[go: up one dir, main page]

HK1044449A1 - 巨噬细胞清除剂受体拮抗剂 - Google Patents

巨噬细胞清除剂受体拮抗剂 Download PDF

Info

Publication number
HK1044449A1
HK1044449A1 HK02106180.5A HK02106180A HK1044449A1 HK 1044449 A1 HK1044449 A1 HK 1044449A1 HK 02106180 A HK02106180 A HK 02106180A HK 1044449 A1 HK1044449 A1 HK 1044449A1
Authority
HK
Hong Kong
Prior art keywords
receptor antagonists
scavenger receptor
macrophage scavenger
macrophage
present compounds
Prior art date
Application number
HK02106180.5A
Other languages
English (en)
Inventor
Weinstock Joseph
G. Franz Robert
E. Gaitanopoulos Dimitri
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of HK1044449A1 publication Critical patent/HK1044449A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
HK02106180.5A 1999-06-24 2000-06-21 巨噬细胞清除剂受体拮抗剂 HK1044449A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14096599P 1999-06-24 1999-06-24
US60/140,965 1999-06-24
PCT/US2000/016988 WO2000078145A1 (en) 1999-06-24 2000-06-21 Macrophage scavenger receptor antagonists

Publications (1)

Publication Number Publication Date
HK1044449A1 true HK1044449A1 (zh) 2002-10-25

Family

ID=22493567

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106180.5A HK1044449A1 (zh) 1999-06-24 2000-06-21 巨噬细胞清除剂受体拮抗剂

Country Status (19)

Country Link
US (1) US6458845B1 (zh)
EP (1) EP1187531A4 (zh)
JP (1) JP2003502347A (zh)
KR (1) KR20020022716A (zh)
CN (1) CN1358062A (zh)
AU (1) AU5881000A (zh)
BR (1) BR0011571A (zh)
CA (1) CA2377288A1 (zh)
CO (1) CO5190711A1 (zh)
CZ (1) CZ20014642A3 (zh)
HK (1) HK1044449A1 (zh)
HU (1) HUP0202142A3 (zh)
IL (1) IL146513A0 (zh)
MX (1) MXPA02000123A (zh)
NO (1) NO20016077L (zh)
PL (1) PL352704A1 (zh)
TR (1) TR200103696T2 (zh)
WO (1) WO2000078145A1 (zh)
ZA (1) ZA200110350B (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001261471A1 (en) * 2000-05-12 2001-11-26 Smithkline Beecham Corporation Phosphate transport inhibitors
WO2002017897A2 (en) * 2000-08-30 2002-03-07 Primecyte, Inc. Methods for treating tumors using sulfonyl compounds
DE10121002A1 (de) * 2001-04-28 2002-11-14 Aventis Pharma Gmbh Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen
DE10121003A1 (de) * 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
US20030216449A1 (en) * 2001-05-11 2003-11-20 Joseph Weinstock Phosphate transport inhibitors
DE10128331A1 (de) * 2001-06-12 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
GB2378179A (en) * 2001-08-03 2003-02-05 Pantherix Ltd Aromatic sulfonamides and their use in treating bacterial diseases
GB0228490D0 (en) * 2002-12-06 2003-01-08 Amersham Plc Novel imaging compounds
UA82872C2 (en) 2003-03-28 2008-05-26 Janssen Pharmaceutica Nv Benzo [1,2,5] thiadiazole compounds
EP1797083A1 (en) 2004-09-24 2007-06-20 Janssen Pharmaceutica, N.V. Sulfonamide compounds
EP2147011A4 (en) 2007-04-16 2012-07-18 Health Research Inc PROCESS FOR INHIBITING SCAVENGER RECEPTOR-A AND INCREASING THE IMMUNE REACTION ON ANTIGENE
EP2456435B1 (en) * 2009-07-21 2015-06-24 The Board of Trustees of the Leland Stanford Junior University Heteroaryl benzamides, compositions and methods of use
US8664425B2 (en) * 2010-02-02 2014-03-04 Honeywell International Inc. Bluegreen fluorescent compounds
EP3569598A1 (en) 2011-11-17 2019-11-20 Dana Farber Cancer Institute, Inc. Inhibitors of c-jun-n-terminal kinase (jnk)
CN103183623A (zh) * 2013-03-12 2013-07-03 中国医学科学院医药生物技术研究所 一组苯磺酰胺基苯甲酰胺类衍生物及制备和应用
EP2990403A1 (en) * 2014-08-29 2016-03-02 Novartis Tiergesundheit AG Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics
CN105395532B (zh) * 2015-11-25 2017-11-14 中国医学科学院医药生物技术研究所 2‑苯磺酰胺基苯甲酰胺类化合物在肝损伤保护和肝纤维化防治中的应用
WO2018043400A1 (ja) * 2016-08-30 2018-03-08 日本曹達株式会社 スルホニルアミノベンズアミド化合物および有害生物防除剤
JP7357009B2 (ja) * 2018-06-01 2023-10-05 プロメガ コーポレイション Ｏｐｌｏｐｈｏｒｕｓルシフェラーゼ由来生物発光性複合体の阻害剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3357977A (en) 1964-01-06 1967-12-12 Minnesota Mining & Mfg Novel anthranyl intermediates
JPS6038695B2 (ja) * 1979-12-05 1985-09-02 富士写真フイルム株式会社 カラ−写真感光材料
JPS57198459A (en) 1981-06-01 1982-12-06 Fuji Photo Film Co Ltd Color photographic sensitive material
EP0420805A3 (en) * 1989-09-26 1991-10-16 Ciba-Geigy Ag Anthelmintic compounds
TW523506B (en) * 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
DE19830431A1 (de) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren

Also Published As

Publication number Publication date
CN1358062A (zh) 2002-07-10
WO2000078145A1 (en) 2000-12-28
CO5190711A1 (es) 2002-08-29
JP2003502347A (ja) 2003-01-21
HUP0202142A2 (en) 2002-10-28
PL352704A1 (en) 2003-09-08
IL146513A0 (en) 2002-07-25
HUP0202142A3 (en) 2005-05-30
US6458845B1 (en) 2002-10-01
TR200103696T2 (tr) 2002-06-21
CZ20014642A3 (cs) 2002-06-12
AU5881000A (en) 2001-01-09
ZA200110350B (en) 2002-09-30
CA2377288A1 (en) 2000-12-28
KR20020022716A (ko) 2002-03-27
EP1187531A1 (en) 2002-03-20
BR0011571A (pt) 2002-03-05
NO20016077D0 (no) 2001-12-13
NO20016077L (no) 2001-12-13
MXPA02000123A (es) 2002-07-02
EP1187531A4 (en) 2003-05-28

Similar Documents

Publication Publication Date Title
HK1044449A1 (zh) 巨噬细胞清除剂受体拮抗剂
EG24411A (en) Pharmaceutically active compounds
IS2173B (is) Pýrróló[2,3-d]pýrimidín efnasambönd sem prótín kínasa hindrar
GB2363229B (en) Tightly-coupled disk-to-cpu storage server
ZA991856B (en) Storage-stable compositions useful for the production of structural foams.
TW375010U (en) Adjustment structure for the keyboard drawer
MXPA02000725A (es) Formulacion opioide de liberacion sostenida.
AU4802500A (en) 2-aminoquinolinecarboxamides: neurokinin receptor ligands
EP1195165A4 (en) FIBROSIS INHIBITORS CONTAINING THE ACTIVE INGREDIENT OF SPHINGOSINE A PHOSPHATE OR ITS RECEPTOR AGONISTS
AU1542201A (en) Compounds having 5-HT6 receptor antagonist activity
NO20020574D0 (no) Substituerte 1,5-dihydropyrrol-2-onderivater som er virksomme som NMDA-reseptorantagonister for behandlingen av smertetilstanden
AU2673201A (en) Alpha-arylethylpiperazine derivatives as neurokinin antagonists
AU6036100A (en) New pharmaceutically active compounds
AU4511901A (en) Nonpeptide kappa opioid receptor antagonists
AU4311600A (en) Cushion insole
GB2350128B (en) Improved floor insulation
TW378683U (en) Improved structure for the combination floor
TW384655U (en) Improved structure for the foot pad of furniture
TW382238U (en) Structure for furniture foot
TW396826U (en) An improved structure for the on-bed tray
TW387452U (en) Improved structure for the plastic floor board
ZA200004599B (en) Process for maintaining the stability of the fortification.
AU1672P (en) Jellibene Bougainvillea hybrid
TW416360U (en) Structure for adjusting dual roller to the same level
AU4948800A (en) Method for searching physiologically active substance