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EP2345896A4 - LIQUID-LIQUID CHROMATOGRAPHY DEVICE AND LIQUID-LIQUID CHROMATOGRAPHY - Google Patents

LIQUID-LIQUID CHROMATOGRAPHY DEVICE AND LIQUID-LIQUID CHROMATOGRAPHY

Info

Publication number
EP2345896A4
EP2345896A4 EP09819171.1A EP09819171A EP2345896A4 EP 2345896 A4 EP2345896 A4 EP 2345896A4 EP 09819171 A EP09819171 A EP 09819171A EP 2345896 A4 EP2345896 A4 EP 2345896A4
Authority
EP
European Patent Office
Prior art keywords
liquid
chromatography
liquid chromatography
chromatography device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09819171.1A
Other languages
German (de)
French (fr)
Other versions
EP2345896A1 (en
EP2345896B1 (en
Inventor
Toshikatsu Sakai
Akira Sezaki
Takeshi Takagi
Takuya Yotani
Makoto Takahara
Takayuki Oka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arkray Inc
Sekisui Medical Co Ltd
Original Assignee
Arkray Inc
Sekisui Medical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arkray Inc, Sekisui Medical Co Ltd filed Critical Arkray Inc
Publication of EP2345896A1 publication Critical patent/EP2345896A1/en
Publication of EP2345896A4 publication Critical patent/EP2345896A4/en
Application granted granted Critical
Publication of EP2345896B1 publication Critical patent/EP2345896B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/202—Injection using a sampling valve rotary valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G01N2030/207—Injection using a sampling valve with metering cavity, e.g. sample loop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP09819171.1A 2008-10-07 2009-10-06 Liquid chromatography device and liquid chromatography method Active EP2345896B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008260465A JP2011141120A (en) 2008-10-07 2008-10-07 Liquid chromatography device and liquid chromatography
PCT/JP2009/067369 WO2010041637A1 (en) 2008-10-07 2009-10-06 Liquid chromatography device and liquid chromatography

Publications (3)

Publication Number Publication Date
EP2345896A1 EP2345896A1 (en) 2011-07-20
EP2345896A4 true EP2345896A4 (en) 2013-07-03
EP2345896B1 EP2345896B1 (en) 2017-05-03

Family

ID=42100587

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09819171.1A Active EP2345896B1 (en) 2008-10-07 2009-10-06 Liquid chromatography device and liquid chromatography method

Country Status (6)

Country Link
US (1) US9310342B2 (en)
EP (1) EP2345896B1 (en)
JP (2) JP2011141120A (en)
KR (1) KR101299644B1 (en)
CN (1) CN102171562B (en)
WO (1) WO2010041637A1 (en)

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* Cited by examiner, † Cited by third party
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KR101365921B1 (en) * 2011-09-02 2014-02-19 주식회사 아모그린텍 Apparatus for Separating Analytes and Apparatus for Detecting Analytes Using the Same
JP2014006241A (en) * 2012-05-30 2014-01-16 Arkray Inc Liquid chromatography apparatus, liquid chromatography analysis method and liquid chromatography analysis program
CN103623612A (en) * 2012-08-29 2014-03-12 奇复康药物研发(苏州)有限公司 Liquid adding device
CN103969349A (en) * 2013-01-29 2014-08-06 深圳普门科技有限公司 A washing method of inspection equipment and the inspection equipment thereof
CN105745535B (en) * 2013-07-17 2017-07-28 积水医疗株式会社 Gradient Liquid Delivery Devices for Sample Analyzers
JP2015052592A (en) 2013-08-07 2015-03-19 アークレイ株式会社 Liquid chromatography device, liquid chromatography analysis method, and liquid chromatography analysis program
WO2017070154A2 (en) 2015-10-20 2017-04-27 Waters Technologies Corporation Systems, methods and devices for cross-stream injection chromatography
CN103713055B (en) * 2013-12-23 2015-01-14 聚光科技(杭州)股份有限公司 High-concentration substance detection device and method
WO2016075503A1 (en) * 2014-11-10 2016-05-19 Agilent Technologies, Inc. Metering device with defined enabled flow direction
US10371674B2 (en) * 2016-04-13 2019-08-06 Horiba Stec, Co., Ltd. Chromatograph sampler and method for operating chromatograph sampler
US10527594B2 (en) * 2016-04-20 2020-01-07 Arkray, Inc. Liquid chromatography measurement method, liquid chromatography measurement instrument, and liquid chromatography measurement program storage medium
AT519146B1 (en) * 2016-10-05 2020-03-15 Univ Wien Tech Device for analyzing a solid sample material
JP6895819B2 (en) * 2017-06-26 2021-06-30 アークレイ株式会社 Liquid chromatography equipment
CN110741251B (en) 2017-07-05 2022-09-09 深圳迈瑞生物医疗电子股份有限公司 Liquid-phase analysis device and analysis method therefor
FR3105016B1 (en) * 2019-12-23 2022-01-14 Commissariat Energie Atomique Devices and methods for mixing liquids back and forth between pump and measuring cell, and physico-chemical analysis of the liquids thus mixed
GB2607489B (en) * 2020-02-24 2024-07-31 Leco Corp Split flow modulator for comprehensive two-dimensional chromatography
DE102020115737A1 (en) 2020-06-15 2020-07-30 Agilent Technologies Inc. Fluid supply devices and fluid component for forming a mobile phase for a sample separator
JP2023067746A (en) * 2021-10-29 2023-05-16 株式会社島津製作所 Method for cleaning liquid chromatograph system and liquid chromatograph system
WO2024219147A1 (en) * 2023-04-17 2024-10-24 株式会社島津製作所 Analysis system, method for controlling same, and recording medium

Citations (5)

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DE4124058A1 (en) * 1990-07-20 1992-01-23 Hitachi Ltd Glyco haemoglobin measurement by HPLC - by simultaneously sepg. glyco haemoglobin, haemoglobin and haemoglobin derivs. and removing labile haemoglobin to measure stable haemoglobin
WO1993007168A2 (en) * 1991-09-30 1993-04-15 Perseptive Biosystems, Inc. Protein chromatography system
US5468643A (en) * 1991-08-28 1995-11-21 The United States Of America As Represented By The Department Of Health And Human Services Switching valve system for direct biological sample injection for LC analysis
US20050194318A1 (en) * 2001-04-25 2005-09-08 Can Ozbal High throughput autosampler
US20080134804A1 (en) * 2006-12-06 2008-06-12 Shimadzu Corporation Auto-sampler cleaning mechanism

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US3504799A (en) * 1968-04-02 1970-04-07 Beckman Instruments Inc Sample injector
USRE29454E (en) * 1972-06-26 1977-10-25 E. I. Du Pont De Nemours And Company Method for producing a gradient elution
US4116046A (en) * 1977-08-05 1978-09-26 Hoffmann-La Roche Inc. Liquid chromatography system
US4158630A (en) * 1978-02-24 1979-06-19 Stearns Stanley D Chromatographic multi-sample valving apparatus
US4274967A (en) * 1978-07-07 1981-06-23 Technicon Instruments Corporation Chromatographic apparatus and method
US4258630A (en) * 1978-07-25 1981-03-31 Northland Aluminum Products, Inc. Portable turntable for use in microwave ovens
US4478713A (en) * 1983-09-23 1984-10-23 Pharmuka Laboratoires Automatic installation for liquid chromatography
US4595496A (en) * 1984-06-29 1986-06-17 Millipore Corporation Liquid composition control
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JPS6336143A (en) * 1986-07-30 1988-02-16 Tosoh Corp Method and device for measuring stable glycated hemoglobin
US5135718A (en) * 1987-03-02 1992-08-04 Tosoh Corporation Apparatus for simultaneously analyzing vanillylmandelic acid, homovanillic acid and creatinine
GB2220369B (en) * 1988-06-10 1993-01-27 Inst Of Child Health Method for testing body fluids by low pressure liquid chromatography
JP2669255B2 (en) * 1992-04-01 1997-10-27 株式会社日立製作所 Method for analyzing hemoglobins, analyzer, and column deterioration suppressing liquid used therefor
US5520817A (en) * 1994-10-04 1996-05-28 Biologica Co. Method of fractionating components in liquid chromatography
JP4603203B2 (en) * 2001-07-02 2010-12-22 積水化学工業株式会社 Liquid chromatograph
JP2003107064A (en) * 2001-09-28 2003-04-09 Shimadzu Corp High performance liquid chromatograph
JP3758585B2 (en) * 2002-02-27 2006-03-22 株式会社島津製作所 Liquid chromatograph system
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JP2007240500A (en) 2006-03-13 2007-09-20 Arkray Inc Liquid chromatograph
WO2008035748A1 (en) * 2006-09-22 2008-03-27 Arkray, Inc. Blood analysis apparatus

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
DE4124058A1 (en) * 1990-07-20 1992-01-23 Hitachi Ltd Glyco haemoglobin measurement by HPLC - by simultaneously sepg. glyco haemoglobin, haemoglobin and haemoglobin derivs. and removing labile haemoglobin to measure stable haemoglobin
US5468643A (en) * 1991-08-28 1995-11-21 The United States Of America As Represented By The Department Of Health And Human Services Switching valve system for direct biological sample injection for LC analysis
WO1993007168A2 (en) * 1991-09-30 1993-04-15 Perseptive Biosystems, Inc. Protein chromatography system
US20050194318A1 (en) * 2001-04-25 2005-09-08 Can Ozbal High throughput autosampler
US20080134804A1 (en) * 2006-12-06 2008-06-12 Shimadzu Corporation Auto-sampler cleaning mechanism

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DEGUCHI K ET AL: "NANOFLOW GRADIENT GENERATOR FOR CAPILLARY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 76, no. 5, 1 March 2004 (2004-03-01), pages 1524 - 1528, XP001196716, ISSN: 0003-2700, DOI: 10.1021/AC0350312 *
See also references of WO2010041637A1 *

Also Published As

Publication number Publication date
JP5367716B2 (en) 2013-12-11
EP2345896A1 (en) 2011-07-20
EP2345896B1 (en) 2017-05-03
KR20110073533A (en) 2011-06-29
US20110186511A1 (en) 2011-08-04
US9310342B2 (en) 2016-04-12
JP2011141120A (en) 2011-07-21
CN102171562B (en) 2014-07-30
CN102171562A (en) 2011-08-31
KR101299644B1 (en) 2013-08-23
JPWO2010041637A1 (en) 2012-03-08
WO2010041637A1 (en) 2010-04-15

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