atrophie musculaire au moyen d'inhibiteurs de l'activation de nf-kb
WO2008079980A1 (fr) * 2006-12-22 2008-07-03 Alcon Research, Ltd. Inhibiteurs de la protéine kinase c-delta pour le traitement du glaucome

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0256452A2 (fr) * 1986-08-08 1988-02-24 Yeda Research And Development Company Limited Compositions pharmaceutiques antivirales contenant de l'hypericine ou du pseudohypericine
US4898891A (en) * 1987-08-07 1990-02-06 Yeda Research And Development Company Ltd. Antiviral compositions
EP0432496A2 (fr) * 1989-11-15 1991-06-19 Yeda Research And Development Company Limited Préparation d'hypéricine
US5514714A (en) * 1990-08-23 1996-05-07 New York University Methods and polycyclic aromatic compound containing compositions for treating T-cell-mediated diseases
WO1993008797A1 (fr) * 1991-11-01 1993-05-13 New York University Compositions a base d'hypercine destinees a traiter les maladies induites par des lymphocytes t
WO1999006347A1 (fr) * 1997-07-31 1999-02-11 Yeda Research And Development Company Ltd. Utilisation de 1,3,4,6-tetrahydroxy-helianthrone et de ses derives dans le traitement photodynamique et certains nouveaux derives
WO2000002455A1 (fr) * 1998-07-09 2000-01-20 Cv Technologies Inc. Hypericine et extrait d'hypericum: agents bloquant les canaux de calcium de type c et leur utilisation comme agents therapeutiques diriges contre le canal de calcium de type t
WO2000057707A1 (fr) * 1999-03-15 2000-10-05 Proteotech, Inc. Methodes de traitement de la maladie d'alzheimer et d'autres amyloses avec l'hypericum perforatum et ses derives
US6159986A (en) * 1999-11-02 2000-12-12 Altman; David A. Compounds and therapy for resisting memory loss in humans
WO2004047821A1 (fr) * 2002-11-25 2004-06-10 New York University Procedes de prevention d'endommagement ph ototoxique de tissus lors de la therapie photodynamique
WO2005009423A1 (fr) * 2003-07-25 2005-02-03 K.U.Leuven Research And Development Agent traceur presentant une avidite pour la necrose
WO2007106884A2 (fr) * 2006-03-15 2007-09-20 Theralogics, Inc. Méthodes de traitement des maladies d'atrophie musculaire au moyen d'inhibiteurs de l'activation de nf-kb
WO2008079980A1 (fr) * 2006-12-22 2008-07-03 Alcon Research, Ltd. Inhibiteurs de la protéine kinase c-delta pour le traitement du glaucome

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BORK P M ET AL: "HYPERICIN AS A NON-ANTIOXIDANT INHIBITOR OF NF-KAPPA B", PLANTA MEDICA, THIEME, STUTTGART, DE, vol. 65, no. 4, 1 January 1999 (1999-01-01), pages 297 - 300, XP000913454, ISSN: 0032-0943 *
LAVIE G ET AL: "A PHOTODYNAMIC PATHWAY TO APOPTOSIS AND NECROSIS INDUCED BY DIMETHYL TETRAHYDROXYHELIANTHRONE AND HYPERICIN IN LEUKAEMIC CELLS:POSSIBLE RELEVANCE TO PHOTODYNAMIC THERAPY", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP, LONDON, GB, vol. 79, 1 February 1999 (1999-02-01), pages 423 - 432, XP000995892, ISSN: 0007-0920 *
LI L-L ET AL: "Hypericin's effects on retinal glutamate in acute ocular hypertension of rabbits", GUOJI YANKE ZAZHI = INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, ZHONGHUA YIXUEHUI, XIAN FENHUI, CN, vol. 7, no. 5, 1 January 2007 (2007-01-01), pages 1308 - 1310, XP001538241, ISSN: 1672-5123 *
SHAI RAHIMIPOUR, NAOMI LITICHEVER-COSLOVSKY, MORAN ALALUF, DALIA FREEMANN, BENJAMIN EHRENBERG, LEV WEINER, YEHUDA MAZUR, MATI FRID: "Novel Methyl Helianthrones as Photosensitizers: Synthesis and Biological Evaluationkin, yitzhal koch", PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. 81, 2005, pages 250 - 258, XP002555732 *

Also Published As

Publication number Publication date
EP2046314A2 (fr) 2009-04-15
CA2659800A1 (fr) 2008-02-07
US20100048728A1 (en) 2010-02-25
WO2008015680A3 (fr) 2009-03-26
WO2008015680A2 (fr) 2008-02-07

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Effective date: 20100730