[go: up one dir, main page]

FR2744448B1 - NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS - Google Patents

NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS

Info

Publication number
FR2744448B1
FR2744448B1 FR9601275A FR9601275A FR2744448B1 FR 2744448 B1 FR2744448 B1 FR 2744448B1 FR 9601275 A FR9601275 A FR 9601275A FR 9601275 A FR9601275 A FR 9601275A FR 2744448 B1 FR2744448 B1 FR 2744448B1
Authority
FR
France
Prior art keywords
medicaments
preparation
well
pharmaceutical compositions
aryl piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9601275A
Other languages
French (fr)
Other versions
FR2744448A1 (en
Inventor
Serge Halazy
Lebrun Catherine Jorand
Peter Pauwels
Chantal Moret
Marc Marien
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9601275A priority Critical patent/FR2744448B1/en
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to NZ331221A priority patent/NZ331221A/en
Priority to AU16070/97A priority patent/AU1607097A/en
Priority to BR9707261A priority patent/BR9707261A/en
Priority to PCT/FR1997/000195 priority patent/WO1997028140A1/en
Priority to CA002244940A priority patent/CA2244940A1/en
Priority to EP97902419A priority patent/EP0886636A1/en
Priority to JP9527373A priority patent/JP2000504004A/en
Priority to CN97192737A priority patent/CN1212690A/en
Publication of FR2744448A1 publication Critical patent/FR2744448A1/en
Application granted granted Critical
Publication of FR2744448B1 publication Critical patent/FR2744448B1/en
Priority to MX9806246A priority patent/MX9806246A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FR9601275A 1996-02-02 1996-02-02 NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS Expired - Fee Related FR2744448B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR9601275A FR2744448B1 (en) 1996-02-02 1996-02-02 NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS
CN97192737A CN1212690A (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-(piperazin-1-yl)-aryl-(oxy/amino)-carbonyl/-4-aryl-piperidine as selective 5-HT1D beta receptor antagonists compound
BR9707261A BR9707261A (en) 1996-02-02 1997-01-31 Compound processes for preparing them and pharmaceutical products and compositions
PCT/FR1997/000195 WO1997028140A1 (en) 1996-02-02 1997-01-31 NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDINE AS SELECTIVE 5-HT1Db RECEPTOR ANTAGONISTS
CA002244940A CA2244940A1 (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl(oxy/amino)carbonyl/-4-aryl-piperidine as selective 5-ht1db receptor antagonists
EP97902419A EP0886636A1 (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl(oxy/amino)carbonyl/-4-aryl-piperidine as selective 5-ht-1d.beta. receptor antagonists
NZ331221A NZ331221A (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl-(oxo/amino)carbonyl/-4-aryl-piperidine as selective 5-ht 1dbeta receptor antagonists
AU16070/97A AU1607097A (en) 1996-02-02 1997-01-31 Novel piperidines derived from 1-/(piperazin-1-yl)aryl(oxy/amino)carbonyl/-4-aryl-piperidin e as selective 5-ht1db receptor antagonists
JP9527373A JP2000504004A (en) 1996-02-02 1997-01-31 Novel piperidine derived from 1-/ (piperazin-1-yl) aryl- (oxy / amino) carbonyl / 4-aryl-piperidine as a selective 5-HT 1Dβ receptor antagonist
MX9806246A MX9806246A (en) 1996-02-02 1998-08-03 NOVEL PIPERIDINES DERIVED FROM 1-/(PIPERAZIN-1-YL)ARYL(OXY/AMINO)CARBONYL/-4-ARYL-PIPERIDIN E AS SELECTIVE 5-HT1Db RECEPTOR ANTAGONISTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9601275A FR2744448B1 (en) 1996-02-02 1996-02-02 NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS

Publications (2)

Publication Number Publication Date
FR2744448A1 FR2744448A1 (en) 1997-08-08
FR2744448B1 true FR2744448B1 (en) 1998-04-24

Family

ID=9488770

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9601275A Expired - Fee Related FR2744448B1 (en) 1996-02-02 1996-02-02 NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS

Country Status (10)

Country Link
EP (1) EP0886636A1 (en)
JP (1) JP2000504004A (en)
CN (1) CN1212690A (en)
AU (1) AU1607097A (en)
BR (1) BR9707261A (en)
CA (1) CA2244940A1 (en)
FR (1) FR2744448B1 (en)
MX (1) MX9806246A (en)
NZ (1) NZ331221A (en)
WO (1) WO1997028140A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2758327B1 (en) * 1997-01-15 1999-04-02 Pf Medicament NEW ARYLPIPERAZINES DERIVED FROM PIPERIDINE
KR20040083472A (en) * 2001-12-21 2004-10-02 다이쇼 세이야꾸 가부시끼가이샤 Piperazine derivatives
UA77536C2 (en) 2002-07-03 2006-12-15 Lundbeck & Co As H Secondary aminoaniline piperidines as mch1 antagonists and their use
GEP20094676B (en) * 2003-07-24 2009-05-10 Euro Celtique Sa Piperidine compounds and pharmaceutical compositions containing them
EP2080757A1 (en) 2003-07-24 2009-07-22 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
PL1867644T3 (en) 2003-07-24 2009-10-30 Euro Celtique Sa Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
AU2008246202B2 (en) 2007-04-27 2011-12-01 Purdue Pharma L.P. Therapeutic agents useful for treating pain
TWI362930B (en) 2007-04-27 2012-05-01 Purdue Pharma Lp Trpv1 antagonists and uses thereof
FR2932482B1 (en) * 2008-06-13 2010-10-08 Sanofi Aventis NOVEL (PHENYL-3,6-DIHYDRO-2H-PYRIDINYL) - (PIPERAZINYL PONTE) -1-ALKANONE DERIVATIVES AND THEIR USE AS P75 INHIBITORS
FR2932481B1 (en) * 2008-06-13 2010-10-08 Sanofi Aventis 4- {2-4-PHENYL-3,6-DIHYDRO-2H-PYRIDIN-1-YL] -2-OXO-ALKYL} -1-PIPERAZIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
US8759362B2 (en) 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
US8703962B2 (en) 2008-10-24 2014-04-22 Purdue Pharma L.P. Monocyclic compounds and their use as TRPV1 ligands
FR2953839A1 (en) 2009-12-14 2011-06-17 Sanofi Aventis NOVEL (HETEROCYCLE-PIPERIDINE CONDENSEE) - (PIPERAZINYL) -1ALCANONE OR (HETEROCYCLE-PYRROLIDINE CONDENSED) - (PIPERAZINYL) -1ALCANONE DERIVATIVES AND THEIR USE AS INHIBITORS OF P75
FR2953836B1 (en) 2009-12-14 2012-03-16 Sanofi Aventis NOVEL DERIVATIVES (HETEROCYCLE-TETRAHYDRO-PYRIDINE) - (PIPERAZINYL) -1-ALKANONE AND (HETEROCYCLE-DIHYDRO-PYRROLIDINE) - (PIPERAZINYL) -1-ALKANONE AND THEIR USE AS INHIBITORS OF P75
JP5876423B2 (en) 2010-06-22 2016-03-02 塩野義製薬株式会社 Compounds having TRPV1 inhibitory activity and uses thereof
WO2012176061A1 (en) 2011-06-22 2012-12-27 Purdue Pharma L.P. Trpv1 antagonists including dihydroxy substituent and uses thereof
WO2013021276A1 (en) 2011-08-10 2013-02-14 Purdue Pharma L.P. Trpv1 antagonists including dihydroxy substituent and uses thereof
EP2606894A1 (en) 2011-12-20 2013-06-26 Sanofi Novel therapeutic use of p75 receptor antagonists
US9221796B2 (en) 2014-01-09 2015-12-29 Bristol-Myers Squibb Company Selective NR2B antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022820D0 (en) * 1990-10-19 1990-12-05 Wyeth John & Brother Ltd Piperazine derivatives
GB9221931D0 (en) * 1992-10-17 1992-12-02 Wyeth John & Brother Ltd Piperazine derivatives
FR2722788B1 (en) * 1994-07-20 1996-10-04 Pf Medicament NOVEL PIPERAZIDES DERIVED FROM ARYL PIPERAZINE, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

Also Published As

Publication number Publication date
CA2244940A1 (en) 1997-08-07
BR9707261A (en) 1999-07-20
WO1997028140A1 (en) 1997-08-07
MX9806246A (en) 1998-11-29
AU1607097A (en) 1997-08-22
EP0886636A1 (en) 1998-12-30
NZ331221A (en) 2000-01-28
JP2000504004A (en) 2000-04-04
CN1212690A (en) 1999-03-31
FR2744448A1 (en) 1997-08-08

Similar Documents

Publication Publication Date Title
FR2744449B1 (en) NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS
FR2744448B1 (en) NOVEL PIPERIDINES DERIVED FROM ARYL PIPERAZINE, AS WELL AS THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS MEDICAMENTS
FR2722788B1 (en) NOVEL PIPERAZIDES DERIVED FROM ARYL PIPERAZINE, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
FR2741342B1 (en) NOVEL FLUORINATED OR HYDROXYLATED PHENYLIMIDAZOLIDINES, METHOD, PREPARATION MEDIA, APPLICATION AS MEDICAMENTS, NEW USE AND PHARMACEUTICAL COMPOSITIONS
FR2694290B1 (en) New phenylimidazolidines which may be substituted, their preparation process, their use as medicaments and the pharmaceutical compositions containing them.
FI955024A7 (en) Novel piperidine compounds, process for their preparation and pharmaceutical compositions containing them
EE9500064A (en) Substituted 1H-imidazoles, methods for their preparation, and pharmaceutical compositions
MA26630A1 (en) NOVEL 4-PHENYLPYPERIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MA26598A1 (en) 4- (2-CETO-1-BENZIMIDAZOLINYL) NEW PIPERIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FI973039A7 (en) Novel farnesyltransferase inhibitors, their preparation and pharmaceutical compositions containing them
DZ2494A1 (en) Pharmaceutical composition of omeprazole.
FI973279A7 (en) Novel farnesyltransferase inhibitors, their preparation and pharmaceutical compositions containing them
FR2575750B1 (en) PIPERIDINE AND PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
DE69902535D1 (en) PHENOXYPROPANOLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CY2008012I2 (en) RAPAMICYN HYDROXYESTERS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NO973922L (en) New taxoids, their preparation and pharmaceutical compositions containing the compounds
FR2735127B1 (en) NEW HETEROAROMATIC PIPERAZINES USEFUL AS MEDICAMENTS.
MA26559A1 (en) D-PROLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE
FI952550A7 (en) Novel N-pyridylcarboxamides and derivatives, processes for their preparation and pharmaceutical compositions containing them
FR2715402B1 (en) New phenylimidazolines optionally substituted, their process and preparation intermediates, their use as medicaments and the pharmaceutical compositions containing them.
HUP0004588A3 (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-oles, method for the production and use thereof as medicaments and pharmaceutical compositions containing them
FR2725896B1 (en) NEW COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS
FI960316L (en) Oxathiolanes, process for their preparation and pharmaceutical compositions containing them
FI953956A0 (en) 2,3-Ring-fused 1,4-dihydropyridines, processes for their preparation and their use as medicaments
FR2528431B1 (en) NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

Legal Events

Date Code Title Description
ST Notification of lapse