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GEP20022654B - Indazole Amide Compounds As Serotoninergic Agents - Google Patents

Indazole Amide Compounds As Serotoninergic Agents

Info

Publication number
GEP20022654B
GEP20022654B GEAP19985083A GEAP1998005083A GEP20022654B GE P20022654 B GEP20022654 B GE P20022654B GE AP19985083 A GEAP19985083 A GE AP19985083A GE AP1998005083 A GEAP1998005083 A GE AP1998005083A GE P20022654 B GEP20022654 B GE P20022654B
Authority
GE
Georgia
Prior art keywords
amide compounds
indazole amide
serotoninergic agents
indazole
serotoninergic
Prior art date
Application number
GEAP19985083A
Inventor
Mario Pinza
Nicola Cazzolla
Alessandra Alisi
Marilena Giannangeli
Mario Brufani
Original Assignee
Aziende Chimiche Riunite Angelini Francesco A C R A F S P A It
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco A C R A F S P A It filed Critical Aziende Chimiche Riunite Angelini Francesco A C R A F S P A It
Publication of GEP20022654B publication Critical patent/GEP20022654B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

1. Technical Result Increase in anagonistic activity of 5HT4. 2. Essence Indazole amide of the formula (1) wherein R6 have the meanings stated in the description, acid addition salts thereof, methods for production and pharmaceutically acceptable composition. 3. Field of Application Chemistry, medicine.
GEAP19985083A 1997-04-15 1998-04-02 Indazole Amide Compounds As Serotoninergic Agents GEP20022654B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000867A IT1291569B1 (en) 1997-04-15 1997-04-15 Indazolamides as serotonergic agents

Publications (1)

Publication Number Publication Date
GEP20022654B true GEP20022654B (en) 2002-03-25

Family

ID=11376888

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19985083A GEP20022654B (en) 1997-04-15 1998-04-02 Indazole Amide Compounds As Serotoninergic Agents

Country Status (26)

Country Link
US (1) US6197769B1 (en)
EP (1) EP0975623B1 (en)
JP (2) JP4578581B2 (en)
KR (1) KR100563867B1 (en)
CN (1) CN1318416C (en)
AR (1) AR012426A1 (en)
AT (1) ATE219490T1 (en)
AU (1) AU740360B2 (en)
BG (1) BG64006B1 (en)
CA (1) CA2286870C (en)
CZ (1) CZ295190B6 (en)
DE (1) DE69806141T2 (en)
DK (1) DK0975623T3 (en)
EA (1) EA002352B1 (en)
ES (1) ES2178205T3 (en)
GE (1) GEP20022654B (en)
HU (1) HU227973B1 (en)
IL (1) IL132127A (en)
IT (1) IT1291569B1 (en)
PL (1) PL193308B1 (en)
PT (1) PT975623E (en)
SK (1) SK284731B6 (en)
TR (1) TR199902546T2 (en)
UA (1) UA58550C2 (en)
WO (1) WO1998046589A2 (en)
ZA (1) ZA982926B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (en) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolamides as serotonergic agents
PT1379520E (en) 2001-02-23 2006-08-31 Merck & Co Inc NMDA / NR2B NON-SUBSTITUTED ANTAGONISTS (NAO-ARIL) -HETEROCYCLICS
AU2002338334B8 (en) * 2001-04-03 2008-09-18 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists
ITMI20030287A1 (en) 2003-02-18 2004-08-19 Acraf INDAZOLAMIDS EQUIPPED WITH ANALGESIC ACTIVITY METHOD, FOR
ITMI20030972A1 (en) * 2003-05-15 2004-11-16 Acraf INDAZOLO EQUIPPED WITH ANALGESIC ACTIVITY, METHOD TO PREPARE IT AND PHARMACEUTICAL COMPOSITION THAT INCLUDES IT.
ITMI20031468A1 (en) * 2003-07-18 2005-01-19 Acraf ATIVE DRUG IN NEUROPATHIC PAIN
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7396933B2 (en) * 2004-11-05 2008-07-08 Theravance, Inc. Quinolinone-carboxamide compounds
DE602005016446D1 (en) * 2004-11-05 2009-10-15 Theravance Inc 5-HT4 receptor agonist compounds
DE602005021696D1 (en) * 2004-12-22 2010-07-15 Theravance Inc INDAZOLCARBONSÄUREAMIDVERBINDUNGEN
EP1848716A1 (en) * 2005-02-17 2007-10-31 Theravance, Inc. Crystalline form of an indazole-carboxamide compound
CN101163701A (en) * 2005-03-02 2008-04-16 施万制药 Quinolinone compounds as 5-HT 4 receptor agonists
ITMI20062230A1 (en) * 2006-11-22 2008-05-23 Acraf 2-ALCHIL-INDAZOLIC COMPOUND PROCEDURE FOR PREPARATION AND PHARMACEUTICAL COMPOSITION THAT INCLUDES IT
UA99927C2 (en) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Pharmaceutical composition that is active in the treatment of neuropathic pain
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
RU2013157374A (en) * 2011-06-07 2015-07-20 Сумитомо Дайниппон Фарма Ко., Лтд. INDAZOLE AND PYROROLOPYRIDINE DERIVATIVE AND ITS PHARMACEUTICAL USE
EP2817301B1 (en) * 2012-02-21 2015-12-23 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. - S.p.A. Use of 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
HUE026893T2 (en) * 2012-02-21 2016-07-28 Acraf 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
EP2961403A4 (en) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd Heterocyclic inhibitors of the sodium channel
CA3146857A1 (en) 2019-07-11 2021-01-14 Praxis Precision Medicines, Inc. Formulations of t-type calcium channel modulators and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
EP0600955A1 (en) * 1991-08-20 1994-06-15 Smithkline Beecham Plc 5-ht4 receptor antagonists
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
CA2222532A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
IT1291569B1 (en) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolamides as serotonergic agents

Also Published As

Publication number Publication date
CN1252798A (en) 2000-05-10
AR012426A1 (en) 2000-10-18
AU7215998A (en) 1998-11-11
PT975623E (en) 2002-10-31
PL336348A1 (en) 2000-06-19
JP2001518906A (en) 2001-10-16
SK142399A3 (en) 2000-08-14
CZ362599A3 (en) 2000-04-12
JP5237324B2 (en) 2013-07-17
EP0975623A2 (en) 2000-02-02
JP2010195813A (en) 2010-09-09
BG64006B1 (en) 2003-09-30
DE69806141D1 (en) 2002-07-25
UA58550C2 (en) 2003-08-15
IT1291569B1 (en) 1999-01-11
EA002352B1 (en) 2002-04-25
PL193308B1 (en) 2007-01-31
EP0975623B1 (en) 2002-06-19
HK1027811A1 (en) 2001-01-23
HUP0002057A2 (en) 2001-04-28
CA2286870A1 (en) 1998-10-22
WO1998046589A3 (en) 1999-01-28
CA2286870C (en) 2007-05-22
EA199900935A1 (en) 2000-04-24
KR100563867B1 (en) 2006-03-24
BG103863A (en) 2000-07-31
HUP0002057A3 (en) 2002-01-28
AU740360B2 (en) 2001-11-01
SK284731B6 (en) 2005-10-06
HU227973B1 (en) 2012-07-30
CZ295190B6 (en) 2005-06-15
ITMI970867A1 (en) 1998-10-15
CN1318416C (en) 2007-05-30
ES2178205T3 (en) 2002-12-16
IL132127A0 (en) 2001-03-19
JP4578581B2 (en) 2010-11-10
DE69806141T2 (en) 2003-01-30
DK0975623T3 (en) 2002-10-14
ZA982926B (en) 1998-10-09
KR20010006120A (en) 2001-01-26
US6197769B1 (en) 2001-03-06
IL132127A (en) 2005-06-19
TR199902546T2 (en) 2000-05-22
WO1998046589A2 (en) 1998-10-22
ATE219490T1 (en) 2002-07-15

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