ES8602764A1 - Un procedimiento para preparar derivados de tiadiazina - Google Patents
Un procedimiento para preparar derivados de tiadiazinaInfo
- Publication number
- ES8602764A1 ES8602764A1 ES537098A ES537098A ES8602764A1 ES 8602764 A1 ES8602764 A1 ES 8602764A1 ES 537098 A ES537098 A ES 537098A ES 537098 A ES537098 A ES 537098A ES 8602764 A1 ES8602764 A1 ES 8602764A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- histamine
- antagonists
- aminothiadiazine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003485 histamine H2 receptor antagonist Substances 0.000 title abstract 2
- IYXOVGUTZBGNDA-UHFFFAOYSA-N 2h-thiadiazin-4-amine Chemical class NC1=NNSC=C1 IYXOVGUTZBGNDA-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- -1 1,3-phenylene, 1,4-phenylene Chemical group 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER DERIVADOS DE TIADIAGINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA II, CON OTRO DE FORMULA III PARA OBTENER DERIVADOS DE TIADIAGINA DE FORMULA GENERAL I Y PARTICULARMENTE 3-3-(3 PIPERIDINAMETILFENOXI) PROPILAMINO-5,6-DIHIDRO-1,2,4-TIADIAGINA-1,1-DIOXIDO. APLICACION FARMACOLOGICA COMO ANTAGONISTAS H2 DE HISTAMINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838328907A GB8328907D0 (en) | 1983-10-28 | 1983-10-28 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES537098A0 ES537098A0 (es) | 1985-12-01 |
| ES8602764A1 true ES8602764A1 (es) | 1985-12-01 |
Family
ID=10550906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES537098A Expired ES8602764A1 (es) | 1983-10-28 | 1984-10-26 | Un procedimiento para preparar derivados de tiadiazina |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0172968A1 (es) |
| JP (1) | JPS60112781A (es) |
| AU (1) | AU572213B2 (es) |
| CA (1) | CA1240322A (es) |
| DK (1) | DK507684A (es) |
| ES (1) | ES8602764A1 (es) |
| GB (1) | GB8328907D0 (es) |
| GR (1) | GR80753B (es) |
| PT (1) | PT79400B (es) |
| ZA (1) | ZA848368B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912101A (en) * | 1987-03-13 | 1990-03-27 | Fujirebio Kabushiki Kaisha | 4-aminomethyl-pyridyl-2-oxy derivatives having anti-ulcer activity |
| WO1992020666A1 (en) * | 1991-05-24 | 1992-11-26 | Taiho Pharmaceutical Company, Limited | Benzothiadiazine derivative |
| WO2014150340A1 (en) * | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | S-imino-s-oxo iminothiadiazine compounds as bace inhibitors, compositions, and their use |
| EP2968357B1 (en) | 2013-03-15 | 2018-07-04 | Merck Sharp & Dohme Corp. | S-imino-s-oxo iminothiazine compounds as bace inhibitors, compositions, and their use |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1419994A (en) * | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
| GB1604674A (en) * | 1977-05-17 | 1981-12-16 | Allen & Hanburys Ltd | Aminoalkyl-benzene derivatives |
| EP0052442B1 (en) * | 1980-11-14 | 1985-09-11 | Imperial Chemical Industries Plc | Heterocyclic compounds |
| ZA827641B (en) * | 1981-11-12 | 1983-09-28 | Ici Plc | Thiadiazine, oxadiazine and triazine derivatives which possess cardiotonic and/or antihypertensive activity |
-
1983
- 1983-10-28 GB GB838328907A patent/GB8328907D0/en active Pending
-
1984
- 1984-10-23 EP EP84307285A patent/EP0172968A1/en not_active Withdrawn
- 1984-10-24 GR GR80753A patent/GR80753B/el unknown
- 1984-10-24 DK DK507684A patent/DK507684A/da not_active Application Discontinuation
- 1984-10-24 PT PT79400A patent/PT79400B/pt unknown
- 1984-10-24 CA CA000466184A patent/CA1240322A/en not_active Expired
- 1984-10-26 AU AU34754/84A patent/AU572213B2/en not_active Ceased
- 1984-10-26 ZA ZA848368A patent/ZA848368B/xx unknown
- 1984-10-26 ES ES537098A patent/ES8602764A1/es not_active Expired
- 1984-10-27 JP JP59226625A patent/JPS60112781A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA848368B (en) | 1985-06-26 |
| AU3475484A (en) | 1985-05-09 |
| PT79400B (en) | 1986-11-14 |
| DK507684D0 (da) | 1984-10-24 |
| JPS60112781A (ja) | 1985-06-19 |
| PT79400A (en) | 1984-11-01 |
| ES537098A0 (es) | 1985-12-01 |
| GR80753B (en) | 1985-02-27 |
| AU572213B2 (en) | 1988-05-05 |
| DK507684A (da) | 1985-04-29 |
| CA1240322A (en) | 1988-08-09 |
| EP0172968A1 (en) | 1986-03-05 |
| GB8328907D0 (en) | 1983-11-30 |
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