EP4027988A4 - Opioid independent surgical anesthetic - Google Patents

Opioid independent surgical anesthetic Download PDF

Info

Publication number: EP4027988A4
Authority: EP; European Patent Office
Prior art keywords: opioid; independent surgical; surgical anesthetic; anesthetic; independent
Prior art date: 2019-09-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP20862568.1A

Other languages

German (de)

French (fr)

Other versions

EP4027988A1 (en

Inventor

Brett Davis

Andrew M. SIMPSON

Jayant P. Agarwal

Jill E. SHEA

Himanshu Jayant Sant

Bruce K. Gale

Susan WOJTALEWICZ

Glenn Prestwich

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Utah Research Foundation Inc

Original Assignee

University of Utah Research Foundation Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-09-13

Filing date

2020-09-14

Publication date

2023-09-13

2020-09-14 Application filed by University of Utah Research Foundation Inc filed Critical University of Utah Research Foundation Inc

2022-07-20 Publication of EP4027988A1 publication Critical patent/EP4027988A1/en

2023-09-13 Publication of EP4027988A4 publication Critical patent/EP4027988A4/en

Status Pending legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP20862568.1A 2019-09-13 2020-09-14 Opioid independent surgical anesthetic Pending EP4027988A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201962900369P	2019-09-13	2019-09-13
US202063014788P	2020-04-24	2020-04-24
PCT/US2020/050727 WO2021051080A1 (en)	2019-09-13	2020-09-14	Opioid independent surgical anesthetic

Publications (2)

Publication Number	Publication Date
EP4027988A1 EP4027988A1 (en)	2022-07-20
EP4027988A4 true EP4027988A4 (en)	2023-09-13

Family

ID=74866515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP20862568.1A Pending EP4027988A4 (en)	2019-09-13	2020-09-14	Opioid independent surgical anesthetic

Country Status (2)

Country	Link
EP (1)	EP4027988A4 (en)
WO (1)	WO2021051080A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5227165A (en) *	1989-11-13	1993-07-13	Nova Pharmaceutical Corporation	Liposphere delivery systems for local anesthetics
CN103816111A (en) *	2014-02-26	2014-05-28	中国人民解放军第二军医大学	Ropivacaine nanometer lipid carrier temperature-sensitive in-situ gel and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6632457B1 (en) *	1998-08-14	2003-10-14	Incept Llc	Composite hydrogel drug delivery systems
DE10044545A1 (en) *	2000-09-05	2002-04-04	Roland Bodmeier	Retardpartikeldispersion
US20110171310A1 (en) *	2010-01-13	2011-07-14	Allergan Industrie, Sas	Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use
CN113197851A (en) *	2015-05-06	2021-08-03	辛纳吉勒公司	Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of use thereof

2020
- 2020-09-14 EP EP20862568.1A patent/EP4027988A4/en active Pending
- 2020-09-14 WO PCT/US2020/050727 patent/WO2021051080A1/en not_active Ceased

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5227165A (en) *	1989-11-13	1993-07-13	Nova Pharmaceutical Corporation	Liposphere delivery systems for local anesthetics
CN103816111A (en) *	2014-02-26	2014-05-28	中国人民解放军第二军医大学	Ropivacaine nanometer lipid carrier temperature-sensitive in-situ gel and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JIA X ET AL: "Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 25, no. 19, 1 August 2004 (2004-08-01), pages 4797 - 4804, XP004505491, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2003.12.012 *
SANDRINE LEMOINE ET AL: "Effect of long-chain triglyceride lipid emulsion on bupivacaine-induced changes in electrophysiological parameters of rabbit Purkinje cells", FUNDAMENTAL & CLINICAL PHARMACOLOGY, ELSEVIER, PARIS, FR, vol. 28, no. 5, 27 November 2013 (2013-11-27), pages 481 - 488, XP071692366, ISSN: 0767-3981, DOI: 10.1111/FCP.12058 *
See also references of WO2021051080A1 *

Also Published As

Publication number	Publication date
EP4027988A1 (en)	2022-07-20
WO2021051080A1 (en)	2021-03-18

Publication	Publication Date	Title
IL283767B (en)	2022-01-01	Intraoperative surgical event summary
EP3908201C0 (en)	2024-04-24	Instruments for medical stapling
EP3777957B8 (en)	2024-08-07	Connecting structure for medical use
EP4003475A4 (en)	2023-08-09	Patient interface
EP3946535A4 (en)	2023-01-04	Patient interface
EP4054399A4 (en)	2023-11-22	Surgical retractor
EP3949884A4 (en)	2022-07-06	Medical device
EP3923721A4 (en)	2022-10-26	Improved endoscope disinfectant
EP3834749A4 (en)	2021-10-20	Medical instrument
EP3784153A4 (en)	2022-01-26	Surgical clamp
EP4037741A4 (en)	2023-12-13	Inhaler
EP4024114A4 (en)	2023-08-30	Endoscope
EP4024116A4 (en)	2022-11-16	Endoscope
EP3965876A4 (en)	2023-01-11	Techniques for stimulation artefact elimination
GB2588421B (en)	2021-11-03	Surgical membrane
EP4027988A4 (en)	2023-09-13	Opioid independent surgical anesthetic
EP3616667B8 (en)	2023-05-17	Surgical table
EP3827734A4 (en)	2022-04-06	Sterilized adaptor
HK40079655A (en)	2023-04-21	Inhaler
EP3919113A4 (en)	2022-04-06	Medical instrument
HK40064746A (en)	2022-07-08	Tissue phantoms
HK40065752A (en)	2022-08-05	Ngf antagonists for medical use
HK40082055A (en)	2023-06-02	Therapeutic compounds
AU2019904852A0 (en)	2020-01-16	Patient Interface
AU2019904513A0 (en)	2019-12-12	Patient Interface

Legal Events

Date	Code	Title	Description
2021-03-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2022-06-17	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2022-06-17	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2022-07-20	17P	Request for examination filed	Effective date: 20220308
2022-07-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2022-12-21	DAV	Request for validation of the european patent (deleted)
2022-12-21	DAX	Request for extension of the european patent (deleted)
2023-07-05	P01	Opt-out of the competence of the unified patent court (upc) registered	Effective date: 20230525
2023-08-07	REG	Reference to a national code	Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61K0031138000 Ipc: A61P0023020000
2023-09-13	A4	Supplementary search report drawn up and despatched	Effective date: 20230811
2023-09-13	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/445 20060101ALI20230807BHEP Ipc: A61K 9/06 20060101ALI20230807BHEP Ipc: A61K 47/44 20170101ALI20230807BHEP Ipc: A61K 9/00 20060101ALI20230807BHEP Ipc: A61P 23/02 20060101AFI20230807BHEP
2025-06-27	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2025-07-30	17Q	First examination report despatched	Effective date: 20250627