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HK1046902A1 - 新型哌嗪基烷基硫代嘧啶衍生物，包含該衍生物的藥物組合物以及製備該活性物質的方法 - Google Patents

新型哌嗪基烷基硫代嘧啶衍生物，包含該衍生物的藥物組合物以及製備該活性物質的方法 Download PDF

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Publication number
HK1046902A1
HK1046902A1 HK02107406.1A HK02107406A HK1046902A1 HK 1046902 A1 HK1046902 A1 HK 1046902A1 HK 02107406 A HK02107406 A HK 02107406A HK 1046902 A1 HK1046902 A1 HK 1046902A1
Authority
HK
Hong Kong
Prior art keywords
pharmaceutical compositions
compositions containing
preparation
same
derivatives
Prior art date
Application number
HK02107406.1A
Other languages
English (en)
Inventor
Ratzne Simonek Ildiko
Bozsing Daniel
Nemeth Gabor
Simig Gyula
Poszavacz Laszlo
Jakoczi Ivan
Levay Gyorgy
Gacsalyi Istvan
Tihanyi Karoly
Wellman Janos
Egyed Andras
Original Assignee
Egis Gyogyszergyar. Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9902214A external-priority patent/HU9902214D0/hu
Priority claimed from HU0002156A external-priority patent/HU227402B1/hu
Application filed by Egis Gyogyszergyar. Rt. filed Critical Egis Gyogyszergyar. Rt.
Publication of HK1046902A1 publication Critical patent/HK1046902A1/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK02107406.1A 1999-06-29 2000-06-29 新型哌嗪基烷基硫代嘧啶衍生物，包含該衍生物的藥物組合物以及製備該活性物質的方法 HK1046902A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU9902214A HU9902214D0 (en) 1999-06-29 1999-06-29 Novel piperazinyl-alkyl-thio-pyrimidine-derivatives, process for producing them and medicaments containing the same
HU9902214 1999-06-29
HU0002156A HU227402B1 (en) 2000-06-06 2000-06-06 Novel piperazinyl alkylthio pyrimidinyl derivatives, pharmaceutical compositions containing such active ingredients and process for producing the active ingredients
PCT/HU2000/000064 WO2001000617A2 (en) 1999-06-29 2000-06-29 Novel piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same, and a process for the preparation of the same

Publications (1)

Publication Number Publication Date
HK1046902A1 true HK1046902A1 (zh) 2003-01-30

Family

ID=89998587

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02107406.1A HK1046902A1 (zh) 1999-06-29 2000-06-29 新型哌嗪基烷基硫代嘧啶衍生物，包含該衍生物的藥物組合物以及製備該活性物質的方法

Country Status (19)

Country Link
US (1) US6469168B1 (zh)
EP (1) EP1194415B1 (zh)
JP (1) JP2003503404A (zh)
KR (1) KR20020016872A (zh)
CN (1) CN1173956C (zh)
AT (1) ATE247645T1 (zh)
AU (1) AU5835400A (zh)
CA (1) CA2376307A1 (zh)
CZ (1) CZ20014575A3 (zh)
DE (1) DE60004671T2 (zh)
DK (1) DK1194415T3 (zh)
ES (1) ES2204643T3 (zh)
HK (1) HK1046902A1 (zh)
HR (1) HRP20010969B1 (zh)
PL (1) PL352476A1 (zh)
PT (1) PT1194415E (zh)
RU (1) RU2245334C2 (zh)
SK (1) SK285670B6 (zh)
WO (1) WO2001000617A2 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2005102586A (ru) 2002-07-02 2005-09-20 Ф.Хоффманн-Ля Рош Аг (Ch) 2,5-замещенные производные пиримидина в качестве антагонистов ix рецептора ccr-3
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
NZ603525A (en) 2008-06-27 2015-02-27 Celgene Avilomics Res Inc Pyrimidine based compound and uses thereof
DK2603081T3 (en) * 2010-08-10 2017-01-16 Celgene Avilomics Res Inc COLLECTED BY A BTK INHIBITOR
TWI545115B (zh) 2010-11-01 2016-08-11 阿維拉製藥公司 雜環化合物及其用途
US9238629B2 (en) 2010-11-01 2016-01-19 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
JP5957003B2 (ja) 2010-11-10 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド 変異体選択的ｅｇｆｒ阻害剤およびその使用
CA2853498A1 (en) 2011-10-28 2013-05-02 Celgene Avilomics Research, Inc. Methods of treating a bruton's tyrosine kinase disease or disorder
CN109053595B (zh) 2012-03-15 2022-04-01 西建卡尔有限责任公司 表皮生长因子受体激酶抑制剂的盐
MY169233A (en) 2012-03-15 2019-03-19 Celgene Car Llc Solid forms of an epidermal growth factor receptor kinase inhibitor
WO2014100748A1 (en) 2012-12-21 2014-06-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EA201591051A1 (ru) 2013-02-08 2016-06-30 Селджен Авиломикс Рисерч, Инк. Ингибиторы erk и варианты их применения
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
WO2016025561A1 (en) 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Forms and compositions of an erk inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79933B (zh) * 1983-06-23 1984-10-31 Nissan Chemical Ind Ltd
HUT76266A (en) * 1995-10-31 1997-07-28 Egyt Gyogyszervegyeszeti Gyar New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components

Also Published As

Publication number Publication date
PL352476A1 (en) 2003-08-25
CA2376307A1 (en) 2001-01-04
DE60004671D1 (de) 2003-09-25
EP1194415B1 (en) 2003-08-20
SK285670B6 (sk) 2007-06-07
CN1359375A (zh) 2002-07-17
PT1194415E (pt) 2004-01-30
JP2003503404A (ja) 2003-01-28
ES2204643T3 (es) 2004-05-01
DE60004671T2 (de) 2004-07-29
WO2001000617A3 (en) 2001-03-01
AU5835400A (en) 2001-01-31
RU2245334C2 (ru) 2005-01-27
HRP20010969B1 (en) 2005-04-30
EP1194415A2 (en) 2002-04-10
CZ20014575A3 (cs) 2002-04-17
ATE247645T1 (de) 2003-09-15
US6469168B1 (en) 2002-10-22
WO2001000617A2 (en) 2001-01-04
HRP20010969A2 (en) 2003-04-30
CN1173956C (zh) 2004-11-03
KR20020016872A (ko) 2002-03-06
SK19272001A3 (sk) 2002-05-09
DK1194415T3 (da) 2003-12-08

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