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FR3112960B1 - Implantable dialysis device for the extraction of circulating molecules from cerebrospinal fluid and/or interstitial fluid - Google Patents

Implantable dialysis device for the extraction of circulating molecules from cerebrospinal fluid and/or interstitial fluid Download PDF

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Publication number
FR3112960B1
FR3112960B1 FR2008022A FR2008022A FR3112960B1 FR 3112960 B1 FR3112960 B1 FR 3112960B1 FR 2008022 A FR2008022 A FR 2008022A FR 2008022 A FR2008022 A FR 2008022A FR 3112960 B1 FR3112960 B1 FR 3112960B1
Authority
FR
France
Prior art keywords
fluid
dialysis
implantable
dialysis device
cerebrospinal fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR2008022A
Other languages
French (fr)
Other versions
FR3112960A1 (en
Inventor
Olivier Tillement
François Lux
Benoît Hautefeuille
Thomas Brichart
Marco Natuzzi
Stéphane Palfi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Assistance Publique Hopitaux de Paris APHP
Mexbrain SAS
Universite Claude Bernard Lyon 1
Original Assignee
Centre National de la Recherche Scientifique CNRS
Assistance Publique Hopitaux de Paris APHP
Mexbrain SAS
Universite Claude Bernard Lyon 1
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Assistance Publique Hopitaux de Paris APHP, Mexbrain SAS, Universite Claude Bernard Lyon 1 filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR2008022A priority Critical patent/FR3112960B1/en
Priority to PCT/FR2021/051422 priority patent/WO2022023679A1/en
Publication of FR3112960A1 publication Critical patent/FR3112960A1/en
Application granted granted Critical
Publication of FR3112960B1 publication Critical patent/FR3112960B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A61M1/1605—Physical characteristics of the dialysate fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1676—Dialysates therefor containing proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1678—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes intracorporal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3493—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate using treatment agents in suspension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0464—Cerebrospinal fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne le domaine des dispositifs médicaux, plus particulièrement les dispositifs médicaux implantables, et concerne particulièrement un dispositif de dialyse implantable permettant d’extraire au sein d’un organisme au moins un cation métallique et/ou au moins une molécule circulante du liquide cérébrospinal et/ou du liquide interstitiel du parenchyme cérébral et médullaire. Grâce à son caractère implantable, le dispositif de dialyse selon l’invention présente beaucoup moins de risque de toxicité. En particulier, il n’ouvre pas de voie d’accès entre les zones cérébrales internes et l’extérieur de l’organisme évitant ainsi de nombreuses complications et effets secondaires comme des méningites.Le dispositif de dialyse implantable selon l’invention comprend un premier cathéter (1) pour la captation du liquide cérébrospinal et/ou du liquide interstitiel, un deuxième cathéter (2) pour la réinjection dudit liquide, une membrane de dialyse poreuse (3), un réservoir (4) comprenant un fluide de dialyse (5), ledit fluide de dialyse comprenant au moins un additif choisi parmi les nanoparticules, les polymères et les biomolécules, ledit additif ayant une taille supérieure au seuil de coupure de ladite membrane de dialyse poreuse, et comprend ou est constitué d’au moins un ligand spécifique d’une molécule circulante du liquide cérébrospinal et/ou du liquide interstitiel d’un mammifère.The present invention relates to the field of medical devices, more particularly implantable medical devices, and particularly relates to an implantable dialysis device making it possible to extract within an organism at least one metal cation and/or at least one circulating molecule from the liquid cerebrospinal fluid and/or interstitial fluid of cerebral and spinal parenchyma. Thanks to its implantable nature, the dialysis device according to the invention presents much less risk of toxicity. In particular, it does not open an access route between the internal cerebral zones and the outside of the body, thus avoiding numerous complications and side effects such as meningitis. The implantable dialysis device according to the invention comprises a first catheter (1) for capturing cerebrospinal fluid and/or interstitial fluid, a second catheter (2) for reinjecting said fluid, a porous dialysis membrane (3), a reservoir (4) comprising a dialysis fluid (5 ), said dialysis fluid comprising at least one additive chosen from among nanoparticles, polymers and biomolecules, said additive having a size greater than the cut-off threshold of said porous dialysis membrane, and comprises or consists of at least one ligand specific for a circulating molecule of cerebrospinal fluid and/or interstitial fluid of a mammal.

FR2008022A 2020-07-29 2020-07-29 Implantable dialysis device for the extraction of circulating molecules from cerebrospinal fluid and/or interstitial fluid Active FR3112960B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR2008022A FR3112960B1 (en) 2020-07-29 2020-07-29 Implantable dialysis device for the extraction of circulating molecules from cerebrospinal fluid and/or interstitial fluid
PCT/FR2021/051422 WO2022023679A1 (en) 2020-07-29 2021-07-29 Implantable dialysis device for extracting circulating molecules from cerebrospinal fluid and/or from interstitial fluid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2008022 2020-07-29
FR2008022A FR3112960B1 (en) 2020-07-29 2020-07-29 Implantable dialysis device for the extraction of circulating molecules from cerebrospinal fluid and/or interstitial fluid

Publications (2)

Publication Number Publication Date
FR3112960A1 FR3112960A1 (en) 2022-02-04
FR3112960B1 true FR3112960B1 (en) 2023-03-10

Family

ID=74347133

Family Applications (1)

Application Number Title Priority Date Filing Date
FR2008022A Active FR3112960B1 (en) 2020-07-29 2020-07-29 Implantable dialysis device for the extraction of circulating molecules from cerebrospinal fluid and/or interstitial fluid

Country Status (2)

Country Link
FR (1) FR3112960B1 (en)
WO (1) WO2022023679A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056318A2 (en) 2002-12-19 2004-07-08 New York University Method for treating amyloid disease
WO2017117138A1 (en) * 2015-12-28 2017-07-06 Cognost Therapeutics Inc. An apparatus and method for cerebral microdialysis to treat neurological disease, including alzheimer's, parkinson's or multiple sclerosis
FR3075649A1 (en) * 2017-12-22 2019-06-28 Mexbrain DEVICE FOR MAINTAINING METAL HOMEOSTASIS AND USES THEREOF

Also Published As

Publication number Publication date
WO2022023679A1 (en) 2022-02-03
FR3112960A1 (en) 2022-02-04

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