HK1041888A1 - 穩定低聚核苷酸及其用途 - Google Patents
穩定低聚核苷酸及其用途 Download PDFInfo
- Publication number
- HK1041888A1 HK1041888A1 HK02103552.2A HK02103552A HK1041888A1 HK 1041888 A1 HK1041888 A1 HK 1041888A1 HK 02103552 A HK02103552 A HK 02103552A HK 1041888 A1 HK1041888 A1 HK 1041888A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- oligonucleotide
- oligonucleotide according
- cys
- asterisk
- nucleotides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4338704 | 1993-11-12 | ||
| DE4338704A DE4338704A1 (de) | 1993-11-12 | 1993-11-12 | Stabilisierte Oligonucleotide und deren Verwendung |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98113031.7A Addition HK1012000A (zh) | 1993-11-12 | 1998-12-10 | 稳定低聚核苷酸及其用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98113031.7A Division HK1012000A (zh) | 1993-11-12 | 1998-12-10 | 稳定低聚核苷酸及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1041888A1 true HK1041888A1 (zh) | 2002-07-26 |
Family
ID=6502470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02103552.2A HK1041888A1 (zh) | 1993-11-12 | 1998-12-10 | 穩定低聚核苷酸及其用途 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6348312B1 (zh) |
| EP (2) | EP1182206A3 (zh) |
| JP (1) | JP3558230B2 (zh) |
| AT (1) | ATE265465T1 (zh) |
| AU (1) | AU696635B2 (zh) |
| CA (1) | CA2135591C (zh) |
| DE (2) | DE4338704A1 (zh) |
| DK (1) | DK0653439T3 (zh) |
| ES (1) | ES2218522T3 (zh) |
| HK (1) | HK1041888A1 (zh) |
| NZ (1) | NZ264894A (zh) |
| PT (1) | PT653439E (zh) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4331670A1 (de) * | 1993-09-17 | 1995-03-23 | Hoechst Ag | Neue Antisense-Oligonucleotide gegen HSV-1 sowie deren Herstellung |
| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6776986B1 (en) | 1996-06-06 | 2004-08-17 | Novartis Ag | Inhibition of HIV-1 replication by antisense RNA expression |
| US5821354A (en) * | 1996-11-26 | 1998-10-13 | Angiogene Inc. | Radiolabeled DNA oligonucleotide and method of preparation |
| DE69808609T2 (de) * | 1997-04-11 | 2003-06-12 | G.D. Searle & Co., Chicago | Antagonistische anti-avb3 integrin antikörper |
| WO1998050540A1 (en) * | 1997-05-05 | 1998-11-12 | Hoechst Marion Roussel Deutschland Gmbh | MODIFIED ANTISENSE NUCLEOTIDES COMPLEMENTARY TO A SECTION OF THE HUMAN Ha-Ras GENE |
| EP0950709A1 (en) * | 1998-04-17 | 1999-10-20 | Hoechst Marion Roussel Deutschland GmbH | Antisense oligonucleotides for the inhibition of integrin alphaV-subunit expression |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| US6693086B1 (en) * | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| EP0979869A1 (en) * | 1998-08-07 | 2000-02-16 | Hoechst Marion Roussel Deutschland GmbH | Short oligonucleotides for the inhibition of VEGF expression |
| EP0978561A1 (en) * | 1998-08-07 | 2000-02-09 | Hoechst Marion Roussel Deutschland GmbH | Antisense oligonucleotides for the inhibition of VEGF expression |
| DE19935303A1 (de) | 1999-07-28 | 2001-02-08 | Aventis Pharma Gmbh | Oligonukleotide zur Inhibierung der Expression von humanem eg5 |
| US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| KR100917101B1 (ko) * | 2000-08-04 | 2009-09-15 | 도요 보세키 가부시키가이샤 | 플렉시블 금속적층체 및 그 제조방법 |
| AU2001297693A1 (en) * | 2000-12-08 | 2002-09-12 | Coley Pharmaceutical Gmbh | Cpg-like nucleic acids and methods of use thereof |
| WO2002066092A2 (en) * | 2001-02-23 | 2002-08-29 | Angiogene Inc. | Drug eluting device for treating vascular diseases |
| DE10159904A1 (de) * | 2001-12-06 | 2003-07-03 | Adnagen Ag | Oligonukleotidanordnung, Verfahren zum Nukleotidnachweis sowie Vorrichtung hierfür |
| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| DE60310944T3 (de) | 2002-08-05 | 2017-08-03 | Silence Therapeutics Gmbh | Weitere neue formen von interferierende rns moleküle |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| KR20110050745A (ko) * | 2002-10-03 | 2011-05-16 | 탈자진 인코포레이티드 | 혈관항상성 유지제 및 그의 사용 방법 |
| US20050282814A1 (en) * | 2002-10-03 | 2005-12-22 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| CA2502015A1 (en) * | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | 5' cpg nucleic acids and methods of use |
| US20040198640A1 (en) * | 2003-04-02 | 2004-10-07 | Dharmacon, Inc. | Stabilized polynucleotides for use in RNA interference |
| US20050013812A1 (en) * | 2003-07-14 | 2005-01-20 | Dow Steven W. | Vaccines using pattern recognition receptor-ligand:lipid complexes |
| EP1663316A2 (en) * | 2003-09-25 | 2006-06-07 | Coley Pharmaceutical Group, Inc. | Nucleic acid lipophilic conjugates |
| WO2005078094A2 (en) * | 2004-02-06 | 2005-08-25 | Dharmacon, Inc. | Stabilized rnas as transfection controls and silencing reagents |
| US20090280567A1 (en) * | 2004-02-06 | 2009-11-12 | Dharmacon, Inc. | Stabilized sirnas as transfection controls and silencing reagents |
| TWI235440B (en) * | 2004-03-31 | 2005-07-01 | Advanced Semiconductor Eng | Method for making leadless semiconductor package |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| EP1809614B1 (en) | 2004-04-08 | 2014-05-07 | TargeGen, Inc. | Benzotriazine inhibitors of kinases |
| US7652051B2 (en) | 2004-08-25 | 2010-01-26 | Targegen, Inc. | Heterocyclic compounds and methods of use |
| MY159370A (en) * | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| US7923207B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Apparatus and system having dry gene silencing pools |
| US7923206B2 (en) * | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Method of determining a cellular response to a biological agent |
| US7935811B2 (en) * | 2004-11-22 | 2011-05-03 | Dharmacon, Inc. | Apparatus and system having dry gene silencing compositions |
| JP2008531018A (ja) * | 2005-02-24 | 2008-08-14 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 免疫刺激性オリゴヌクレオチド |
| US20060223777A1 (en) * | 2005-03-29 | 2006-10-05 | Dharmacon, Inc. | Highly functional short hairpin RNA |
| CA2611720A1 (en) * | 2005-06-08 | 2006-12-14 | Targegen, Inc. | Methods and compositions for the treatment of ocular disorders |
| BR122021011788B1 (pt) * | 2005-11-01 | 2022-01-25 | Impact Biomedicines, Inc | Inibidores de biaril meta pirimidina de cinases, composição farmacêutica e processo para preparar uma composição farmacêutica |
| US8604042B2 (en) * | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US8133900B2 (en) * | 2005-11-01 | 2012-03-13 | Targegen, Inc. | Use of bi-aryl meta-pyrimidine inhibitors of kinases |
| EP1991678B2 (en) * | 2006-02-15 | 2020-07-15 | Rechtsanwalt Thomas Beck | Compositions and methods for oligonucleotide formulations |
| US7691858B2 (en) * | 2006-04-25 | 2010-04-06 | Targegen, Inc. | Kinase inhibitors and methods of use thereof |
| US8252755B2 (en) * | 2006-09-22 | 2012-08-28 | Dharmacon, Inc. | Duplex oligonucleotide complexes and methods for gene silencing by RNA interference |
| NZ575437A (en) | 2006-09-27 | 2012-02-24 | Coley Pharm Gmbh | Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity |
| CN101874111B (zh) | 2007-11-28 | 2013-06-05 | 国立大学法人东京医科齿科大学 | 利用内源性乳糜微粒递送用于抑制靶基因表达的核酸的体系 |
| US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| US20130267576A1 (en) * | 2010-07-16 | 2013-10-10 | Napajen Pharma, Inc. | (nucleic acid)-polysaccharide complex |
| WO2012027206A1 (en) | 2010-08-24 | 2012-03-01 | Merck Sharp & Dohme Corp. | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
| ES2663009T3 (es) | 2010-10-29 | 2018-04-10 | Sirna Therapeutics, Inc. | Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic) |
| AU2010363329A1 (en) | 2010-11-07 | 2013-05-09 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| US9347065B2 (en) | 2012-03-29 | 2016-05-24 | International Aids Vaccine Initiative | Methods to improve vector expression and genetic stability |
| EP2781523A1 (en) | 2013-03-18 | 2014-09-24 | Miltenyi Biotec GmbH | Lipophilic oligonucleotide analogs |
| CN110997933B (zh) * | 2017-08-02 | 2024-01-09 | 萨斯特德特股份有限两合公司 | 用于稳定无细胞核酸和细胞的方法和组合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
| US5276019A (en) * | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US5110802A (en) * | 1987-07-14 | 1992-05-05 | City Of Hope | Oligonucleotide phosphonates and method of inhibiting a human immunodeficiency virus in vitro utilizing said oligonucleotide phosphonates |
| JPH04501052A (ja) * | 1988-02-26 | 1992-02-27 | ザ・ウスター・フアウンデーシヨン・フオー・バイオメデイカル・リサーチ | 外来性オリゴヌクレオチドによるhtlv―3の抑制 |
| CA2029273A1 (en) * | 1989-12-04 | 1991-06-05 | Christine L. Brakel | Modified nucleotide compounds |
| EP0544716B1 (en) * | 1990-08-14 | 2002-12-18 | Isis Pharmaceuticals, Inc. | Oligonucleotide modulation of cell adhesion |
| JPH04154794A (ja) * | 1990-10-15 | 1992-05-27 | Yodogawa Seiyaku Kk | アンチセンスオリゴデオキシリボヌクレオチドおよびそれを有効成分とするhiv活性阻害剤 |
| EP0588881A1 (en) * | 1991-05-10 | 1994-03-30 | HYBRIDON, Inc. | 3'-end blocked oligonucleotides |
| WO1992020348A1 (en) * | 1991-05-23 | 1992-11-26 | Temple University - Of The Commonwealth System Of Higher Education | Treatment of colorectal carcinoma with antisense oligonucleotides to c-myb proto-oncogene |
| AU659482B2 (en) * | 1991-06-28 | 1995-05-18 | Massachusetts Institute Of Technology | Localized oligonucleotide therapy |
| KR930016437A (ko) | 1992-01-22 | 1993-08-26 | 귀틀라인, 슈미트 | 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도 |
| AU3596593A (en) * | 1992-02-19 | 1993-09-13 | Baylor College Of Medicine | Oligonucleotide modulation of cell growth |
| AU678980B2 (en) * | 1992-07-02 | 1997-06-19 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Method of inhibiting viral replication |
| ATE162198T1 (de) * | 1992-07-27 | 1998-01-15 | Hybridon Inc | Oligonukleotid alkylphosphonothiate |
| US5821234A (en) * | 1992-09-10 | 1998-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of proliferation of vascular smooth muscle cell |
| DE4321946A1 (de) * | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| JP2000203104A (ja) * | 1999-01-14 | 2000-07-25 | Minolta Co Ltd | プリンタ及びプリンタ制御装置 |
| US7821415B1 (en) * | 2008-04-04 | 2010-10-26 | Kimberlin Denver K | Pneumatically operated patient bed monitor |
-
1993
- 1993-11-12 DE DE4338704A patent/DE4338704A1/de not_active Withdrawn
-
1994
- 1994-11-07 ES ES94117513T patent/ES2218522T3/es not_active Expired - Lifetime
- 1994-11-07 PT PT94117513T patent/PT653439E/pt unknown
- 1994-11-07 EP EP01124078A patent/EP1182206A3/de not_active Withdrawn
- 1994-11-07 EP EP94117513A patent/EP0653439B1/de not_active Expired - Lifetime
- 1994-11-07 DE DE59410371T patent/DE59410371D1/de not_active Expired - Lifetime
- 1994-11-07 DK DK94117513T patent/DK0653439T3/da active
- 1994-11-07 AT AT94117513T patent/ATE265465T1/de active
- 1994-11-10 NZ NZ264894A patent/NZ264894A/en not_active IP Right Cessation
- 1994-11-10 US US08/337,120 patent/US6348312B1/en not_active Expired - Lifetime
- 1994-11-10 CA CA2135591A patent/CA2135591C/en not_active Expired - Lifetime
- 1994-11-11 JP JP27810494A patent/JP3558230B2/ja not_active Expired - Lifetime
- 1994-11-11 AU AU77799/94A patent/AU696635B2/en not_active Expired
-
1998
- 1998-12-10 HK HK02103552.2A patent/HK1041888A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE4338704A1 (de) | 1995-05-18 |
| EP1182206A3 (de) | 2002-08-21 |
| JPH07194385A (ja) | 1995-08-01 |
| CA2135591A1 (en) | 1995-05-13 |
| EP0653439B1 (de) | 2004-04-28 |
| DK0653439T3 (da) | 2004-08-09 |
| AU696635B2 (en) | 1998-09-17 |
| AU7779994A (en) | 1995-05-18 |
| DE59410371D1 (de) | 2004-06-03 |
| EP0653439A3 (de) | 1995-10-25 |
| JP3558230B2 (ja) | 2004-08-25 |
| NZ264894A (en) | 1997-07-27 |
| EP0653439A2 (de) | 1995-05-17 |
| US6348312B1 (en) | 2002-02-19 |
| ATE265465T1 (de) | 2004-05-15 |
| PT653439E (pt) | 2004-09-30 |
| ES2218522T3 (es) | 2004-11-16 |
| EP1182206A2 (de) | 2002-02-27 |
| CA2135591C (en) | 2010-10-26 |
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