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HK1044543B - 贝他分泌酶组合物及其方法 - Google Patents

贝他分泌酶组合物及其方法 Download PDF

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Publication number
HK1044543B
HK1044543B HK02104530.7A HK02104530A HK1044543B HK 1044543 B HK1044543 B HK 1044543B HK 02104530 A HK02104530 A HK 02104530A HK 1044543 B HK1044543 B HK 1044543B
Authority
HK
Hong Kong
Prior art keywords
beta
secretase
enzyme
methods
implicated
Prior art date
Application number
HK02104530.7A
Other languages
English (en)
Other versions
HK1044543A1 (zh
Inventor
P Anderson John
Basi Guriqbal
Tam Doane Minh
Frigon Normand
John Varghese
Power Michael
Sinha Sukanto
Tatsuno Gwen
Tung Jay
Wang Shuwen
Mcconlogue Lisa
Original Assignee
Elan Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals Inc filed Critical Elan Pharmaceuticals Inc
Priority to HK04104024.8A priority Critical patent/HK1062377B/zh
Priority to HK04104027.5A priority patent/HK1062445B/zh
Priority to HK04104025.7A priority patent/HK1062474B/zh
Publication of HK1044543A1 publication Critical patent/HK1044543A1/zh
Publication of HK1044543B publication Critical patent/HK1044543B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK02104530.7A 1999-02-10 2000-02-10 贝他分泌酶组合物及其方法 HK1044543B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
HK04104024.8A HK1062377B (zh) 1999-02-10 2002-06-18 鼠b-分泌酶酵素
HK04104027.5A HK1062445B (zh) 1999-02-10 2002-06-18 B-分泌酶抑制剂
HK04104025.7A HK1062474B (zh) 1999-02-10 2002-06-18 精制b-分泌酶的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11957199P 1999-02-10 1999-02-10
US60/119,571 1999-02-10
US13917299P 1999-06-15 1999-06-15
US60/139,172 1999-06-15
PCT/US2000/003819 WO2000047618A2 (en) 1999-02-10 2000-02-10 HUMAN β-SECRETASE ENZYME, INHIBITORS AND THEIR COMPOSITIONS AND USES

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
HK04104027.5A Division HK1062445B (zh) 1999-02-10 2002-06-18 B-分泌酶抑制剂
HK04104025.7A Division HK1062474B (zh) 1999-02-10 2002-06-18 精制b-分泌酶的方法
HK04104024.8A Division HK1062377B (zh) 1999-02-10 2002-06-18 鼠b-分泌酶酵素

Related Child Applications (3)

Application Number Title Priority Date Filing Date
HK04104027.5A Addition HK1062445B (zh) 1999-02-10 2002-06-18 B-分泌酶抑制剂
HK04104025.7A Addition HK1062474B (zh) 1999-02-10 2002-06-18 精制b-分泌酶的方法
HK04104024.8A Addition HK1062377B (zh) 1999-02-10 2002-06-18 鼠b-分泌酶酵素

Publications (2)

Publication Number Publication Date
HK1044543A1 HK1044543A1 (zh) 2002-10-25
HK1044543B true HK1044543B (zh) 2004-12-03

Family

ID=26817477

Family Applications (2)

Application Number Title Priority Date Filing Date
HK02104538.9A HK1044545A1 (zh) 1999-02-10 2000-02-10 贝他分泌酶组合物及其方法
HK02104530.7A HK1044543B (zh) 1999-02-10 2000-02-10 贝他分泌酶组合物及其方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK02104538.9A HK1044545A1 (zh) 1999-02-10 2000-02-10 贝他分泌酶组合物及其方法

Country Status (10)

Country Link
US (3) US7109017B1 (zh)
EP (1) EP1165609A2 (zh)
JP (1) JP4653318B2 (zh)
CN (1) CN1390232A (zh)
AU (1) AU4000900A (zh)
CA (1) CA2359785A1 (zh)
GB (1) GB2364059B (zh)
HK (2) HK1044545A1 (zh)
NZ (1) NZ534876A (zh)
WO (1) WO2000047618A2 (zh)

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HK1044543A1 (zh) 2002-10-25
US7067271B1 (en) 2006-06-27
US7109017B1 (en) 2006-09-19
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CN1390232A (zh) 2003-01-08
WO2000047618A9 (en) 2001-10-25
GB0121314D0 (en) 2001-10-24
CA2359785A1 (en) 2000-08-17
JP2003524393A (ja) 2003-08-19
GB2364059B (en) 2004-01-14
WO2000047618A2 (en) 2000-08-17
WO2000047618A3 (en) 2001-09-07
JP4653318B2 (ja) 2011-03-16
US6627739B1 (en) 2003-09-30
NZ534876A (en) 2006-02-24
HK1044545A1 (zh) 2002-10-25
EP1165609A2 (en) 2002-01-02

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