GB741645A - Improvements in or relating to coumaran derivatives - Google Patents
Improvements in or relating to coumaran derivativesInfo
- Publication number
- GB741645A GB741645A GB32148/53A GB3214853A GB741645A GB 741645 A GB741645 A GB 741645A GB 32148/53 A GB32148/53 A GB 32148/53A GB 3214853 A GB3214853 A GB 3214853A GB 741645 A GB741645 A GB 741645A
- Authority
- GB
- United Kingdom
- Prior art keywords
- coumaranyl
- bis
- piperidinomethyl
- ketone
- relating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical class C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 2
- UCSGXPINVFRSSX-UHFFFAOYSA-N 1-[[5-[[2-(piperidin-1-ylmethyl)-2,3-dihydro-1-benzofuran-5-yl]methyl]-2,3-dihydro-1-benzofuran-2-yl]methyl]piperidine Chemical compound N1(CCCCC1)CC1OC2=CC=C(C=C2C1)CC=1C=C2CC(OC2=CC=1)CN1CCCCC1 UCSGXPINVFRSSX-UHFFFAOYSA-N 0.000 abstract 1
- DKHLVDMTINQOBI-UHFFFAOYSA-N O1CCN(CC1)C1(OC2=CC=C(C=C2C1)C(=O)C=1C=C2CC(OC2=CC=1)(N1CCOCC1)C)C Chemical compound O1CCN(CC1)C1(OC2=CC=C(C=C2C1)C(=O)C=1C=C2CC(OC2=CC=1)(N1CCOCC1)C)C DKHLVDMTINQOBI-UHFFFAOYSA-N 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- LBEKDTWCJGSLHH-UHFFFAOYSA-N bis[2-(piperidin-1-ylmethyl)-2,3-dihydro-1-benzofuran-5-yl]methanone Chemical compound C=1C=C2OC(CN3CCCCC3)CC2=CC=1C(=O)C(C=C1C2)=CC=C1OC2CN1CCCCC1 LBEKDTWCJGSLHH-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 125000001302 tertiary amino group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention comprises coumaran derivatives of the formula <FORM:0741645/IV(a)/1> where X is -O-, -CH2-, -CO- or a direct linkage, and R is a tertiary amino radical, and salt thereof. They are made by treating the compounds (R = Hal; see Specification 741,648) with secondary amines in the presence of acid-binding agents, preferably excess of the secon dary amine. Salts are formed by treatment with the appropriate acid. Examples show the preparation of bis-(2-piperidinomethyl-5-coumaranyl), bis - (2 - piperidinomethyl - 5 - coumaranyl) - methane, bis - (2 - piperidinomethyl-5 - (coumaranyl)-ether, bis-(2-piperidinomethyl-5-coumaranyl)-ketone and bis-(2-morpholino-methyl - 5 - coumaranyl)-ketone, and their hydrochlorides. R may als be a dialkylamino group such as dimethylamino or diethylamino.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR741645X | 1952-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB741645A true GB741645A (en) | 1955-12-07 |
Family
ID=9138742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32148/53A Expired GB741645A (en) | 1952-11-28 | 1953-11-19 | Improvements in or relating to coumaran derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB741645A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7538138B2 (en) * | 2001-03-16 | 2009-05-26 | Abbott Laboratories | Amines as histamine-3 receptor ligands and their therapeutic applications |
-
1953
- 1953-11-19 GB GB32148/53A patent/GB741645A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7538138B2 (en) * | 2001-03-16 | 2009-05-26 | Abbott Laboratories | Amines as histamine-3 receptor ligands and their therapeutic applications |
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