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ES2034891B1 - Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. - Google Patents

Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.

Info

Publication number
ES2034891B1
ES2034891B1 ES9101859A ES9101859A ES2034891B1 ES 2034891 B1 ES2034891 B1 ES 2034891B1 ES 9101859 A ES9101859 A ES 9101859A ES 9101859 A ES9101859 A ES 9101859A ES 2034891 B1 ES2034891 B1 ES 2034891B1
Authority
ES
Spain
Prior art keywords
nanocapsules
nanoparticles
chemically
preparing
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9101859A
Other languages
English (en)
Other versions
ES2034891A1 (es
Inventor
Valdivia F Javier Galan
Mas Jose Alberto Vallet
Michael V W Bergamini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Cusi SA
Original Assignee
Laboratorios Cusi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Cusi SA filed Critical Laboratorios Cusi SA
Priority to ES9101859A priority Critical patent/ES2034891B1/es
Priority to DE4128910A priority patent/DE4128910A1/de
Priority to AT92202434T priority patent/ATE150642T1/de
Priority to EP92202434A priority patent/EP0529711B1/en
Priority to JP4212681A priority patent/JP2542149B2/ja
Publication of ES2034891A1 publication Critical patent/ES2034891A1/es
Application granted granted Critical
Publication of ES2034891B1 publication Critical patent/ES2034891B1/es
Priority to US08/309,797 priority patent/US5705196A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/778—Nanostructure within specified host or matrix material, e.g. nanocomposite films
    • Y10S977/783—Organic host/matrix, e.g. lipid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/835—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/835—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial
    • Y10S977/836—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial having biological reactive capability
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/90—Manufacture, treatment, or detection of nanostructure having step or means utilizing mechanical or thermal property, e.g. pressure, heat

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE ELABORACION EN CONTINUO DE SISTEMAS COLOIDALES DISPERSOS, EN FORMA DE NANOCAPSULAS O NANOPARTICULAS. COMPRENDE: (1) PREPARAR UNA FASE ACUOSA CONTENIENDO AGENTES TENSOACTIVOS, SUSPENSORES Y, OPCIONALMENTE, UNA SUSTANCIA QUIMICA O BIOLOGICAMENTE ACTIVA; (2) PREPARAR UNA FASE ORGANICA CONTENIENDO UN POLIMERO O MONOMERO BIOCMPATIBLE Y, OPCIONALMENTE, UN LIPIDO O UNA SUSTANCIA QUIMICA O BIOLOGICAMENTE ACTIVA; (3) MEZCLAR AMBAS FASES EN FORMA CONTINUA EN UNA RELACION DE FASES Y VOLUMEN MEDIO CONSTANTE, RETIRANDO CONTINUAMENTE A SUSPENSION COLOIDAL RECIEN FORMADA; (4) ELIMINAR DE FORMA CONTINUA EL DISOLVENTE DE LA SUSPENSION COLOIDAL; Y (5) ELIMINAR POR COMPLETO EL DISOLVENTE ORGANICO Y PARTE O TODA EL AGUA PARA OBTENER LA CONCENTRACION DESEADA DE NANOESFERAS O EL PRODUCTO SECO. APLICACION EN BIOMEDICINA, FARMACIA, MEDICINA, COSMETICA, INDUSTRIA QUIMICA, AGRICULTURA Y VETERINARIA, ETC.
ES9101859A 1991-08-08 1991-08-08 Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. Expired - Lifetime ES2034891B1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES9101859A ES2034891B1 (es) 1991-08-08 1991-08-08 Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
DE4128910A DE4128910A1 (de) 1991-08-08 1991-08-30 Verfahren zur kontinuierlichen herstellung feinverteilter kolloidsysteme in form von nanokapseln oder nanopartikeln
AT92202434T ATE150642T1 (de) 1991-08-08 1992-08-05 Verfahren zur kontinuierlichen herstellung von dispersen kolloide-systemen in form von nanokapseln oder nanopartikeln
EP92202434A EP0529711B1 (en) 1991-08-08 1992-08-05 Process of continuous preparation of disperse colloidal systems in the form of nanocapsules or nanoparticles
JP4212681A JP2542149B2 (ja) 1991-08-08 1992-08-10 ナノカプセルあるいはナノ粒子の分散コロイダル系の連続製造方法
US08/309,797 US5705196A (en) 1991-08-08 1994-09-21 Process of continuous preparation of disperse colloidal systems in the form of nanocapsules or nanoparticles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9101859A ES2034891B1 (es) 1991-08-08 1991-08-08 Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.

Publications (2)

Publication Number Publication Date
ES2034891A1 ES2034891A1 (es) 1993-04-01
ES2034891B1 true ES2034891B1 (es) 1993-12-16

Family

ID=8273277

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9101859A Expired - Lifetime ES2034891B1 (es) 1991-08-08 1991-08-08 Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.

Country Status (6)

Country Link
US (1) US5705196A (es)
EP (1) EP0529711B1 (es)
JP (1) JP2542149B2 (es)
AT (1) ATE150642T1 (es)
DE (1) DE4128910A1 (es)
ES (1) ES2034891B1 (es)

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ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
ATE252894T1 (de) * 1995-01-05 2003-11-15 Univ Michigan Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
DE69526787T2 (de) * 1995-07-05 2002-12-05 European Community, Luxemburg/Luxembourg Biokompatibele und biodegradierbare Nanokapseln zur Absorption und Verabreichung von proteinischen Arzneimitteln
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
JP3650582B2 (ja) 1998-11-30 2005-05-18 ナノスフェアー インコーポレイテッド ポリマー−ナノ粒子ハイブリッド粒子
WO2000035577A1 (de) * 1998-12-11 2000-06-22 Henkel Kommanditgesellschaft Auf Aktien Verfahren zur herstellung von nanopartikeldispersionen
GB9919693D0 (en) * 1999-08-19 1999-10-20 Rhone Poulenc Rorer Ltd Process
FR2805761B1 (fr) 2000-03-02 2002-08-30 Mainelab Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
CA2309575A1 (en) * 2000-05-26 2001-11-26 James E. Guillet Internally cross-linked macromolecules
JP2004534811A (ja) * 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク ポリマーと薬剤の集合体を含む医薬組成物
KR100681213B1 (ko) * 2002-09-11 2007-02-09 다나베 세이야꾸 가부시키가이샤 마이크로스피어의 제조 방법 및 제조 장치
US7112620B2 (en) * 2002-10-18 2006-09-26 Albright Robert L Hemocompatible polymer systems & related methods
JP4341238B2 (ja) * 2002-12-16 2009-10-07 日油株式会社 繊維加工方法および繊維
WO2005016976A2 (en) * 2003-05-27 2005-02-24 Albright Robert L Hemocompatible polymer systems and related methods
US20060151899A1 (en) * 2003-08-06 2006-07-13 Akira Kato Process for producing drug ultramicroparticle and apparatus therefor
US7714015B2 (en) * 2003-08-07 2010-05-11 Lil Brat Pharmaceuticals Of Marlette, Mi Method and composition for treating sunburned skin
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US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
US20100215747A1 (en) * 2007-07-13 2010-08-26 Corey Jay Bloom Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
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Also Published As

Publication number Publication date
ES2034891A1 (es) 1993-04-01
EP0529711B1 (en) 1997-03-26
JP2542149B2 (ja) 1996-10-09
JPH0657005A (ja) 1994-03-01
ATE150642T1 (de) 1997-04-15
DE4128910A1 (de) 1993-02-11
EP0529711A1 (en) 1993-03-03
US5705196A (en) 1998-01-06

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