HK1175820A - Methods to predict clinical outcome of cancer - Google Patents
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Oncologists have a number of treatment options available to them, including different combinations of therapeutic regimens that are characterized as "standard of care." The absolute benefit from adjuvant treatment is larger for patients with poor prognostic features, and this has resulted in the policy to select only these so-called 'high-risk' patients for adjuvant chemotherapy. See, e.g., S. Paik, et al., J Clin Oncol. 24(23):3726-34 (2006). Therefore, the best likelihood of good treatment outcome requires that patients be assigned to optimal available cancer treatment, and that this assignment be made as quickly as possible following diagnosis.
Today our healthcare system is riddled with inefficiency and wasteful spending - one example of this is that the efficacy rate of many oncology therapeutics working only about 25% of the time. Many of those cancer patients are experiencing toxic side effects for costly therapies that may not be working. This imbalance between high treatment costs and low therapeutic efficacy is often a result of treating a specific diagnosis one way across a diverse patient population. But with the advent of gene profiling tools, genomic testing, and advanced diagnostics, this is beginning to change.
In particular, once a patient is diagnosed with breast cancer there is a strong need for methods that allow the physician to predict the expected course of disease, including the likelihood of cancer recurrence, long-term survival of the patient, and the like, and select the most appropriate treatment option accordingly. Accepted prognostic and predictive factors in breast cancer include age, tumor size, axillary lymph node status, histological tumor type, pathological grade and hormone receptor status. Molecular diagnostics, however, have been demonstrated to identify more patients with a low risk of breast cancer than was possible with standard prognostic indicators. S. Paik, The Oncologist 12(6):631-635 (2007). Despite recent advances, the challenge of breast cancer treatment remains to target specific treatment regimens to pathogenically distinct tumor types, and ultimately personalize tumor treatment in order to maximize outcome. Accurate prediction of prognosis
and clinical outcome would allow the oncologist to tailor the administration of adjuvant chemotherapy such that women with a higher risk of a recurrence or poor prognosis would receive more aggressive treatment. Furthermore, accurately stratifying patients based on risk would greatly advance the understanding of expected absolute benefit from treatment, thereby increasing success rates for clinical trials for new breast cancer therapies.
Currently, most diagnostic tests used in clinical practice are frequently not quantitative, relying on immunohistochemistry (IHC). This method often yields different results in different laboratories, in part because the reagents are not standardized, and in part because the interpretations are subjective and cannot be easily quantified. Other RNA-based molecular diagnostics require fresh-frozen tissues, which presents a myriad of challenges including incompatibilities with current clinical practices and sample transport regulations. Fixed paraffin-embedded tissue is more readily available and methods have been established to detect RNA in fixed tissue. However, these methods typically do not allow for the study of large numbers of genes (DNA or RNA) from small amounts of material. Thus, traditionally fixed tissue has been rarely used other than for IHC detection of proteins. Karczewska et al., Cancer, v 88, no 9, p 2061-2071, 2000, investigates expression of IL6, IL6R and IL6ST in breast cancer.
The present invention is defined in the claims.
The present invention provides a gene, IL6ST, the expression level of which is associated with a good prognosis in breast cancer. The good prognosis assumes the patient receives the standard of care. The clinical outcome may be defined by clinical endpoints, such as disease or recurrence free survival, metastasis free survival, overall survival, etc.
The present invention accommodates the use of archived paraffin-embedded biopsy material for assay of the gene, and therefore is compatible with the most widely available type of biopsy material. It is also compatible with several different methods of tumor tissue harvest, for example, via core biopsy or fine needle aspiration. The tissue sample may comprise cancer cells.
In one aspect, the present disclosure concerns a method of predicting a clinical outcome of a cancer patient, comprising (a) obtaining an expression level of an expression product (e.g., an RNA transcript) of at least one prognostic gene listed in Tables 1-12 from a tissue sample obtained from a tumor of the patient; (b) normalizing the expression level of the expression product of the at least one prognostic gene, to obtain a normalized expression level; and (c) calculating a risk score based on the normalized expression value, wherein increased expression of prognostic genes in Tables 1, 3, 5, and 7 are positively correlated
with good prognosis, and wherein increased expression of prognostic genes in Tables 2, 4, 6, and 8 are negatively associated with good prognosis. In some embodiments, the tumor is estrogen receptor-positive. In other embodiments, the tumor is estrogen receptor negative.
In one aspect, the present disclosure provides a method of predicting a clinical outcome of a cancer patient, comprising (a) obtaining an expression level of an expression product (e.g., an RNA transcript) of at least one prognostic gene from a tissue sample obtained from a tumor of the patient, where the at least one prognostic gene is selected from GSTM2, IL6ST, GSTM3, C8orf4, TNFRSF11B, NAT1, RUNX1, CSF1, ACTR2, LMNB1, TFRC, LAPTM4B, ENO1, CDC20, and IDH2; (b) normalizing the expression level of the expression product of the at least one prognostic gene, to obtain a normalized expression level; and (c) calculating a risk score based on the normalized expression value, wherein increased expression of a prognostic gene selected from GSTM2, IL6ST, GSTM3, C8orf4, TNFRSF11B, NAT1, RUNX1, and CSF1 is positively correlated with good prognosis, and wherein increased expression of a prognostic gene selected from ACTR2, LMNB1, TFRC, LAPTM4B, ENO1, CDC20, and IDH2 is negatively associated with good prognosis. In some embodiments, the tumor is estrogen receptor-positive. In other embodiments, the tumor is estrogen receptor negative.
In various embodiments, the normalized expression level of at least 2, or at least 5, or at least 10, or at least 15, or at least 20, or a least 25 prognostic genes (as determined by assaying a level of an expression product of the gene) is determined. In alternative embodiments, the normalized expression levels of at least one of the genes that co-expresses with prognostic genes in Tables 16-18 is obtained.
In another embodiment, the risk score is determined using normalized expression levels of at least one a stromal or transferrin receptor group gene, or a gene that co-expresses with a stromal or transferrin receptor group gene.
In another embodiment, the cancer is breast cancer. In another embodiment, the patient is a human patient.
In yet another embodiment, the cancer is ER-positive breast cancer.
In yet another embodiment, the cancer is ER-negative breast cancer.
In a further embodiment, the expression product comprises RNA. For example, the RNA could be exonic RNA, intronic RNA, or short RNA (e.g., microRNA, siRNA, promoter-associated small RNA, shRNA, etc.). In various embodiments, the RNA is fragmented RNA.
In a different aspect, the invention concerns an array comprising polynucleotides hybridizing to an RNA transcription of at least one of the prognostic genes listed in Tables 1-12.
In a still further aspect, the invention concerns a method of preparing a personalized genomics profile for a patient, comprising (a) obtaining an expression level of an expression product (e.g., an RNA transcript) of at least one prognostic gene listed in Tables 1-12 from a tissue sample obtained from a tumor of the patient; (b) normalizing the expression level of the expression product of the at least one prognostic gene to obtain a normalized expression level; and (c) calculating a risk score based on the normalized expression value, wherein increased expression of prognostic genes in Tables 1, 3, 5, and 7 are positively correlated with good prognosis, and wherein increased expression of prognostic genes in Tables 2, 4, 6, and 8 are negatively associated with good prognosis. In some embodiments, the tumor is estrogen receptor-positive, and in other embodiments the tumor is estrogen receptor negative.
In various embodiments, a subject method can further include providing a report. The report may include prediction of the likelihood of risk that said patient will have a particular clinical outcome.
The invention further provides a computer-implemented method for classifying a cancer patient based on risk of cancer recurrence, comprising (a) classifying, on a computer, said patient as having a good prognosis or a poor prognosis based on an expression profile comprising measurements of expression levels of expression products of a plurality of prognostic genes in a tumor tissue sample taken from the patient, said plurality of genes comprising at least three different prognostic genes listed in any of Tables 1-12, wherein a good prognosis predicts no recurrence or metastasis within a predetermined period after initial diagnosis, and wherein a poor prognosis predicts recurrence or metastasis within said predetermined period after initial diagnosis; and (b) calculating a risk score based on said expression levels.
Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Singleton et al., Dictionary of Microbiology and Molecular Biology 2nd ed., J. Wiley & Sons (New York, NY 1994), and March, Advanced Organic Chemistry Reactions, Mechanisms and Structure 4th ed., John Wiley & Sons (New York, NY 1992), provide one skilled in the art with a general guide to many of the terms used in the present application.
One skilled in the art will recognize many methods and materials similar or equivalent to those described herein, which could be used in the practice of the present invention. Indeed, the present invention is in no way limited to the methods and materials described. For purposes of the present invention, the following terms are defined below.
"Prognostic factors" are those variables related to the natural history of cancer, which influence the recurrence rates and outcome of patients once they have developed cancer. Clinical parameters that have been associated with a worse prognosis include, for example, lymph node involvement, and high grade tumors. Prognostic factors are frequently used to categorize patients into subgroups with different baseline relapse risks.
The term "prognosis" is used herein to refer to the prediction of the likelihood of cancer-attributable death or progression, including recurrence, metastatic spread, and drug resistance, of a neoplastic disease, such as breast cancer. The term "good prognosis" means a desired or "positive" clinical outcome. For example, in the context of breast cancer, a good prognosis may be an expectation of no recurrences or metastasis within two, three, four, five or more years of the initial diagnosis of breast cancer. The terms "bad prognosis" or "poor prognosis" are used herein interchangeably herein to mean an undesired clinical outcome. For example, in the context of breast cancer, a bad prognosis may be an expectation of a recurrence or metastasis within two, three, four, five or more years of the initial diagnosis of breast cancer.
The term "prognostic gene" is used herein to refer to a gene, the expression of which is correlated, positively or negatively, with a good prognosis for a cancer patient treated with the standard of care. A gene may be both a prognostic and predictive gene, depending on the correlation of the gene expression level with the corresponding endpoint. For example, using a Cox proportional hazards model, if a gene is only prognostic, its hazard ratio (HR) does not change when measured in patients treated with the standard of care or in patients treated with a new intervention.
The term "predictive gene" is used herein to refer to a gene, the expression of which is correlated, positively or negatively, with response to a beneficial response to treatment. For example, treatment could include chemotherapy.
The terms "risk score" or "risk classification" are used interchangeably herein to describe a level of risk (or likelihood) that a patient will experience a particular clinical outcome. A patient may be classified into a risk group or classified at a level of risk based on the methods of the present disclosure, e.g. high, medium, or low risk. A "risk group" is a group of subjects or individuals with a similar level of risk for a particular clinical outcome.
A clinical outcome can be defined using different endpoints. The term "long-term" survival is used herein to refer to survival for a particular time period, e.g., for at least 3 years, more preferably for at least 5 years. The term "Recurrence-Free Survival" (RFS) is used herein to refer to survival for a time period (usually in years) from randomization to first cancer recurrence or death due to recurrence of cancer. The term "Overall Survival" (OS) is used herein to refer to the time (in years) from randomization to death from any cause. The term "Disease-Free Survival" (DFS) is used herein to refer to survival for a time period (usually in years) from randomization to first cancer recurrence or death from any cause.
The calculation of the measures listed above in practice may vary from study to study depending on the definition of events to be either censored or not considered.
The term "biomarker" as used herein refers to a gene, the expression level of which, as measured using a gene product.
The term "microarray" refers to an ordered arrangement of hybridizable array elements, preferably polynucleotide probes, on a substrate.
As used herein, the term "normalized expression level" as applied to a gene refers to the normalized level of a gene product, e.g. the normalized value determined for the RNA expression level of a gene or for the polypeptide expression level of a gene.
The term "Ct" as used herein refers to threshold cycle, the cycle number in quantitative polymerase chain reaction (qPCR) at which the fluorescence generated within a reaction well exceeds the defined threshold, i.e. the point during the reaction at which a sufficient number of amplicons have accumulated to meet the defined threshold.
The term "gene product" or "expression product" are used herein to refer to the RNA transcription products (transcripts) of the gene, including mRNA, and the polypeptide translation products of such RNA transcripts. A gene product can be, for example, an unspliced RNA, an mRNA, a splice variant mRNA, a microRNA, a fragmented RNA, a polypeptide, a post-translationally modified polypeptide, a splice variant polypeptide, etc.
The term "RNA transcript" as used herein refers to the RNA transcription products of a gene, including, for example, mRNA, an unspliced RNA, a splice variant mRNA, a microRNA, and a fragmented RNA. "Fragmented RNA" as used herein refers to RNA a mixture of intact RNA and RNA that has been degraded as a result of the sample processing (e.g., fixation, slicing tissue blocks, etc.).
Unless indicated otherwise, each gene name used herein corresponds to the Official Symbol assigned to the gene and provided by Entrez Gene (URL: www.ncbi.nlm.nih.gov/sites/entrez) as of the filing date of this application.
The terms "correlated" and "associated" are used interchangeably herein to refer to a strength of association between two measurements (or measured entities). The disclosure provides genes and gene subsets, the expression levels of which are associated with a particular outcome measure. For example, the increased expression level of a gene may be positively correlated (positively associated) with an increased likelihood of good clinical outcome for the patient, such as an increased likelihood of long-term survival without recurrence of the cancer and/or metastasis-free survival. Such a positive correlation may be demonstrated statistically in various ways, e.g. by a low hazard ratio (e.g. HR < 1.0). In another example, the increased expression level of a gene may be negatively correlated (negatively associated) with an increased likelihood of good clinical outcome for the patient. In that case, for example, the patient may have a decreased likelihood of long-term survival without recurrence of the cancer and/or cancer metastasis, and the like. Such a negative correlation indicates that the patient likely has a poor prognosis, e.g., a high hazard ratio (e.g., HR > 1.0). "Correlated" is also used herein to refer to a strength of association between the expression levels of two different genes, such that expression level of a first gene can be substituted with an expression level of a second gene in a given algorithm in view of their correlation of expression. Such "correlated expression" of two genes that are substitutable in an algorithm usually gene expression levels that are positively correlated with one another, e.g., if increased expression of a first gene is positively correlated with an outcome (e.g., increased likelihood of good clinical outcome), then the second gene that is co-expressed and exhibits correlated expression with the first gene is also positively correlated with the same outcome
The term "recurrence," as used herein, refers to local or distant (metastasis) recurrence of cancer. For example, breast cancer can come back as a local recurrence (in the treated breast or near the tumor surgical site) or as a distant recurrence in the body. The most common sites of breast cancer recurrence include the lymph nodes, bones, liver, or lungs.
The term "polynucleotide," when used in singular or plural, generally refers to any polyribonucleotide or polydeoxribonucleotide, which may be unmodified RNA or DNA or modified RNA or DNA. Thus, for instance, polynucleotides as defined herein include, without limitation, single- and double-stranded DNA, DNA including single- and double-stranded regions, single- and double-stranded RNA, and RNA including single- and double-stranded regions, hybrid molecules comprising DNA and RNA that may be single-stranded or, more typically, double-stranded or include single- and double-stranded regions. In addition, the term "polynucleotide" as used herein refers to triple-stranded regions comprising RNA or DNA or both RNA and DNA. The strands in such regions may be from the same molecule or from different molecules. The regions may include all of one or more of the molecules, but more typically involve only a region of some of the molecules. One of the molecules of a triple-helical region often is an oligonucleotide. The term "polynucleotide" specifically includes cDNAs. The term includes DNAs (including cDNAs) and RNAs that contain one or more modified bases. Thus, DNAs or RNAs with backbones modified for stability or for other reasons are "polynucleotides" as that term is intended herein. Moreover, DNAs or RNAs comprising unusual bases, such as inosine, or modified bases, such as tritiated bases, are included within the term "polynucleotides" as defined herein. In general, the term "polynucleotide" embraces all chemically, enzymatically and/or metabolically modified forms of unmodified polynucleotides, as well as the chemical forms of DNA and RNA characteristic of viruses and cells, including simple and complex cells.
The term "oligonucleotide" refers to a relatively short polynucleotide, including, without limitation, single-stranded deoxyribonucleotides, single- or double-stranded ribonucleotides, RNA:DNA hybrids and double-stranded DNAs. Oligonucleotides, such as single-stranded DNA probe oligonucleotides, are often synthesized by chemical methods, for example using automated oligonucleotide synthesizers that are commercially available. However, oligonucleotides can be made by a variety of other methods, including in vitro recombinant DNA-mediated techniques and by expression of DNAs in cells and organisms.
The phrase "amplification" refers to a process by which multiple copies of a gene or RNA transcript are formed in a particular sample or cell line. The duplicated region (a stretch of amplified polynucleotide) is often referred to as "amplicon." Usually, the amount of the messenger RNA (mRNA) produced, i.e., the level of gene expression, also increases in the proportion of the number of copies made of the particular gene expressed.
The term "estrogen receptor (ER)" designates the estrogen receptor status of a cancer patient. A tumor is ER-positive if there is a significant number of estrogen receptors present in the cancer cells, while ER-negative indicates that the cells do not have a significant number of receptors present. The definition of "significant" varies amongst testing sites and methods (e.g., immunohistochemistry, PCR). The ER status of a cancer patient can be evaluated by various known means. For example, the ER level of breast cancer is determined by measuring an expression level of a gene encoding the estrogen receptor in a breast tumor sample obtained from a patient.
The term "tumor," as used herein, refers to all neoplastic cell growth and proliferation, whether malignant or benign, and all pre-cancerous and cancerous cells and tissues.
The terms "cancer" and "cancerous" refer to or describe the physiological condition in mammals that is typically characterized by unregulated cell growth. Examples of cancer include, but are not limited to, breast cancer, ovarian cancer, colon cancer, lung cancer, prostate cancer, hepatocellular cancer, gastric cancer, pancreatic cancer, cervical cancer, liver cancer, bladder cancer, cancer of the urinary tract, thyroid cancer, renal cancer, carcinoma, melanoma, and brain cancer.
The gene subset identified herein as the "stromal group" includes genes that are synthesized predominantly by stromal cells and are involved in stromal response and genes that co-express with stromal group genes. "Stromal cells" are defined herein as connective tissue cells that make up the support structure of biological tissues. Stromal cells include fibroblasts, immune cells, pericytes, endothelial cells, and inflammatory cells. "Stromal response" refers to a desmoplastic response of the host tissues at the site of a primary tumor or invasion. See, e.g., E. Rubin, J. Farber, Pathology, 985-986 (2nd Ed. 1994). The stromal group includes, for example, CDH11, TAGLN, ITGA4, INHBA, COLIA1, COLIA2, FN1, CXCL14, TNFRSF1, CXCL12, C10ORF116, RUNX1, GSTM2, TGFB3, CAV1, DLC1, TNFRSF10, F3, and DICER1, and co-expressed genes identified in Tables 16-18.
The gene subset identified herein as the "metabolic group" includes genes that are associated with cellular metabolism, including genes associated with carrying proteins for transferring iron, the cellular iron homeostasis pathway, and homeostatic biochemical metabolic pathways, and genes that co-express with metabolic group genes. The metabolic group includes, for example, TFRC, ENO1, IDH2, ARF1, CLDN4, PRDX1, and GBP1, and co-expressed genes identified in Tables 16-18.
The gene subset identified herein as the "immune group" includes genes that are involved in cellular immunoregulatory functions, such as T and B cell trafficking, lymphocyte-associated or lymphocyte markers, and interferon regulation genes, and genes that co-express with immune group genes. The immune group includes, for example, CCL19 and IRF1, and co-expressed genes identified in Tables 16-18.
The gene subset identified herein as the "proliferation group" includes genes that are associated with cellular development and division, cell cycle and mitotic regulation, angiogenesis, cell replication, nuclear transport/stability, wnt signaling, apoptosis, and genes that co-express with proliferation group genes. The proliferation group includes, for example, PGF, SPC25, AURKA, BIRC5, BUB1, CCNB1, CENPA, KPNA, LMNB1, MCM2, MELK, NDC80, TPX2M, and WISP1, and co-expressed genes identified in Tables 16-18.
The term "co-expressed", as used herein, refers to a statistical correlation between the expression level of one gene and the expression level of another gene. Pairwise co-expression may be calculated by various methods known in the art, e.g., by calculating Pearson correlation coefficients or Spearman correlation coefficients. Co-expressed gene cliques may also be identified using a graph theory.
As used herein, the terms "gene clique" and "clique" refer to a subgraph of a graph in which every vertex is connected by an edge to every other vertex of the subgraph.
As used herein, a "maximal clique" is a clique in which no other vertex can be added and still be a clique.
The "pathology" of cancer includes all phenomena that compromise the well-being of the patient. This includes, without limitation, abnormal or uncontrollable cell growth, metastasis, interference with the normal functioning of neighboring cells, release of cytokines or other secretory products at abnormal levels, suppression or aggravation of inflammatory or immunological response, neoplasia, premalignancy, malignancy, invasion of surrounding or distant tissues or organs, such as lymph nodes, etc.
A "computer-based system" refers to a system of hardware, software, and data storage medium used to analyze information. The minimum hardware of a patient computer-based system comprises a central processing unit (CPU), and hardware for data input, data output (e.g., display), and data storage. An ordinarily skilled artisan can readily appreciate that any currently available computer-based systems and/or components thereof are suitable for use in connection with the methods of the present disclosure. The data storage medium may comprise any manufacture comprising a recording of the present information as described above, or a memory access device that can access such a manufacture.
To "record" data, programming or other information on a computer readable medium refers to a process for storing information, using any such methods as known in the art. Any convenient data storage structure may be chosen, based on the means used to access the stored information. A variety of data processor programs and formats can be used for storage, e.g. word processing text file, database format, etc.
A "processor" or "computing means" references any hardware and/or software combination that will perform the functions required of it. For example, a suitable processor may be a programmable digital microprocessor such as available in the form of an electronic controller, mainframe, server or personal computer (desktop or portable). Where the processor is programmable, suitable programming can be communicated from a remote location to the processor, or previously saved in a computer program product (such as a portable or fixed computer readable storage medium, whether magnetic, optical or solid state device based). For example, a magnetic medium or optical disk may carry the programming, and can be read by a suitable reader communicating with each processor at its corresponding station.
As used herein, "graph theory" refers to a field of study in Computer Science and Mathematics in which situations are represented by a diagram containing a set of points and lines connecting some of those points. The diagram is referred to as a "graph", and the points and lines referred to as "vertices" and "edges" of the graph. In terms of gene co-expression analysis, a gene (or its equivalent identifier, e.g. an array probe) may be represented as a node or vertex in the graph. If the measures of similarity (e.g., correlation coefficient, mutual information, and alternating conditional expectation) between two genes are higher than a significant threshold, the two genes are said to be co-expressed and an edge will be drawn in the graph. When co-expressed edges for all possible gene pairs for a given study have been drawn, all maximal cliques are computed. The resulting maximal clique is defined as a gene clique. A gene clique is a computed co-expressed gene group that meets predefined criteria.
"Stringency" of hybridization reactions is readily determinable by one of ordinary skill in the art, and generally is an empirical calculation dependent upon probe length, washing temperature, and salt concentration. In general, longer probes require higher temperatures for proper annealing, while shorter probes need lower temperatures. Hybridization generally depends on the ability of denatured DNA to reanneal when complementary strands are present in an environment below their melting temperature. The higher the degree of desired homology between the probe and hybridizable sequence, the higher the relative temperature which can be used. As a result, it follows that higher relative temperatures would tend to make the reaction conditions more stringent, while lower temperatures less so. For additional details and explanation of stringency of hybridization reactions, see Ausubel et al., Current Protocols in Molecular Biology, Wiley Interscience Publishers, (1995).
"Stringent conditions" or "high stringency conditions", as defined herein, typically: (1) employ low ionic strength and high temperature for washing, for example 0.015 M sodium chloride/0.0015 M sodium citrate/0.1% sodium dodecyl sulfate at 50°C; (2) employ during hybridization a denaturing agent, such as formamide, for example, 50% (v/v) formamide with 0.1% bovine serum albumin/0.1 % Ficoll/0.1% polyvinylpyrrolidone/50mM sodium phosphate buffer at pH 6.5 with 750 mM sodium chloride, 75 mM sodium citrate at 42°C; or (3) employ 50% formamide, 5 x SSC (0.75 M NaCl, 0.075 M sodium citrate), 50 mM sodium phosphate (pH 6.8), 0.1% sodium pyrophosphate, 5 x Denhardt's solution, sonicated salmon sperm DNA (50 µg/ml), 0.1% SDS, and 10% dextran sulfate at 42°C, with washes at 42°C in 0.2 x SSC (sodium chloride/sodium citrate) and 50% formamide at 55°C, followed by a high-stringency wash consisting of 0.1 x SSC containing EDTA at 55°C.
"Moderately stringent conditions" may be identified as described by Sambrook et al., Molecular Cloning: A Laboratory Manual, New York: Cold Spring Harbor Press, 1989, and include the use of washing solution and hybridization conditions (e.g., temperature, ionic strength and %SDS) less stringent that those described above. An example of moderately stringent conditions is overnight incubation at 37°C in a solution comprising: 20% formamide, 5 x SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), 5 x Denhardt's solution, 10% dextran sulfate, and 20 mg/ml denatured sheared salmon sperm DNA, followed by washing the filters in 1 x SSC at about 37-50°C. The skilled artisan will recognize how to adjust the temperature, ionic strength, etc. as necessary to accommodate factors such as probe length and the like.
In the context of the present invention, reference to "at least one," "at least two," "at least five," etc. of the genes listed in any particular gene set means any one or any and all combinations of the genes listed.
The term "node negative" cancer, such as "node negative" breast cancer, is used herein to refer to cancer that has not spread to the lymph nodes.
The terms "splicing" and "RNA splicing" are used interchangeably and refer to RNA processing that removes introns and joins exons to produce mature mRNA with continuous coding sequence that moves into the cytoplasm of a eukaryotic cell.
In theory, the term "exon" refers to any segment of an interrupted gene that is represented in the mature RNA product (B. Lewin. Genes IV Cell Press, Cambridge Mass. 1990). In theory the term "intron" refers to any segment of DNA that is transcribed but removed from within the transcript by splicing together the exons on either side of it. Operationally, exon sequences occur in the mRNA sequence of a gene as defined by Ref. SEQ ID numbers. Operationally, intron sequences are the intervening sequences within the genomic DNA of a gene, bracketed by exon sequences and having GT and AG splice consensus sequences at their 5' and 3' boundaries.
The present disclosure provides methods that employ, unless otherwise indicated, conventional techniques of molecular biology (including recombinant techniques), microbiology, cell biology, and biochemistry, which are within the skill of the art. Such techniques are explained fully in the literature, such as, "Molecular Cloning: A Laboratory Manual", 2nd edition (Sambrook et al., 1989); "Oligonucleotide Synthesis" (M.J. Gait, ed., 1984); "Animal Cell Culture" (R.I. Freshney, ed., 1987); "Methods in Enzymology" (Academic Press, Inc.); "Handbook of Experimental Immunology", 4th edition (D.M. Weir & C.C. Blackwell, eds., Blackwell Science Inc., 1987); "Gene Transfer Vectors for Mammalian Cells" (J.M. Miller & M.P. Calos, eds., 1987); "Current Protocols in Molecular Biology" (F.M. Ausubel et al., eds., 1987); and "PCR: The Polymerase Chain Reaction", (Mullis et al., eds., 1994).
Methods of gene expression profiling include methods based on hybridization analysis of polynucleotides, methods based on sequencing of polynucleotides, and proteomics-based methods. The most commonly used methods known in the art for the quantification of mRNA expression in a sample include northern blotting and in situ hybridization (Parker & Barnes, Methods in Molecular Biology 106:247-283 (1999)); RNAse protection assays (Hod, Biotechniques 13:852-854 (1992)); and PCR-based methods, such as reverse transcription polymerase chain reaction (RT-PCR) (Weis et al., Trends in Genetics 8:263-264 (1992)). Alternatively, antibodies may be employed that can recognize specific duplexes, including DNA duplexes, RNA duplexes, and DNA-RNA hybrid duplexes or DNA-protein duplexes.
Of the techniques listed above, the most sensitive and most flexible quantitative method is RT-PCR, which can be used to compare mRNA levels in different sample populations, in normal and tumor tissues, with or without drug treatment, to characterize patterns of gene expression, to discriminate between closely related mRNAs, and to analyze RNA structure.
The first step is the isolation of mRNA from a target sample. The starting material is typically total RNA isolated from human tumors or tumor cell lines, and corresponding normal tissues or cell lines, respectively. Thus RNA can be isolated from a variety of primary tumors, including breast, lung, colon, prostate, brain, liver, kidney, pancreas, spleen, thymus, testis, ovary, uterus, etc., tumor, or tumor cell lines, with pooled DNA from healthy donors. If the source of mRNA is a primary tumor, mRNA can be extracted, for example, from frozen or archived paraffin-embedded and fixed (e.g. formalin-fixed) tissue samples.
General methods for mRNA extraction are well known in the art and are disclosed in standard textbooks of molecular biology, including Ausubel et al., Current Protocols of Molecular Biology, John Wiley and Sons (1997). Methods for RNA extraction from paraffin embedded tissues are disclosed, for example, in Rupp and Locker, Lab Invest. 56:A67 (1987), and De Andrés et al., BioTechniques 18:42044 (1995). In particular, RNA isolation can be performed using purification kit, buffer set and protease from commercial manufacturers, such as Qiagen, according to the manufacturer's instructions. For example, total RNA from cells in culture can be isolated using Qiagen RNeasy mini-columns. Other commercially available RNA isolation kits include MasterPure™ Complete DNA and RNA Purification Kit (EPICENTRE®, Madison, WI), and Paraffin Block RNA Isolation Kit (Ambion, Inc.). Total RNA from tissue samples can be isolated using RNA Stat-60 (Tel-Test). RNA prepared from tumor can be isolated, for example, by cesium chloride density gradient centrifugation.
In some cases, it may be appropriate to amplify RNA prior to initiating expression profiling. It is often the case that only very limited amounts of valuable clinical specimens are available for molecular analysis. This may be due to the fact that the tissues have already be used for other laboratory analyses or may be due to the fact that the original specimen is very small as in the case of needle biopsy or very small primary tumors. When tissue is limiting in quantity it is generally also the case that only small amounts of total RNA can be recovered from the specimen and as a result only a limited number of genomic markers can be analyzed in the specimen. RNA amplification compensates for this limitation by faithfully reproducing the original RNA sample as a much larger amount of RNA of the same relative composition. Using this amplified copy of the original RNA specimen, unlimited genomic analysis can be done to discovery biomarkers associated with the clinical characteristics of the original biological sample. This effectively immortalizes clinical study specimens for the purposes of genomic analysis and biomarker discovery.
As RNA cannot serve as a template for PCR, the first step in gene expression profiling by real-time RT-PCR (RT-PCR) is the reverse transcription of the RNA template into cDNA, followed by its exponential amplification in a PCR reaction. The two most commonly used reverse transcriptases are avian myeloblastosis virus reverse transcriptase (AMV-RT) and Moloney murine leukemia virus reverse transcriptase (MMLV-RT). The reverse transcription step is typically primed using specific primers, random hexamers, or oligo-dT primers, depending on the circumstances and the goal of expression profiling. For example, extracted RNA can be reverse-transcribed using a GeneAmp RNA PCR kit (Perkin Elmer, CA, USA), following the manufacturer's instructions. The derived cDNA can then be used as a template in the subsequent PCR reaction. For further details see, e.g. Held et al., Genome Research 6:986-994 (1996).
Although the PCR step can use a variety of thermostable DNA-dependent DNA polymerases, it typically employs the Taq DNA polymerase, which has a 5'-3' nuclease activity but lacks a 3'-5' proofreading endonuclease activity. Thus, TaqMan® PCR typically utilizes the 5'-nuclease activity of Taq or Tth polymerase to hydrolyze a hybridization probe bound to its target amplicon, but any enzyme with equivalent 5' nuclease activity can be used. Two oligonucleotide primers are used to generate an amplicon typical of a PCR reaction. A third oligonucleotide, or probe, is designed to detect nucleotide sequence located between the two PCR primers. The probe is non-extendible by Taq DNA polymerase enzyme, and is labeled with a reporter fluorescent dye and a quencher fluorescent dye. Any laser-induced emission from the reporter dye is quenched by the quenching dye when the two dyes are located close together as they are on the probe. During the amplification reaction, the Taq DNA polymerase enzyme cleaves the probe in a template-dependent manner. The resultant probe fragments disassociate in solution, and signal from the released reporter dye is free from the quenching effect of the second fluorophore. One molecule of reporter dye is liberated for each new molecule synthesized, and detection of the unquenched reporter dye provides the basis for quantitative interpretation of the data.
TaqMan® RT-PCR can be performed using commercially available equipment, such as, for example, ABI PRISM 7900® Sequence Detection System™ (Perkin-Elmer-Applied Biosystems, Foster City, CA, USA), or LightCycler® 480 Real-Time PCR System (Roche Diagnostics, GmbH, Penzberg, Germany). In a preferred embodiment, the 5' nuclease procedure is run on a real-time quantitative PCR device such as the ABI PRISM 7900® Sequence Detection System™. The system consists of a thermocycler, laser, charge-coupled device (CCD), camera and computer. The system amplifies samples in a 384-well format on a thermocycler. During amplification, laser-induced fluorescent signal is collected in real-time through fiber optics cables for all 384 wells, and detected at the CCD. The system includes software for running the instrument and for analyzing the data.
5'-Nuclease assay data are initially expressed as Ct, or the threshold cycle. As discussed above, fluorescence values are recorded during every cycle and represent the amount of product amplified to that point in the amplification reaction. The point when the fluorescent signal is first recorded as statistically significant is the threshold cycle (Ct).
To minimize errors and the effect of sample-to-sample variation, RT-PCR is usually performed using an internal standard. The ideal internal standard is expressed at a constant level among different tissues, and is unaffected by the experimental treatment. RNAs most frequently used to normalize patterns of gene expression are mRNAs for the housekeeping genes glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) and β-actin.
The steps of a representative protocol for profiling gene expression using fixed, paraffin-embedded tissues as the RNA source, including mRNA isolation, purification, primer extension and amplification are given in various published journal articles. M. Cronin, Am J Pathol 164(1):35-42 (2004). Briefly, a representative process starts with cutting about 10 µm thick sections of paraffin-embedded tumor tissue samples. The RNA is then extracted, and protein and DNA are removed. After analysis of the RNA concentration, RNA repair and/or amplification steps may be included, if necessary, and RNA is reverse transcribed using gene specific primers followed by RT-PCR.
PCR primers and probes can be designed based upon exon or intron sequences present in the mRNA transcript of the gene of interest. Prior to carrying out primer/probe design, it is necessary to map the target gene sequence to the human genome assembly in order to identify intron-exon boundaries and overall gene structure. This can be performed using publicly available software, such as Primer3 (Whitehead Inst.) and Primer Express® (Applied Biosystems).
Where necessary or desired, repetitive sequences of the target sequence can be masked to mitigate non-specific signals. Exemplary tools to accomplish this include the Repeat Masker program available on-line through the Baylor College of Medicine, which screens DNA sequences against a library of repetitive elements and returns a query sequence in which the repetitive elements are masked. The masked intron and exon sequences can then be used to design primer and probe sequences for the desired target sites using any commercially or otherwise publicly available primer/probe design packages, such as Primer Express (Applied Biosystems); MGB assay-by-design (Applied Biosystems); Primer3 (Steve Rozen and Helen J. Skaletsky (2000) Primer3 on the WWW for general users and for biologist programmers. In: Rrawetz S, Misener S (eds) Bioinformatics Methods and Protocols: Methods in Molecular Biology. Humana Press, Totowa, NJ, pp 365-386).
Other factors that can influence PCR primer design include primer length, melting temperature (Tm), and G/C content, specificity, complementary primer sequences, and 3 '-end sequence. In general, optimal PCR primers are generally 17-30 bases in length, and contain about 20-80%, such as, for example, about 50-60% G+C bases, and exhibit Tm's between 50 and 80 0C, e.g. about 50 to 70 0C.
For further guidelines for PCR primer and probe design see, e.g. Dieffenbach, CW. et al, "General Concepts for PCR Primer Design" in: PCR Primer, A Laboratory Manual, Cold Spring Harbor Laboratory Press,. New York, 1995, pp. 133-155; Innis and Gelfand, "Optimization of PCRs" in: PCR Protocols, A Guide to Methods and Applications, CRC Press, London, 1994, pp. 5-11; and Plasterer, T.N. Primerselect: Primer and probe design. Methods Mol. Biol. 70:520-527 (1997).
Table A provides further information concerning the primer, probe, and amplicon sequences associated with the Examples disclosed herein.
In the MassARRAY-based gene expression profiling method, developed by Sequenom, Inc. (San Diego, CA) following the isolation of RNA and reverse transcription, the obtained cDNA is spiked with a synthetic DNA molecule (competitor), which matches the targeted cDNA region in all positions, except a single base, and serves as an internal standard. The cDNA/competitor mixture is PCR amplified and is subjected to a post-PCR shrimp alkaline phosphatase (SAP) enzyme treatment, which results in the dephosphorylation of the remaining nucleotides. After inactivation of the alkaline phosphatase, the PCR products from the competitor and cDNA are subjected to primer extension, which generates distinct mass signals for the competitor- and cDNA-derives PCR products. After purification, these products are dispensed on a chip array, which is preloaded with components needed for analysis with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis. The cDNA present in the reaction is then quantified by analyzing the ratios of the peak areas in the mass spectrum generated. For further details see, e.g. Ding and Cantor, Proc. Natl. Acad. Sci. USA 100:3059-3064 (2003).
Further PCR-based techniques include, for example, differential display (Liang and Pardee, Science 257:967-971 (1992)); amplified fragment length polymorphism (iAFLP) (Kawamoto et al., Genome Res. 12:1305-1312 (1999)); BeadArray™ technology (Illumina, San Diego, CA; Oliphant et al., Discovery of Markers for Disease (Supplement to Biotechniques), June 2002; Ferguson et al., Analytical Chemistry 72:5618 (2000)); BeadsArray for Detection of Gene Expression (BADGE), using the commercially available Luminex100 LabMAP system and multiple color-coded microspheres (Luminex Corp., Austin, TX) in a rapid assay for gene expression (Yang et al., Genome Res. 11:1888-1898 (2001)); and high coverage expression profiling (HiCEP) analysis (Fukumura et al., Nucl. Acids. Res. 31(16) e94 (2003)).
Differential gene expression can also be identified, or confirmed using the microarray technique. Thus, the expression profile of breast cancer-associated genes can be measured in either fresh or paraffin-embedded tumor tissue, using microarray technology. In this method, polynucleotide sequences of interest (including cDNAs and oligonucleotides) are plated, or arrayed, on a microchip substrate. The arrayed sequences are then hybridized with specific DNA probes from cells or tissues of interest. Just as in the RT-PCR method, the source of mRNA typically is total RNA isolated from human tumors or tumor cell lines, and corresponding normal tissues or cell lines. Thus RNA can be isolated from a variety of primary tumors or tumor cell lines. If the source of mRNA is a primary tumor, mRNA can be extracted, for example, from frozen or archived paraffin-embedded and fixed (e.g. formalin-fixed) tissue samples, which are routinely prepared and preserved in everyday clinical practice.
In a specific embodiment of the microarray technique, PCR amplified inserts of cDNA clones are applied to a substrate in a dense array. Preferably at least 10,000 nucleotide sequences are applied to the substrate. The microarrayed genes, immobilized on the microchip at 10,000 elements each, are suitable for hybridization under stringent conditions. Fluorescently labeled cDNA probes may be generated through incorporation of fluorescent nucleotides by reverse transcription of RNA extracted from tissues of interest. Labeled cDNA probes applied to the chip hybridize with specificity to each spot of DNA on the array. After stringent washing to remove non-specifically bound probes, the chip is scanned by confocal laser microscopy or by another detection method, such as a CCD camera. Quantitation of hybridization of each arrayed element allows for assessment of corresponding mRNA abundance. With dual color fluorescence, separately labeled cDNA probes generated from two sources of RNA are hybridized pairwise to the array. The relative abundance of the transcripts from the two sources corresponding to each specified gene is thus determined simultaneously. The miniaturized scale of the hybridization affords a convenient and rapid evaluation of the expression pattern for large numbers of genes. Such methods have been shown to have the sensitivity required to detect rare transcripts, which are expressed at a few copies per cell, and to reproducibly detect at least approximately twofold differences in the expression levels (Schena et al., Proc. Natl. Acad. Sci. USA 93(2):106-149 (1996)). Microarray analysis can be performed by commercially available equipment, following manufacturer's protocols, such as by using the Affymetrix GenChip technology, or Agilent's microarray technology.
The development of microarray methods for large-scale analysis of gene expression makes it possible to search systematically for molecular markers of cancer classification and outcome prediction in a variety of tumor types.
Nucleic acid sequencing technologies are suitable methods for analysis of gene expression. The principle underlying these methods is that the number of times a cDNA sequence is detected in a sample is directly related to the relative expression of the mRNA corresponding to that sequence. These methods are sometimes referred to by the term Digital Gene Expression (DGE) to reflect the discrete numeric property of the resulting data. Early methods applying this principle were Serial Analysis of Gene Expression (SAGE) and Massively Parallel Signature Sequencing (MPSS). See, e.g., S. Brenner, et al., Nature Biotechnology 18(6):630-634 (2000). More recently, the advent of "next-generation" sequencing technologies has made DGE simpler, higher throughput, and more affordable. As a result, more laboratories are able to utilize DGE to screen the expression of more genes in more individual patient samples than previously possible. See, e.g., J. Marioni, Genome Research 18(9):1509-1517 (2008); R. Morin, Genome Research 18(4):610-621 (2008); A. Mortazavi, Nature Methods 5(7):621-628 (2008); N. Cloonan, Nature Methods 5(7):613-619 (2008).
Methods of isolating RNA for expression analysis from blood, plasma and serum (See for example, Tsui NB et al. (2002) 48,1647-53 and references cited therein) and from urine (See for example, Boom R et al. (1990) J Clin Microbiol. 28, 495-503 and reference cited therein) have been described.
Immunohistochemistry methods are also suitable for detecting the expression levels of the prognostic marker of the present invention. Thus, antibodies or antisera, preferably polyclonal antisera, and most preferably monoclonal antibodies specific for each marker are used to detect expression. The antibodies can be detected by direct labeling of the antibodies themselves, for example, with radioactive labels, fluorescent labels, hapten labels such as, biotin, or an enzyme such as horse radish peroxidase or alkaline phosphatase. Alternatively, unlabeled primary antibody is used in conjunction with a labeled secondary antibody, comprising antisera, polyclonal antisera or a monoclonal antibody specific for the primary antibody. Immunohistochemistry protocols and kits are well known in the art and are commercially available.
The term "proteome" is defined as the totality of the proteins present in a sample (e.g. tissue, organism, or cell culture) at a certain point of time. Proteomics includes, among other things, study of the global changes of protein expression in a sample (also referred to as "expression proteomics"). Proteomics typically includes the following steps: (1) separation of individual proteins in a sample by 2-D gel electrophoresis (2-D PAGE); (2) identification of the individual proteins recovered from the gel, e.g. my mass spectrometry or N-terminal sequencing, and (3) analysis of the data using bioinformatics. Proteomics methods are valuable supplements to other methods of gene expression profiling, and can be used, alone or in combination with other methods, to detect the products of the prognostic marker of the present invention.
The steps of a representative protocol for profiling gene expression using fixed, paraffin-embedded tissues as the RNA source, including mRNA isolation, purification, primer extension and amplification are provided in various published journal articles (for example: T.E. Godfrey et al,. J. Molec. Diagnostics 2: 84-91 [2000]; K. Specht et al., Am. J. Pathol. 158: 419-29 [2001]). Briefly, a representative process starts with cutting about 10 µm thick sections of paraffin-embedded tumor tissue samples. The RNA is then extracted, and protein and DNA are removed. After analysis of the RNA concentration, RNA repair and/or amplification steps may be included, if necessary, and RNA is reverse transcribed using gene specific primers followed by RT-PCR. Finally, the data are analyzed to identify the best treatment option(s) available to the patient on the basis of the characteristic gene expression pattern identified in the tumor sample examined, dependent on the predicted likelihood of cancer recurrence.
The expression data used in the methods disclosed herein can be normalized. Normalization refers to a process to correct for (normalize away), for example, differences in the amount of RNA assayed and variability in the quality of the RNA used, to remove unwanted sources of systematic variation in Ct measurements, and the like. With respect to RT-PCR experiments involving archived fixed paraffin embedded tissue samples, sources of systematic variation are known to include the degree of RNA degradation relative to the age of the patient sample and the type of fixative used to preserve the sample. Other sources of systematic variation are attributable to laboratory processing conditions.
Assays can provide for normalization by incorporating the expression of certain normalizing genes, which genes do not significantly differ in expression levels under the relevant conditions. Exemplary normalization genes include housekeeping genes such as PGK1 and UBB. (See, e.g., E. Eisenberg, et al., Trends in Genetics 19(7):362-365 (2003).) Normalization can be based on the mean or median signal (CT) of all of the assayed genes or a large subset thereof (global normalization approach). In general, the normalizing genes, also referred to as reference genes should be genes that are known not to exhibit significantly different expression in colorectal cancer as compared to non-cancerous colorectal tissue, and are not significantly affected by various sample and process conditions, thus provide for normalizing away extraneous effects.
Unless noted otherwise, normalized expression levels for each mRNA/tested tumor/patient will be expressed as a percentage of the expression level measured in the reference set. A reference set of a sufficiently high number (e.g. 40) of tumors yields a distribution of normalized levels of each mRNA species. The level measured in a particular tumor sample to be analyzed falls at some percentile within this range, which can be determined by methods well known in the art.
In exemplary embodiments, one or more of the following genes are used as references by which the expression data is normalized: AAMP, ARF1, EEF1A1, ESD, GPS1, H3F3A, HNRPC, RPL13A, RPL41, RPS23, RPS27, SDHA, TCEA1, UBB, YWHAZ, B-actin, GUS, GAPDH, RPLPO, and TFRC. For example, the calibrated weighted average Ct measurements for each of the prognostic genes may be normalized relative to the mean of at least three reference genes, at least four reference genes, or at least five reference genes.
Those skilled in the art will recognize that normalization may be achieved in numerous ways, and the techniques described above are intended only to be exemplary, not exhaustive.
The methods of the present disclosure are suited for the preparation of reports summarizing the expected or predicted clinical outcome resulting from the methods of the present disclosure. A "report," as described herein, is an electronic or tangible document that includes report elements that provide information of interest relating to a likelihood assessment or a risk assessment and its results. A subject report includes at least a likelihood assessment or a risk assessment, e.g., an indication as to the risk of recurrence of breast cancer, including local recurrence and metastasis of breast cancer. A subject report can include an assessment or estimate of one or more of disease-free survival, recurrence-free survival, metastasis-free survival, and overall survival. A subject report can be completely or partially electronically generated, e.g., presented on an electronic display (e.g., computer monitor). A report can further include one or more of: 1) information regarding the testing facility; 2) service provider information; 3) patient data; 4) sample data; 5) an interpretive report, which can include various information including: a) indication; b) test data, where test data can include a normalized level of one or more genes of interest, and 6) other features.
The present disclosure thus provides for methods of creating reports and the reports resulting therefrom. The report may include a summary of the expression levels of the RNA transcripts, or the expression products of such RNA transcripts, for certain genes in the cells obtained from the patient's tumor. The report can include information relating to prognostic covariates of the patient. The report may include an estimate that the patient has an increased risk of recurrence. That estimate may be in the form of a score or patient stratifier scheme (e.g., low, intermediate, or high risk of recurrence). The report may include information relevant to assist with decisions about the appropriate surgery (e.g., partial or total mastectomy) or treatment for the patient.
Thus, in some embodiments, the methods of the present disclosure further include generating a report that includes information regarding the patient's likely clinical outcome, e.g. risk of recurrence. For example, the methods disclosed herein can further include a step of generating or outputting a report providing the results of a subject risk assessment, which report can be provided in the form of an electronic medium (e.g., an electronic display on a computer monitor), or in the form of a tangible medium (e.g., a report printed on paper or other tangible medium).
A report that includes information regarding the patient's likely prognosis (e.g., the likelihood that a patient having breast cancer will have a good prognosis or positive clinical outcome in response to surgery and/or treatment) is provided to a user. An assessment as to the likelihood is referred to below as a "risk report" or, simply, "risk score." A person or entity that prepares a report ("report generator") may also perform the likelihood assessment. The report generator may also perform one or more of sample gathering, sample processing, and data generation, e.g., the report generator may also perform one or more of: a) sample gathering; b) sample processing; c) measuring a level of a risk gene; d) measuring a level of a reference gene; and e) determining a normalized level of a risk gene. Alternatively, an entity other than the report generator can perform one or more sample gathering, sample processing, and data generation.
For clarity, it should be noted that the term "user," which is used interchangeably with "client," is meant to refer to a person or entity to whom a report is transmitted, and may be the same person or entity who does one or more of the following: a) collects a sample; b) processes a sample; c) provides a sample or a processed sample; and d) generates data (e.g., level of a risk gene; level of a reference gene product(s); normalized level of a risk gene ("prognosis gene") for use in the likelihood assessment. In some cases, the person(s) or entity(ies) who provides sample collection and/or sample processing and/or data generation, and the person who receives the results and/or report may be different persons, but are both referred to as "users" or "clients" herein to avoid confusion. In certain embodiments, e.g., where the methods are completely executed on a single computer, the user or client provides for data input and review of data output. A "user" can be a health professional (e.g., a clinician, a laboratory technician, a physician (e.g., an oncologist, surgeon, pathologist), etc.).
In embodiments where the user only executes a portion of the method, the individual who, after computerized data processing according to the methods of the present disclosure, reviews data output (e.g., results prior to release to provide a complete report, a complete, or reviews an "incomplete" report and provides for manual intervention and completion of an interpretive report) is referred to herein as a "reviewer." The reviewer may be located at a location remote to the user (e.g., at a service provided separate from a healthcare facility where a user may be located).
Where government regulations or other restrictions apply (e.g., requirements by health, malpractice, or liability insurance), all results, whether generated wholly or partially electronically, are subjected to a quality control routine prior to release to the user.
The gene expression assay and information provided by the practice of the methods disclosed herein facilitates physicians in making more well-informed treatment decisions, and to customize the treatment of cancer to the needs of individual patients, thereby maximizing the benefit of treatment and minimizing the exposure of patients to unnecessary treatments which may provide little or no significant benefits and often carry serious risks due to toxic side-effects.
Single or multi-analyte gene expression tests can be used measure the expression level of one or more genes involved in each of several relevant physiologic processes or component cellular characteristics. The expression level(s) may be used to calculate such a quantitative score, and such score may be arranged in subgroups (e.g., tertiles) wherein all patients in a given range are classified as belonging to a risk category (e.g., low, intermediate, or high). The grouping of genes may be performed at least in part based on knowledge of the contribution of the genes according to physiologic functions or component cellular characteristics, such as in the groups discussed above.
The utility of a gene marker in predicting cancer may not be unique to that marker. An alternative marker having an expression pattern that is parallel to that of a selected marker gene may be substituted for, or used in addition to, a test marker. Due to the co-expression of such genes, substitution of expression level values should have little impact on the overall prognostic utility of the test. The closely similar expression patterns of two genes may result from involvement of both genes in the same process and/or being under common regulatory control in colon tumor cells. The present disclosure thus contemplates the use of such co-expressed genes or gene sets as substitutes for, or in addition to, prognostic methods of the present disclosure.
The molecular assay and associated information provided by the methods disclosed herein for predicting the clinical outcome in cancer, e.g. breast cancer, have utility in many areas, including in the development and appropriate use of drugs to treat cancer, to stratify cancer patients for inclusion in (or exclusion from) clinical studies, to assist patients and physicians in making treatment decisions, provide economic benefits by targeting treatment based on personalized genomic profile, and the like. For example, the recurrence score may be used on samples collected from patients in a clinical trial and the results of the test used in conjunction with patient outcomes in order to determine whether subgroups of patients are more or less likely to demonstrate an absolute benefit from a new drug than the whole group or other subgroups. Further, such methods can be used to identify from clinical data subsets of patients who are expected to benefit from adjuvant therapy. Additionally, a patient is more likely to be included in a clinical trial if the results of the test indicate a higher likelihood that the patient will have a poor clinical outcome if treated with surgery alone and a patient is less likely to be included in a clinical trial if the results of the test indicate a lower likelihood that the patient will have a poor clinical outcome if treated with surgery alone.
One skilled in the art will recognize that there are many statistical methods that may be used to determine whether there is a significant relationship between an outcome of interest (e.g., likelihood of survival, likelihood of response to chemotherapy) and expression levels of a marker gene as described here. This relationship can be presented as a continuous recurrence score (RS), or patients may stratified into risk groups (e.g., low, intermediate, high). For example, a Cox proportional hazards regression model may fit to a particular clinical endpoint (e.g., RFS, DFS, OS). One assumption of the Cox proportional hazards regression model is the proportional hazards assumption, i.e. the assumption that effect parameters multiply the underlying hazard.
The present disclosure provides genes that co-express with particular prognostic and/or predictive gene that has been identified as having a significant correlation to recurrence and/or treatment benefit. To perform particular biological processes, genes often work together in a concerted way, i.e. they are co-expressed. Co-expressed gene significant in the amplified RNA studies described above. The meta-analysis included both fixed-effect and random-effect models, which are further described in L. Hedges and J. Vevea, Psychological Methods 3 (4): 486-504 (1998) and K. Sidik and J. Jonkman, Statistics in Medicine 26:1964-1981 (2006). The results of the validation for all genes identified as having a stastistically significant association with breast cancer clinical outcome are described in Table 13. In those tables, "Est" designates an estimated coefficient of a covariate (gene expression); "SE" is standard error; "t" is the t-score for this estimate (i.e., Est/SE); and "fe" is the fixed estimate of effect from the meta analysis. Several of gene families with significant statistical association with clinical outcome (including metabolic, proliferation, immune, and stromal group genes) in breast cancer were confirmed using the SIB dataset. For example, Table 14 contains analysis of genes included in the metabolic group and Table 15 the stromal group.
A co-expression analysis was conducted using microarray data from six (6) breast cancer data sets. The "processed" expression values are taken from the GEO website, however, further processing was necessary. If the expression values are RMA, they are median normalized on the sample level. If the expression values are MAS5.0, they are: (1) changed to 10 if they are <10; (2) log base e transformed; and (3) median normalized on the sample level.
Generating Correlation Pairs: A rank matrix was generated by arranging the expression values for each sample in decreasing order. Then a correlation matrix was created by calculating the Spearman correlation values for every pair of probe IDs. Pairs of probes which had a Spearman value ≥ 0.7 were considered co-expressed. Redundant or overlapping correlation pairs in multiple datasets were identified. For each correlation matrix generated from an array dataset, pairs of significant probes that occur in >1 dataset were identified. This served to filter "non-significant" pairs from the analysis as well as provide extra evidence for "significant" pairs with their presence in multiple datasets. Depending on the number of datasets included in each tissue specific analysis, only pairs which occur in a minimum # or % of datasets were included.
Co-expression cliques were generated using the Bron-Kerbosch algorithm for maximal clique finding in an undirected graph. The algorithm generates three sets of nodes: compsub, candidates, and not. Compsub contains the set of nodes to be extended or shrunk by one depending on its traversal direction on the tree search. Candidates consists of all the above; c) an output device, connected to the computing environment, to provide information to a user (e.g., medical personnel); and d) an algorithm executed by the central computing environment (e.g., a processor), where the algorithm is executed based on the data received by the input device, and wherein the algorithm calculates a, risk, risk score, or treatment group classification, gene co-expression analysis, thresholding, or other functions described herein. The methods provided by the present invention may also be automated in whole or in part.
The methods and systems described herein can be implemented in numerous ways. In one embodiment of particular interest, the methods involve use of a communications infrastructure, for example the Internet. Several embodiments are discussed below. It is also to be understood that the present disclosure may be implemented in various forms of hardware, software, firmware, processors, or a combination thereof. The methods and systems described herein can be implemented as a combination of hardware and software. The software can be implemented as an application program tangibly embodied on a program storage device, or different portions of the software implemented in the user's computing environment (e.g., as an applet) and on the reviewer's computing environment, where the reviewer may be located at a remote site associated (e.g., at a service provider's facility).
For example, during or after data input by the user, portions of the data processing can be performed in the user-side computing environment. For example, the user-side computing environment can be programmed to provide for defined test codes to denote a likelihood "risk score," where the score is transmitted as processed or partially processed responses to the reviewer's computing environment in the form of test code for subsequent execution of one or more algorithms to provide a results and/or generate a report in the reviewer's computing environment. The risk score can be a numerical score (representative of a numerical value, e.g. likelihood of recurrence based on validation study population) or a non-numerical score representative of a numerical value or range of numerical values (e.g., low, intermediate, or high).
The application program for executing the algorithms described herein may be uploaded to, and executed by, a machine comprising any suitable architecture. In general, the machine involves a computer platform having hardware such as one or more central processing units (CPU), a random access memory (RAM), and input/output (I/O) interface(s). The computer platform also includes an operating system and microinstruction code. The various processes and functions described herein may either be part of the microinstruction code or part of the application program (or a combination thereof) that is executed via the operating system. In addition, various other peripheral devices may be connected to the computer platform such as an additional data storage device and a printing device.
As a computer system, the system generally includes a processor unit. The processor unit operates to receive information, which can include test data (e.g., level of a risk gene, level of a reference gene product(s); normalized level of a gene; and may also include other data such as patient data. This information received can be stored at least temporarily in a database, and data analyzed to generate a report as described above.
Part or all of the input and output data can also be sent electronically; certain output data (e.g., reports) can be sent electronically or telephonically (e.g., by facsimile, e.g., using devices such as fax back). Exemplary output receiving devices can include a display element, a printer, a facsimile device and the like. Electronic forms of transmission and/or display can include email, interactive television, and the like. In an embodiment of particular interest, all or a portion of the input data and/or all or a portion of the output data (e.g., usually at least the final report) are maintained on a web server for access, preferably confidential access, with typical browsers. The data may be accessed or sent to health professionals as desired. The input and output data, including all or a portion of the final report, can be used to populate a patient's medical record which may exist in a confidential database at the healthcare facility.
A system for use in the methods described herein generally includes at least one computer processor (e.g., where the method is carried out in its entirety at a single site) or at least two networked computer processors (e.g., where data is to be input by a user (also referred to herein as a "client") and transmitted to a remote site to a second computer processor for analysis, where the first and second computer processors are connected by a network, e.g., via an intranet or internet). The system can also include a user component(s) for input; and a reviewer component(s) for review of data, generated reports, and manual intervention. Additional components of the system can include a server component(s); and a database(s) for storing data (e.g., as in a database of report elements, e.g., interpretive report elements, or a relational database (RDB) which can include data input by the user and data output. The computer processors can be processors that are typically found in personal desktop computers (e.g., IBM, Dell, Macintosh), portable computers, mainframes, minicomputers, or other computing devices.
The networked client/server architecture can be selected as desired, and can be, for example, a classic two or three tier client server model. A relational database management system (RDMS), either as part of an application server component or as a separate component (RDB machine) provides the interface to the database.
In one example, the architecture is provided as a database-centric client/server architecture, in which the client application generally requests services from the application server which makes requests to the database (or the database server) to populate the report with the various report elements as required, particularly the interpretive report elements, especially the interpretation text and alerts. The server(s) (e.g., either as part of the application server machine or a separate RDB/relational database machine) responds to the client's requests.
The input client components can be complete, stand-alone personal computers offering a full range of power and features to run applications. The client component usually operates under any desired operating system and includes a communication element (e.g., a modem or other hardware for connecting to a network), one or more input devices (e.g., a keyboard, mouse, keypad, or other device used to transfer information or commands), a storage element (e.g., a hard drive or other computer-readable, computer-writable storage medium), and a display element (e.g., a monitor, television, LCD, LED, or other display device that conveys information to the user). The user enters input commands into the computer processor through an input device. Generally, the user interface is a graphical user interface (GUI) written for web browser applications.
The server component(s) can be a personal computer, a minicomputer, or a mainframe and offers data management, information sharing between clients, network administration and security. The application and any databases used can be on the same or different servers.
Other computing arrangements for the client and server(s), including processing on a single machine such as a mainframe, a collection of machines, or other suitable configuration are contemplated. In general, the client and server machines work together to accomplish the processing of the present disclosure.
Where used, the database(s) is usually connected to the database server component and can be any device that will hold data. For example, the database can be a any magnetic or optical storing device for a computer (e.g., CDROM, internal hard drive, tape drive). The database can be located remote to the server component (with access via a network, modem, etc.) or locally to the server component.
Where used in the system and methods, the database can be a relational database that is organized and accessed according to relationships between data items. The relational database is generally composed of a plurality of tables (entities). The rows of a table represent records (collections of information about separate items) and the columns represent fields (particular attributes of a record). In its simplest conception, the relational database is a collection of data entries that "relate" to each other through at least one common field.
Additional workstations equipped with computers and printers may be used at point of service to enter data and, in some embodiments, generate appropriate reports, if desired. The computer(s) can have a shortcut (e.g., on the desktop) to launch the application to facilitate initiation of data entry, transmission, analysis, report receipt, etc. as desired.
The present disclosure also contemplates a computer-readable storage medium (e.g. CD-ROM, memory key, flash memory card, diskette, etc.) having stored thereon a program which, when executed in a computing environment, provides for implementation of algorithms to carry out all or a portion of the results of a response likelihood assessment as described herein. Where the computer-readable medium contains a complete program for carrying out the methods described herein, the program includes program instructions for collecting, analyzing and generating output, and generally includes computer readable code devices for interacting with a user as described herein, processing that data in conjunction with analytical information, and generating unique printed or electronic media for that user.
Where the storage medium provides a program that provides for implementation of a portion of the methods described herein (e.g., the user-side aspect of the methods (e.g., data input, report receipt capabilities, etc.)), the program provides for transmission of data input by the user (e.g., via the internet, via an intranet, etc.) to a computing environment at a remote site. Processing or completion of processing of the data is carried out at the remote site to generate a report. After review of the report, and completion of any needed manual intervention, to provide a complete report, the complete report is then transmitted back to the user as an electronic document or printed document (e.g., fax or mailed paper report). The storage medium containing a program according to the present disclosure can be packaged with instructions (e.g., for program installation, use, etc.) recorded on a suitable substrate or a web address where such instructions may be obtained. The computer-readable storage medium can also be provided in combination with one or more reagents for carrying out response likelihood assessment (e.g., primers, probes, arrays, or other such kit components).
All aspects of the present invention may also be practiced such that a limited number of additional genes that are co-expressed with the disclosed genes, for example as evidenced by statistically meaningful Pearson and/or Spearman correlation coefficients, are included in a prognostic or predictive test in addition to and/or in place of disclosed genes.
Having described the invention, the same will be more readily understood through reference to the following Examples, which are provided by way of illustration, and are not intended to limit the invention in any way.
The study included breast cancer tumor samples obtained from 136 patients diagnosed with breast cancer ("Providence study"). Biostatistical modeling studies of prototypical data sets demonstrated that amplified RNA is a useful substrate for biomarker identification studies. This was verified in this study by including known breast cancer biomarkers along with candidate prognostic genesin the tissues samples. The known biomarkers were shown to be associated with clinical outcome in amplified RNA based on the criteria outlined in this protocol.
Refer to the original Providence Phase II study protocol for biopsy specimen information. The study looked at the statistical association between clinical outcome and 384candidate biomarkers tested in amplified samples derived from 25 ng of mRNA that was extracted from fixed, paraffin-embedded tissue samples obtained from 136 of the original Providence Phase II study samples. The expression level of the candidate genes was normalized using reference genes. Several reference genes were analyzed in this study: AAMP, ARF1, EEF1A1, ESD, GPS1, H3F3A, HNRPC, RPL13A, RPL41, RPS23, RPS27, SDHA, TCEA1, UBB, YWHAZ, B-actin, GUS, GAPDH, RPLPO, and TFRC.
The 136 samples were split into 3 automated RT plates each with 2X 48 samples and 40 samples and 3 RT positive and negative controls. Quantitative PCR assays were performed in 384 wells without replicate using the QuantiTect Probe PCR Master Mix® (Qiagen). Plates were analyzed on the Light Cycler® 480 and, after data quality control, all samples from the RT plate 3 were repeated and new RT-PCR data was generated. The data was normalized by subtracting the median crossing point (CP) (point at which detection rises above background signal) for five reference genes from the CP value for each individual candidate gene. This normalization is performed on each sample resulting in final data that has been adjusted for differences in overall sample CP. This data set was used for the final data analysis.
For each gene, a standard z test was run.. (S. Darby, J. Reissland, Journal of the Royal Statistical Society 144(3):298-331 (1981)). This returns a z score (measure of distance in standard deviations of a sample from the mean), p value, and residuals along with other statistics and parameters from the model. If the z score is negative, expression is positively correlated with a good prognosis; if positive, expression is negatively correlated to a good prognosis. Using the p values, a q value was created using a library q value. The poorly correlated and weakly expressed genes were excluded from the calculation of the distribution used for the q values. For each gene, Cox Proportional Hazard Model test was run checking survival time matched with the event vector against gene expression. This returned a hazard ratio (HR) estimating the effect of expression of each gene (individually) on the risk of a cancer-related event. The resulting data is provided in Tables 1-6. A HR < 1 indicates that expression of that gene is positively associated with a good prognosis, while a HR > 1 indicates that expression of that gene is negatively associated with a good prognosis.
Amplified samples were derived from 25 ng of mRNA that was extracted from fixed, paraffin-embedded tissue samples obtained from 78 evaluable cases from a Phase II breast cancer study conducted at Rush University Medical Center. Three of the samples failed to provide sufficient amplified RNA at 25 ng, so amplification was repeated a second time with 50 ng of RNA. The study also analyzed several reference genes for use in normalization: AAMP, ARF1, EEF1A1, ESD, GPS1, H3F3A, HNRPC, RPL13A, RPL41, RPS23, RPS27, SDHA, TCEA1, UBB, YWHAZ, Beta-actin, RPLPO, TFRC, GUS, and GAPDH.
Assays were performed in 384 wells without replicate using the QuantiTect Probe PCR Master Mix. Plates were analyzed on the Light Cycler 480 instruments. This data set was used for the final data analysis. The data was normalized by subtracting the median CP for five reference genes from the CP value for each individual candidate gene. This normalization was performed on each sample resulting in final data that was adjusted for differences in overall sample CP.
There were 34 samples with average CP values above 35. However, none of the samples were excluded from analysis because they were deemed to have sufficient valuable information to remain in the study. Principal Component Analysis (PCA) was used to determine whether there was a plate effect causing variation across the different RT plates. The first principal component correlated well with the median expression values, indicating that expression level accounted for most of the variation between samples. Also, there were no unexpected variations between plates.
Group - The patients were divided into two groups (cancer/non-cancer). There was little difference between the two in overall gene expression as the difference between median CP value in each group was minimal (0.7).
Sample Age - The samples varied widely in their overall gene expression but there was a trend toward lower CP values as they decreased in age.
Instrument - The overall sample gene expression from instrument to instrument was consistent. One instrument showed a slightly higher median CP compared to the other three, but it was well within the acceptable variation.
RT Plate - The overall sample gene expression between RT plates was also very consistent. The median CP for each of the 3 RT plates (2 automated RT plates and 1 manual plate containing repeated samples) were all within 1 CP of each other.
The genes were analyzed using the z-test and Cox Proportional Hazard Model, as described in Example 1. The resulting data can be seen in Tables 7-12.
The statistical correlations between clinical outcome and expression levels of the genes identified in Examples 1 and 2 were validated in breast cancer gene expression datasets maintained by the Swiss Institute of Bioinformatics (SIB). Further information concerning the SIB database, study datasets, and processing methods, is providing in P. Wirapati, et al., Breast Cancer Research 10(4):R65 (2008). Univariate Cox proportional hazards analyses were performed to confirm the relationship between clinical outcome (DFS, MFS, OS) of breast cancer patients and expression levels of the genes identified as groups identified for a disease process like cancer can serve as biomarkers for disease progression and response to treatment. Such co-expressed genes can be assayed in lieu of, or in addition to, assaying of the prognostic and/or predictive gene with which they are co-expressed.
One skilled in the art will recognize that many co-expression analysis methods now known or later developed will fall within the scope of the present claims. These methods may incorporate, for example, correlation coefficients, co-expression network analysis, clique analysis, etc., and may be based on expression data from RT-PCR, microarrays, sequencing, and other similar technologies. For example, gene expression clusters can be identified using pair-wise analysis of correlation based on Pearson or Spearman correlation coefficients. (See, e.g., Pearson K. and Lee A., Biometrika 2, 357 (1902); C. Spearman, Amer. J. Psychol 15:72-101 (1904); J. Myers, A. Well, Research Design and Statistical Analysis, p. 508 (2nd Ed., 2003).) In general, a correlation coefficient of equal to or greater than 0.3 is considered to be statistically significant in a sample size of at least 20. (See, e.g., G. Norman, D. Streiner, Biostatistics: The Bare Essentials, 137-138 (3rd Ed. 2007).) In one embodiment disclosed herein, co-expressed genes were identified using a Spearman correlation value of at least 0.7.
The values from the assays described above, such as expression data, recurrence score, treatment score and/or benefit score, can be calculated and stored manually. Alternatively, the above-described steps can be completely or partially performed by a computer program product. The present disclosure thus provides a computer program product including a computer readable storage medium having a computer program stored on it. The program can, when read by a computer, execute relevant calculations based on values obtained from analysis of one or more biological sample from an individual (e.g., gene expression levels, normalization, thresholding, and conversion of values from assays to a score and/or graphical depiction of likelihood of recurrence/response to chemotherapy, gene co-expression or clique analysis, and the like). The computer program product has stored therein a computer program for performing the calculation.
The present disclosure provides systems for executing the program described above, which system generally includes: a) a central computing environment; b) an input device, operatively connected to the computing environment, to receive patient data, wherein the patient data can include, for example, expression level or other value obtained from an assay using a biological sample from the patient, or microarray data, as described in detail nodes eligible to be added to compsub. Not contains the set of nodes that have been added to compsub and are now excluded from extension. The algorithm consists of five steps: selection of a candidate; adding the candidate node to compsub; creating new sets candidates and not from the old sets by removing all points not connected to the candidate node; recursively calling the extension operator on the new candidates and not sets; and upon return, remove the candidate node from compsub and place in the old not set.
There was a depth-first search with pruning, and the selection of candidate nodes had an effect on the run time of the algorithm. By selecting nodes in decreasing order of frequency in the pairs, the run time was optimized. Also, recursive algorithms generally cannot be implemented in a multi-threaded manner, but was multi-threaded the extension operator of the first recursive level. Since the data between the threads were independent because they were at the top-level of the recursive tree, they were run in parallel.
Clique Mapping and Normalization: Since the members of the co-expression pairs and cliques are at the probe level, one must map the probe IDs to genes (or Refseqs) before they can be analyzed. The Affymetrix gene map information was used to map every probe ID to a gene name. Probes may map to multiple genes, and genes may be represented by multiple probes. The data for each clique is validated by manually calculating the correlation values for each pair from a single clique.
The results of this co-expression analysis are set forth in Tables 16-18. TABLE A
Table 1: Cox proportional hazards for Prognostic Genes that are positively associated with good prognosis for breast cancer (Providence study)
Table 2: Cox proportional hazards for Prognostic Genes that are negatively associated with good prognosis for breast cancer (Providence study)
Table 3: Cox proportional hazards for Prognostic Genes that are positively associated with good prognosis for ER-negative (ER0) breast cancer (Providence study)
Table 4: Cox proportional hazards for Prognostic Genes that are negatively associated with good prognosis for ER-negative (ER0) breast cancer (Providence study)
Table 5: Cox proportional hazards for Prognostic Genes that are positively associated with good prognosis for ER-positive (ER1) breast cancer (Providence study)
Table 6: Cox proportional hazards for Prognostic Genes that are negatively associated with good prognosis for ER-positive (ER1) breast cancer (Providence study)
Table 7: Cox proportional hazards for Prognostic Genes that are positively associated with good prognosis for breast cancer (Rush study)
Table 8: Cox proportional hazards for Prognostic Genes that are negatively associated with good prognosis for breast cancer (Rush study)
Table 9: Cox proportional hazards for Prognostic Genes that are positively associated with good prognosis for ER-negative (ER0) breast cancer (Rush study)
Table 10: Cox proportional hazards for Prognostic Genes that are negatively associated with good prognosis for ER-negative (ER0) breast cancer (Rush study)
Table 11: Cox proportional hazards for Prognostic Genes that are positively associated with good prognosis for ER-positive (ER1) breast cancer (Rush study)
Table 12: Cox proportional hazards for Prognostic Genes that are negatively associated with good prognosis for ER-positive (ER1) breast cancer (Rush study)
Table 14: Validation of Transferrin Receptor Group genes in SIB data sets.
Table 15: Validation of Stromal Group genes in SIB data sets.
Table 15: Validation of Stromal Group genes in SIB data sets.
Table 16: Genes that co-express with Prognostic genes in ER+ breast cancer tumors (Spearman corr. coef. ≥ 0.7)
Table 17: Genes that co-express with Prognostic Genes in ER- breast cancer tumors (Spearman corr. coef. ≥ 0.7)
Table 18: Genes that co-express with Prognostic Genes in all breast cancer tumors (Spearman corr. coef. ≥ 0.7)
| Gene | Sequence ID | Official Symbol | F Primer Seq | SEQ ID NO: | R Primer Seq | SEQ ID NO: | Probe Seq | SEQ ID NO: | Target Seq Length | Amplicon Sequence | SEQ ID NO: |
| A-Catenin | NM_001903.1 | CTNNAI | 1 | 385 | 769 | 78 | 1153 | ||||
| AAMP | NM_001087.3 | AAMP | 2 | 386 | 770 | 66 | 1154 | ||||
| ABCB1 | NM_000927.2 | ABCB1 | 3 | 387 | 771 | 77 | 1155 | ||||
| ABCC10 | NM_033450.2 | ABCC10 | 4 | 388 | 772 | 68 | 1156 | ||||
| ABCC5 | NM_005688.1 | ABCC5 | 5 | 389 | 773 | 76 | 1157 | ||||
| ABR | NM_001092.3 | ABR | 6 | 390 | 774 | 67 | 1158 | ||||
| ACTR2 | NM_005722.2 | ACTR2 | 7 | 391 | 775 | 66 | 1159 | ||||
| ACVR2B | NM_001106.2 | ACVR2B | 8 | 392 | 776 | 74 | 1160 | ||||
| AD024 | NM_020675.3 | SPC25 | 9 | 393 | 777 | 74 | 1161 | ||||
| ADAM12 | NM_021641.2 | ADAM12 | 10 | 394 | 778 | 66 | 1162 | ||||
| ADAM17 | NM_003183.3 | ADAM17 | 11 | 395 | 779 | 73 | 1163 | ||||
| ADAM23 | NM_003812.1 | ADAM23 | 12 | 396 | 780 | 62 | 1164 | ||||
| ADAMTS8 | NM_007037.2 | ADAMTS8 | 13 | 397 | 781 | 72 | 1165 | ||||
| ADM | NM_001124.1 | ADM | 14 | 398 | 782 | 75 | 1166 | ||||
| AES | NM_001130.4 | AES | 15 | 399 | 783 | 78 | 1167 | ||||
| AGR2 | NM_006408.2 | AGR2 | 16 | 400 | 784 | 70 | 1168 | ||||
| AK055699 | NM_194317 | LYPD6 | 17 | 401 | 785 | 78 | 1169 | ||||
| AKR7A3 | NM_012067.2 | AKR7A3 | 18 | 402 | 786 | 67 | 1170 | ||||
| AKT3 | NM_005465.1 | AKT3 | 19 | 403 | 787 | 75 | 1171 | ||||
| ALCAM | NM_001627.1 | ALCAM | 20 | 404 | 788 | 66 | 1172 | ||||
| ALDH4 | NM_003748.2 | ALDH4A1 | 21 | 405 | 789 | 68 | 1173 | ||||
| ANGPT2 | NM_001147.1 | ANGPT2 | 22 | 406 | 790 | 69 | 1174 | ||||
| ANXA2 | NM_004039.1 | ANXA2 | 23 | 407 | 791 | 71 | 1175 | ||||
| AP-1 (JUN official) | NM_002228.2 | JUN | 24 | 408 | 792 | 81 | 1176 | ||||
| APEX-1 | NM_001641.2 | APEX1 | 25 | 409 | 793 | 68 | 1177 | ||||
| APOD | NM_001647.1 | APOD | 26 | 410 | 794 | 67 | 1178 | ||||
| ARF1 | NM_001658.2 | ARF1 | 27 | 411 | 795 | 64 | 1179 | ||||
| ARHI | NM_004675.1 | DIRAS3 | 28 | 412 | 796 | 67 | 1180 | ||||
| ARNT2 | NM_014862.3 | ARNT2 | 29 | 413 | 797 | 68 | 1181 | ||||
| ARSD | NM_001669.1 | ARSD | 30 | 414 | 798 | 79 | 1182 | ||||
| AURKB | NM_004217.1 | AURKB | 31 | 415 | 799 | 67 | 1183 | ||||
| B-actin | NM_001101.2 | ACTB | 32 | 416 | 800 | 66 | 1184 | ||||
| B-Catenin | NM_001904.1 | CTNNB1 | 33 | 417 | 801 | 80 | 1185 | ||||
| BAD | NM_032989.1 | BAD | 34 | 418 | 802 | 73 | 1186 | ||||
| BAG1 | NM_004323.2 | BAG1 | 35 | 419 | 803 | 81 | 1187 | ||||
| BAG4 | NM_004874.2 | BAG4 | 36 | 420 | 804 | 76 | 1188 | ||||
| BASE | NM_173859.1 | 37 | 421 | 805 | 72 | 1189 | |||||
| Bax | NM_004324.1 | BAX | 38 | 422 | 806 | 70 | 1190 | ||||
| BBC3 | NM_014417.1 | BBC3 | 39 | 423 | 807 | 83 | 1191 | ||||
| BCAR1 | NM_014567.1 | BCAR1 | 40 | 424 | 808 | 65 | 1192 | ||||
| BCAR3 | NM_003567.1 | BCAR3 | 41 | 425 | 809 | 75 | 1193 | ||||
| BCAS1 | NM_003657.1 | BCAS1 | 42 | 426 | 810 | 73 | 1194 | ||||
| Bcl2 | NM_000633.1 | BCL2 | 43 | 427 | 811 | 73 | 1195 | ||||
| BCL2L12 | NM_138639.1 | BCL2L12 | 44 | 428 | 812 | 73 | 1196 | ||||
| BGN | NM_001711.3 | BGN | 45 | 429 | 813 | 66 | 1197 | ||||
| BIK | NM_001197.3 | BIK | 46 | 430 | 814 | 70 | 1198 | ||||
| BNIP3 | NM_004052.2 | BNIP3 | 47 | 431 | 815 | 68 | 1199 | ||||
| BSG | NM_001728.2 | BSG | 48 | 432 | 816 | 66 | 1200 | ||||
| BTRC | NM_033637.2 | BTRC | 49 | 433 | 817 | 63 | 1201 | ||||
| BUB1 | NM_004336.1 | BUB1 | 50 | 434 | 818 | 68 | 1202 | ||||
| BUB1B | NM_001211.3 | BUB1B | 51 | 435 | 819 | 82 | 1203 | ||||
| BUB3 | NM_004725.1 | BUB3 | 52 | 436 | 820 | 73 | 1204 | ||||
| c-kit | NM_000222.1 | KIT | 53 | 437 | 821 | 75 | 1205 | ||||
| C10orf116 | NM_006829.2 | C10orf116 | 54 | 438 | 822 | 67 | 1206 | ||||
| C17orf37 | NM_032339.3 | C17orf37 | 55 | 439 | 823 | 67 | 1207 | ||||
| C20 orf1 | NM_012112 | TPX2 | 56 | 440 | 824 | 65 | 1208 | ||||
| C6orf66 | NM_014165.1 | NDUFAF4 | 57 | 441 | 825 | 70 | 1209 | ||||
| C8orf4 | NM_020130.2 | C8orf4 | 58 | 442 | 826 | 67 | 1210 | ||||
| CACNA2D 2 | NM_006030.1 | CACNA2D 2 | 59 | 443 | 827 | 67 | 1211 | ||||
| CAT | NM_001752.1 | CAT | 60 | 444 | 828 | 78 | 1212 | ||||
| CAV1 | NM_001753.3 | CAV1 | 61 | 445 | 829 | 74 | 1213 | ||||
| CBX5 | NM_012117.1 | CBX5 | 62 | 446 | 830 | 78 | 1214 | ||||
| CCL19 | NM_006274.2 | CCL19 | 63 | 447 | 831 | 78 | 1215 | ||||
| CCL3 | NM_002983.1 | CCL3 | 64 | 448 | 832 | 77 | 1216 | ||||
| CCL5 | NM_002985.2 | CCL5 | 65 | 449 | 833 | 65 | 1217 | ||||
| CCNB1 | NM_031966.1 | CCNB1 | 66 | 450 | 834 | 84 | 1218 | ||||
| CCND3 | NM_001760.2 | CCND3 | 67 | 451 | 835 | 76 | 1219 | ||||
| CCNE2 variant 1 | NM_057749var 1 | CCNE2 | 68 | 452 | 836 | 85 | 1220 | ||||
| CCR5 | NM_000579.1 | CCR5 | 69 | 453 | 837 | 67 | 1221 | ||||
| CCR7 | NM_001838.2 | CCR7 | 70 | 454 | 838 | 64 | 1222 | ||||
| CD1A | NM_001763.1 | CD1A | 71 | 455 | 839 | 78 | 1223 | ||||
| CD24 | NM_013230.1 | CD24 | 72 | 456 | 840 | 77 | 1224 | ||||
| CD4 | NM_000616.2 | CD4 | 73 | 457 | 841 | 67 | 1225 | ||||
| CD44E | X55150 | 74 | 458 | 842 | 90 | 1226 | |||||
| CD44s | M59040.1 | 75 | 459 | 843 | 78 | 1227 | |||||
| CD44v6 | AJ251595v6 | 76 | 460 | 844 | 78 | 1228 | |||||
| CD68 | NM_001251.1 | CD68 | 77 | 461 | 845 | 74 | 1229 | ||||
| CD82 | NM_002231.2 | CD82 | 78 | 462 | 846 | 84 | 1230 | ||||
| CDC20 | NM_001255.1 | CDC20 | 79 | 463 | 847 | 68 | 1231 | ||||
| cdc25A | NM_001789.1 | CDC25A | 80 | 464 | 848 | 71 | 1232 | ||||
| CDC25C | NM_001790.2 | CDC25C | 81 | 465 | 49 | 67 | 1233 | ||||
| CDC4 | NM_018315.2 | FBXW7 | 82 | 466 | 850 | 77 | 1234 | ||||
| CDC42BP A | NM_003607.2 | CDC42BPA | 83 | 467 | 851 | 67 | 1235 | ||||
| CDC42EP4 | NM_012121.4 | CDC42EP4 | 84 | 468 | 852 | 67 | 1236 | ||||
| CDH11 | NM_001797.2 | CDH11 | 85 | 469 | 853 | 70 | 1237 | ||||
| CDH3 | NM_001793.3 | CDH3 | 86 | 470 | 854 | 71 | 1238 | ||||
| CDK4 | NM_000075.2 | CDK4 | 87 | 471 | 855 | 66 | 1239 | ||||
| CDK5 | NM_004935.2 | CDK5 | 88 | 472 | 856 | 67 | 1240 | ||||
| CDKN3 | NM_005192.2 | CDKN3 | 89 | 473 | 857 | 70 | 1241 | ||||
| CEACAM1 | NM_001712.2 | CEACAM1 | 90 | 474 | 858 | 71 | 1242 | ||||
| CEBPA | NM_004364.2 | CEBPA | 91 | 475 | 859 | 66 | 1243 | ||||
| CEGP1 | NM_020974.1 | SCUBE2 | 92 | 476 | 860 | 77 | 1244 | ||||
| CENPA | NM_001809.2 | CENPA | 93 | 477 | 861 | 63 | 1245 | ||||
| CGA (CHGA official) | NM_001275.2 | CHGA | 94 | 478 | 862 | 76 | 1246 | ||||
| CGalpha | NM_000735.2 | CGA | 95 | 479 | 863 | 69 | 1247 | ||||
| CGB | NM_000737.2 | CGB | 96 | 480 | 864 | 80 | 1248 | ||||
| CHAF1B | NM_005441.1 | CHAF1B | 97 | 481 | 865 | 72 | 1249 | ||||
| CHFR | NM_018223.1 | CHFR | 98 | 482 | 866 | 76 | 1250 | ||||
| CHI3L1 | NM_001276.1 | CHI3L1 | 99 | 483 | 867 | 66 | 1251 | ||||
| CKS2 | NM_001827.1 | CKS2 | 100 | 484 | CTGCGCCCGCTCTTCGCG | 868 | 62 | 1252 | |||
| Claudin 4 | NM_001305.2 | CLDN4 | 101 | 485 | 869 | 72 | 1253 | ||||
| CLIC1 | NM_001288.3 | CLIC1 | 102 | 486 | 870 | 68 | 1254 | ||||
| CLU | NM_001831.1 | CLU | 103 | 487 | 871 | 76 | 1255 | ||||
| CNOT2 | NM_014515.3 | CNOT2 | 104 | 488 | 872 | 67 | 1256 | ||||
| COL1A1 | NM_000088.2 | COL1A1 | 105 | 489 | 873 | 68 | 1257 | ||||
| COL1A2 | NM_000089.2 | COL1A2 | 106 | 490 | 874 | 80 | 1258 | ||||
| COMT | NM_000754.2 | COMT | 107 | 491 | 875 | 67 | 1259 | ||||
| Contig 51037 | NM_198477 | CXCL17 | 108 | 492 | 876 | 81 | 1260 | ||||
| COPS3 | NM_003653.2 | COPS3 | 109 | 493 | 877 | 72 | 1261 | ||||
| CRYAB | NM_001885.1 | CRYAB | 110 | 494 | 878 | 69 | 1262 | ||||
| CRYZ | NM_001889.2 | CRYZ | 111 | 495 | 879 | 78 | 1263 | ||||
| CSF1 isoC | NM_172211.1 | CSF1 | 112 | 496 | 880 | 68 | 1264 | ||||
| CSF1 | NM_000757.3 | CSF1 | 113 | 497 | 881 | 74 | 1265 | ||||
| CSF1R | NM_005211.1 | CSF1R | 114 | 498 | 882 | 80 | 1266 | ||||
| CSF2RA | NM_006140.3 | CSF2RA | 115 | 499 | 883 | 67 | 1267 | ||||
| CSK (SRC) | NM_004383.1 | CSK | 116 | 500 | 884 | 64 | 1268 | ||||
| CTGF | NM_001901.1 | CTGF | 117 | 501 | 885 | 76 | 1269 | ||||
| CTHRC1 | NM_138455.2 | CTHRC1 | 118 | 502 | 886 | 67 | 1270 | ||||
| CTSD | NM_001909.1 | CTSD | 119 | 503 | 887 | 80 | 1271 | ||||
| CTSL2 | NM_001333.2 | CTSL2 | 120 | 504 | 888 | 67 | 1272 | ||||
| CTSL2int2 | NM_001333.2in t2 | 121 | 505 | 889 | 79 | 1273 | |||||
| CXCL10 | NM_001565.1 | CXCL10 | 122 | 506 | 890 | 68 | 1274 | ||||
| CXCL12 | NM_000609.3 | CXCL12 | 123 | 507 | 891 | 67 | 1275 | ||||
| CXCL14 | NM_004887.3 | CXCL14 | 124 | 508 | 892 | 74 | 1276 | ||||
| CXCR4 | NM_003467.1 | CXCR4 | 125 | 509 | 893 | 72 | 1277 | ||||
| CYP17A1 | NM_000102.2 | CYP17A1 | 126 | 510 | 894 | 76 | 1278 | ||||
| CYP19A1 | NM_000103.2 | CYP19A1 | 127 | 511 | 895 | 70 | 1279 | ||||
| CYP1B1 | NM_000104.2 | CYP1B1 | 128 | 512 | 896 | 71 | 1280 | ||||
| CYR61 | NM_001554.3 | CYR61 | 129 | 513 | 897 | 76 | 1281 | ||||
| DAB2 | NM_001343.1 | DAB2 | 130 | 514 | 898 | 67 | 1282 | ||||
| DCC | NM_005215.1 | DCC | 131 | 515 | 899 | 75 | 1283 | ||||
| DCC_exons 18-23 | X76132_18-23 | 132 | 516 | 900 | 66 | 1284 | |||||
| DCC_exons 6-7 | X76132_6-7 | 133 | 517 | 901 | 74 | 1285 | |||||
| DCK | NM_000788.1 | DCK | 134 | 518 | 902 | 110 | 1286 | ||||
| DICER1 | NM_177438.1 | DICER1 | 135 | 519 | 903 | 68 | 1287 | ||||
| DLC1 | NM_006094.3 | DLC1 | 136 | 520 | 904 | 68 | 1288 | ||||
| DLL4 | NM_019074.2 | DLL4 | 137 | 521 | 905 | 67 | 1289 | ||||
| DR5 | NM_003842.2 | TNFRSF10 B | 138 | 522 | 906 | 84 | 1290 | ||||
| DSP | NM_004415.1 | DSP | 139 | 523 | 907 | 73 | 1291 | ||||
| DTYMK | NM_012145.1 | DTYMK | 140 | 524 | 908 | 78 | 1292 | ||||
| DUSP1 | NM_004417.2 | DUSP1 | 141 | 525 | 909 | 76 | 1293 | ||||
| DUSP4 | NM_001394.4 | DUSP4 | 142 | 526 | 910 | 68 | 1294 | ||||
| E2F1 | NM_005225.1 | E2F1 | 143 | 527 | 911 | 75 | 1295 | ||||
| EBRP | AF243433.1 | 144 | 528 | 912 | 76 | 1296 | |||||
| EDN1 endothelin | NM_001955.1 | EDN1 | 145 | 529 | 913 | 73 | 1297 | ||||
| EDN2 | NM_001956.2 | EDN2 | 146 | 530 | 914 | 79 | 1298 | ||||
| EDNRA | NM_001957.1 | EDNRA | 147 | 531 | 915 | 76 | 1299 | ||||
| EDNRB | NM_000115.1 | EDNRB | 148 | 532 | 916 | 72 | 1300 | ||||
| EEF1A1 | NM_001402.5 | EEF1A1 | 149 | 533 | 917 | 67 | 1301 | ||||
| EEF1A2 | NM_001958.2 | EEF1A2 | 150 | 534 | 918 | 66 | 1302 | ||||
| EFP | NM_005082.2 | TRIM25 | 151 | 535 | 919 | 74 | 1303 | ||||
| EGR1 | NM_001964.2 | EGR1 | 152 | 536 | 920 | 76 | 1304 | ||||
| EGR3 | NM_004430.2 | EGR3 | 153 | 537 | 921 | 78 | 1305 | ||||
| EIF4EBP1 | NM_004095.2 | EIF4EBP1 | 154 | 538 | 922 | 66 | 1306 | ||||
| ELF3 | NM_004433.2 | ELF3 | 155 | 539 | 923 | 71 | 1307 | ||||
| EMP1 | NM_001423.1 | EMP1 | 156 | 540 | 924 | 75 | 1308 | ||||
| ENO1 | NM_001428.2 | ENO1 | 157 | 541 | 925 | 68 | 1309 | ||||
| EP300 | NM_001429.1 | EP300 | 158 | 542 | 926 | 75 | 1310 | ||||
| EpCAM | NM_002354.1 | EPCAM | 159 | 543 | 927 | 75 | 1311 | ||||
| EPHA2 | NM_004431.2 | EPHA2 | 160 | 544 | 928 | 72 | 1312 | ||||
| EPHB2 | NM_004442.4 | EPHB2 | 161 | 545 | 929 | 66 | 1313 | ||||
| EPHB4 | NM_004444.3 | EPHB4 | 162 | 546 | 930 | 77 | 1314 | ||||
| ER2 | NM_001437.1 | ESR2 | 163 | 547 | 931 | 76 | 1315 | ||||
| ERBB4 | NM_005235.1 | ERBB4 | 164 | 548 | 932 | 86 | 1316 | ||||
| ERCC1 | NM_001983.1 | ERCC1 | 165 | 549 | 933 | 67 | 1317 | ||||
| ERG | NM_004449.3 | ERG | 166 | 550 | 934 | 70 | 1318 | ||||
| ERRa | NM_004451.3 | ESRRA | 167 | 551 | 935 | 67 | 1319 | ||||
| ESD | NM_001984.1 | ESD | 168 | 552 | 936 | 66 | 1320 | ||||
| ESPL1 | NM_012291.1 | ESPL1 | 169 | 553 | 937 | 70 | 1321 | ||||
| ESRRG | NM_001438.1 | ESRRG | 170 | 554 | 938 | 67 | 1322 | ||||
| EstR1 | NM_000125.1 | ESR1 | 171 | 555 | 939 | 68 | 1323 | ||||
| ETV5 | NM_004454.1 | ETV5 | 172 | 556 | 940 | 67 | 1324 | ||||
| EZH2 | NM_004456.3 | EZH2 | 173 | 557 | 941 | 78 | 1325 | ||||
| F3 | NM_001993.2 | F3 | 174 | 558 | 942 | 73 | 1326 | ||||
| FAP | NM_004460.2 | FAP | 175 | 559 | 943 | 66 | 1327 | ||||
| FASN | NM_004104.4 | FASN | 176 | 560 | 944 | 66 | 1328 | ||||
| FGFR2 isoform 1 | NM_000141.2 | FGFR2 | 177 | 561 | 945 | 80 | 1329 | ||||
| FGFR4 | NM_002011.3 | FGFR4 | 178 | 562 | 946 | 81 | 1330 | ||||
| FHIT | NM_002012.1 | FHIT | 179 | 563 | 947 | 67 | 1331 | ||||
| FLOT2 | NM_004475.1 | FLOT2 | 180 | 564 | 948 | 66 | 1332 | ||||
| FN1 | NM_002026.2 | FN1 | 181 | 565 | 949 | 69 | 1333 | ||||
| FOS | NM_005252.2 | FOS | 182 | 566 | 950 | 67 | 1334 | ||||
| FOXC2 | NM_005251.1 | FOXC2 | 183 | 567 | 951 | 66 | 1335 | ||||
| FOXO3A | NM_001455.1 | FOXO3 | 184 | 568 | 952 | 83 | 1336 | ||||
| FOXP1 | NM_032682.3 | FOXP1 | 185 | 569 | 953 | 70 | 1337 | ||||
| FOXP3 | NM_014009.2 | FOXP3 | 186 | 570 | 954 | 66 | 1338 | ||||
| FSCN1 | NM_003088.1 | FSCN1 | 187 | 571 | 955 | 74 | 1339 | ||||
| FUS | NM_004960.1 | FUS | 188 | 572 | 956 | 80 | 1340 | ||||
| FYN | NM_002037.3 | FYN | 189 | 573 | 957 | 69 | 1341 | ||||
| G-Catenin | NM_002230.1 | JUP | 190 | 574 | 958 | 68 | 1342 | ||||
| GAB2 | NM_012296.2 | GAB2 | 191 | 575 | 959 | 74 | 1343 | ||||
| GADD45 | NM_001924.2 | GADD45A | 192 | 576 | 960 | 73 | 1344 | ||||
| GADD45B | NM_015675.1 | GADD45B | 193 | 577 | 961 | 70 | 1345 | ||||
| GAPDH | NM_002046.2 | GAPDH | 194 | 578 | 962 | 74 | 1346 | ||||
| GATA3 | NM_00205 1.1 | GATA3 | 195 | 579 | 963 | 75 | 1347 | ||||
| GBP1 | NM_002053.1 | GBP1 | 196 | 580 | 964 | 73 | 1348 | ||||
| GBP2 | NM_004120.2 | GBP2 | 197 | 581 | 965 | 83 | 1349 | ||||
| GCLM | NM_002061.1 | GCLM | 198 | 582 | 966 | 85 | 1350 | ||||
| GDF15 | NM_004864.1 | GDF15 | 199 | 583 | 967 | 72 | 1351 | ||||
| GH1 | NM_000515.3 | GH1 | 200 | 584 | 968 | 66 | 1352 | ||||
| GJA1 | NM_000165.2 | GJA1 | 201 | 585 | 969 | 68 | 1353 | ||||
| GJB2 | NM_004004.3 | GJB2 | 202 | 586 | 970 | 74 | 1354 | ||||
| GMNN | NM_015895.3 | GMNN | 203 | 587 | 971 | 67 | 1355 | ||||
| GNAZ | NM_002073.2 | GNAZ | 204 | 588 | 972 | 68 | 1356 | ||||
| GPR30 | NM_001505.1 | GPER | 205 | 589 | 973 | 70 | 1357 | ||||
| GPS1 | NM_004127.4 | GPS1 | 206 | 590 | 974 | 66 | 1358 | ||||
| GPX1 | NM_000581.2 | GPX1 | 207 | 591 | 975 | 67 | 1359 | ||||
| GPX2 | NM_002083.1 | GPX2 | 208 | 592 | 976 | 75 | 1360 | ||||
| GPX4 | NM_002085.1 | GPX4 | 209 | 593 | 977 | 66 | 1361 | ||||
| GRB7 | NM_005310.1 | GRB7 | 210 | 594 | 978 | 67 | 1362 | ||||
| GREB1 variant a | NM_014668.2 | GREB1 | 211 | 595 | 979 | 71 | 1363 | ||||
| GREB1 variant b | NM_033090.1 | GREB1 | 212 | 596 | 980 | 73 | 1364 | ||||
| GREB1 variant c | NM_148903.1 | GREB1 | 213 | 597 | 981 | 64 | 1365 | ||||
| GRN | NM_002087.1 | GRN | 214 | 598 | 982 | 72 | 1366 | ||||
| GSTM1 | NM_000561.1 | GSTM1 | 215 | 599 | 983 | 86 | 1367 | ||||
| GSTM2 gene | NM_000848gen e | 216 | 600 | 984 | 71 | 1368 | |||||
| GSTM2 | NM_000848.2 | GSTM2 | 217 | 601 | 985 | 68 | 1369 | ||||
| GSTM3 | NM_000849.3 | GSTM3 | 218 | 602 | 986 | 76 | 1370 | ||||
| GSTT1 | NM_000853.1 | GSTT1 | 219 | 603 | 987 | 66 | 1371 | ||||
| GUS | NM_000181.1 | GUSB | 220 | 604 | 988 | 73 | 1372 | ||||
| H3F3A | NM_002107.3 | H3F3A | 221 | 605 | 989 | 70 | 1373 | ||||
| HDAC1 | NM_004964.2 | HDAC1 | 222 | 606 | 990 | 74 | 1374 | ||||
| HDAC6 | NM_006044.2 | HDAC6 | 223 | 607 | 991 | 66 | 1375 | ||||
| HER2 | NM_004448.1 | ERBB2 | 224 | 608 | 992 | 70 | 1376 | ||||
| HES1 | NM_005524.2 | HES1 | 225 | 609 | 993 | 68 | 1377 | ||||
| HGFAC | NM_001528.2 | HGFAC | 226 | 610 | 994 | 72 | 1378 | ||||
| HLA-DPB1 | NM_002121.4 | HLA-DPB1 | 227 | 611 | 995 | 73 | 1379 | ||||
| HMGB 1 | NM_002128.3 | HMGB 1 | 228 | 612 | 996 | 71 | 1380 | ||||
| HNF3A | NM_004496.1 | FOXA1 | 229 | 613 | 997 | 73 | 1381 | ||||
| HNRPAB | NM_004499.3 | HNRNPAB | 230 | 614 | 998 | 84 | 1382 | ||||
| HNRPC | NM_004500.3 | HNRNPC | 231 | 615 | 999 | 68 | 1383 | ||||
| HoxA1 | NM_005522.3 | HOXA1 | 232 | 616 | 1000 | 69 | 1384 | ||||
| HoxA5 | NM_019102.2 | HOXA5 | 233 | 617 | 1001 | 78 | 1385 | ||||
| HOXB13 | NM_006361.2 | HOXB13 | 234 | 618 | 1002 | 71 | 1386 | ||||
| HOXB7 | NM_004502.2 | HOXB7 | 235 | 619 | 1003 | 68 | 1387 | ||||
| HSD17B1 | NM_000413.1 | HSD17B1 | 236 | 620 | 1004 | 78 | 1388 | ||||
| HSD17B2 | NM_002153.1 | HSD17B2 | 237 | 621 | 1005 | 68 | 1389 | ||||
| HSHIN1 | NM_017493.3 | OTUD4 | 238 | 622 | 1006 | 77 | 1390 | ||||
| HSPA1A | NM_005345.4 | HSPA1A | 239 | 623 | 1007 | 70 | 1391 | ||||
| HSPA1B | NM_005346.3 | HSPA1B | 240 | 624 | 1008 | 63 | 1392 | ||||
| HSPA4 | NM_002154.3 | HSPA4 | 241 | 625 | 1009 | 72 | 1393 | ||||
| HSPA5 | NM_005347.2 | HSPA5 | 242 | 626 | 1010 | 84 | 1394 | ||||
| HSPA8 | NM_006597.3 | HSPA8 | 243 | 627 | 1011 | 73 | 1395 | ||||
| HSPB1 | NM_001540.2 | HSPB1 | 244 | 628 | 1012 | 84 | 1396 | ||||
| IBSP | NM_004967.2 | IBSP | 245 | 629 | 1013 | 83 | 1397 | ||||
| ICAM1 | NM_000201.1 | ICAM1 | 246 | 630 | 1014 | 68 | 1398 | ||||
| ID1 | NM_002165.1 | ID1 | 247 | 631 | 1015 | 70 | 1399 | ||||
| ID4 | NM_001546.2 | ID4 | 248 | 632 | 1016 | 83 | 1400 | ||||
| IDH2 | NM_002168.2 | IDH2 | 249 | 633 | 1017 | 74 | 1401 | ||||
| IGF1R | NM_000875.2 | IGF1R | 250 | 634 | 1018 | 83 | 1402 | ||||
| IGF2 | NM_000612.2 | IGF2 | 251 | 635 | 1019 | 72 | 1403 | ||||
| IGFBP6 | NM_002178.1 | IGFBP6 | 252 | 636 | 1020 | 77 | 1404 | ||||
| IGFBP7 | NM_001553.1 | IGFBP7 | 253 | 637 | 1021 | 68 | 1405 | ||||
| IKBKE | NM_014002.2 | IKBKE | 254 | 638 | 1022 | 66 | 1406 | ||||
| IL-8 | NM_000584.2 | IL8 | 255 | 639 | 1023 | 70 | 1407 | ||||
| IL10 | NM_000572.1 | IL10 | 256 | 640 | 1024 | 79 | 1408 | ||||
| IL11 | NM_000641.2 | IL11 | 257 | 641 | 1025 | 66 | 1409 | ||||
| IL17RB | NM_018725.2 | IL17RB | 258 | 642 | 1026 | 76 | 1410 | ||||
| IL6ST | NM_002184.2 | IL6ST | 259 | 643 | 1027 | 74 | 1411 | ||||
| ING1 | NM_005537.2 | ING1 | 260 | 644 | 1028 | 66 | 1412 | ||||
| INHBA | NM_002192.1 | INHBA | 261 | 645 | 1029 | 72 | 1413 | ||||
| IRF1 | NM_002198.1 | IRF1 | 262 | 646 | 1030 | 69 | 1414 | ||||
| IRS1 | NM_005544.1 | IRS1 | 263 | 647 | 1031 | 74 | 1415 | ||||
| ITGA3 | NM_002204.1 | ITGA3 | 264 | 648 | 1032 | 77 | 1416 | ||||
| ITGA4 | NM_000885.2 | ITGA4 | 265 | 649 | 1033 | 66 | 1417 | ||||
| ITGA5 | NM_002205.1 | ITGA5 | 266 | 650 | 1034 | 75 | 1418 | ||||
| ETGA6 | NM_000210.1 | ETGA6 | 267 | 651 | 1035 | 69 | 1419 | ||||
| ITGAV | NM_002210.2 | ITGAV | 268 | 652 | 1036 | 79 | 1420 | ||||
| ITGB1 | NM_002211.2 | ITGB1 | 269 | 653 | 1037 | 74 | 1421 | ||||
| ITGB3 | NM_000212.2 | ITGB3 | 270 | 654 | 1038 | 78 | 1422 | ||||
| ITGB4 | NM_000213.2 | ITGB4 | 271 | 655 | 1039 | 66 | 1423 | ||||
| ITGB5 | NM_002213.3 | ITGB5 | 272 | 656 | 1040 | 71 | 1424 | ||||
| JAG1 | NM_000214.1 | JAG1 | 273 | 657 | 1041 | 69 | 1425 | ||||
| JUNB | NM_002229.2 | JUNB | 274 | 658 | 1042 | 70 | 1426 | ||||
| Ki-67 | NM_002417.1 | MKI67 | 275 | 659 | 1043 | 80 | 1427 | ||||
| KIAA0555 | NM_014790.3 | JAKMIP2 | 276 | 660 | 1044 | 67 | 1428 | ||||
| KIAA1199 | NM_018689.1 | KIAA1199 | 277 | 661 | 1045 | 66 | 1429 | ||||
| KIF14 | NM_014875.1 | KIF14 | 278 | 662 | 1046 | 69 | 1430 | ||||
| KIF20A | NM_005733.1 | KIF20A | 279 | 663 | 1047 | 67 | 1431 | ||||
| KIF2C | NM_006845.2 | KIF2C | 280 | 664 | 1048 | 73 | 1432 | ||||
| KLK11 | NM_006853.1 | KLK11 | 281 | 665 | 1049 | 66 | 1433 | ||||
| KLK6 | NM_002774.2 | KLK6 | 282 | 666 | 1050 | 78 | 1434 | ||||
| KLRC1 | NM_002259.3 | KLRC1 | 283 | 667 | 1051 | 67 | 1435 | ||||
| KNSL2 | BC000712.1 | 284 | 668 | 1052 | 77 | 1436 | |||||
| KNTC2 | NM_006101.1 | NDC80 | 285 | 669 | 1053 | 71 | 1437 | ||||
| KPNA2 | NM_002266.1 | KPNA2 | 286 | 670 | 1054 | 67 | 1438 | ||||
| L1CAM | NM_000425.2 | L1CAM | 287 | 671 | 1055 | 66 | 1439 | ||||
| LAMA3 | NM_000227.2 | LAMA3 | 288 | 672 | 1056 | 73 | 1440 | ||||
| LAMA5 | NM_005560.3 | LAMA5 | 289 | 673 | 1057 | 67 | 1441 | ||||
| LAMB1 | NM_002291.1 | LAMB1 | 290 | 674 | 1058 | 66 | 1442 | ||||
| LAMB3 | NM_000228.1 | LAMB3 | 291 | 675 | 1059 | 67 | 1443 | ||||
| LAMC2 | NM_005562.1 | LAMC2 | 292 | 676 | 1060 | 80 | 1444 | ||||
| LAPTM4B | NM_018407.4 | LAPTM4B | 293 | 677 | 1061 | 67 | 1445 | ||||
| LGALS3 | NM_002306.1 | LGALS3 | 294 | 678 | 1062 | 69 | 1446 | ||||
| LIMK1 | NM_016735.1 | 295 | 679 | 1063 | 67 | 1447 | |||||
| LIMS 1 | NM_004987.3 | LIMS1 | 296 | 680 | 1064 | 71 | 1448 | ||||
| LMNB1 | NM_005573.1 | LMNB1 | 297 | 681 | 1065 | 66 | 1449 | ||||
| LOX | NM_002317.3 | LOX | 298 | 682 | 1066 | 66 | 1450 | ||||
| LRIG1 | NM_015541.1 | 299 | 683 | 1067 | 67 | 1451 | |||||
| LSM1 | NM_014462.1 | LSM1 | 300 | 684 | 1068 | 66 | 1452 | ||||
| LTBP1 | NM_ 206943.1 | LTBP1 | 301 | 685 | 1069 | 67 | 1453 | ||||
| LYRIC | NM_178812.2 | MTDH | 302 | 686 | 1070 | 67 | 1454 | ||||
| MAD1L1 | NM_003550.1 | MAD1L1 | 303 | 687 | 1071 | 67 | 1455 | ||||
| MCM2 | NM_004526.1 | MCM2 | 304 | 688 | 1072 | 75 | 1456 | ||||
| MELK | NM_014791.1 | MELK | 305 | 689 | 1073 | 70 | 1457 | ||||
| MGMT | NM_002412.1 | MGMT | 306 | 690 | 1074 | 69 | 1458 | ||||
| mGST1 | NM_020300.2 | MGST1 | 307 | 691 | 1075 | 79 | 1459 | ||||
| MMP1 | NM_002421.2 | MMP1 | 308 | 692 | 1076 | 72 | 1460 | ||||
| MMP12 | NM_002426.1 | MMP12 | 309 | 693 | 1077 | 78 | 1461 | ||||
| MMP2 | NM_004530.1 | MMP2 | 310 | 694 | 1078 | 86 | 1462 | ||||
| MMP7 | NM_002423.2 | MMP7 | 311 | 695 | 1079 | 79 | 1463 | ||||
| MMP8 | NM_002424.1 | MMP8 | 312 | 696 | 1080 | 79 | 1464 | ||||
| MMTV-like env | AF346816.1 | 313 | 697 | 1081 | 72 | 1465 | |||||
| MNAT1 | NM_002431.1 | MNAT1 | 314 | 698 | 1082 | 75 | 1466 | ||||
| MRP1 | NM_004996.2 | ABCC1 | 315 | 699 | 1083 | 79 | 1467 | ||||
| MRP3 | NM_003786.2 | ABCC3 | 316 | 700 | 1084 | 91 | 1468 | ||||
| MS4A1 | NM_021950.2 | MS4A1 | 317 | 701 | 1085 | 70 | 1469 | ||||
| MSH2 | NM_00025 1.1 | MSH2 | 318 | 702 | 1086 | 73 | 1470 | ||||
| MTA3 | XM_038567 | 319 | 703 | 1087 | 69 | 1471 | |||||
| MX1 | NM_002462.2 | MX1 | 320 | 704 | 1088 | 78 | 1472 | ||||
| MYBL2 | NM_002466.1 | MYBL2 | 321 | 705 | 1089 | 74 | 1473 | ||||
| NAT1 | NM_000662.4 | NAT1 | 322 | 706 | 1090 | 75 | 1474 | ||||
| NAT2 | NM_000015.1 | NAT2 | 323 | 707 | 1091 | 73 | 1475 | ||||
| NRG1 | NM_013957.1 | NRG1 | 324 | 708 | 1092 | 83 | 1476 | ||||
| OPN, osteopontin | NM_000582.1 | SPP1 | 325 | 709 | 1093 | 80 | 1477 | ||||
| p16-INK4 | L27211.1 | 326 | 710 | 1094 | 76 | 1478 | |||||
| PAI1 | NM_000602.1 | SERPINE1 | 327 | 711 | 1095 | 81 | 1479 | ||||
| PGF | NM_002632.4 | PGF | 328 | 712 | 1096 | 71 | 1480 | ||||
| PR | NM_000926.2 | PGR | 329 | 713 | 1097 | 85 | 1481 | ||||
| PRDX1 | NM_002574.2 | PRDX1 | 330 | 714 | 1098 | 67 | 1482 | ||||
| PTEN | NM_000314.1 | PTEN | 331 | 715 | 1099 | 81 | 1483 | ||||
| PTP4A3 | NM_007079.2 | PTP4A3 | 332 | 716 | 1100 | 70 | 1484 | ||||
| RhoB | NM_004040.2 | RHOB | 333 | 717 | 1101 | 67 | 1485 | ||||
| RPL13A | NM_012423.2 | RPL13A | 334 | 718 | 1102 | 68 | 1486 | ||||
| RPL41 | NM_021104.1 | RPL41 | 335 | 719 | 1103 | 66 | 1487 | ||||
| RPLPO | NM_001002.2 | RPLP0 | 336 | 720 | 1104 | 75 | 1488 | ||||
| RPS23 | NM_001025.1 | RPS23 | 337 | 721 | 1105 | 67 | 1489 | ||||
| RPS27 | NM_001030.3 | RPS27 | 338 | 722 | 1106 | 80 | 1490 | ||||
| RRM1 | NM_001033.1 | RRM1 | 339 | 723 | 1107 | 66 | 1491 | ||||
| RRM2 | NM_001034.1 | RRM2 | 340 | 724 | 1108 | 71 | 1492 | ||||
| RUNX1 | NM_001754.2 | RUNX1 | 341 | 725 | 1109 | 69 | 1493 | ||||
| S100A10 | NM_002966.1 | S100A10 | 342 | 726 | 1110 | 77 | 1494 | ||||
| S100A2 | NM_005978.2 | S100A2 | 343 | 727 | 1111 | 73 | 1495 | ||||
| S100A4 | NM_002961.2 | S100A4 | 344 | 728 | 1112 | 70 | 1496 | ||||
| S100A7 | NM_002963.2 | S100A7 | 345 | 729 | 1113 | 75 | 1497 | ||||
| S100A8 | NM_002964.3 | S100A8 | 346 | 730 | 1114 | 76 | 1498 | ||||
| S100A9 | NM_002965.3 | S100A9 | 347 | 731 | 1115 | 67 | 1499 | ||||
| S100B | NM_006272.1 | S100B | 348 | 732 | 1116 | 70 | 1500 | ||||
| S100G | NM_004057.2 | S100G | 349 | 733 | 1117 | 67 | 1501 | ||||
| S100P | NM_005980.2 | S100P | 350 | 734 | 1118 | 67 | 1502 | ||||
| SDHA | NM_004168.1 | SDHA | 351 | 735 | 1119 | 67 | 1503 | ||||
| SEMA3F | NM_004186.1 | SEMA3F | 352 | 736 | 1120 | 86 | 1504 | ||||
| SFRP2 | NM_003013.2 | SFRP2 | 353 | 737 | 1121 | 66 | 1505 | ||||
| SIR2 | NM_012238.3 | SIRT1 | 354 | 738 | 1122 | 72 | 1506 | ||||
| SKIL | NM_005414.2 | SKIL | 355 | 739 | 1123 | 66 | 1507 | ||||
| SKP2 | NM_005983.2 | SKP2 | 356 | 740 | 1124 | 71 | 1508 | ||||
| SLPI | NM_003064.2 | SLPI | 357 | 741 | 1125 | 74 | 1509 | ||||
| SNAI1 | NM_005985.2 | SNAI1 | 358 | 742 | 1126 | 69 | 1510 | ||||
| STK15 | NM_003600.1 | AURKA | 359 | 743 | 1127 | 69 | 1511 | ||||
| STMN1 | NM_005563.2 | STMN1 | 360 | 744 | 1128 | 71 | 1512 | ||||
| STMY3 | NM_005940.2 | MMP11 | 361 | 745 | 1129 | 90 | 1513 | ||||
| SURV | NM_001168.1 | BIRC5 | 362 | 746 | 1130 | 80 | 1514 | ||||
| SYK | NM_003177.1 | SYK | 363 | 747 | 1131 | 85 | 1515 | ||||
| TAGLN | NM_003186.2 | TAGLN | 364 | 748 | 1132 | 73 | 1516 | ||||
| TCEA1 | NM_201437.1 | TCEA1 | 365 | 749 | 1133 | 72 | 1517 | ||||
| TFRC | NM_003234.1 | TFRC | 366 | 750 | 1134 | 68 | 1518 | ||||
| TGFB2 | NM_003238.1 | TGFB2 | 367 | 751 | 1135 | 75 | 1519 | ||||
| TGFB3 | NM_003239.1 | TGFB3 | 368 | 752 | 1136 | 65 | 1520 | ||||
| TGFBR2 | NM_003242.2 | TGFBR2 | 369 | 753 | 1137 | 66 | 1521 | ||||
| TIMP3 | NM_000362.2 | TIMP3 | 370 | 754 | 1138 | 67 | 1522 | ||||
| TNFRSF11 A | NM_003839.2 | TNFRSF11 A | 371 | 755 | 1139 | 67 | 1523 | ||||
| TNFRSF11 B | NM_002546.2 | TNFRSF11 B | 372 | 756 | 1140 | 67 | 1524 | ||||
| TNFSF11 | NM_003701.2 | TNFSF11 | 373 | 757 | 1141 | 71 | 1525 | ||||
| TWIST1 | NM_000474.2 | TWIST1 | 374 | 758 | 1142 | 64 | 1526 | ||||
| UBB | NM_018955.1 | UBB | 375 | 759 | 1143 | 522 | 1527 | ||||
| VCAM1 | NM_001078.2 | VCAM1 | 376 | 760 | 1144 | 89 | 1528 | ||||
| VIM | NM_003380.1 | VIM | 377 | 761 | 1145 | 72 | 1529 | ||||
| VTN | NM_000638.2 | VTN | 378 | 762 | 1146 | 67 | 1530 | ||||
| WAVE3 | NM_006646.4 | WASF3 | 379 | 763 | 1147 | 68 | 1531 | ||||
| WISP1 | NM_003882.2 | WISP1 | 380 | 764 | 1148 | 75 | 1532 | ||||
| Wnt-5a | NM_003392.2 | WNT5A | 381 | 765 | 1149 | 75 | 1533 | ||||
| Wnt-5b | NM_032642.2 | WNT5B | 382 | 766 | 1150 | 79 | 1534 | ||||
| WWOX | NM_016373.1 | WWOX | 383 | 767 | 1151 | 74 | 1535 | ||||
| YWHAZ | NM_003406.2 | YWHAZ | 384 | 768 | 1152 | 81 | 1536 |
| GSTM2 | -4.306 | 0.525 | 0.000 |
| IL6ST | -3.730 | 0.522 | 0.000 |
| CEGP1 | -3.712 | 0.756 | 0.000 |
| Bcl2 | -3.664 | 0.555 | 0.000 |
| GSTM1 | -3.573 | 0.679 | 0.000 |
| ERBB4 | -3.504 | 0.767 | 0.000 |
| GADD45 | -3.495 | 0.601 | 0.000 |
| PR | -3.474 | 0.759 | 0.001 |
| GPR30 | -3.348 | 0.660 | 0.001 |
| CAV1 | -3.344 | 0.649 | 0.001 |
| C10orf116 | -3.194 | 0.681 | 0.001 |
| DR5 | -3.102 | 0.543 | 0.002 |
| DICER1 | -3.097 | 0.296 | 0.002 |
| EstR1 | -2.983 | 0.825 | 0.003 |
| BTRC | -2.976 | 0.639 | 0.003 |
| GSTM3 | -2.931 | 0.722 | 0.003 |
| GATA3 | -2.874 | 0.745 | 0.004 |
| DLC1 | -2.858 | 0.564 | 0.004 |
| CXCL14 | -2.804 | 0.693 | 0.005 |
| IL17RB | -2.796 | 0.744 | 0.005 |
| C8orf4 | -2.786 | 0.699 | 0.005 |
| FOXO3A | -2.786 | 0.617 | 0.005 |
| TNFRSF11B | -2.690 | 0.739 | 0.007 |
| BAG1 | -2.675 | 0.451 | 0.008 |
| SNAI1 | -2.632 | 0.692 | 0.009 |
| TGFB3 | -2.617 | 0.623 | 0.009 |
| NAT1 | -2.576 | 0.820 | 0.010 |
| FUS | -2.543 | 0.376 | 0.011 |
| F3 | -2.527 | 0.705 | 0.012 |
| GSTM2 gene | -2.461 | 0.668 | 0.014 |
| EPHB2 | -2.451 | 0.708 | 0.014 |
| LAMA3 | -2.448 | 0.778 | 0.014 |
| BAD | -2.425 | 0.506 | 0.015 |
| IGF1R | -2.378 | 0.712 | 0.017 |
| RUNX1 | -2.356 | 0.511 | 0.018 |
| ESRRG | -2.289 | 0.825 | 0.022 |
| HSHIN1 | -2.275 | 0.371 | 0.023 |
| CXCL12 | -2.151 | 0.623 | 0.031 |
| IGFBP7 | -2.137 | 0.489 | 0.033 |
| SKIL | -2.121 | 0.593 | 0.034 |
| PTEN | -2.110 | 0.449 | 0.035 |
| AKT3 | -2.104 | 0.665 | 0.035 |
| MGMT | -2.060 | 0.571 | 0.039 |
| LRIG1 | -2.054 | 0.649 | 0.040 |
| S100B | -2.024 | 0.798 | 0.043 |
| GREB1 variant a | -1.996 | 0.833 | 0.046 |
| CSF1 | -1.976 | 0.624 | 0.048 |
| ABR | -1.973 | 0.575 | 0.048 |
| AK055699 | -1.972 | 0.790 | 0.049 |
| S100A7 | 1.965 | 1.100 | 0.049 |
| MCM2 | 1.999 | 1.424 | 0.046 |
| Contig 51037 | 2.063 | 1.185 | 0.039 |
| S100P | 2.066 | 1.170 | 0.039 |
| ACTR2 | 2.119 | 2.553 | 0.034 |
| MYBL2 | 2.158 | 1.295 | 0.031 |
| DUSP1 | 2.166 | 1.330 | 0.030 |
| HOXB13 | 2.192 | 1.206 | 0.028 |
| SURV | 2.216 | 1.329 | 0.027 |
| MELK | 2.234 | 1.336 | 0.026 |
| HSPA8 | 2.240 | 2.651 | 0.025 |
| cdc25A | 2.314 | 1.478 | 0.021 |
| C20_orf1 | 2.336 | 1.497 | 0.019 |
| LMNB1 | 2.387 | 1.682 | 0.017 |
| S100A9 | 2.412 | 1.185 | 0.016 |
| CENPA | 2.419 | 1.366 | 0.016 |
| CDC25C | 2.437 | 1.384 | 0.015 |
| GAPDH | 2.498 | 1.936 | 0.012 |
| KNTC2 | 2.512 | 1.450 | 0.012 |
| PRDX1 | 2.540 | 2.131 | 0.011 |
| RRM2 | 2.547 | 1.439 | 0.011 |
| ADM | 2.590 | 1.445 | 0.010 |
| ARF1 | 2.634 | 2.973 | 0.008 |
| E2F1 | 2.716 | 1.486 | 0.007 |
| TFRC | 2.720 | 1.915 | 0.007 |
| STK15 | 2.870 | 1.860 | 0.004 |
| LAPTM4B | 2.880 | 1.538 | 0.004 |
| EpCAM | 2.909 | 1.919 | 0.004 |
| ENO1 | 2.958 | 2.232 | 0.003 |
| CCNB1 | 3.003 | 1.738 | 0.003 |
| BUB1 | 3.018 | 1.590 | 0.003 |
| Claudin 4 | 3.034 | 2.151 | 0.002 |
| CDC20 | 3.056 | 1.555 | 0.002 |
| Ki-67 | 3.329 | 1.717 | 0.001 |
| KPNA2 | 3.523 | 1.722 | 0.000 |
| IDH2 | 3.994 | 1.638 | 0.000 |
| SYK | 0.185 | -2.991 | 0.003 |
| Wnt-5a | 0.443 | -2.842 | 0.005 |
| WISP1 | 0.455 | -2.659 | 0.008 |
| CYR61 | 0.405 | -2.484 | 0.013 |
| GADD45 | 0.520 | -2.474 | 0.013 |
| TAGLN | 0.364 | -2.376 | 0.018 |
| TGFB3 | 0.465 | -2.356 | 0.018 |
| INHBA | 0.610 | -2.255 | 0.024 |
| CDH11 | 0.584 | -2.253 | 0.024 |
| CHAF1B | 0.551 | -2.113 | 0.035 |
| ITGAV | 0.192 | -2.101 | 0.036 |
| SNAI1 | 0.655 | -2.077 | 0.038 |
| IL11 | 0.624 | -2.026 | 0.043 |
| KIAA1199 | 0.692 | -2.005 | 0.045 |
| TNFRSF11B | 0.659 | -1.989 | 0.047 |
| RPL41 | 3.547 | 2.062 | 0.039 |
| Claudin 4 | 2.883 | 2.117 | 0.034 |
| LYRIC | 4.029 | 2.364 | 0.018 |
| TFRC | 3.223 | 2.596 | 0.009 |
| VTN | 2.484 | 3.205 | 0.001 |
| DR5 | 0.428 | -3.478 | 0.001 |
| GSTM2 | 0.526 | -3.173 | 0.002 |
| HSHIN1 | 0.175 | -3.031 | 0.002 |
| ESRRG | 0.736 | -3.028 | 0.003 |
| VTN | 0.622 | -2.935 | 0.003 |
| Bcl2 | 0.469 | -2.833 | 0.005 |
| ERBB4 | 0.705 | -2.802 | 0.005 |
| GPR30 | 0.625 | -2.794 | 0.005 |
| BAG1 | 0.339 | -2.733 | 0.006 |
| CAV1 | 0.635 | -2.644 | 0.008 |
| IL6ST | 0.503 | -2.551 | 0.011 |
| C10orf116 | 0.679 | -2.497 | 0.013 |
| FOXO3A | 0.607 | -2.473 | 0.013 |
| DICER1 | 0.311 | -2.354 | 0.019 |
| GADD45 | 0.645 | -2.338 | 0.019 |
| CSF1 | 0.500 | -2.312 | 0.021 |
| F3 | 0.677 | -2.300 | 0.021 |
| GBP2 | 0.604 | -2.294 | 0.022 |
| APEX-1 | 0.234 | -2.253 | 0.024 |
| FUS | 0.322 | -2.252 | 0.024 |
| BBC3 | 0.581 | -2.248 | 0.025 |
| GSTM3 | 0.737 | -2.203 | 0.028 |
| ITGA4 | 0.620 | -2.161 | 0.031 |
| EPHB2 | 0.685 | -2.128 | 0.033 |
| IRF1 | 0.708 | -2.105 | 0.035 |
| CRYZ | 0.593 | -2.103 | 0.035 |
| CCL19 | 0.773 | -2.076 | 0.038 |
| SKIL | 0.540 | -2.019 | 0.043 |
| MRP1 | 0.515 | -1.964 | 0.050 |
| CTHRC1 | 2.083 | 1.958 | 0.050 |
| RRM2 | 1.450 | 1.978 | 0.048 |
| BUB1 | 1.467 | 1.988 | 0.047 |
| LMNB1 | 1.764 | 2.009 | 0.045 |
| SURV | 1.380 | 2.013 | 0.044 |
| EpCAM | 1.966 | 2.076 | 0.038 |
| CDC20 | 1.504 | 2.081 | 0.037 |
| GAPDH | 2.405 | 2.126 | 0.033 |
| STK15 | 1.796 | 2.178 | 0.029 |
| HSPA8 | 3.095 | 2.215 | 0.027 |
| LAPTM4B | 1.503 | 2.278 | 0.023 |
| MCM2 | 1.872 | 2.370 | 0.018 |
| CDC25C | 1.485 | 2.423 | 0.015 |
| ADM | 1.695 | 2.486 | 0.013 |
| MMP1 | 1.365 | 2.522 | 0.012 |
| CCNB1 | 1.893 | 2.646 | 0.008 |
| Ki-67 | 1.697 | 2.649 | 0.008 |
| E2F1 | 1.662 | 2.689 | 0.007 |
| KPNA2 | 1.683 | 2.701 | 0.007 |
| DUSP1 | 1.573 | 2.824 | 0.005 |
| GDF15 | 1.440 | 2.896 | 0.004 |
| GSTM2 | -3.275 | 0.752 | 0.001 |
| GSTM1 | -2.946 | 0.772 | 0.003 |
| C8orf4 | -2.639 | 0.793 | 0.008 |
| ELF3 | -2.478 | 0.769 | 0.013 |
| RUNX1 | -2.388 | 0.609 | 0.017 |
| IL6ST | -2.350 | 0.738 | 0.019 |
| AAMP | -2.325 | 0.715 | 0.020 |
| PR | -2.266 | 0.887 | 0.023 |
| FHIT | -2.193 | 0.790 | 0.028 |
| CD44v6 | -2.191 | 0.754 | 0.028 |
| GREB1 variant c | -2.120 | 0.874 | 0.034 |
| ADAM17 | -2.101 | 0.686 | 0.036 |
| EstR1 | -2.084 | 0.919 | 0.037 |
| NAT1 | -2.081 | 0.878 | 0.037 |
| TNFRSF11B | -2.074 | 0.843 | 0.038 |
| ITGB4 | -2.006 | 0.740 | 0.045 |
| CSF1 | -1.963 | 0.750 | 0.050 |
| STK15 | 1.968 | 1.298 | 0.049 |
| TFRC | 2.049 | 1.399 | 0.040 |
| ITGB1 | 2.071 | 1.812 | 0.038 |
| ITGAV | 2.081 | 1.922 | 0.037 |
| MYBL2 | 2.089 | 1.205 | 0.037 |
| MRP3 | 2.092 | 1.165 | 0.036 |
| SKP2 | 2.143 | 1.379 | 0.032 |
| LMNB1 | 2.155 | 1.357 | 0.031 |
| ALCAM | 2.234 | 1.282 | 0.025 |
| COMT | 2.271 | 1.412 | 0.023 |
| CDC20 | 2.300 | 1.253 | 0.021 |
| GAPDH | 2.307 | 1.572 | 0.021 |
| GRB7 | 2.340 | 1.205 | 0.019 |
| S100A9 | 2.374 | 1.120 | 0.018 |
| S100A7 | 2.374 | 1.092 | 0.018 |
| HER2 | 2.425 | 1.210 | 0.015 |
| ACTR2 | 2.499 | 1.788 | 0.012 |
| S100A8 | 2.745 | 1.144 | 0.006 |
| ENO1 | 2.752 | 1.687 | 0.006 |
| MMP1 | 2.758 | 1.212 | 0.006 |
| LAPTM4B | 2.775 | 1.375 | 0.006 |
| FGFR4 | 3.005 | 1.215 | 0.003 |
| C17orf37 | 3.260 | 1.387 | 0.001 |
| SEMA3F | -2.465 | 0.503 | 0.014 |
| LAMA3 | -2.461 | 0.519 | 0.014 |
| CD44E | -2.418 | 0.719 | 0.016 |
| AD024 | -2.256 | 0.617 | 0.024 |
| LAMB3 | -2.237 | 0.690 | 0.025 |
| Ki-67 | -2.209 | 0.650 | 0.027 |
| MMP7 | -2.208 | 0.768 | 0.027 |
| GREB1 variant c | -2.019 | 0.693 | 0.044 |
| ITGB4 | -1.996 | 0.657 | 0.046 |
| CRYZ | -1.976 | 0.662 | 0.048 |
| CD44s | -1.967 | 0.650 | 0.049 |
| S100A8 | 1.972 | 1.212 | 0.049 |
| EEF1A2 | 2.031 | 1.195 | 0.042 |
| TAGLN | 2.072 | 2.027 | 0.038 |
| GRB7 | 2.086 | 1.231 | 0.037 |
| HER2 | 2.124 | 1.232 | 0.034 |
| ITGAV | 2.217 | 3.258 | 0.027 |
| CDH11 | 2.237 | 2.728 | 0.025 |
| COL1A1 | 2.279 | 2.141 | 0.023 |
| C17orf37 | 2.319 | 1.329 | 0.020 |
| COL1A2 | 2.336 | 2.577 | 0.020 |
| ITGB5 | 2.375 | 3.236 | 0.018 |
| ITGA5 | 2.422 | 2.680 | 0.015 |
| RPL41 | 2.428 | 6.665 | 0.015 |
| ALCAM | 2.470 | 1.414 | 0.013 |
| CTHRC1 | 2.687 | 3.454 | 0.007 |
| PTEN | 2.692 | 8.706 | 0.007 |
| FN1 | 2.833 | 2.206 | 0.005 |
| GSTM1 | -3.938 | 0.628 | 0.000 |
| HNF3A | -3.220 | 0.500 | 0.001 |
| EstR1 | -3.165 | 0.643 | 0.002 |
| Bcl2 | -2.964 | 0.583 | 0.003 |
| GATA3 | -2.641 | 0.624 | 0.008 |
| ELF3 | -2.579 | 0.741 | 0.010 |
| C8orf4 | -2.451 | 0.730 | 0.014 |
| GSTM2 | -2.416 | 0.774 | 0.016 |
| PR | -2.416 | 0.833 | 0.016 |
| RUNX1 | -2.355 | 0.537 | 0.019 |
| CSF1 | -2.261 | 0.662 | 0.024 |
| IL6ST | -2.239 | 0.627 | 0.025 |
| AAMP | -2.046 | 0.704 | 0.041 |
| TNFRSF11B | -2.028 | 0.806 | 0.043 |
| NAT1 | -2.025 | 0.833 | 0.043 |
| ADAM17 | -1.981 | 0.642 | 0.048 |
| HSPA1B | 1.966 | 1.382 | 0.049 |
| AD024 | 1.967 | 1.266 | 0.049 |
| FGFR4 | 1.991 | 1.175 | 0.047 |
| CDK4 | 2.014 | 1.576 | 0.044 |
| ITGB1 | 2.021 | 2.163 | 0.043 |
| EPHB2 | 2.121 | 1.342 | 0.034 |
| LYRIC | 2.139 | 1.583 | 0.032 |
| MYBL2 | 2.174 | 1.273 | 0.030 |
| PGF | 2.176 | 1.439 | 0.030 |
| EZH2 | 2.199 | 1.390 | 0.028 |
| HSPA1A | 2.209 | 1.452 | 0.027 |
| RPLPO | 2.273 | 2.824 | 0.023 |
| LMNB1 | 2.322 | 1.529 | 0.020 |
| IL-8 | 2.404 | 1.166 | 0.016 |
| C6orf66 | 2.468 | 1.803 | 0.014 |
| GAPDH | 2.489 | 1.950 | 0.013 |
| P16-INK4 | 2.490 | 1.541 | 0.013 |
| CLIC1 | 2.557 | 2.745 | 0.011 |
| ENO1 | 2.719 | 2.455 | 0.007 |
| ACTR2 | 2.878 | 2.543 | 0.004 |
| CDC20 | 2.931 | 1.452 | 0.003 |
| SKP2 | 2.952 | 1.916 | 0.003 |
| LAPTM4B | 3.124 | 1.558 | 0.002 |
| TFRC | ENO1 | IDH2 | ARF1 | CLDN4 | PRDX1 | GBP1 | |
| EMC2∼Est | NA | NA | NA | NA | NA | NA | NA |
| EMC2∼SE | NA | NA | NA | NA | NA | NA | NA |
| EMC2∼t | NA | NA | NA | NA | NA | NA | NA |
| JRH1∼Est | -0.91825 | NA | -0.0525 | 0.839013 | -0.54144 | NA | 0.137268 |
| JRH1∼SE | 0.636275 | NA | 0.232201 | 0.346692 | 0.470758 | NA | 0.159849 |
| JRH1∼t | -1.44317 | NA | -0.22611 | 2.420053 | -1.15014 | NA | 0.858735 |
| JRH2∼Est | 0.162921 | 0.179739 | 0.151299 | 0.369609 | 0.33033 | -0.41082 | -0.07418 |
| JRH2∼SE | 0.352486 | 0.312848 | 0.327466 | 0.40789 | 0.351865 | 0.47383 | 0.198642 |
| JRH2∼t | 0.462206 | 0.574525 | 0.46203 | 0.906149 | 0.938798 | -0.86703 | -0.37345 |
| MGH∼Est | 0.029015 | NA | NA | 2.03958 | 0.185116 | NA | 0.15434 |
| MGH∼SE | 0.193689 | NA | NA | 0.804729 | 0.314723 | NA | 0.188083 |
| MGH∼t | 0.149803 | NA | NA | 2.534493 | 0.588187 | NA | 0.820595 |
| NCH∼Est | 0.056174 | -0.01727 | 0.265828 | -0.15337 | -0.23129 | 0.253047 | 0.095457 |
| NCH∼SE | 0.166875 | 0.097939 | 0.105592 | 0.204529 | 0.426627 | 0.182621 | 0.1323 |
| NCH∼t | 0.336622 | -0.17629 | 2.517501 | -0.74984 | -0.54213 | 1.38564 | 0.721522 |
| NKI∼Est | 0.157216 | 0.3682 | 0.284862 | 0.944168 | 0.564756 | 0.231612 | 0.13712 |
| NKI∼SE | 0.10845 | 0.094778 | 0.089145 | 0.204641 | 0.210595 | 0.161791 | 0.075391 |
| NKI∼t | 1.449663 | 3.884888 | 3.195498 | 4.613777 | 2.681716 | 1.431551 | 1.818777 |
| STNO∼Est | 0.406546 | NA | 0.127942 | 0 | 0.40922 | NA | 0.298139 |
| STNO∼SE | 0.131339 | NA | 0.255302 | 0.107397 | 0.128817 | NA | 0.113901 |
| STNO∼t | 3.095394 | NA | 0.50114 | 0 | 3.176755 | NA | 2.617528 |
| STOCK∼Est | 0.178145 | 0.428884 | 0.574289 | 0.862387 | 1.20235 | 1.52553 | 0.068821 |
| STOCK-SE | 0.153331 | 0.194952 | 0.193387 | 0.279535 | 0.33711 | 0.420489 | 0.183692 |
| STOCK∼t | 1.161833 | 2.199947 | 2.969636 | 3.085077 | 3.56664 | 3.62799 | 0.374652 |
| TRANSBIG∼Est | -0.03263 | NA | NA | NA | 0.03236 | NA | NA |
| TRANSBIG∼SE | 0.051129 | NA | NA | NA | 0.053171 | NA | NA |
| TRANSBIG∼t | -0.63826 | NA | NA | NA | 0.608591 | NA | NA |
| UCSF∼Est | -0.22576 | 0.899319 | -0.009 | 0.304097 | 0 | 0.358079 | -0.43879 |
| UCSF∼SE | 0.249301 | 0.369574 | 0.554612 | 0.58718 | 1.8541 | 0.32938 | 0.874728 |
| UCSF∼t | -0.90558 | 2.433394 | -0.01623 | 0.517894 | 0 | 1.08713 | -0.50163 |
| UPP∼Est | 0.545839 | 0.288434 | 0.659908 | 0.751279 | 0.08503 | 0.706059 | 0.119778 |
| UPP∼SE | 0.208978 | 0.179833 | 0.186426 | 0.361093 | 0.258939 | 0.303105 | 0.117879 |
| UPP∼t | 2.611945 | 1.603899 | 3.539785 | 2.080569 | 0.328378 | 2.32942 | 1.01611 |
| Fe | 0.062825 | 0.233559 | 0.303626 | 0.281544 | 0.125868 | 0.347764 | 0.139381 |
| Sefe | 0.038345 | 0.058687 | 0.056121 | 0.07587 | 0.045235 | 0.10081 | 0.044464 |
| Gene | CXCL14 | TNFRSF11B | CXCL12 | C10orf116 | RUNX1 | GSTM2 | TGFB3 | BCAR3 | CAV1 | DLC1 | TNFRSF10B | F3 | DICER1 |
| EMC2∼Est | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| EMC2∼SE | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| EMC2∼t | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| JRH1∼Est | -0.23692 | NA | -0.36476 | -0.1418 | -0.22834 | NA | -1.0219 | NA | -0.20701 | 0.13581 | -0.09001 | 0.719395 | NA |
| JRH1∼SE | 0.333761 | NA | 0.372499 | 0.261554 | 0.318666 | NA | 0.358953 | NA | 0.254401 | 0.37927 | 0.619057 | 0.524742 | NA |
| JRH1∼t | -0.70985 | NA | -0.97921 | -0.54216 | -0.71656 | NA | -2.84689 | NA | -0.81372 | 0.358083 | -0.1454 | 1.37095 | NA |
| JRH2∼Est | 0.361375 | -0.10399 | -0.4566 | 0.036378 | 0.302803 | NA | -0.39774 | -0.29238 | -0.19588 | -0.4102 | 0.80742 | -0.21237 | -0.33943 |
| JRH2∼SE | 0.159544 | 0.440721 | 0.219587 | 0.182183 | 0.420043 | NA | 0.470041 | 0.522706 | 0.289251 | 0.387258 | 0.544479 | 0.363632 | 0.39364 |
| JRH2∼t | 2.265049 | -0.23595 | -2.07935 | 0.19968 | 0.720886 | NA | -0.84619 | -0.55935 | -0.67721 | -1.05923 | 1.482922 | -0.58402 | -0.8623 |
| MGH∼Est | NA | -1.15976 | NA | NA | 0.277566 | NA | 0.046498 | -0.41595 | -0.06896 | -0.09793 | 0.159018 | -0.00167 | 0.038811 |
| MGH∼SE | NA | 0.400921 | NA | NA | 0.267511 | NA | 0.2296 | 0.216837 | 0.2269 | 0.247069 | 0.456205 | 0.448211 | 0.409835 |
| MGH∼t | NA | -2.89274 | NA | NA | 1.037587 | NA | 0.202518 | -1.91825 | -0.30391 | -0.39638 | 0.348567 | -0.00372 | 0.0947 |
| NCH∼Est | -0.06592 | -0.2492 | -0.08863 | 0.064337 | 0.124568 | NA | -0.30473 | 0.072246 | 0.078825 | -0.03473 | -0.19927 | -0.13187 | 0.086141 |
| NCH∼SE | 0.093353 | 0.289075 | 0.138097 | 0.14087 | 0.088457 | NA | 0.247338 | 0.304443 | 0.340843 | 0.238947 | 0.160381 | 0.134218 | 0.143687 |
| NCH∼t | -0.70609 | -0.86207 | -0.64183 | 0.456713 | 1.408231 | NA | -1.23202 | 0.237306 | 0.231265 | -0.14533 | -1.24248 | -0.98248 | 0.599504 |
| NKI∼Est | -0.16877 | -0.22072 | -0.36944 | -0.22589 | -0.18878 | -0.15655 | -0.36531 | -0.26067 | -0.30885 | -0.35001 | 0.053214 | -0.29217 | -0.46887 |
| NKI∼SE | 0.054117 | 0.10171 | 0.138735 | 0.082836 | 0.138365 | 0.118111 | 0.09592 | 0.114992 | 0.133788 | 0.130472 | 0.164091 | 0.093753 | 0.150367 |
| NKI∼t | -3.11866 | -2.17005 | -2.66293 | -2.72696 | -1.36435 | -1.32547 | -3.80851 | -2.26685 | -2.30848 | -2.68262 | 0.324294 | -3.11637 | -3.11814 |
| STNO∼Est | -0.20969 | 0 | 0.066487 | -0.09621 | -0.17832 | NA | -0.07166 | NA | 0.135002 | 0.519601 | -0.03773 | NA | NA |
| STNO∼SE | 0.073458 | 0.08306 | 0.189775 | 0.085948 | 0.165636 | NA | 0.134442 | NA | 0.093948 | 0.221066 | 0.174479 | NA | NA |
| STNO∼t | -2.8546 | 0 | 0.350348 | -1.11936 | -1.07657 | NA | -0.53298 | NA | 1.436991 | 2.350434 | -0.21623 | NA | NA |
| STOCK∼Est | -0.14079 | -0.10987 | -0.65036 | -0.34745 | -0.39722 | NA | -1.08462 | -0.49692 | -0.65852 | -0.66099 | -0.03558 | -0.3284 | -1.06544 |
| STOCK∼SE | 0.096118 | 0.128194 | 0.168426 | 0.112777 | 0.244634 | NA | 0.322799 | 0.265837 | 0.275751 | 0.298518 | 0.198203 | 0.132658 | 0.322204 |
| STOCK∼t | -1.46476 | -0.85708 | -3.86137 | -3.08087 | -1.62372 | NA | -3.36005 | -1.86927 | -2.38811 | -2.21425 | -0.1795 | -2.47552 | -3.30672 |
| Gene | CXXL14 | TNFRSF11B | CXCL12 | C10orf116 | RUNX1 | GSTM2 | TGFB3 | BCAR3 | CAV1 | DLC1 | TNFRSF10B | F3 | DICER1 |
| TRANSBIG∼Est | NA | NA | NA | NA | NA | NA | 0.013681 | NA | NA | NA | NA | NA | N/A |
| TRANSBIG∼SE | NA | NA | NA | NA | NA | NA | 0.046103 | NA | NA | NA | NA | NA | N/A |
| TRANSBIG∼t | NA | NA | NA | NA | NA | NA | 0.296755 | NA | NA | NA | NA | NA | N/A |
| UCSF∼Est | NA | NA | -0.05795 | 0.013111 | -0.58909 | -0.12675 | -0.25719 | NA | -0.54391 | -0.31503 | 0.932141 | -0.08026 | 0 |
| UCSF-SE | NA | NA | 0.270065 | 156.117 | 0.385997 | 0.336406 | 0.253264 | NA | 0.428883 | 0.345828 | 0.524911 | 0.491948 | 0.311799 |
| UCSF∼t | NA | NA | -0.21456 | 8.40E-05 | -1.52616 | -0.37676 | -1.01551 | NA | -1.2682 | -0.91094 | 1.775808 | -0.16315 | 0 |
| UPP∼Est | -0.1861 | -0.03866 | -0.35344 | -0.00923 | -0.2142 | NA | -0.49773 | -0.29435 | -0.31503 | -0.404 | 0.127348 | -0.20405 | 0.208326 |
| UPP∼SE | 0.08384 | 0.087545 | 0.150278 | 0.100902 | 0.105479 | NA | 0.225603 | 0.182614 | 0.150431 | 0.200673 | 0.157658 | 0.109227 | 0.307144 |
| UPP∼t | -2.21976 | -0.44163 | -2.35189 | -0.09148 | -2.03071 | NA | -2.20621 | -1.61186 | -2.09415 | -2.01324 | 0.807748 | -1.86809 | 0.678268 |
| Fe | -0.14219 | -0.09599 | -0.28998 | -0.13 | -0.07498 | -0.15328 | -0.10353 | -0.28755 | -0.11726 | -0.19876 | 0.02034 | -0.22911 | -0.19602 |
| Sefe | 0.032611 | 0.046815 | 0.062826 | 0.042521 | 0.052758 | 0.111442 | 0.03709 | 0.080198 | 0.058989 | 0.076441 | 0.072745 | 0.055029 | 0.085879 |
| INHBA | AEBP1 | CDH11 | COL10A1 | COL11A1 | COL1A2 |
| COL5A1 | COL5A2 | COL8A2 | ENTPD4 | LOXL2 | |
| LRRC15 | MMP11 | NOX4 | PLAU | THBS2 | |
| THY1 | VCAN | ||||
| CAV1 | ANK2 | ANXA1 | AQP1 | C10orf56 | CAV2 |
| CFH | COL14A1 | CRYAB | CXCL12 | DAB2 | |
| DCN | ECM2 | FHL1 | FLRT2 | GNG11 | |
| GSN | IGF1 | JAM2 | LDB2 | NDN | |
| NRN1 | PCSK5 | PLSCR4 | PROS1 | TGFBR2 | |
| NAT1 | PSD3 | ||||
| GSTM1 | GSTM2 | ||||
| GSTM2 | GSTM1 | ||||
| ITGA4 | ARHGAP15 | ARHGAP25 | CCL5 | CD3D | CD48 |
| CD53 | CORO1A | EVI2B | FGL2 | GIMAP4 | |
| IRF8 | LCK | PTPRC | TFEC | TRAC | |
| TRAF3IP3 | TRBC1 | EVI2A | FLI1 | GPR65 | |
| IL2RB | LCP2 | LOC100133233 | MNDA | PLAC8 | |
| PLEK | TNFAIP8 | ||||
| CCL19 | ARHGAP15 | ARHGAP25 | CCL5 | CCR2 | CCR7 |
| CD2 | CD247 | CD3D | CD3E | CD48 | |
| CD53 | FLJ78302 | GPR171 | IL10RA | IL7R | |
| IRF8 | LAMP3 | LCK | LTB | PLAC8 | |
| PRKCB1 | PTPRC | PTPRCAP | SASH3 | SPOCK2 | |
| TRA@ | TRBC1 | TRD@ | PPP1R16B | TRAC | |
| CDH11 | TAGLN | ADAM12 | AEBP1 | ANGPTL2 | ASPN |
| BGN | BICC1 | C10orf56 | C1R | C1S | |
| C20orf39 | CALD1 | COL10A1 | COL11A1 | COL1A1 | |
| COL1A2 | COL3A1 | COL5A1 | COL5A2 | COL6A1 | |
| COL6A2 | COL6A3 | COL8A2 | COMP | COPZ2 | |
| CRISPLD2 | CTSK | DACT1 | DCN | DPYSL3 | |
| ECM2 | EFEMP2 | ENTPD4 | FAP | FBLN1 | |
| FBLN2 | FBN1 | FERMT2 | FLRT2 | FN1 | |
| FSTL1 | GAS1 | GLT8D2 | HEPH | HTRA1 | |
| ISLR | ITGBL1 | JAM3 | KDELC1 | LAMA4 | |
| LAMB1 | LOC100133502 | LOX | LOXL2 | LRRC15 | |
| LRRC17 | LUM | MFAP2 | MFAP5 | MMP2 | |
| MRC2 | MXRA5 | MXRA8 | MYL9 | NDN | |
| NID1 | NID2 | NINJ2 | NOX4 | OLFML2B | |
| OMD | PALLD | PCOLCE | PDGFRA | PDGFRB | |
| PDGFRL | POSTN | PRKCDBP | PRKD1 | PTRF | |
| RARRES2 | RCN3 | SERPINF1 | SERPINH1 | SFRP4 | |
| SNAI2 | SPARC | SPOCK1 | SPON1 | SRPX2 | |
| SSPN | TCF4 | THBS2 | THY1 | TNFAIP6 | |
| VCAN | WWTR1 | ZEB1 | ZFPM2 | INHBA | |
| PLS3 | SEC23A | WISP1 | |||
| TAGLN | CDH11 | ADAM12 | AEBP1 | ANGPTL2 | ASPN |
| BGN | BICC1 | C10orf56 | C1R | C1S | |
| C20orf39 | CALD1 | COL10A1 | COL11A1 | COL1A1 | |
| COL1A2 | COL3A1 | COL5A1 | COL5A2 | COL6A1 | |
| COL6A2 | COL6A3 | COL8A2 | COMP | COPZ2 | |
| CRISPLD2 | CTSK | DACT1 | DCN | DPYSL3 | |
| ECM2 | EFEMP2 | ENTPD4 | FAP | FBLN1 | |
| FBLN2 | FBN1 | FERMT2 | FLRT2 | FN1 | |
| FSTL1 | GAS1 | GLT8D2 | HEPH | HTRA1 | |
| ISLR | ITGBL1 | JAM3 | KDELC1 | LAMA4 | |
| LAMB1 | LOC100133502 | LOX | LOXL2 | LRRC15 | |
| LRRC17 | LUM | MFAP2 | MFAP5 | MMP2 | |
| MRC2 | MXRA5 | MXRA8 | MYL9 | NDN | |
| NID1 | NID2 | NINJ2 | NOX4 | OLFML2B | |
| OMD | PALLD | PCOLCE | PDGFRA | PDGFRB | |
| PDGFRL | POSTN | PRKCDBP | PRKD1 | PTRF | |
| RARRES2 | RCN3 | SERPINF1 | SERPINH1 | SFRP4 | |
| SNAI2 | SPARC | SPOCK1 | SPON1 | SRPX2 | |
| SSPN | TCF4 | THBS2 | THY1 | TNFAIP6 | |
| VCAN | WWTR1 | ZEB1 | ZFPM2 | ACTA2 | |
| CNN1 | DZIP1 | EMILIN1 | |||
| ENO1 | ATP5J2 | C10orf10 | CLDN15 | CNGB1 | DET1 |
| EIF3CL | HS2ST1 | IGHG4 | KIAA0195 | KIR2DS5 | |
| PARP6 | PRH1 | RAD1 | RIN3 | RPL10 | |
| SGCG | SLC16A2 | SLC9A3R1 | SYNPO2L | THBS1 | |
| ZNF230 | |||||
| IDH2 | AEBP1 | HIST1H2BN | PCDHAC1 | ||
| ARF1 | CRIM1 | ||||
| DICER1 | ADM | LOC100133583 | |||
| AKT3 | AKAP12 | ECM2 | FERMT2 | FLRT2 | JAM3 |
| LOC100133502 | PROS1 | TCF4 | WWTR1 | ZEB1 | |
| CXCL12 | ANXA1 | C1R | C1S | CAV1 | DCN |
| FLRT2 | SRPX | ||||
| CYR61 | CTGF | ||||
| IGFBP7 | VIM | ||||
| KIAA1199 | COL11A1 | PLAU | |||
| SPC25 | ASPM | BUB1 | BUB1B | CCNA2 | CCNE2 |
| CDC2 | CDC25C | CENPA | CEP55 | FANCI | |
| GINS1 | HJURP | KIAA0101 | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF4A | MAD2L1 | |
| MELK | NCAPG | NEK2 | NUSAP1 | PRC1 | |
| STIL | ZWINT | ||||
| WISP1 | CDH11 | COL5A2 | |||
| IRF1 | APOL6 | CXCL10 | GABBR1 | GBP1 | HCP5 |
| HLA-E | HLA-F | HLA-G | HLA-J | INDO | |
| PSMB8 | PSMB9 | STAT1 | TAP1 | UBD | |
| UBE2L6 | WARS | APOBEC3F | APOBEC3G | APOL1 | |
| APOL3 | ARHGAP25 | BTN3A1 | BTN3A2 | BTN3A3 | |
| C1QB | CCL5 | CD2 | CD38 | CD40 | |
| CD53 | CD74 | CD86 | CSF2RB | CTSS | |
| CYBB | FGL2 | GIMAP5 | GZMA | hCG_1998957 | |
| HCLS1 | HLA-C | HLA-DMA | HLA-DMB | HLA-DPA1 | |
| HLA-DQB1 | HLA-DQB2 | HLA-DRA | HLA-DRB1 | HLA-DRB2 | |
| HLA-DRB3 | HLA-DRB4 | HLA-DRB5 | HLA-DRB6 | IL10RA | |
| IL2RB | LAP3 | LAPTM5 | LOC100133484 | LOC100133583 | |
| LOC100133661 | LOC100133811 | LOC730415 | NKG7 | PLEK | |
| PSMB10 | PTPRC | RNASE2 | SLAMF8 | TFEC | |
| TNFRSF1B | TRA@ | TRAC | TRAJ17 | TRAV20 | |
| ZNF749 | |||||
| CDH11 | ADAM12 | AEBP1 | ANGPTL2 | ASPN | CFH |
| CFHR1 | COL10A1 | COL11A1 | COL1A1 | COL1A2 | |
| COL3A1 | COL5A1 | COL5A2 | COL6A3 | CRISPLD2 | |
| CTSK | DACT1 | DCN | FAP | FBN1 | |
| FN1 | HTRA1 | LOX | LRRC15 | LUM | |
| NID2 | PCOLCE | PDGFRB | POSTN | SERPINF1 | |
| SPARC | THBS2 | THY1 | VCAN | DAB2 | |
| GLT8D2 | ITGB5 | JAM3 | LOC100133502 | MMP2 | |
| PRSS23 | TIMP3 | ZEB1 | |||
| CCL19 | ITGA4 | ADAM28 | AIF1 | APOBEC3F | APOBEC3G |
| APOL3 | ARHGAP15 | ARHGAP25 | CASP1 | CCDC69 | |
| CCR2 | CCR7 | CD2 | CD247 | CD27 | |
| CD37 | CD3D | CD3G | CD48 | CD52 | |
| CD53 | CD74 | CD86 | CD8A | CLEC4A | |
| CORO1A | CTSS | CXCL13 | DOCK10 | EVI2A | |
| EVI2B | FGL2 | FLJ78302 (CCR2) | FYB | GIMAP4 | |
| GIMAP5 | GIMAP6 | GMFG | GPR171 | GPR18 | |
| GPR65 | GZMA | GZMB | GZMK | hCG_1998957 | |
| HCLS1 | HLA-DMA | HLA-DMB | HLA-DPA1 | HLA-DQA1 | |
| HLA-DQA2 | HLA-DQB1 | HLA-DQB2 | HLA-DRB1 | HLA-DRB2 | |
| HLA-DRB3 | HLA-DRB4 | HLA-DRB5 | HLA-E | IGHM | |
| IGSF6 | IL10RA | IL2RG | IL7R | IRF8 | |
| KLRB1 | KLRK1 | LAPTM5 | LAT2 | LCK | |
| LCP2 | LOC100133484 | LOC100133583 | LOC100133661 | LOC100133811 | |
| LOC730415 | LPXN | LRMP | LST1 | LTB | |
| LY96 | LYZ | MFNG | MNDA | MS4A4A | |
| NCKAP1L | PLAC8 | PLEK | PRKCB1 | PSCDBP | |
| PTPRC | PTPRCAP | RAC2 | RNASE2 | RNASE6 | |
| SAMHD1 | SAMSN1 | SASH3 | SELL | SELPLG | |
| SLA | SLAMF1 | SLC7A7 | SP140 | SRGN | |
| TCL1A | TFEC | TNFAIP8 | TNFRSF1B | TRA@ | |
| TRAC | TRAJ17 | TRAT1 | TRAV20 | TRBC1 | |
| TYROBP | ZNF749 | ITM2A | LTB | P2RY13 | |
| PRKCB1 | PTPRCAP | SELL | TRBC1 | ||
| ITGA4 | CCL19 | ADAM28 | AIF1 | APOBEC3F | APOBEC3G |
| APOL3 | ARHGAP15 | ARHGAP25 | CASP1 | CCDC69 | |
| CCR2 | CCR7 | CD2 | CD247 | CD27 | |
| CD37 | CD3D | CD3G | CD48 | CD52 | |
| CD53 | CD74 | CD86 | CD8A | CLEC4A | |
| CORO1A | CTSS | CXCL13 | DOCK10 | EVI2A | |
| EVI2B | FGL2 | FLJ78302 (CCR2) | FYB | GIMAP4 | |
| GIMAP5 | GIMAP6 | GMFG | GPR171 | GPR18 | |
| GPR65 | GZMA | GZMB | GZMK | hCG_1998957 | |
| HCLS1 | HLA-DMA | HLA-DMB | HLA-DPA1 | HLA-DQA1 | |
| HLA-DQA2 | HLA-DQB1 | HLA-DQB2 | HLA-DRB1 | HLA-DRB2 | |
| HLA-DRB3 | HLA-DRB4 | HLA-DRB5 | HLA-E | IGHM | |
| IGSF6 | IL10RA | IL2RG | IL7R | IRF8 | |
| KLRB1 | KLRK1 | LAPTM5 | LAT2 | LCK | |
| LCP2 | LOC100133484 | LOC100133583 | LOC100133661 | LOC100133811 | |
| LOC730415 | LPXN | LRMP | LST1 | LTB | |
| LY96 | LYZ | MFNG | MNDA | MS4A4A | |
| NCKAP1L | PLAC8 | PLEK | PRKCB1 | PSCDBP | |
| PTPRC | PTPRCAP | RAC2 | RNASE2 | RNASE6 | |
| SAMHD1 | SAMSN1 | SASH3 | SELL | SELPLG | |
| SLA | SLAMF1 | SLC7A7 | SP140 | SRGN | |
| TCL1A | TFEC | TNFAIP8 | TNFRSF1B | TRA@ | |
| TRAC | TRAJ17 | TRAT1 | TRAV20 | TRBC1 | |
| TYROBP | ZNF749 | MARCH1 | C17orf60 | CSF1R | |
| FLI1 | FLJ78302 | FYN | IKZF1 | INPP5D | |
| NCF4 | NR3C1 | P2RY13 | PLXNC1 | PSCD4 | |
| PTPN22 | SERPINB9 | SLCO2B1 | VAMP3 | WIPF1 | |
| IDH2 | AEBP1 | DSG3 | HIST1H2BN | PCDHAC1 | |
| ARF1 | FABP5L2 | FLNB | IL1RN | PAX6 | |
| DICER1 | ARS2 | IGHA1 | VDAC3 | ||
| TFRC | RGS20 | ||||
| ADAM17 | TFDP3 | GPR107 | |||
| CAV1 | CAV2 | CXCL12 | IGF1 | ||
| CYR61 | CTGF | ||||
| ESR1 | CBLN1 | SLC45A2 | |||
| GSTM1 | GSTM2 | ||||
| GSTM2 | GSTM1 | ||||
| IL11 | FAM135A | ||||
| IL6ST | P2RY5 | ||||
| IGFBP7 | SPARCL1 | TMEM204 | |||
| INHBA | COL10A1 | FN1 | SULF1 | ||
| SPC25 | KIF4A | KIF20A | NCAPG | ||
| TAGLN | ACTA2 | MYL9 | NNMT | PTRF | |
| TGFB3 | GALNT10 | HTRA1 | LIMA1 | ||
| TNFRSF10B | BIN3 | ||||
| FOXA1 | CLCA2 | TFAP2B | AGR2 | MLPH | SPDEF |
| CXCL12 | DCN | CAV1 | IGF1 | CFH | |
| GBP2 | APOL1 | APOL3 | CD2 | CTSS | CXCL9 |
| CXCR6 | GBP1 | GZMA | HLA-DMA | HLA-DMB | |
| IL2RB | PTPRC | TRBC1 | |||
| S100A8 | S100A9 | ||||
| S100A9 | S100A8 | ||||
| MKI67 | BIRC5 | KIF20A | MCM10 | ||
| MTDH | ARMC1 | AZIN1 | ENY2 | MTERFD1 | POLR2K |
| PTDSS1 | RAD54B | SLC25A32 | TMEM70 | UBE2V2 | |
| GSTM1 | GSTM2 | ||||
| GSTM2 | GSTM1 | ||||
| CXCL12 | AKAP12 | DCN | F13A1 | ||
| TGFB3 | C10orf56 | JAM3 | |||
| TAGLN | ACTA2 | CALD1 | COPZ2 | FERMT2 | HEPH |
| MYL9 | NNMT | PTRF | TPM2 | ||
| PGF | ALMS1 | ATP8B1 | CEP27 | DBT | FAM128B |
| FBXW12 | FGFR1 | FLJ12151 | FLJ42627 | GTF2H3 | |
| HCG2P7 | KIAA0894 | KLHL24 | LOC152719 | PDE4C | |
| PODNL1 | POLR1B | PRDX2 | PRR11 | RIOK3 | |
| RP5-886K2.1 | SLC35E1 | SPN | USP34 | ZC3H7B | |
| ZNF160 | ZNF611 | ||||
| CCL19 | ARHGAP15 | ARHGAP25 | CCL5 | CCR2 | CCR7 |
| CD2 | CD37 | CD3D | CD48 | CD52 | |
| CSF2RB | FLJ78302 | GIMAP5 | GIMAP6 | GPR171 | |
| GZMK | IGHM | IRF8 | LCK | LTB | |
| PLAC8 | PRKCB1 | PTGDS | PTPRC | PTPRCAP | |
| SASH3 | TNFRSF1B | TRA@ | TRAC | TRAJ17 | |
| TRAV20 | TRBC1 | ||||
| IRF1 | ITGA4 | MARCH1 | AIF1 | APOBEC3F | APOBEC3G |
| APOL1 | APOL3 | ARHGAP15 | ARHGAP25 | BTN3A2 | |
| BTN3A3 | CASP1 | CCL4 | CCL5 | CD2 | |
| CD37 | CD3D | CD48 | CD53 | CD69 | |
| CD8A | CORO1A | CSF2RB | CST7 | CYBB | |
| EVI2A | EVI2B | FGL2 | FLI1 | GBP1 | |
| GIMAP4 | GIMAP5 | GIMAP6 | GMFG | GPR65 | |
| GZMA | GZMK | hCG_1998957 | HCLS1 | HLA-DMA | |
| HLA-DMB | HLA-DPA1 | HLA-DQB1 | HLA-DQB2 | HLA-DRA | |
| HLA-DRB1 | HLA-DRB2 | HLA-DRB3 | HLA-DRB4 | HLA-DRB5 | |
| HLA-E | HLA-F | IGSF6 | IL10RA | IL2RB | |
| IRF8 | KLRK1 | LCK | LCP2 | LOC100133583 | |
| LOC100133661 | LOC100133811 | LST1 | LTB | LY86 | |
| MFNG | MNDA | NKG7 | PLEK | PRKCB1 | |
| PSCDBP | PSMB10 | PSMB8 | PSMB9 | PTPRC | |
| PTPRCAP | RAC2 | RNASE2 | RNASE6 | SAMSN1 | |
| SLA | SRGN | TAP1 | TFEC | TNFAIP3 | |
| TNFRSF1B | TRA@ | TRAC | TRAJ17 | TRAV20 | |
| TRBC1 | TRIM22 | ZNF749 | |||
| ITGA4 | IRF1 | MARCH1 | AIF1 | APOBEC3F | APOBEC3G |
| APOL1 | APOL3 | ARHGAP15 | ARHGAP25 | BTN3A2 | |
| BTN3A3 | CASP1 | CCL4 | CCL5 | CD2 | |
| CD37 | CD3D | CD48 | CD53 | CD69 | |
| CD8A | CORO1A | CSF2RB | CST7 | CYBB | |
| EVI2A | EVI2B | FGL2 | FLI1 | GBP1 | |
| GIMAP4 | GIMAP5 | GIMAP6 | GMFG | GPR65 | |
| GZMA | GZMK | hCG_1998957 | HCLS1 | HLA-DMA | |
| HLA-DMB | HLA-DPA1 | HLA-DQB1 | HLA-DQB2 | HLA-DRA | |
| HLA-DRB1 | HLA-DRB2 | HLA-DRB3 | HLA-DRB4 | HLA-DRB5 | |
| HLA-E | HLA-F | IGSF6 | IL10RA | IL2RB | |
| IRF8 | KLRK1 | LCK | LCP2 | LOC100133583 | |
| LOC100133661 | LOC100133811 | LST1 | LTB | LY86 | |
| MFNG | MNDA | NKG7 | PLEK | PRKCB1 | |
| PSCDBP | PSMB10 | PSMB8 | PSMB9 | PTPRC | |
| PTPRCAP | RAC2 | RNASE2 | RNASE6 | SAMSN1 | |
| SLA | SRGN | TAP1 | TFEC | TNFAIP3 | |
| TNFRSF1B | TRA@ | TRAC | TRAJ17 | TRAV20 | |
| TRBC1 | TRIM22 | ZNF749 | CTSS | ||
| SPC25 | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | BUB1 | CCNB1 | |
| CENPA | KPNA2 | LMNB1 | MCM2 | MELK | |
| NDC80 | TPX2 | ||||
| AURKA | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | SPC25 | BIRC5 | BUB1 | CCNB1 | |
| CENPA | KPNA2 | LMNB1 | MCM2 | MELK | |
| NDC80 | TPX2 | PSMA7 | CSE1L | ||
| BIRC5 | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | SPC25 | BUB1 | CCNB1 | |
| CENPA | KPNA2 | LMNB1 | MCM2 | MELK | |
| NDC80 | TPX2 | MKI67 | |||
| BUB1 | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | SPC25 | CCNB1 | |
| CENPA | KPNA2 | LMNB1 | MCM2 | MELK | |
| NDC80 | TPX2 | ||||
| CCNB1 | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | BUB1 | SPC25 | |
| CENPA | KPNA2 | LMNB1 | MCM2 | MELK | |
| NDC80 | TPX2 | ||||
| CENPA | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | BUB1 | CCNB1 | |
| SPC25 | KPNA2 | LMNB1 | MCM2 | MELK | |
| NDC80 | TPX2 | ||||
| KPNA2 | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | BUB1 | CCNB1 | |
| CENPA | SPC25 | LMNB1 | MCM2 | MELK | |
| NDC80 | TPX2 | NOL11 | PSMD12 | ||
| LMNB1 | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | BUB1 | CCNB1 | |
| CENPA | KPNA2 | SPC25 | MCM2 | MELK | |
| NDC80 | TPX2 | ||||
| MCM2 | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | BUB1 | CCNB1 | |
| CENPA | KPNA2 | LMNB1 | SPC25 | MELK | |
| NDC80 | TPX2 | ||||
| MELK | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | BUB1 | CCNB1 | |
| CENPA | KPNA2 | LMNB1 | MCM2 | SPC25 | |
| NDC80 | TPX2 | ||||
| NDC80 | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | BUB1 | CCNB1 | |
| CENPA | KPNA2 | LMNB1 | MCM2 | MELK | |
| SPC25 | TPX2 | ||||
| TPX2 | ASPM | ATAD2 | AURKB | BUB1B | C12orf48 |
| CCNA2 | CCNE1 | CCNE2 | CDC2 | CDC45L | |
| CDC6 | CDCA3 | CDCA8 | CDKN3 | CENPE | |
| CENPF | CENPN | CEP55 | CHEK1 | CKS1B | |
| CKS2 | DBF4 | DEPDC1 | DLG7 | DNAJC9 | |
| DONSON | E2F8 | ECT2 | ERCC6L | FAM64A | |
| FBXO5 | FEN1 | FOXM1 | GINS1 | GTSE1 | |
| H2AFZ | HJURP | HMMR | KIF11 | KIF14 | |
| KIF15 | KIF18A | KIF20A | KIF23 | KIF2C | |
| KIF4A | KIFC1 | MAD2L1 | MCM10 | MCM6 | |
| NCAPG | NEK2 | NUSAP1 | OIP5 | PBK | |
| PLK4 | PRC1 | PTTG1 | RACGAP1 | RAD51AP1 | |
| RFC4 | SMC2 | STIL | STMN1 | TACC3 | |
| top2A | TRIP 13 | TTK | TYMS | UBE2C | |
| UBE2S | AURKA | BIRC5 | BUB1 | CCNB1 | |
| CENPA | KPNA2 | LMNB1 | MCM2 | MELK | |
| NDC80 | SPC25 | ||||
| CDH11 | INHBA | WISP1 | COL1A1 | COL1A2 | FN1 |
| ADAM12 | AEBP1 | ANGPTL2 | ASPN | BGN | |
| BNC2 | C1QTNF3 | COL10A1 | COL11A1 | COL3A1 | |
| COL5A1 | COL5A2 | COL5A3 | COL6A3 | COMP | |
| CRISPLD2 | CTSK | DACT1 | DCN | DKK3 | |
| DPYSL3 | EFEMP2 | EMILIN1 | FAP | FBN1 | |
| FSTL1 | GLT8D2 | HEG1 | HTRA1 | ITGBL1 | |
| JAM3 | KIAA1462 | LAMA4 | LOX | LOXL1 | |
| LRP1 | LRRC15 | LRRC17 | LRRC32 | LUM | |
| MFAP5 | MICAL2 | MMP11 | MMP2 | MXRA5 | |
| MXRA8 | NID2 | NOX4 | OLFML2B | PCOLCE | |
| PDGFRB | PLAU | POSTN | SERPINF1 | SPARC | |
| SPOCK1 | SPON1 | SRPX2 | SULF1 | TCF4 | |
| THBS2 | THY1 | VCAN | ZEB1 | ||
| INHBA | CDH11 | WISP1 | COL1A1 | COL1A2 | FN1 |
| ADAM12 | AEBP1 | ANGPTL2 | ASPN | BGN | |
| BNC2 | C1QTNF3 | COL10A1 | COL11A1 | COL3A1 | |
| COL5A1 | COL5A2 | COL5A3 | COL6A3 | COMP | |
| CRISPLD2 | CTSK | DACT1 | DCN | DKK3 | |
| DPYSL3 | EFEMP2 | EMILIN1 | FAP | FBN1 | |
| FSTL1 | GLT8D2 | HEG1 | HTRA1 | ITGBL1 | |
| JAM3 | KIAA1462 | LAMA4 | LOX | LOXL1 | |
| LRP1 | LRRC15 | LRRC17 | LRRC32 | LUM | |
| MFAP5 | MICAL2 | MMP11 | MMP2 | MXRA5 | |
| MXRA8 | NID2 | NOX4 | OLFML2B | PCOLCE | |
| PDGFRB | PLAU | POSTN | SERPINF1 | SPARC | |
| SPOCK1 | SPON1 | SRPX2 | SULF1 | TCF4 | |
| THBS2 | THY1 | VCAN | ZEB1 | ||
| WISP1 | INHBA | CDH11 | COL1A1 | COL1A2 | FN1 |
| ADAM12 | AEBP1 | ANGPTL2 | ASPN | BGN | |
| BNC2 | C1QTNF3 | COL10A1 | COL11A1 | COL3A1 | |
| COL5A1 | COL5A2 | COL5A3 | COL6A3 | COMP | |
| CRISPLD2 | CTSK | DACT1 | DCN | DKK3 | |
| DPYSL3 | EFEMP2 | EMILIN1 | FAP | FBN1 | |
| FSTL1 | GLT8D2 | HEG1 | HTRA1 | ITGBL1 | |
| JAM3 | KIAA1462 | LAMA4 | LOX | LOXL1 | |
| LRP1 | LRRC15 | LRRC17 | LRRC32 | LUM | |
| MFAP5 | MICAL2 | MMP11 | MMP2 | MXRA5 | |
| MXRA8 | NID2 | NOX4 | OLFML2B | PCOLCE | |
| PDGFRB | PLAU | POSTN | SERPINF1 | SPARC | |
| SPOCK1 | SPON1 | SRPX2 | SULF1 | TCF4 | |
| THBS2 | THY1 | VCAN | ZEB1 | ||
| COL1A1 | INHBA | WISP1 | CDH11 | COL1A2 | FN1 |
| ADAM12 | AEBP1 | ANGPTL2 | ASPN | BGN | |
| BNC2 | C1QTNF3 | COL10A1 | COL11A1 | COL3A1 | |
| COL5A1 | COL5A2 | COL5A3 | COL6A3 | COMP | |
| CRISPLD2 | CTSK | DACT1 | DCN | DKK3 | |
| DPYSL3 | EFEMP2 | EMILIN1 | FAP | FBN1 | |
| FSTL1 | GLT8D2 | HEG1 | HTRA1 | ITGBL1 | |
| JAM3 | KIAA1462 | LAMA4 | LOX | LOXL1 | |
| LRP1 | LRRC15 | LRRC17 | LRRC32 | LUM | |
| MFAP5 | MICAL2 | MMP11 | MMP2 | MXRA5 | |
| MXRA8 | NID2 | NOX4 | OLFML2B | PCOLCE | |
| PDGFRB | PLAU | POSTN | SERPINF1 | SPARC | |
| SPOCK1 | SPON1 | SRPX2 | SULF1 | TCF4 | |
| THBS2 | THY1 | VCAN | ZEB1 | ||
| COL1A2 | INHBA | WISP1 | COL1A1 | CDH11 | FN1 |
| ADAM12 | AEBP1 | ANGPTL2 | ASPN | BGN | |
| BNC2 | C1QTNF3 | COL10A1 | COL11A1 | COL3A1 | |
| COL5A1 | COL5A2 | COL5A3 | COL6A3 | COMP | |
| CRISPLD2 | CTSK | DACT1 | DCN | DKK3 | |
| DPYSL3 | EFEMP2 | EMILIN1 | FAP | FBN1 | |
| FSTL1 | GLT8D2 | HEG1 | HTRA1 | ITGBL1 | |
| JAM3 | KIAA1462 | LAMA4 | LOX | LOXL1 | |
| LRP1 | LRRC15 | LRRC17 | LRRC32 | LUM | |
| MFAP5 | MICAL2 | MMP11 | MMP2 | MXRA5 | |
| MXRA8 | NID2 | NOX4 | OLFML2B | PCOLCE | |
| PDGFRB | PLAU | POSTN | SERPINF1 | SPARC | |
| SPOCK1 | SPON1 | SRPX2 | SULF1 | TCF4 | |
| THBS2 | THY1 | VCAN | ZEB1 | ||
| FN1 | INHBA | WISP1 | COL1A1 | COL1A2 | CDH11 |
| ADAM12 | AEBP1 | ANGPTL2 | ASPN | BGN | |
| BNC2 | C1QTNF3 | COL10A1 | COL11A1 | COL3A1 | |
| COL5A1 | COL5A2 | COL5A3 | COL6A3 | COMP | |
| CRISPLD2 | CTSK | DACT1 | DCN | DKK3 | |
| DPYSL3 | EFEMP2 | EMILIN1 | FAP | FBN1 | |
| FSTL1 | GLT8D2 | HEG1 | HTRA1 | ITGBL1 | |
| JAM3 | KIAA1462 | LAMA4 | LOX | LOXL1 | |
| LRP1 | LRRC15 | LRRC17 | LRRC32 | LUM | |
| MFAP5 | MICAL2 | MMP11 | MMP2 | MXRA5 | |
| MXRA8 | NID2 | NOX4 | OLFML2B | PCOLCE | |
| PDGFRB | PLAU | POSTN | SERPINF1 | SPARC | |
| SPOCK1 | SPON1 | SRPX2 | SULF1 | TCF4 | |
| THBS2 | THY1 | VCAN | ZEB1 | ||
- <110> Genomic Health, Inc. BAKER, JOFFRE B. Cronin, Maureen T. Collin, Francois Liu, Mei-Lan
- <120> Methods To Predict Clinical Outcome Of Cancer
- <130> GHDX-040WO
- <150> US 61/263,763 <151> 2009-11-23
- <160> 1536
- <170> FastSEQ for Windows Version 4.0
- <210> 1 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 1 cgttccgatc ctctatactg cat 23
- <210> 2 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 2 gtgtggcagg tggacactaa 20
- <210> 3 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 3 aaacaccact ggagcattga 20
- <210> 4 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 4 accagtgcca caatgcag 18
- <210> 5 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 5 tgcagactgt accatgctga 20
- <210> 6 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 6 acacgtctgt caccatggaa 20
- <210> 7 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 7 atccgcattg aagaccca 18
- <210> 8 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 8 gactgtctcg tttccctggt 20
- <210> 9 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 9 tcaaaagtac ggacacctcc t 21
- <210> 10 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 10 gagcatgcgt ctactgcct 19
- <210> 11 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 11 gaagtgccag gaggcgatta 20
- <210> 12 <211> 19
- <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 12 caaggcccca tctgaatca 19
- <210> 13 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 13 gcgagttcaa agtgttcgag 20
- <210> 14 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 14 taagccacaa gcacacgg 18
- <210> 15 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 15 acgagatgtc ctacggcttg a 21
- <210> 16 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 16 agccaacatg tgactaattg ga 22
- <210> 17 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 17 ctgcatgtga ttgaataaga aacaaga 27
- <210> 18 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 18 gtggaaacgg agctcttcc 19
- <210> 19 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 19 ttgtctctgc cttggactat ctaca 25
- <210> 20 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 20 gaggaatatg gaatccaagg g 21
- <210> 21 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 21 ggacagggta agaccgtgat 20
- <210> 22 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 22 ccgtgaaagc tgctctgtaa 20
- <210> 23 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 23 caagacacta agggcgacta cca 23
- <210> 24 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 24 gactgcaaag atggaaacga 20
- <210> 25 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 25 gatgaagcct ttcgcaagtt 20
- <210> 26 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 26 gtttatgcca tcggcacc 18
- <210> 27 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 27 cagtagagat ccccgcaact 20
- <210> 28 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 28 atcagagatt accgcgtcgt 20
- <210> 29 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 29 gactgggtca gtgatggca 19
- <210> 30 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 30 tccctgagaa cgaaaccact 20
- <210> 31 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 31 agctgcagaa gagctgcaca t 21
- <210> 32 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 32 cagcagatgt ggatcagcaa g 21
- <210> 33 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 33 ggctcttgtg cgtactgtcc tt 22
- <210> 34 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 34 gggtcaggtg cctcgagat 19
- <210> 35 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 35 cgttgtcagc acttggaata caa 23
- <210> 36 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 36 cctacggccg ctactacg 18
- <210> 37 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 37 gactcctcag ggcagacttt ctt 23
- <210> 38 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 38 ccgccgtgga cacagact 18
- <210> 39 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 39 cctggagggt cctgtacaat 20
- <210> 40 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 40 actgacaaga ccagcagcat 20
- <210> 41 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 41 tgacttccta gttcgtgact ctctgt 26
- <210> 42 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 42 ccccgagaca acggagataa 20
- <210> 43 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 43 cagatggacc tagtacccac tgaga 25
- <210> 44 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 44 aacccacccc tgtcttgg 18
- <210> 45 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 45 gagctccgca aggatgac 18
- <210> 46 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 46 attcctatgg ctctgcaatt gtc 23
- <210> 47 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 47 ctggacggag tagctccaag 20
- <210> 48 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 48 aattttatga gggccacgg 19
- <210> 49 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 49 gttgggacac agttggtctg 20
- <210> 50 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 50 ccgaggttaa tccagcacgt a 21
- <210> 51 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 51 tcaacagaag gctgaaccac taga 24
- <210> 52 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 52 ctgaagcaga tggttcatca tt 22
- <210> 53 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 53 gaggcaactg cttatggctt aatta 25
- <210> 54 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 54 caagagcaga gccaccgt 18
- <210> 55 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 55 gtgactgcac aggactctgg 20
- <210> 56 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 56 tcagctgtga gctgcggata 20
- <210> 57 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 57 gcggtatcag gaatttcaac ct 22
- <210> 58 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 58 ctacgagtca gcccatccat 20
- <210> 59 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 59 tgatgctgca gagaacttcc 20
- <210> 60 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 60 atccattcga tctcaccaag gt 22
- <210> 61 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 61 gtggctcaac attgtgttcc 20
- <210> 62 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 62 aggggatggt ctctgtcatt 20
- <210> 63 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 63 gaacgcatca tccagagact g 21
- <210> 64 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 64 agcagacagt ggtcagtcct t 21
- <210> 65 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 65 aggttctgag ctctggcttt 20
- <210> 66 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 66 ttcaggttgt tgcaggagac 20
- <210> 67 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 67 cctctgtgct acagattata cctttgc 27
- <210> 68 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 68 ggtcaccaag aaacatcagt atgaa 25
- <210> 69 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 69 cagactgaat gggggtgg 18
- <210> 70 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 70 ggatgacatg cactcagctc 20
- <210> 71 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 71 ggagtggaag gaactggaaa 20
- <210> 72 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 72 tccaactaat gccaccacca a 21
- <210> 73 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 73 gtgctggagt cgggactaac 20
- <210> 74 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 74 atcaccgaca gcacagaca 19
- <210> 75 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 75 gacgaagaca gtccctggat 20
- <210> 76 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 76 ctcataccag ccatccaatg 20
- <210> 77 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 77 tggttcccag ccctgtgt 18
- <210> 78 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 78 gtgcaggctc aggtgaagtg 20
- <210> 79 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 79 tggattggag ttctgggaat g 21
- <210> 80 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 80 tcttgctggc tacgcctctt 20
- <210> 81 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 81 ggtgagcaga agtggcctat 20
- <210> 82 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 82 gcagtccgct gtgttcaa 18
- <210> 83 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 83 gagctgaaag acgcacactg 20
- <210> 84 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 84 cggagaaggg caccagta 18
- <210> 85 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 85 gtcggcagaa gcaggact 18
- <210> 86 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 86 acccatgtac cgtcctcg 18
- <210> 87 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 87 ccttcccatc agcacagttc 20
- <210> 88 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 88 aagccctatc cgatgtaccc 20
- <210> 89 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 89 tggatctcta ccagcaatgt g 21
- <210> 90 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 90 acttgcctgt tcagagcact ca 22
- <210> 91 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 91 ttggttttgc tcggatactt g 21
- <210> 92 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 92 tgacaatcag cacacctgca t 21
- <210> 93 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 93 taaattcact cgtggtgtgg a 21
- <210> 94 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 94 ctgaaggagc tccaagacct 20
- <210> 95 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 95 ccagaatgca cgctacagga a 21
- <210> 96 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 96 ccaccatagg cagaggca 18
- <210> 97 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 97 gaggccagtg gtggaaacag 20
- <210> 98 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 98 aaggaagtgg tccctctgtg 20
- <210> 99 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 99 agaatgggtg tgaaggcg 18
- <210> 100 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 100 ggctggacgt ggttttgtct 20
- <210> 101 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 101 ggctgctttg ctgcaactg 19
- <210> 102 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 102 cggtacttga gcaatgccta 20
- <210> 103 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 103 ccccaggata cctaccacta cct 23
- <210> 104 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 104 aaatcgcagc ttatcacaag g 21
- <210> 105 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 105 gtggccatcc agctgacc 18
- <210> 106 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 106 cagccaagaa ctggtatagg agct 24
- <210> 107 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 107 ccttatcggc tggaacgagt t 21
- <210> 108 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 108 cgacagttgc gatgaaagtt ctaa 24
- <210> 109 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 109 atgcccagtg ttcctgactt 20
- <210> 110 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 110 gatgtgattg aggtgcatgg 20
- <210> 111 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 111 aagtcctgaa attgcgatca 20
- <210> 112 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 112 cagcaagaac tgcaacaaca 20
- <210> 113 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 113 tgcagcggct gattgaca 18
- <210> 114 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 114 gagcacaacc aaacctacga 20
- <210> 115 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 115 taccacaccc agcattcctc 20
- <210> 116 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 116 cctgaacatg aaggagctga 20
- <210> 117 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 117 gagttcaagt gccctgacg 19
- <210> 118 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 118 gctcacttcg gctaaaatgc 20
- <210> 119 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 119 gtacatgatc ccctgtgaga aggt 24
- <210> 120 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 120 tgtctcactg agcgagcaga a 21
- <210> 121 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 121 accaggcaat aacctaacag c 21
- <210> 122 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 122 ggagcaaaat cgatgcagt 19
- <210> 123 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 123 gagctacaga tgcccatgc 19
- <210> 124 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 124 tgcgcccttt cctctgta 18
- <210> 125 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 125 tgaccgcttc taccccaatg 20
- <210> 126 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 126 ccggagtgac tctatcacca 20
- <210> 127 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 127 tccttatagg tactttcagc catttg 26
- <210> 128 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 128 ccagctttgt gcctgtcact at 22
- <210> 129 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 129 tgctcattct tgaggagcat 20
- <210> 130 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 130 tggtgggtct aggtggtgta 20
- <210> 131 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 131 aaatgtcctc ctcgactgct 20
- <210> 132 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 132 ggtcaccgtt ggtgtcatca 20
- <210> 133 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 133 atggagatgt ggtcattcct agtg 24
- <210> 134 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 134 gccgccacaa gactaaggaa t 21
- <210> 135 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 135 tccaattcca gcatcactgt 20
- <210> 136 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 136 gattcagacg aggatgagcc 20
- <210> 137 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 137 cacggaggta taaggcagga g 21
- <210> 138 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 138 ctctgagaca gtgcttcgat gact 24
- <210> 139 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 139 tggcactact gcatgattga ca 22
- <210> 140 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 140 aaatcgctgg gaacaagtg 19
- <210> 141 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 141 agacatcagc tcctggttca 20
- <210> 142 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 142 tggtgacgat ggaggagc 18
- <210> 143 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 143 actccctcta cccttgagca 20
- <210> 144 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 144 ctgctggatg accttcctc 19
- <210> 145 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 145 tgccacctgg acatcatttg 20
- <210> 146 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 146 cgacaaggag tgcgtctact tct 23
- <210> 147 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 147 tttcctcaaa tttgcctcaa g 21
- <210> 148 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 148 actgtgaact gcctggtgc 19
- <210> 149 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 149 cgagtggaga ctggtgttct c 21
- <210> 150 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 150 atggactcca cagagccg 18
- <210> 151 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 151 ttgaacagag cctgaccaag 20
- <210> 152 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 152 gtccccgctg cagatctct 19
- <210> 153 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 153 ccatgtggat gaatgaggtg 20
- <210> 154 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 154 ggcggtgaag agtcacagt 19
- <210> 155 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 155 tcgagggcaa gaagagcaa 19
- <210> 156 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 156 gctagtactt tgatgctccc ttgat 25
- <210> 157 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 157 caaggccgtg aacgagaagt 20
- <210> 158 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 158 agccccagca actacagtct 20
- <210> 159 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 159 gggccctcca gaacaatgat 20
- <210> 160 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 160 cgcctgttca ccaagattga c 21
- <210> 161 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 161 caaccaggca gctccatc 18
- <210> 162 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 162 tgaacggggt atcctcctta 20
- <210> 163 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 163 tggtccatcg ccagttatca 20
- <210> 164 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 164 tggctcttaa tcagtttcgt tacct 25
- <210> 165 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 165 gtccaggtgg atgtgaaaga 20
- <210> 166 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 166 ccaacactag gctcccca 18
- <210> 167 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 167 ggcattgagc ctctctacat ca 22
- <210> 168 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 168 gtcactccgc caccgtag 18
- <210> 169 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 169 acccccagac cggatcag 18
- <210> 170 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 170 ccagcaccat tgttgaagat 20
- <210> 171 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 171 cgtggtgccc ctctatgac 19
- <210> 172 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 172 accatgtatc gagaggggc 19
- <210> 173 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 173 tggaaacagc gaaggataca 20
- <210> 174 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 174 gtgaaggatg tgaagcagac gta 23
- <210> 175 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 175 ctgaccagaa ccacggct 18
- <210> 176 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 176 gcctcttcct gttcgacg 18
- <210> 177 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 177 gagggactgt tggcatgca 19
- <210> 178 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 178 ctggcttaag gatggacagg 20
- <210> 179 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 179 ccagtggagc gcttccat 18
- <210> 180 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 180 gacatctgcg ctccatcc 18
- <210> 181 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 181 ggaagtgaca gacgtgaagg t 21
- <210> 182 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 182 cgagcccttt gatgacttcc t 21
- <210> 183 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 183 gagaacaagc agggctgg 18
- <210> 184 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 184 tgaagtccag gacgatgatg 20
- <210> 185 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 185 cgacagagct tgtgcacct 19
- <210> 186 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 186 ctgtttgctg tccggagg 18
- <210> 187 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 187 ccagctgcta ctttgacatc ga 22
- <210> 188 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 188 ggataattca gacaacaaca ccatct 26
- <210> 189 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 189 gaagcgcaga tcatgaagaa 20
- <210> 190 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 190 tcagcagcaa gggcatcat 19
- <210> 191 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 191 tgtttggagg gaagggct 18
- <210> 192 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 192 gtgctggtga cgaatcca 18
- <210> 193 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 193 accctcgaca agaccacact 20
- <210> 194 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 194 attccaccca tggcaaattc 20
- <210> 195 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 195 caaaggagct cactgtggtg tct 23
- <210> 196 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 196 ttgggaaata tttgggcatt 20
- <210> 197 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 197 gcatgggaac catcaacca 19
- <210> 198 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 198 tgtagaatca aactcttcat catcaactag 30
- <210> 199 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 199 cgctccagac ctatgatgac t 21
- <210> 200 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 200 gatcccaagg cccaactc 18
- <210> 201 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 201 gttcactggg ggtgtatgg 19
- <210> 202 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 202 tgtcatgtac gacggcttct 20
- <210> 203 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 203 gttcgctacg aggattgagc 20
- <210> 204 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 204 ttctggacct gggaccttag 20
- <210> 205 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 205 cgtgcctcta caccatcttc 20
- <210> 206 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 206 agtacaagca ggctgccaag 20
- <210> 207 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 207 gcttatgacc gaccccaa 18
- <210> 208 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 208 cacacagatc tcctactcca tcca 24
- <210> 209 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 209 ctgagtgtgg tttgcggat 19
- <210> 210 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 210 ccatctgcat ccatcttgtt 20
- <210> 211 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 211 cagatgacaa tggccacaat 20
- <210> 212 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 212 tgcttaggtg cggtaaaacc a 21
- <210> 213 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 213 ccccaggcac cagcttta 18
- <210> 214 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 214 tgcccccaag acactgtgt 19
- <210> 215 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 215 aagctatgag gaaaagaagt acacgat 27
- <210> 216 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 216 ctgggctgtg aggctgaga 19
- <210> 217 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 217 ctgcaggcac tccctgaaat 20
- <210> 218 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 218 caatgccatc ttgcgctaca t 21
- <210> 219 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 219 caccatcccc accctgtct 19
- <210> 220 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 220 cccactcagt agccaagtca 20
- <210> 221 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 221 ccaaacgtgt aacaattatg cc 22
- <210> 222 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 222 caagtaccac agcgatgact acattaa 27
- <210> 223 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 223 tcctgtgctc tggaagcc 18
- <210> 224 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 224 cggtgtgaga agtgcagcaa 20
- <210> 225 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 225 gaaagatagc tcgcggca 18
- <210> 226 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 226 caggacacaa gtgccagatt 20
- <210> 227 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 227 tccatgatgg ttctgcaggt t 21
- <210> 228 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 228 tggcctgtcc attggtgat 19
- <210> 229 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 229 tccaggatgt taggaactgt gaag 24
- <210> 230 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 230 agcaggagcg accaactga 19
- <210> 231 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 231 gcagcagtcg gcttctct 18
- <210> 232 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 232 agtgacagat ggacaatgca aga 23
- <210> 233 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 233 tcccttgtgt tccttctgtg aa 22
- <210> 234 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 234 cgtgccttat ggttactttg g 21
- <210> 235 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 235 cagcctcaag ttcggttttc 20
- <210> 236 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 236 ctggaccgca cggacatc 18
- <210> 237 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 237 gctttccaag tggggaatta 20
- <210> 238 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 238 cagtctcgcc atgttgaagt 20
- <210> 239 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 239 ctgctgcgac agtccacta 19
- <210> 240 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 240 ggtccgcttc gtctttcga 19
- <210> 241 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 241 ttcagtgtgt ccagtgcatc 20
- <210> 242 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 242 ggctagtaga actggatccc aaca 24
- <210> 243 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 243 cctccctctg gtggtgctt 19
- <210> 244 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 244 ccgactggag gagcataaa 19
- <210> 245 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 245 gaataccaca ctttctgcta caacact 27
- <210> 246 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 246 gcagacagtg accatctaca gctt 24
- <210> 247 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 247 agaaccgcaa ggtgagcaa 19
- <210> 248 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 248 tggcctggct cttaatttg 19
- <210> 249 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 249 ggtggagagt ggagccatga 20
- <210> 250 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 250 gcatggtagc cgaagatttc a 21
- <210> 251 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 251 ccgtgcttcc ggacaactt 19
- <210> 252 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 252 tgaaccgcag agaccaacag 20
- <210> 253 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 253 gggtcactat ggagttcaaa gga 23
- <210> 254 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 254 gcctcccata gctccttacc 20
- <210> 255 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 255 aaggaaccat ctcactgtgt gtaaac 26
- <210> 256 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 256 ggcgctgtca tcgatttctt 20
- <210> 257 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 257 tggaaggttc cacaagtcac 20
- <210> 258 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 258 accctctggt ggtaaatgga 20
- <210> 259 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 259 ggcctaatgt tccagatcct 20
- <210> 260 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 260 actttcctgc gaggtcagtc 20
- <210> 261 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 261 gtgcccgagc catatagca 19
- <210> 262 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 262 agtccagccg agatgctaag 20
- <210> 263 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 263 ccacagctca ccttctgtca 20
- <210> 264 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 264 ccatgatcct cactctgctg 20
- <210> 265 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 265 caacgcttca gtgatcaatc c 21
- <210> 266 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 266 aggccagccc tacattatca 20
- <210> 267 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 267 cagtgacaaa cagcccttcc 20
- <210> 268 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 268 actcggactg cacaagctat t 21
- <210> 269 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 269 tcagaattgg atttggctca 20
- <210> 270 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 270 accggggagc cctacatga 19
- <210> 271 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 271 caaggtgccc tcagtgga 18
- <210> 272 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 272 tcgtgaaaga tgaccaggag 20
- <210> 273 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 273 tggcttacac tggcaatgg 19
- <210> 274 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 274 ctgtcagctg ctgcttgg 18
- <210> 275 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 275 cggactttgg gtgcgactt 19
- <210> 276 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 276 aagcccgagg cactcatt 18
- <210> 277 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 277 gctgggaggc aggacttc 18
- <210> 278 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 278 gagctccatg gctcatcc 18
- <210> 279 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 279 tctcttgcag gaagccaga 19
- <210> 280 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 280 aattcctgct ccaaaagaaa gtctt 25
- <210> 281 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 281 caccccggct tcaacaac 18
- <210> 282 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 282 gacgtgaggg tcctgattct 20
- <210> 283 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 283 catcctcatg gattggtgtg 20
- <210> 284 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 284 ccacctcgcc atgatttttc 20
- <210> 285 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 285 atgtgccagt gagcttgagt 20
- <210> 286 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 286 tgatggtcca aatgaacgaa 20
- <210> 287 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 287 cttgctggcc aatgccta 18
- <210> 288 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 288 cagatgaggc acatggagac 20
- <210> 289 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 289 ctcctggcca acagcact 18
- <210> 290 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 290 caaggagact gggaggtgtc 20
- <210> 291 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 291 actgaccaag cctgagacct 20
- <210> 292 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 292 actcaagcgg aaattgaagc a 21
- <210> 293 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 293 agcgatgaag atggtcgc 18
- <210> 294 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 294 agcggaaaat ggcagacaat 20
- <210> 295 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 295 gcttcaggtg ttgtgactgc 20
- <210> 296 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 296 tgaacagtaa tggggagctg 20
- <210> 297 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 297 tgcaaacgct ggtgtcaca 19
- <210> 298 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 298 ccaatgggag aacaacgg 18
- <210> 299 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 299 ctgcaacacc gaagtggac 19
- <210> 300 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 300 agaccaagct ggaagcagag 20
- <210> 301 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 301 acatccaggg ctctgtgg 18
- <210> 302 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 302 gacctggcct tgctgaag 18
- <210> 303 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 303 agaagctgtc cctgcaagag 20
- <210> 304 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 304 gacttttgcc cgctaccttt c 21
- <210> 305 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 305 aggatcgcct gtcagaagag 20
- <210> 306 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 306 gtgaaatgaa acgcaccaca 20
- <210> 307 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 307 acggatctac cacaccattg c 21
- <210> 308 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 308 gggagatcat cgggacaact c 21
- <210> 309 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 309 ccaacgcttg ccaaatcct 19
- <210> 310 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 310 ccatgatgga gaggcagaca 20
- <210> 311 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 311 ggatggtagc agtctaggga ttaact 26
- <210> 312 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 312 tcacctctca tcttcaccag gat 23
- <210> 313 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 313 ccatacgtgc tgctacctgt 20
- <210> 314 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 314 cgagagtctg taggagggaa acc 23
- <210> 315 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 315 tcatggtgcc cgtcaatg 18
- <210> 316 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 316 tcatcctggc gatctacttc ct 22
- <210> 317 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 317 tgagaaacaa actgcaccca 20
- <210> 318 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 318 gatgcagaat tgaggcagac 20
- <210> 319 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 319 gctcgtggtt ctgtagtcca 20
- <210> 320 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 320 gaaggaatgg gaatcagtca tga 23
- <210> 321 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 321 gccgagatcg ccaagatg 18
- <210> 322 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 322 tggttttgag accacgatgt 20
- <210> 323 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 323 taactgacat tcttgagcac cagat 25
- <210> 324 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 324 cgagactctc ctcatagtga aaggtat 27
- <210> 325 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 325 caaccgaagt tttcactcca gtt 23
- <210> 326 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 326 gcggaaggtc cctcagaca 19
- <210> 327 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 327 ccgcaacgtg gttttctca 19
- <210> 328 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 328 gtggttttcc ctcggagc 18
- <210> 329 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 329 gcatcaggct gtcattatgg 20
- <210> 330 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 330 aggactggga cccatgaac 19
- <210> 331 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 331 tggctaagtg aagatgacaa tcatg 25
- <210> 332 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 332 aatatttgtg cggggtatgg 20
- <210> 333 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 333 aagcatgaac aggacttgac c 21
- <210> 334 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 334 gcaaggaaag ggtcttagtc ac 22
- <210> 335 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 335 gaaacctctg cgccatga 18
- <210> 336 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 336 ccattctatc atcaacgggt acaa 24
- <210> 337 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 337 gttctggttg ctggatttgg 20
- <210> 338 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 338 tcaccacggt ctttagcca 19
- <210> 339 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 339 gggctactgg cagctacatt 20
- <210> 340 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 340 cagcgggatt aaacagtcct 20
- <210> 341 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 341 aacagagaca ttgccaacca 20
- <210> 342 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 342 acaccaaaat gccatctcaa 20
- <210> 343 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 343 tggctgtgct ggtcactacc t 21
- <210> 344 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 344 gactgctgtc atggcgtg 18
- <210> 345 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 345 cctgctgacg atgatgaagg a 21
- <210> 346 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 346 actccctgat aaaggggaat tt 22
- <210> 347 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 347 caccctgcct ctacccaac 19
- <210> 348 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 348 catggccgtg tagaccctaa 20
- <210> 349 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 349 accctgagca ctggaggaa 19
- <210> 350 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 350 agacaaggat gccgtggata a 21
- <210> 351 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 351 gcagaactga agatgggaag at 22
- <210> 352 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 352 cgcgagcccc tcattataca 20
- <210> 353 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 353 caagctgaac ggtgtgtcc 19
- <210> 354 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 354 agctggggtg tctgtttcat 20
- <210> 355 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 355 agaggctgaa tatgcaggac a 21
- <210> 356 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 356 agttgcagaa tctaagcctg gaa 23
- <210> 357 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 357 atggccaatg tttgatgct 19
- <210> 358 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 358 cccaatcgga agcctaacta 20
- <210> 359 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 359 catcttccag gaggaccact 20
- <210> 360 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 360 aatacccaac gcacaaatga 20
- <210> 361 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 361 cctggaggct gcaacatacc 20
- <210> 362 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 362 tgttttgatt cccgggctta 20
- <210> 363 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 363 tctccagcaa aagcgatgtc t 21
- <210> 364 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 364 gatggagcag gtggctcagt 20
- <210> 365 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 365 cagccctgag gcaagaga 18
- <210> 366 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 366 gccaactgct ttcatttgtg 20
- <210> 367 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 367 accagtcccc cagaagacta 20
- <210> 368 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 368 ggatcgagct cttccagatc ct 22
- <210> 369 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 369 aacaccaatg ggttccatct 20
- <210> 370 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 370 ctacctgcct tgctttgtga 20
- <210> 371 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 371 ccagcccaca gaccagtta 19
- <210> 372 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 372 tggcgaccaa gacacctt 18
- <210> 373 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 373 catatcgttg gatcacagca c 21
- <210> 374 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 374 gcgctgcgga agatcatc 18
- <210> 375 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 375 gagtcgaccc tgcacctg 18
- <210> 376 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 376 tggcttcagg agctgaatac c 21
- <210> 377 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 377 tgcccttaaa ggaaccaatg a 21
- <210> 378 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 378 agtcaatctt cgcacacgg 19
- <210> 379 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 379 ctctccagtg tgggcacc 18
- <210> 380 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 380 agaggcatcc atgaacttca ca 22
- <210> 381 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 381 gtatcaggac cacatgcagt acatc 25
- <210> 382 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 382 tgtcttcagg gtcttgtcca 20
- <210> 383 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 383 atcgcagctg gtgggtgtac 20
- <210> 384 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic primer
- <400> 384 gtggacatcg gatacccaag 20
- <210> 385 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 385 aggtccctgt tggccttata gg 22
- <210> 386 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 386 ctccatccac tccaggtctc 20
- <210> 387 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 387 caagcctgga acctatagcc 20
- <210> 388 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 388 atagcgctga ccactgcc 18
- <210> 389 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 389 ggccagcacc ataatcctat 20
- <210> 390 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 390 actagggtgc tccgagtgac 20
- <210> 391 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 391 atccgctaga actgcaccac 20
- <210> 392 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 392 tgggcttaga tgcttgactc 20
- <210> 393 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 393 tgcaaatgct ttgatggaat 20
- <210> 394 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 394 ctggtcacgg tctccatgt 19
- <210> 395 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 395 cgggcactca ctgctattac c 21
- <210> 396 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 396 acccagaatc caacagtgca a 21
- <210> 397 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 397 cacagatggc cagtgtttct 20
- <210> 398 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 398 tgggcgccta aatcctaa 18
- <210> 399 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 399 gggcacaaat cccgttcag 19
- <210> 400 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 400 tctgatctcc atctgcctca 20
- <210> 401 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 401 tgtggacctg atccctgtac ac 22
- <210> 402 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 402 ccagagggtt gaaggcatag 20
- <210> 403 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 403 ccagcattag attctccaac ttga 24
- <210> 404 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 404 gtggcggaga tcaagagg 18
- <210> 405 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 405 aaccggaaga agtcgatgag 20
- <210> 406 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 406 ttgcagtggg aagaacagtc 20
- <210> 407 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 407 cgtgtcgggc ttcagtcat 19
- <210> 408 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 408 tagccataag gtccgctctc 20
- <210> 409 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 409 aggtctccac acagcacaag 20
- <210> 410 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 410 ggaatacacg agggcatagt tc 22
- <210> 411 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 411 acaagcacat ggctatggaa 20
- <210> 412 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 412 acttgtgcag cagcgtactt 20
- <210> 413 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 413 ggagtgacgc atggacaga 19
- <210> 414 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 414 tggtgccatt ttcctatgag 20
- <210> 415 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 415 gcatctgcca actcctccat 20
- <210> 416 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 416 gcatttgcgg tggacgat 18
- <210> 417 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 417 tcagatgacg aagagcacag atg 23
- <210> 418 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 418 ctgctcactc ggctcaaact c 21
- <210> 419 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 419 gttcaacctc ttcctgtgga ctgt 24
- <210> 420 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 420 gggcgaagag gatataaggg 20
- <210> 421 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 421 cgaaggcact actcaatggt ttc 23
- <210> 422 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 422 ttgccgtcag aaaacatgtc a 21
- <210> 423 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 423 ctaattgggc tccatctcg 19
- <210> 424 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 424 tcctgggagg tgaacttagg 20
- <210> 425 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 425 tgagcgaggt tcttccactg a 21
- <210> 426 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 426 ctcgggtttg gcctctttc 19
- <210> 427 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 427 cctatgattt aagggcattt ttcc 24
- <210> 428 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 428 ctcagctgac gggaaagg 18
- <210> 429 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 429 cttgttgttc accaggacga 20
- <210> 430 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 430 ggcaggagtg aatggctctt c 21
- <210> 431 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 431 ggtatcttgt ggtgtctgcg 20
- <210> 432 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 432 gtggccaaga ggtcagagtc 20
- <210> 433 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 433 tgaagcagtc agttgtgctg 20
- <210> 434 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 434 aagacatggc gctctcagtt c 21
- <210> 435 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 435 caacagagtt tgccgagaca ct 22
- <210> 436 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 436 gctgattccc aagagtctaa cc 22
- <210> 437 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 437 ggcactcggc ttgagcat 18
- <210> 438 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 438 tgagaccgtt ggattggatt 20
- <210> 439 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 439 aggaccaaag ggagaccaa 19
- <210> 440 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 440 acggtcctag gtttgaggtt aaga 24
- <210> 441 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 441 gcgacagagg gcttcatctt 20
- <210> 442 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 442 tgcccacggc tttcttac 18
- <210> 443 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 443 cacgatgtct tcctccttga 20
- <210> 444 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 444 tccggtttaa gaccagttta cca 23
- <210> 445 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 445 caatggcctc cattttacag 20
- <210> 446 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 446 aaaggggtgg gtagaaagga 20
- <210> 447 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 447 cctctgcacg gtcataggtt 20
- <210> 448 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 448 ctgcatgatt ctgagcaggt 20
- <210> 449 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 449 atgctgactt ccttcctggt 20
- <210> 450 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 450 catcttcttg ggcacacaat 20
- <210> 451 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 451 cactgcagcc ccaatgct 18
- <210> 452 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 452 ttcaatgata atgcaaggac tgatc 25
- <210> 453 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 453 ctggtttgtc tggagaaggc 20
- <210> 454 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 454 cctgacattt cccttgtcct 20
- <210> 455 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 455 tcatgggcgt atctacgaat 20
- <210> 456 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 456 gagagagtga gaccacgaag agact 25
- <210> 457 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 457 tccctgcatt caagaggc 18
- <210> 458 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 458 acctgtgttt ggatttgcag 20
- <210> 459 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 459 actggggtgg aatgtgtctt 20
- <210> 460 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 460 ttgggttgaa gaaatcagtc c 21
- <210> 461 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 461 ctcctccacc ctgggttgt 19
- <210> 462 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 462 gacctcaggg cgattcatga 20
- <210> 463 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 463 gcttgcactc cacaggtaca ca 22
- <210> 464 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 464 ctgcattgtg gcacagttct g 21
- <210> 465 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 465 cttcagtctt ggcctgttca 20
- <210> 466 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 466 ggatcccaca cctttaccat aa 22
- <210> 467 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 467 gccgctcatt gatctcca 18
- <210> 468 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 468 ccgtcattgg ccttcttc 18
- <210> 469 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 469 ctactcatgg gcgggatg 18
- <210> 470 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 470 ccgccttcag gttctcaat 19
- <210> 471 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 471 ttgggatgct caaaagcc 18
- <210> 472 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 472 ctgtggcatt gagtttggg 19
- <210> 473 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 473 atgtcaggag tccctccatc 20
- <210> 474 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 474 tggcaaatcc gaattagagt ga 22
- <210> 475 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 475 gtctcagacc cttccccc 18
- <210> 476 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 476 tgtgactaca gccgtgatcc tta 23
- <210> 477 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 477 gcctcttgta gggccaatag 20
- <210> 478 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 478 caaaaccgct gtgtttcttc 20
- <210> 479 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 479 gcccatgcac tgaagtattg g 21
- <210> 480 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 480 agtcgtcgag tgctagggac 20
- <210> 481 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 481 tccgaggcca cagcaaac 18
- <210> 482 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 482 gacgcagtct ttctgtctgg 20
- <210> 483 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 483 tgcagagcag cactggag 18
- <210> 484 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 484 cgctgcagaa aatgaaacga 20
- <210> 485 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 485 cagagcgggc agcagaata 19
- <210> 486 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 486 tcgatctcct catcatctgg 20
- <210> 487 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 487 tgcgggactt gggaaaga 18
- <210> 488 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 488 tgttggtacc cctgttgttg 20
- <210> 489 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 489 cagtggtagg tgatgttctg gga 23
- <210> 490 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 490 aaactggctg ccagcattg 19
- <210> 491 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 491 ctccttggtg tcacccatga g 21
- <210> 492 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 492 ggctgctaga gaccatggac at 22
- <210> 493 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 493 ctccccatta caagtgctga 20
- <210> 494 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 494 gaactccctg gagatgaaac c 21
- <210> 495 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 495 cacatgcatg gaccttgatt 20
- <210> 496 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 496 atccctcgga ctgcctct 18
- <210> 497 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 497 caactgttcc tggtctacaa actca 25
- <210> 498 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 498 cctgcagaga tgggtatgaa 20
- <210> 499 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 499 ctagaggctg gtgccactgt 20
- <210> 500 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 500 catcacgtct ccgaactcc 19
- <210> 501 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 501 agttgtaatg gcaggcacag 20
- <210> 502 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 502 tcagctccat tgaatgtgaa a 21
- <210> 503 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 503 gggacagctt gtagcctttg c 21
- <210> 504 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 504 accattgcag ccctgattg 19
- <210> 505 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 505 ctgttctcca agccaagaca 20
- <210> 506 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 506 tagggaagtg atgggagagg 20
- <210> 507 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 507 tttgagatgc ttgacgttgg 20
- <210> 508 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 508 caatgcggca tatactggg 19
- <210> 509 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 509 aggataaggc caaccatgat gt 22
- <210> 510 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 510 gccagcattg ccattatct 19
- <210> 511 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 511 caccatggcg atgtactttc c 21
- <210> 512 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 512 gggaatgtgg tagcccaaga 20
- <210> 513 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 513 gtggctgcat tagtgtccat 20
- <210> 514 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 514 accaaagatg ctgtgttcca 20
- <210> 515 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 515 tgaatgccat ctttcttcca 20
- <210> 516 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 516 gagcgtcggg tgcaaatc 18
- <210> 517 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 517 caccacccca agtatccgta ag 22
- <210> 518 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 518 cgatgttccc ttcgatggag 20
- <210> 519 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 519 ggcagtgaag gcgataaagt 20
- <210> 520 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 520 cacctcttgc tgtccctttg 20
- <210> 521 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 521 agaaggaagg tccagccg 18
- <210> 522 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 522 ccatgaggcc caacttcct 19
- <210> 523 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 523 cctgccgcat tgttttcag 19
- <210> 524 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 524 aatgcgtatc tgtccacgac 20
- <210> 525 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 525 gacaaacacc cttcctccag 20
- <210> 526 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 526 ctcgtcccgg ttcatcag 18
- <210> 527 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 527 caggcctcag ttccttcagt 20
- <210> 528 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 528 ccaacagtac agccagttgc 20
- <210> 529 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 529 tggacctagg gcttccaagt c 21
- <210> 530 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 530 caggccgtaa ggagctgtct 20
- <210> 531 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 531 ttacacatcc aaccagtgcc 20
- <210> 532 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 532 accacagcat gggtgagag 19
- <210> 533 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 533 ccgttgtaac gttgactgga 20
- <210> 534 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 534 ggcgctgact tccttgac 18
- <210> 535 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 535 tgttgagatt cctcgcagtt 20
- <210> 536 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 536 ctccagctta gggtagttgt ccat 24
- <210> 537 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 537 tgcctgagaa gaggtgaggt 20
- <210> 538 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 538 ttggtagtgc tccacacgat 20
- <210> 539 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 539 gatgaggatg tcccggatga 20
- <210> 540 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 540 gaacagctgg aggccaagtc 20
- <210> 541 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 541 cggtcacgga gccaatct 18
- <210> 542 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 542 tgttcaaagg ttgaccatgc 20
- <210> 543 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 543 tgcactgctt ggccttaaag a 21
- <210> 544 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 544 gtggcgtgcc tcgaagtc 18
- <210> 545 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 545 gtaatgctgt ccacggtgc 19
- <210> 546 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 546 aggtacctct cggtcagtgg 20
- <210> 547 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 547 tgttctagcg atcttgcttc aca 23
- <210> 548 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 548 caaggcatat cgatcctcat aaagt 25
- <210> 549 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 549 cggccaggat acacatctta 20
- <210> 550 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 550 cctccgccag gtctttagt 19
- <210> 551 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 551 tctccgagga accctttgg 19
- <210> 552 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 552 ctgtccaatt gctgattgct t 21
- <210> 553 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 553 tgtagggcag acttcctcaa aca 23
- <210> 554 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 554 agtctcttgg gcatcgagtt 20
- <210> 555 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 555 ggctagtggg cgcatgtag 19
- <210> 556 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 556 tgaccaggaa ctgccacag 19
- <210> 557 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 557 caccgaacac tccctagtcc 20
- <210> 558 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 558 aaccggtgct ctccacattc 20
- <210> 559 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 559 ggaagtgggt catgtggg 18
- <210> 560 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 560 gctttgcccg gtagctct 18
- <210> 561 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 561 gagtgagaat tcgatccaag tcttc 25
- <210> 562 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 562 acgagactcc agtgctgatg 20
- <210> 563 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 563 ctctctgggt cgtctgaaac aa 22
- <210> 564 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 564 caaactggtc ccggtcct 18
- <210> 565 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 565 acacggtagc cggtcact 18
- <210> 566 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 566 ggagcgggct gtctcaga 18
- <210> 567 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 567 cttgacgaag cactcgttga 20
- <210> 568 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 568 acggcttgct tactgaaggt 20
- <210> 569 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 569 ggtcgtccat tggaatcct 19
- <210> 570 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 570 gtggaggaac tctgggaatg 20
- <210> 571 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 571 ggtcacaaac ttgccattgg a 21
- <210> 572 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 572 tgaagtaatc agccacagac tcaat 25
- <210> 573 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 573 ctcctcagac accactgcat 20
- <210> 574 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 574 ggtggttttc ttgagcgtgt act 23
- <210> 575 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 575 gaagatagct gagggctgtg ac 22
- <210> 576 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 576 cccggcaaaa acaaataagt 20
- <210> 577 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 577 tgggagttca tgggtacaga 20
- <210> 578 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 578 gatgggattt ccattgatga ca 22
- <210> 579 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 579 gagtcagaat ggcttattca cagatg 26
- <210> 580 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 580 agaagctagg gtggttgtcc 20
- <210> 581 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 581 tgaggagttt gccttgattc g 21
- <210> 582 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 582 cacagaatcc agctgtgcaa ct 22
- <210> 583 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 583 acagtggaag gaccaggact 20
- <210> 584 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 584 agccattgca gctaggtgag 20
- <210> 585 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 585 aaataccaac atgcacctct ctt 23
- <210> 586 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 586 agtccacagt gttgggacaa 20
- <210> 587 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 587 tgcgtaccca cttcctgc 18
- <210> 588 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 588 aaagagctgt gagtggctgg 20
- <210> 589 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 589 atgttcacca ccaggatcag 20
- <210> 590 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 590 gcagctcagg gaagtcaca 19
- <210> 591 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 591 aaagttccag gcaacatcgt 20
- <210> 592 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 592 ggtccagcag tgtctcctga a 21
- <210> 593 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 593 tactccctgg ctcctgctt 19
- <210> 594 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 594 ggccaccagg gtattatctg 20
- <210> 595 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 595 gaagcctttc tttccacagc 20
- <210> 596 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 596 caagagcctg aatgcgtcag t 21
- <210> 597 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 597 acttcggctg tgtgttatat gca 23
- <210> 598 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 598 gaggtccgtg gtagcgttct c 21
- <210> 599 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 599 ggcccagctt gaatttttca 20
- <210> 600 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 600 gcgaatctgc tccttttctg a 21
- <210> 601 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 601 ccaagaaacc atggctgctt 20
- <210> 602 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 602 gtccactcga atcttttctt cttca 25
- <210> 603 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 603 ggcctcagtg tgcatcattc t 21
- <210> 604 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 604 cacgcaggtg gtatcagtct 20
- <210> 605 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 605 tcttaagcac gttctccacg 20
- <210> 606 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 606 gcttgctgta ctccgacatg tt 22
- <210> 607 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 607 ctccacggtc tcagttgatc t 21
- <210> 608 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 608 cctctcgcaa gtgctccat 19
- <210> 609 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 609 ggaggtgctt cactgtcatt t 21
- <210> 610 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 610 gcagggagct ggagtagc 18
- <210> 611 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 611 tgagcagcac catcagtaac g 21
- <210> 612 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 612 gcttgtcatc tgcagcagtg tt 22
- <210> 613 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 613 gcgtgtctgc gtagtagctg tt 22
- <210> 614 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 614 gtttgccaag ttaaatttgg tacataat 28
- <210> 615 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 615 gggagggaga agagattcga t 21
- <210> 616 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 616 ccgagtcgcc actgctaagt 20
- <210> 617 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 617 ggcaataaac aggctcatga ttaa 24
- <210> 618 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 618 cacagggttt cagcgagc 18
- <210> 619 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 619 gttggaagca aacgcaca 18
- <210> 620 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 620 cgcctcgcga aagacttg 18
- <210> 621 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 621 tgcctgcgat atttgttagg 20
- <210> 622 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 622 ataaacgctt caaatttctc tctg 24
- <210> 623 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 623 caggttcgct ctgggaag 18
- <210> 624 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 624 gcacaggttc gctctggaa 19
- <210> 625 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 625 atctgtttcc attggctcct 20
- <210> 626 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 626 ggtctgccca aatgcttttc 20
- <210> 627 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 627 gctacatcta cacttggttg gcttaa 26
- <210> 628 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 628 atgctggctg actctgctc 19
- <210> 629 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 629 ggattgcagc taaccctgta tacc 24
- <210> 630 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 630 cttctgagac ctctggcttc gt 22
- <210> 631 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 631 tccaactgaa ggtccctgat g 21
- <210> 632 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 632 tgcaatcatg caagaccac 19
- <210> 633 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 633 gctcgttcag cttcacattg c 21
- <210> 634 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 634 tttccggtaa tagtctgtct catagatatc 30
- <210> 635 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 635 tggactgctt ccaggtgtca 20
- <210> 636 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 636 gtcttggaca cccgcagaat 20
- <210> 637 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 637 gggtctgaat ggccaggtt 19
- <210> 638 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 638 cagagctctt gcatgtggag 20
- <210> 639 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 639 atcaggaagg ctgccaagag 20
- <210> 640 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 640 tggagcttat taaaggcatt cttca 25
- <210> 641 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 641 tcttgacctt gcagctttgt 20
- <210> 642 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 642 ggccccaatg aaatagactg 20
- <210> 643 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 643 aaaattgtgc cttggaggag 20
- <210> 644 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 644 aactccgagt ggtgatcca 19
- <210> 645 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 645 cggtagtggt tgatgactgt tga 23
- <210> 646 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 646 agaaggtatc agggctggaa 20
- <210> 647 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 647 cctcagtgcc agtctcttcc 20
- <210> 648 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 648 gaagctttgt agccggtgat 20
- <210> 649 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 649 gtctggccgg gattcttt 18
- <210> 650 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 650 gtcttctcca cagtccagca 20
- <210> 651 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 651 gtttagcctc atgggcgtc 19
- <210> 652 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 652 tgccatcacc attgaaatct 20
- <210> 653 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 653 cctgagctta gctggtgttg 20
- <210> 654 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 654 ccttaagctc tttcactgac tcaatct 27
- <210> 655 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 655 gcgcacacct tcatctcat 19
- <210> 656 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 656 ggtgaacatc atgacgcagt 20
- <210> 657 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 657 gcatagctgt gagatgcgg 19
- <210> 658 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 658 agggggtgtc cgtaaagg 18
- <210> 659 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 659 ttacaactct tccactggga cgat 24
- <210> 660 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 660 tgtctgtgag cttggtcctg 20
- <210> 661 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 661 gaagcaggtc agagtgagcc 20
- <210> 662 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 662 tcacacccac tgaatcctac tg 22
- <210> 663 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 663 ccgtagggcc aattcagac 19
- <210> 664 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 664 cgtgatgcga agctctgaga 20
- <210> 665 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 665 catcttcacc agcatgatgt ca 22
- <210> 666 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 666 tcctcactca tcacgtcctc 20
- <210> 667 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 667 gccaaaccat tcattgtcac 20
- <210> 668 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 668 gcaatctctt caaacacttc atcct 25
- <210> 669 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 669 tgagcccctg gttaacagta 20
- <210> 670 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 670 aagcttcaca agttggggc 19
- <210> 671 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 671 tgattgtccg cagtcagg 18
- <210> 672 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 672 ttgaaatggc agaacggtag 20
- <210> 673 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 673 acacaaggcc cagcctct 18
- <210> 674 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 674 cggcagaact gacagtgttc 20
- <210> 675 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 675 gtcacacttg cagcatttca 20
- <210> 676 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 676 actccctgaa gccgagacac t 21
- <210> 677 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 677 gacatggcag cacaagca 18
- <210> 678 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 678 cttgagggtt tgggtttcca 20
- <210> 679 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 679 aagagctgcc catccttctc 20
- <210> 680 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 680 ttctgggaac tgctggaag 19
- <210> 681 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 681 ccccacgagt tctggttctt c 21
- <210> 682 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 682 cgctgaggct ggtactgtg 19
- <210> 683 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 683 gtctctggac acaggctgg 19
- <210> 684 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 684 gaggaatgga aagacctcgg 20
- <210> 685 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 685 gcagacacaa tggaaagaac c 21
- <210> 686 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 686 cggacagttt cttccggtt 19
- <210> 687 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 687 agccgtacca gctcagactt 20
- <210> 688 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 688 gccactaact gcttcagtat gaagag 26
- <210> 689 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 689 tgcacataag caacagcaga 20
- <210> 690 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 690 gaccctgctc acaaccagac 20
- <210> 691 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 691 tccatatcca acaaaaaaac tcaaag 26
- <210> 692 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 692 gggcctggtt gaaaagcat 19
- <210> 693 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 693 acggtagtga cagcatcaaa actc 24
- <210> 694 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 694 ggagtccgtc cttaccgtca a 21
- <210> 695 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 695 ggaatgtccc atacccaaag aa 22
- <210> 696 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 696 tgtcaccgtg atctctttgg taa 23
- <210> 697 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 697 cctaaaggtt tgaatggcag a 21
- <210> 698 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 698 ggttccgata tttggtggtc ttac 24
- <210> 699 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 699 cgattgtctt tgctcttcat gtg 23
- <210> 700 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 700 ccgttgagtg gaatcagcaa 20
- <210> 701 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 701 caaggcctca aatctcaagg 20
- <210> 702 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 702 tcttggcaag tcggttaaga 20
- <210> 703 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 703 acaaagggag agcgtgaagt 20
- <210> 704 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 704 gtctattaga gtcagatccg ggacat 26
- <210> 705 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 705 cttttgatgg tagagttcca gtgattc 27
- <210> 706 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 706 tgaatcatgc cagtgctgta 20
- <210> 707 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 707 atggcttgcc cacaatgc 18
- <210> 708 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 708 cttggcgtgt ggaaatctac ag 22
- <210> 709 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 709 cctcagtcca taaaccacac tatca 25
- <210> 710 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 710 tgatgatcta agtttcccga ggtt 24
- <210> 711 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 711 tgctgggttt ctcctcctgt t 21
- <210> 712 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 712 agcaagggaa cagcctcat 19
- <210> 713 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 713 agtagttgtg ctgcccttcc 20
- <210> 714 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 714 cccataatcc tgagcaatgg 20
- <210> 715 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 715 tgcacatatc attacaccag ttcgt 25
- <210> 716 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 716 aacgagatcc ctgtgcttgt 20
- <210> 717 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 717 cctccccaag tcagttgc 18
- <210> 718 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 718 acacctgcac aattctccg 19
- <210> 719 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 719 ttcttttgcg cttcagcc 18
- <210> 720 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 720 tcagcaagtg ggaaggtgta atc 23
- <210> 721 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 721 ccttaaagcg gactccagg 19
- <210> 722 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 722 tcctcctgta ggctggca 18
- <210> 723 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 723 ctctcagcat cggtacaagg 20
- <210> 724 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 724 atctgcgttg aagcagtgag 20
- <210> 725 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 725 gtgatttgcc caggaaagtt t 21
- <210> 726 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 726 tttatcccca gcgaatttgt 20
- <210> 727 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 727 tcccccttac tcagcttgaa ct 22
- <210> 728 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 728 cgagtacttg tggaaggtgg ac 22
- <210> 729 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 729 gcgaggtaat ttgtgccctt t 21
- <210> 730 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 730 tgaggacact cggtctctag c 21
- <210> 731 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 731 ctagccccac agccaaga 18
- <210> 732 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 732 agttttaagg gtgccccg 18
- <210> 733 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 733 gagactttgg gggattcca 19
- <210> 734 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 734 gaagtccacc tgggcatctc 20
- <210> 735 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 735 ccctttccaa acttgaggc 19
- <210> 736 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 736 cactcgccgt tgacatcct 19
- <210> 737 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 737 tgcaagctgt ctttgagcc 19
- <210> 738 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 738 acagcaaggc gagcataaat 20
- <210> 739 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 739 ctatcggcct cagcatgg 18
- <210> 740 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 740 tgagtttttt gcgagagtat tgaca 25
- <210> 741 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 741 acacttcaag tcacgcttgc 20
- <210> 742 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 742 gtagggctgc tggaaggtaa 20
- <210> 743 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 743 tccgaccttc aatcatttca 20
- <210> 744 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 744 ggagacaatg caaaccacac 20
- <210> 745 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 745 tacaatggct ttggaggata gca 23
- <210> 746 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 746 caaagctgtc agctctagca aaag 24
- <210> 747 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 747 ttcatccctc gatatggctt ct 22
- <210> 748 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 748 agtctggaac atgtcagtct tgatg 25
- <210> 749 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 749 cgagcatttg tctcatcctt t 21
- <210> 750 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 750 actcaggccc atttccttta 20
- <210> 751 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 751 cctggtgctg ttgtagatgg 20
- <210> 752 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 752 gccaccgata tagcgctgtt 20
- <210> 753 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 753 cctcttcatc aggccaaact 20
- <210> 754 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 754 accgaaattg gagagcatgt 20
- <210> 755 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 755 ttcagagaaa ggaggtgtgg a 21
- <210> 756 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 756 gggaaagtgg tacgtctttg ag 22
- <210> 757 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 757 ttggccagat ctaaccatga 20
- <210> 758 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 758 gcttgagggt ctgaatcttg ct 22
- <210> 759 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 759 gcgaatgcca tgactgaa 18
- <210> 760 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 760 tgctgtcgtg atgagaaaat agtg 24
- <210> 761 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 761 gcttcaacgg caaagttctc tt 22
- <210> 762 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 762 gtactgagcg atggagcgt 19
- <210> 763 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 763 gcggtgtagc tcccagagt 19
- <210> 764 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 764 caaactccac agtacttggg ttga 24
- <210> 765 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 765 tgtcggaatt gatactggca tt 22
- <210> 766 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 766 gtgcacgtgg atgaaagagt 20
- <210> 767 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 767 agctccctgt tgcatggact t 21
- <210> 768 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic reverse primer
- <400> 768 gcagacaaaa gttggaaggc 20
- <210> 769 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 769 atgcctacag caccctgatg tcgca 25
- <210> 770 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 770 cgcttcaaag gaccagacct cctc 24
- <210> 771 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 771 ctcgccaatg atgctgctca agtt 24
- <210> 772 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 772 ccatgagctg tagccgaatg tcca 24
- <210> 773 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 773 ctgcacacgg ttctaggctc cg 22
- <210> 774 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 774 tctgctctac aagcccattg accg 24
- <210> 775 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 775 cccgcagaaa gcacatggta ttcc 24
- <210> 776 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 776 ctctgtcacc aatgtggacc tgcc 24
- <210> 777 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 777 tgtaggtatc tcttagtccc gccatctga 29
- <210> 778 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 778 ctgacactca tctgagccct ccca 24
- <210> 779 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 779 tgctacttgc aaaggcgtgt cctactgc 28
- <210> 780 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 780 ctgcgctgga tggacaccgc 20
- <210> 781 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 781 cacacagggt gccatcaatc acct 24
- <210> 782 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 782 cgagtggaag tgctccccac tttc 24
- <210> 783 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 783 cgatctcagc ctgtttgtgc atctcgat 28
- <210> 784 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 784 caacacgtca ccaccctttg ctct 24
- <210> 785 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 785 tgaccacacc aaagcctccc tgg 23
- <210> 786 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 786 acctcagtcc aaagtgcctg aggc 24
- <210> 787 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 787 tcacggtaca caatctttcc gga 23
- <210> 788 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 788 ccagttcctg ccgtctgctc ttct 24
- <210> 789 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 789 ctgcagcgtc aatctccgct tg 22
- <210> 790 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 790 aagctgacac agccctccca agtg 24
- <210> 791 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 791 ccaccacaca ggtacagcag cgct 24
- <210> 792 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 792 ctatgacgat gccctcaacg cctc 24
- <210> 793 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 793 ctttcgggaa gccaggccct t 21
- <210> 794 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 794 actggatcct ggccaccgac tatg 24
- <210> 795 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 795 cttgtccttg ggtcaccctg ca 22
- <210> 796 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 796 acaccagcgg tgccgactac c 21
- <210> 797 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 797 ctagagccat ccttggccat cctg 24
- <210> 798 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 798 caagaatctt gcagcagcat ggct 24
- <210> 799 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 799 tgacgagcag cgaacagcca cg 22
- <210> 800 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 800 aggagtatga cgagtccggc ccc 23
- <210> 801 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 801 aggctcagtg atgtcttccc tgtcaccag 29
- <210> 802 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 802 tgggcccaga gcatgttcca gate 24
- <210> 803 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 803 cccaattaac atgacccggc aaccat 26
- <210> 804 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 804 agatgtgccg gtacacccac ctc 23
- <210> 805 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 805 ccagcctgca gacaactggc ctc 23
- <210> 806 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 806 tgccactcgg aaaaagacct ctcgg 25
- <210> 807 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 807 catcatggga ctcctgccct tacc 24
- <210> 808 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 808 agtcacgacc cctgccctca c 21
- <210> 809 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 809 cagccctggg aactttgtcc tgacc 25
- <210> 810 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 810 ctttccgttg gcatccgcaa cag 23
- <210> 811 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 811 ttccacgccg aaggacagcg at 22
- <210> 812 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 812 tccgggtagc tctcaaactc gagg 24
- <210> 813 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 813 caagggtctc cagcacctct acgc 24
- <210> 814 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 814 ccggttaact gtggcctgtg ccc 23
- <210> 815 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 815 ctctcactgt gacagcccac ctcg 24
- <210> 816 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 816 ctgtgttcga ctcagcctca ggga 24
- <210> 817 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 817 cagtcggccc aggacggtct act 23
- <210> 818 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 818 tgctgggagc ctacacttgg ccc 23
- <210> 819 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 819 tacagtccca gcaccgacaa ttcc 24
- <210> 820 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 820 cctcgctttg tttaacagcc cagg 24
- <210> 821 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 821 ttacagcgac agtcatggcc gcat 24
- <210> 822 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 822 ccggagtcct agcctcccaa attc 24
- <210> 823 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 823 cctgctctgt tctggggtcc aaac 24
- <210> 824 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 824 caggtcccat tgccgggcg 19
- <210> 825 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 825 tgatttcccg ttccgctcgg ttct 24
- <210> 826 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 826 catggctacc acttcgacac agcc 24
- <210> 827 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 827 aaagcacacc gctggcagga c 21
- <210> 828 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 828 tggcctcaca aggactaccc tctcatcc 28
- <210> 829 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 829 atttcagctg atcagtgggc ctcc 24
- <210> 830 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 830 cataatacat tcacctccct gcctcctc 28
- <210> 831 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 831 cgcttcatct tggctgaggt cctc 24
- <210> 832 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 832 ctctgctgac actcgagccc acat 24
- <210> 833 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 833 acagagccct ggcaaagcca ag 22
- <210> 834 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 834 tgtctccatt attgatcggt tcatgca 27
- <210> 835 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 835 tacccgccat ccatgatcgc ca 22
- <210> 836 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 836 cccagataat acaggtggcc aacaattcct 30
- <210> 837 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 837 tggaataagt acctaaggcg ccccc 25
- <210> 838 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 838 ctcccatccc agtggagcca a 21
- <210> 839 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 839 cgcaccattc ggtcatttga gg 22
- <210> 840 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 840 ctgttgactg cagggcacca cca 23
- <210> 841 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 841 caggtccctt gtcccaagtt ccac 24
- <210> 842 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 842 ccctgctacc aatatggact ccagtca 27
- <210> 843 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 843 caccgacagc acagacagaa tccc 24
- <210> 844 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 844 caccaagccc agaggacagt tcct 24
- <210> 845 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 845 ctccaagccc agattcagat tcgagtca 28
- <210> 846 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 846 tcagcttcta caactggaca gacaacgctg 30
- <210> 847 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 847 actggccgtg gcactggaca aca 23
- <210> 848 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 848 tgtccctgtt agacgtcctc cgtccata 28
- <210> 849 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 849 ctccccgtcg atgccagaga act 23
- <210> 850 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 850 tgctccacta acaaccctcc tgcc 24
- <210> 851 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 851 aattcctgca tggccagttt cctc 24
- <210> 852 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 852 ctgcccaaga gcctgtcatc cag 23
- <210> 853 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 853 ccttctgccc atagtgatca gcga 24
- <210> 854 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 854 ccaacccaga tgaaatcggc aact 24
- <210> 855 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 855 ccagtcgcct cagtaaagcc acct 24
- <210> 856 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 856 cacaacatcc ctggtgaacg tcgt 24
- <210> 857 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 857 atcacccatc atcatccaat cgca 24
- <210> 858 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 858 tccttcccac ccccagtcct gtc 23
- <210> 859 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 859 aaaatgagac tctccgtcgg cagc 24
- <210> 860 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 860 caggccctct tccgagcggt 20
- <210> 861 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 861 cttcaattgg caagcccagg c 21
- <210> 862 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 862 tgctgatgtg ccctctcctt gg 22
- <210> 863 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 863 acccattctt ctcccagccg gg 22
- <210> 864 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 864 acaccctact ccctgtgcct ccag 24
- <210> 865 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 865 agctgatgag tctgccctac cgcctg 26
- <210> 866 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 866 tgaagtctcc agctttgcct cagc 24
- <210> 867 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 867 caccaggacc acaaagcctg tttg 24
- <210> 868 <211> 18 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 868 ctgcgcccgc tcttcgcg 18
- <210> 869 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 869 cgcacagaca agccttactc cgcc 24
- <210> 870 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 870 cgggaagaat tcgcttccac ctg 23
- <210> 871 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 871 cccttcagcc tgccccaccg 20
- <210> 872 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 872 actcagttac cgagccacgt cacg 24
- <210> 873 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 873 tcctgcgcct gatgtccacc g 21
- <210> 874 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 874 tctcctagcc agacgtgttt cttgtccttg 30
- <210> 875 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 875 cctgcagccc atccacaacc t 21
- <210> 876 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 876 cctcctcctg ttgctgccac taatgct 27
- <210> 877 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 877 cgaaacgcta ttctcacagg ttcagc 26
- <210> 878 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 878 tgttcatcct ggcgctcttc atgt 24
- <210> 879 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 879 ccgattccaa aagaccatca ggttct 26
- <210> 880 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 880 tttgctgaat gctccagcca agg 23
- <210> 881 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 881 tcagatggag acctcgtgcc aaattaca 28
- <210> 882 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 882 agccactccc cacgctgttg t 21
- <210> 883 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 883 cgcagatccg atttctctgg gatc 24
- <210> 884 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 884 tcccgatggt ctgcagcagc t 21
- <210> 885 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 885 aacatcatgt tcttcttcat gacctcgc 28
- <210> 886 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 886 accaacgctg acagcatgca tttc 24
- <210> 887 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 887 accctgcccg cgatcacact ga 22
- <210> 888 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 888 cttgaggacg cgaacagtcc acca 24
- <210> 889 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 889 aggtgcaata tgggcatata tctccattg 29
- <210> 890 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 890 tctgtgtggt ccatccttgg aagc 4
- <210> 891 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 891 ttcttcgaaa gccatgttgc caga 24
- <210> 892 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 892 tacccttaag aacgccccct ccac 24
- <210> 893 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 893 ctgaaactgg aacacaacca cccacaag 28
- <210> 894 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 894 tggacacact gatgcaagcc aaga 24
- <210> 895 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 895 cacagccacg gggcccaaa 19
- <210> 896 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 896 ctcatgccac cactgccaac acctc 25
- <210> 897 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 897 cagcaccctt ggcagtttcg aaat 24
- <210> 898 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 898 ctgtcacact ccctcaggca ggac 24
- <210> 899 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 899 atcactggaa ctcctcggtc ggac 24
- <210> 900 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 900 cagccacgat gaccactacc agcact 26
- <210> 901 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 901 tgcttcctcc cactatctga aaataa 26
- <210> 902 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 902 agctgcccgt ctttctcagc cagc 24
- <210> 903 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 903 agaaaagctg tttgtctccc cagca 25
- <210> 904 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 904 aaagtccatt tgccactgat ggca 24
- <210> 905 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 905 ctacctggac atccctgctc agcc 24
- <210> 906 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 906 cagacttggt gccctttgac tcc 23
- <210> 907 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 907 cagggccatg acaatcgcca a 21
- <210> 908 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 908 cgccctggct caacttttcc ttaa 24
- <210> 909 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 909 cgaggccatt gacttcatag actcca 26
- <210> 910 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 910 ttgagcacac tgcagtccat ctcc 24
- <210> 911 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 911 cagaagaaca gctcagggac ccct 24
- <210> 912 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 912 ctcaccagaa gccccaacct caac 24
- <210> 913 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 913 cactcccgag cacgttgttc cgt 23
- <210> 914 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 914 ccacttggac atcatctggg tgaacactc 29
- <210> 915 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 915 cctttgcctc agggcatcct ttt 23
- <210> 916 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 916 tgctacctgc ccctttgtca tgtg 24
- <210> 917 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 917 caaaggtgac caccataccg ggtt 24
- <210> 918 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 918 ctcgtcgtag cgcttctcgc tgta 24
- <210> 919 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 919 tgatgctttc tccagaaact cgaactca 28
- <210> 920 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 920 cggatccttt cctcactcgc cca 23
- <210> 921 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 921 acccagtctc accttctccc cacc 24
- <210> 922 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 922 tgagatggac atttaaagca ccagcc 26
- <210> 923 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 923 cgcccagagg cacccacctg 20
- <210> 924 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 924 ccagagagcc tccctgcagc ca 22
- <210> 925 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 925 ctgcaactgc ctcctgctca aagtca 26
- <210> 926 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 926 cactgacatc atggctggcc ttg 23
- <210> 927 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 927 ccgctctcat cgcagtcagg atcat 25
- <210> 928 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 928 tgcgcccgat gagatcaccg 20
- <210> 929 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 929 cacctgatgc atgatggaca ctgc 24
- <210> 930 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 930 cgtcccattt gagcctgtca atgt 24
- <210> 931 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 931 atctgtatgc ggaacctcaa aagagtccct 30
- <210> 932 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 932 tgtcccacga ataatgcgta aattctccag 30
- <210> 933 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 933 cagcaggccc tcaaggagct g 21
- <210> 934 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 934 agccatatgc cttctcatct gggc 24
- <210> 935 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 935 agagccggcc agccctgaca g 21
- <210> 936 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 936 tcgcctacca tttggtgcaa gcaa 24
- <210> 937 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 937 ctggccctca tgtccccttc acg 23
- <210> 938 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 938 ccccagacca agtgtgaata catgct 26
- <210> 939 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 939 ctggagatgc tggacgccc 19
- <210> 940 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 940 ttaccagagg cgaggttccc ttca 24
- <210> 941 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 941 tcctgacttc tgtgagctca ttgcg 25
- <210> 942 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 942 tggcacgggt cttctcctac c 21
- <210> 943 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 943 cggcctgtcc acgaaccact tata 24
- <210> 944 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 944 tcgcccacct acgtactggc ctac 24
- <210> 945 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 945 tcccagagac caacgttcaa gcagttg 27
- <210> 946 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 946 cctttcatgg ggagaaccgc att 23
- <210> 947 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 947 tcggccactt catcaggacg cag 23
- <210> 948 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 948 aatctgctcc actgtcaggg tccc 24
- <210> 949 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 949 actctcaggc ggtgtccaca tgat 24
- <210> 950 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 950 tcccagcatc atccaggccc ag 22
- <210> 951 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 951 agaacagcat ccgccacaac ctct 24
- <210> 952 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 952 ctctacagca gctcagccag cctg 24
- <210> 953 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 953 cagaccaagc ctttgcccag aatt 24
- <210> 954 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 954 tgtttccatg gctaccccac aggt 24
- <210> 955 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 955 tgaccggcgc atcacactga gg 22
- <210> 956 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 956 tcaattgtaa cattctcacc caggccttg 29
- <210> 957 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 957 ctgaagcacg acaagctggt ccag 24
- <210> 958 <211> 19 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 958 cgcccgcagg cctcatcct 19
- <210> 959 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 959 tgagccagat tccacacctc acgt 24
- <210> 960 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 960 ttcatctcaa tggaaggatc ctgcc 25
- <210> 961 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 961 aacttcagcc ccagctccca agtc 24
- <210> 962 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 962 ccgttctcag ccttgacggt gc 22
- <210> 963 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 963 tgttccaacc actgaatctg gacc 24
- <210> 964 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 964 ttgggacatt gtagacttgg ccagac 26
- <210> 965 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 965 ccatggacca acttcactat gtgacagagc 30
- <210> 966 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 966 tgcagttgac atggcctgtt cagtcc 26
- <210> 967 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 967 tgttagccaa agactgccac tgca 24
- <210> 968 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 968 tgtccacagg accctgagtg gttc 24
- <210> 969 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 969 atcccctccc tctccaccca tcta 24
- <210> 970 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 970 aggcgttgca cttcaccagc c 21
- <210> 971 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 971 cctcttgccc acttactggg tgga 24
- <210> 972 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 972 ccgggtgaca gcactaacca gacc 24
- <210> 973 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 973 ctcttcccca tcggctttgt gg 22
- <210> 974 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 974 cctcctgctg gcttcctttg atca 24
- <210> 975 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 975 ctcatcacct ggtctccggt gtgt 24
- <210> 976 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 976 catgctgcat cctaaggctc ctcagg 26
- <210> 977 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 977 ctggccttcc cgtgtaacca gttc 24
- <210> 978 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 978 ctccccaccc ttgagaagtg cct 23
- <210> 979 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 979 cacaattccc agagaaacca agaagagc 28
- <210> 980 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 980 accacgcgaa cggtgcatcg 20
- <210> 981 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 981 tccccgagcc cagcaggaca 20
- <210> 982 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 982 tgacctgatc cagagtaagt gcctctcca 29
- <210> 983 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 983 tcagccactg gcttctgtca taatcaggag 30
- <210> 984 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 984 cccgcctacc ctcgtaaagc agattca 27
- <210> 985 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 985 ctgaagctct actcacagtt tctggg 26
- <210> 986 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 986 ctcgcaagca caacatgtgt ggtgaga 27
- <210> 987 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 987 cacagccgcc tgaaagccac aat 23
- <210> 988 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 988 tcaagtaaac gggctgtttt ccaaaca 27
- <210> 989 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 989 aaagacatcc agctagcacg ccg 23
- <210> 990 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 990 ttcttgcgct ccatccgtcc aga 23
- <210> 991 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 991 caagaacctc ccagaagggc tcaa 24
- <210> 992 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 992 ccagaccata gcacactcgg gcac 24
- <210> 993 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 993 cagaatgtcc gccttctcca gctt 24
- <210> 994 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 994 cgctcacgtt ctcatccaag tgg 23
- <210> 995 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 995 ccccggacag tggctctgac g 21
- <210> 996 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 996 ttccacatct ctcccagttt cttcgcaa 28
- <210> 997 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 997 agtcgctggt ttcatgccct tcca 24
- <210> 998 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 998 ctccatatcc aaacaaagca tgtgtgcg 28
- <210> 999 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 999 agtctcctac tcccgggttc tgcg 24
- <210> 1000 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1000 tgaactcctt cctggaatac ccca 24
- <210> 1001 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1001 agccctgttc tcgttgccct aattcatc 28
- <210> 1002 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1002 acactcggca ggagtagtac ccgc 24
- <210> 1003 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1003 accggagcct tcccagaaca aact 24
- <210> 1004 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1004 accgcttcta ccaatacctc gccca 25
- <210> 1005 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1005 agttgcttcc atccaacctg gagg 24
- <210> 1006 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1006 cagaatggcc tgtattcact atcttcgaga 30
- <210> 1007 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1007 agagtgactc ccgttgtccc aagg 24
- <210> 1008 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1008 tgactcccgc ggtcccaagg 20
- <210> 1009 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1009 cattttcctc agacttgtga acctccact 29
- <210> 1010 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1010 taattagacc taggcctcag ctgcactgcc 30
- <210> 1011 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1011 ctcagggccc accattgaag aggttg 26
- <210> 1012 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1012 cgcacttttc tgagcagacg tcca 24
- <210> 1013 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1013 ccaggcgtgg cgtcctctcc ata 23
- <210> 1014 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1014 ccggcgccca acgtgattct 20
- <210> 1015 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1015 tggagattct ccagcacgtc atcgac 26
- <210> 1016 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1016 cttttgtttt gcccagtata gactcggaag 30
- <210> 1017 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1017 ccgtgaatgc agcccgccag 20
- <210> 1018 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1018 cgcgtcatac caaaatctcc gattttga 28
- <210> 1019 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1019 taccccgtgg gcaagttctt ccaa 24
- <210> 1020 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1020 atccaggcac ctctaccacg ccctc 25
- <210> 1021 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1021 cccggtcacc aggcaggagt tct 23
- <210> 1022 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1022 cagccctaca cgaaaggacc tgct 24
- <210> 1023 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1023 tgacttccaa gctggccgtg gc 22
- <210> 1024 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1024 ctgctccacg gccttgctct tg 22
- <210> 1025 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1025 cctgtgatca acagtacccg tatggg 26
- <210> 1026 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1026 tcggcttccc tgtagagctg aaca 24
- <210> 1027 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1027 catattgccc agtggtcacc tcaca 25
- <210> 1028 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1028 attcaaaaca gagcccccaa agcc 24
- <210> 1029 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1029 acgtccgggt cctcactgtc cttcc 25
- <210> 1030 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1030 cccacatgac ttcctcttgg cctt 24
- <210> 1031 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1031 tccatcccag ctccagccag 20
- <210> 1032 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1032 cactccagac ctcgcttagc atgg 24
- <210> 1033 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1033 cgatcctgca tctgtaaatc gccc 24
- <210> 1034 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1034 tctgagcctt gtcctctatc cggc 24
- <210> 1035 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1035 tcgccatctt ttgtgggatt cctt 24
- <210> 1036 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1036 ccgacagcca cagaataacc caaa 24
- <210> 1037 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1037 tgctaatgta aggcatcaca gtcttttcca 30
- <210> 1038 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1038 aaatacctgc aaccgttact gccgtgac 28
- <210> 1039 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1039 caccaacctg tacccgtatt gcga 24
- <210> 1040 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1040 tgctatgttt ctacaaaacc gccaagg 27
- <210> 1041 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1041 actcgatttc ccagccaacc acag 24
- <210> 1042 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1042 caagggacac gccttctgaa cgt 23
- <210> 1043 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1043 ccacttgtcg aaccaccgct cgt 23
- <210> 1044 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1044 cccttcaagc tgccaatgaa gacc 24
- <210> 1045 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1045 cttcaaggcc atgctgacca tcag 24
- <210> 1046 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1046 tgcattcctc tgagctcact gctg 24
- <210> 1047 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1047 agtcagtggc ccatcagcaa tcag 24
- <210> 1048 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1048 aagccgctcc actcgcatgt cc 22
- <210> 1049 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1049 cctccccaac aaagaccacc gca 23
- <210> 1050 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1050 ttaccccagc tccatccttg catc 24
- <210> 1051 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1051 ttcgtaacag cagtcatcat ccatgg 26
- <210> 1052 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1052 tttgaccggg tattcccacc aggaa 25
- <210> 1053 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1053 ccttggagaa acacaagcac ctgc 24
- <210> 1054 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1054 actcctgttt tcaccaccat gcca 24
- <210> 1055 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1055 atctacgttg tccagctgcc agcc 24
- <210> 1056 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1056 ctgattcctc aggtccttgg cctg 24
- <210> 1057 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1057 ctgttcctgg agcatggcct cttc 24
- <210> 1058 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1058 caagtgcctg taccacacgg aagg 24
- <210> 1059 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1059 ccactcgcca tactgggtgc agt 23
- <210> 1060 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1060 aggtcttatc agcacagtct ccgcctcc 28
- <210> 1061 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1061 ctggacgcgg ttctactcca acag 24
- <210> 1062 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1062 acccagataa cgcatcatgg agcga 25
- <210> 1063 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1063 tgcctccctg tcgcaccagt acta 24
- <210> 1064 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1064 actgagcgca cacgaaacac tgct 24
- <210> 1065 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1065 cagcccccca actgacctca tc 22
- <210> 1066 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1066 caggctcagc aagctgaaca cctg 24
- <210> 1067 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1067 ttactccagg ggacaagcct tcca 24
- <210> 1068 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1068 ccttcagggc ctgcactttc aact 24
- <210> 1069 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1069 ctgtgtttag gcactcccct tgcg 24
- <210> 1070 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1070 ttcttcttct gttcctcgct ccgg 24
- <210> 1071 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1071 catgttcttc acaatcgctg catcc 25
- <210> 1072 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1072 acagctcatt gttgtcacgc cgga 24
- <210> 1073 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1073 cccgggttgt cttccgtcag atag 24
- <210> 1074 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1074 cagccctttg gggaagctgg 20
- <210> 1075 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1075 tttgacaccc cttccccagc ca 22
- <210> 1076 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1076 agcaagattt cctccaggtc catcaaaagg 30
- <210> 1077 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1077 aaccagctct ctgtgacccc aatt 24
- <210> 1078 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1078 ctgggagcat ggcgatggat accc 24
- <210> 1079 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1079 cctgtatgct gcaactcatg aacttggc 28
- <210> 1080 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1080 aagcaatgtt gatatctgcc tctccctgtg 30
- <210> 1081 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1081 tcatcaaacc atggttcatc accaatatc 29
- <210> 1082 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1082 cgagggcaac cctgatcgtc ca 22
- <210> 1083 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1083 acctgatacg tcttggtctt catcgccat 29
- <210> 1084 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1084 tctgtcctgg ctggagtcgc tttcat 26
- <210> 1085 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1085 tgaactccgc agctagcatc caaa 24
- <210> 1086 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1086 caagaagatt tacttcgtcg attcccaga 29
- <210> 1087 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1087 tcagtcaaca tcaccctcct aggatga 27
- <210> 1088 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1088 tcaccctgga gatcagctcc cga 23
- <210> 1089 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1089 cagcattgtc tgtcctccct ggca 24
- <210> 1090 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1090 tggagtgctg taaacatacc ctccca 26
- <210> 1091 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1091 cgggctgttc cctttgagaa ccttaaca 28
- <210> 1092 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1092 atgaccaccc cggctcgtat gtca 24
- <210> 1093 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1093 tccccacagt agacacatat gatggccg 28
- <210> 1094 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1094 ctcagagcct ctctggttct ttcaatcgg 29
- <210> 1095 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1095 ctcggtgttg gccatgctcc ag 22
- <210> 1096 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1096 atcttctcag acgtcccgag ccag 24
- <210> 1097 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1097 tgtccttacc tgtgggagct gtaaggtc 28
- <210> 1098 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1098 tcctttggta tcagacccga agcg 24
- <210> 1099 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1099 cctttccagc tttacagtga attgctgca 29
- <210> 1100 <211> 29 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1100 ccaagagaaa cgagatttaa aaacccacc 29
- <210> 1101 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1101 ctttccaacc cctggggaag acat 24
- <210> 1102 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1102 cctcccgaag ttgcttgaaa gcac 24
- <210> 1103 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1103 cattcgcttc ttcctccact tggc 24
- <210> 1104 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1104 tctccacaga caaggccagg actcg 25
- <210> 1105 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1105 atcaccaaca gcatgacctt tgcg 24
- <210> 1106 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1106 aggacagtgg agcagccaac acac 24
- <210> 1107 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1107 cattggaatt gccattagtc ccagc 25
- <210> 1108 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1108 ccagcacagc cagttaaaag atgca 25
- <210> 1109 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1109 ttggatctgc ttgctgtcca aacc 24
- <210> 1110 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1110 cacgccatgg aaaccatgat gttt 24
- <210> 1111 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1111 cacaagtact cctgccaaga gggcgac 27
- <210> 1112 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1112 atcacatcca gggccttctc caga 24
- <210> 1113 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1113 ttccccaact tccttagtgc ctgtgaca 28
- <210> 1114 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1114 catgccgtct acagggatga cctg 24
- <210> 1115 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1115 cccggggcct gttatgtcaa act 23
- <210> 1116 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1116 ccggagggaa ccctgactac agaa 24
- <210> 1117 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1117 aggataagac cacagcacag gcgc 24
- <210> 1118 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1118 ttgctcaagg acctggacgc caa 23
- <210> 1119 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1119 ctgtccacca aatgcacgct gata 24
- <210> 1120 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1120 ctccccacag cgcatcgagg aa 22
- <210> 1121 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1121 cagcaccgat ttcttcaggt ccct 24
- <210> 1122 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1122 cctgacttca ggtcaaggga tgg 23
- <210> 1123 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1123 ccaatctctg cctcagttct gcca 24
- <210> 1124 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1124 cctgcggctt tcggatccca 20
- <210> 1125 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1125 tggccatcca tctcacagaa attgg 25
- <210> 1126 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1126 tctggattag agtcctgcag ctcgc 25
- <210> 1127 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1127 ctctgtggca ccctggacta cctg 24
- <210> 1128 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1128 cacgttctct gccccgtttc ttg 23
- <210> 1129 <211> 25 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1129 atcctcctga agcccttttc gcagc 25
- <210> 1130 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1130 tgccttcttc ctccctcact tctcacct 28
- <210> 1131 <211> 30 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1131 ccataggaga atgcttccca catcaacact 30
- <210> 1132 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1132 cccatagtcc tcagccgcct tcag 24
- <210> 1133 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1133 cttccagcgg caatgtaagc aaca 24
- <210> 1134 <211> 28 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1134 agggatctga accaatacag agcagaca 28
- <210> 1135 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1135 tcctgagccc gaggaagtcc c 21
- <210> 1136 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1136 cggccagatg agcacattgc c 21
- <210> 1137 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1137 ttctgggctc ctgattgctc aagc 24
- <210> 1138 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1138 ccaagaacga gtgtctctgg accg 24
- <210> 1139 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1139 tgttcctcac tgagcctgga agca 24
- <210> 1140 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1140 agggcctaat gcacgcacta aagc 24
- <210> 1141 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1141 tccaccatcg ctttctctgc tctg 24
- <210> 1142 <211> 21 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1142 ccacgctgcc ctcggacaag c 21
- <210> 1143 <211> 23 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1143 aattaacagc cacccctcag gcg 23
- <210> 1144 <211> 26 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1144 caggcacaca caggtgggac acaaat 26
- <210> 1145 <211> 22 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1145 atttcacgca tctggcgttc ca 22
- <210> 1146 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1146 tggacactgt ggaccctccc tacc 24
- <210> 1147 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1147 ccagaacaga tgcgagcagt ccat 24
- <210> 1148 <211> 20 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1148 cgggctgcat cagcacacgc 20
- <210> 1149 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1149 ttgatgcctg tcttcgcgcc ttct 24
- <210> 1150 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1150 ttccgtaaga ggcctggtgc tctc 24
- <210> 1151 <211> 27 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1151 ctgctgttta ccttggcgag gcctttc 27
- <210> 1152 <211> 24 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic probe
- <400> 1152 cccctccttc tcctgcttca gctt 24
- <210> 1153 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1153
- <210> 1154 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1154
- <210> 1155 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1155
- <210> 1156 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1156
- <210> 1157 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1157
- <210> 1158 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1158
- <210> 1159 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1159
- <210> 1160 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1160
- <210> 1161 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1161
- <210> 1162 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1162
- <210> 1163 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1163
- <210> 1164 <211> 62 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1164
- <210> 1165 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1165
- <210> 1166 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1166
- <210> 1167 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1167
- <210> 1168 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1168
- <210> 1169 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1169
- <210> 1170 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1170
- <210> 1171 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1171
- <210> 1172 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1172
- <210> 1173 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1173
- <210> 1174 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1174
- <210> 1175 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1175
- <210> 1176 <211> 81 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1176
- <210> 1177 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1177
- <210> 1178 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1178
- <210> 1179 <211> 64 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1179
- <210> 1180 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1180
- <210> 1181 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1181
- <210> 1182 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1182
- <210> 1183 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1183
- <210> 1184 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1184
- <210> 1185 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1185
- <210> 1186 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1186
- <210> 1187 <211> 81 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1187
- <210> 1188 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1188
- <210> 1189 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1189
- <210> 1190 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1190
- <210> 1191 <211> 83 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1191
- <210> 1192 <211> 65 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1192
- <210> 1193 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1193
- <210> 1194 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1194
- <210> 1195 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1195
- <210> 1196 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1196
- <210> 1197 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1197
- <210> 1198 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1198
- <210> 1199 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1199
- <210> 1200 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1200
- <210> 1201 <211> 63 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1201
- <210> 1202 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1202
- <210> 1203 <211> 82 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1203
- <210> 1204 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1204
- <210> 1205 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1205
- <210> 1206 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1206
- <210> 1207 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1207
- <210> 1208 <211> 65 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1208
- <210> 1209 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1209
- <210> 1210 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1210
- <210> 1211 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1211
- <210> 1212 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1212
- <210> 1213 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1213
- <210> 1214 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1214
- <210> 1215 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1215
- <210> 1216 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1216
- <210> 1217 <211> 65 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1217
- <210> 1218 <211> 84 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1218
- <210> 1219 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1219
- <210> 1220 <211> 85 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1220
- <210> 1221 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1221
- <210> 1222 <211> 64 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1222
- <210> 1223 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1223
- <210> 1224 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1224
- <210> 1225 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1225
- <210> 1226 <211> 90 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1226
- <210> 1227 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1227
- <210> 1228 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1228
- <210> 1229 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1229
- <210> 1230 <211> 84 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1230
- <210> 1231 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1231
- <210> 1232 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1232
- <210> 1233 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1233
- <210> 1234 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1234
- <210> 1235 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1235
- <210> 1236 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1236
- <210> 1237 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1237
- <210> 1238 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1238
- <210> 1239 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1239
- <210> 1240 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1240
- <210> 1241 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1241
- <210> 1242 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1242
- <210> 1243 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1243
- <210> 1244 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1244
- <210> 1245 <211> 63 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1245
- <210> 1246 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1246
- <210> 1247 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1247
- <210> 1248 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1248
- <210> 1249 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1249
- <210> 1250 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1250
- <210> 1251 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1251
- <210> 1252 <211> 62 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1252
- <210> 1253 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1253
- <210> 1254 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1254
- <210> 1255 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1255
- <210> 1256 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1256
- <210> 1257 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1257
- <210> 1258 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1258
- <210> 1259 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1259
- <210> 1260 <211> 81 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1260
- <210> 1261 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1261
- <210> 1262 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1262
- <210> 1263 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1263
- <210> 1264 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1264
- <210> 1265 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1265
- <210> 1266 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1266
- <210> 1267 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1267
- <210> 1268 <211> 64 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1268
- <210> 1269 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1269
- <210> 1270 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1270
- <210> 1271 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1271
- <210> 1272 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1272
- <210> 1273 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1273
- <210> 1274 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1274
- <210> 1275 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1275
- <210> 1276 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1276
- <210> 1277 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1277
- <210> 1278 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1278
- <210> 1279 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1279
- <210> 1280 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1280
- <210> 1281 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1281
- <210> 1282 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1282
- <210> 1283 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1283
- <210> 1284 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1284
- <210> 1285 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1285
- <210> 1286 <211> 110 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1286
- <210> 1287 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1287
- <210> 1288 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1288
- <210> 1289 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1289
- <210> 1290 <211> 84 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1290
- <210> 1291 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1291
- <210> 1292 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1292
- <210> 1293 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1293
- <210> 1294 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1294
- <210> 1295 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1295
- <210> 1296 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1296
- <210> 1297 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1297
- <210> 1298 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1298
- <210> 1299 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1299
- <210> 1300 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1300
- <210> 1301 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1301
- <210> 1302 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1302
- <210> 1303 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1303
- <210> 1304 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1304
- <210> 1305 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1305
- <210> 1306 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1306
- <210> 1307 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1307
- <210> 1308 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1308
- <210> 1309 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1309
- <210> 1310 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1310
- <210> 1311 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1311
- <210> 1312 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1312
- <210> 1313 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1313
- <210> 1314 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1314
- <210> 1315 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1315
- <210> 1316 <211> 86 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1316
- <210> 1317 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1317
- <210> 1318 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1318
- <210> 1319 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1319
- <210> 1320 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1320
- <210> 1321 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1321
- <210> 1322 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1322
- <210> 1323 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1323
- <210> 1324 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1324
- <210> 1325 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1325
- <210> 1326 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1326
- <210> 1327 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1327
- <210> 1328 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1328
- <210> 1329 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1329
- <210> 1330 <211> 81 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1330
- <210> 1331 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1331
- <210> 1332 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1332
- <210> 1333 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1333
- <210> 1334 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1334
- <210> 1335 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1335
- <210> 1336 <211> 83 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1336
- <210> 1337 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1337
- <210> 1338 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1338
- <210> 1339 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1339
- <210> 1340 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1340
- <210> 1341 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1341
- <210> 1342 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1342
- <210> 1343 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1343
- <210> 1344 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1344
- <210> 1345 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1345
- <210> 1346 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1346
- <210> 1347 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1347
- <210> 1348 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1348
- <210> 1349 <211> 83 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1349
- <210> 1350 <211> 85 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1350
- <210> 1351 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1351
- <210> 1352 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1352
- <210> 1353 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1353
- <210> 1354 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1354
- <210> 1355 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1355
- <210> 1356 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1356
- <210> 1357 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1357
- <210> 1358 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1358
- <210> 1359 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1359
- <210> 1360 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1360
- <210> 1361 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1361
- <210> 1362 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1362
- <210> 1363 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1363
- <210> 1364 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1364
- <210> 1365 <211> 64 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1365
- <210> 1366 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1366
- <210> 1367 <211> 86 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1367
- <210> 1368 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1368
- <210> 1369 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1369
- <210> 1370 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1370
- <210> 1371 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1371
- <210> 1372 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1372
- <210> 1373 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1373
- <210> 1374 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1374
- <210> 1375 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1375
- <210> 1376 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1376
- <210> 1377 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1377
- <210> 1378 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1378
- <210> 1379 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1379
- <210> 1380 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1380
- <210> 1381 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1381
- <210> 1382 <211> 84 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1382
- <210> 1383 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1383
- <210> 1384 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1384
- <210> 1385 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1385
- <210> 1386 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1386
- <210> 1387 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1387
- <210> 1388 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1388
- <210> 1389 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1389
- <210> 1390 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1390
- <210> 1391 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1391
- <210> 1392 <211> 63 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1392
- <210> 1393 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1393
- <210> 1394 <211> 84 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1394
- <210> 1395 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1395
- <210> 1396 <211> 84 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1396
- <210> 1397 <211> 83 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1397
- <210> 1398 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1398
- <210> 1399 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1399
- <210> 1400 <211> 83 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1400
- <210> 1401 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1401
- <210> 1402 <211> 83 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1402
- <210> 1403 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1403
- <210> 1404 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1404
- <210> 1405 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1405
- <210> 1406 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1406
- <210> 1407 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1407
- <210> 1408 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1408
- <210> 1409 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1409
- <210> 1410 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1410
- <210> 1411 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1411
- <210> 1412 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1412
- <210> 1413 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1413
- <210> 1414 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1414
- <210> 1415 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1415
- <210> 1416 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1416
- <210> 1417 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1417
- <210> 1418 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1418
- <210> 1419 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1419
- <210> 1420 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1420
- <210> 1421 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1421
- <210> 1422 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1422
- <210> 1423 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1423
- <210> 1424 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1424
- <210> 1425 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1425
- <210> 1426 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1426
- <210> 1427 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1427
- <210> 1428 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1428
- <210> 1429 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1429
- <210> 1430 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1430
- <210> 1431 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1431
- <210> 1432 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1432
- <210> 1433 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1433
- <210> 1434 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1434
- <210> 1435 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1435
- <210> 1436 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1436
- <210> 1437 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1437
- <210> 1438 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1438
- <210> 1439 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1439
- <210> 1440 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1440
- <210> 1441 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1441
- <210> 1442 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1442
- <210> 1443 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1443
- <210> 1444 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1444
- <210> 1445 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1445
- <210> 1446 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1446
- <210> 1447 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1447
- <210> 1448 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1448
- <210> 1449 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1449
- <210> 1450 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1450
- <210> 1451 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1451
- <210> 1452 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1452
- <210> 1453 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1453
- <210> 1454 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1454
- <210> 1455 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1455
- <210> 1456 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1456
- <210> 1457 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1457
- <210> 1458 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1458
- <210> 1459 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1459
- <210> 1460 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1460
- <210> 1461 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1461
- <210> 1462 <211> 86 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1462
- <210> 1463 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1463
- <210> 1464 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1464
- <210> 1465 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1465
- <210> 1466 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1466
- <210> 1467 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1467
- <210> 1468 <211> 91 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1468
- <210> 1469 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1469
- <210> 1470 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1470
- <210> 1471 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1471
- <210> 1472 <211> 78 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1472
- <210> 1473 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1473
- <210> 1474 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1474
- <210> 1475 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1475
- <210> 1476 <211> 83 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1476
- <210> 1477 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1477
- <210> 1478 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1478
- <210> 1479 <211> 81 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1479
- <210> 1480 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1480
- <210> 1481 <211> 85 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1481
- <210> 1482 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1482
- <210> 1483 <211> 81 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1483
- <210> 1484 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1484
- <210> 1485 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1485
- <210> 1486 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1486
- <210> 1487 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1487
- <210> 1488 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1488
- <210> 1489 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1489
- <210> 1490 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1490
- <210> 1491 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1491
- <210> 1492 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1492
- <210> 1493 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1493
- <210> 1494 <211> 77 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1494
- <210> 1495 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1495
- <210> 1496 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1496
- <210> 1497 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1497
- <210> 1498 <211> 76 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1498
- <210> 1499 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1499
- <210> 1500 <211> 70 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1500
- <210> 1501 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1501
- <210> 1502 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1502
- <210> 1503 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1503
- <210> 1504 <211> 86 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1504
- <210> 1505 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1505
- <210> 1506 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1506
- <210> 1507 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1507
- <210> 1508 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1508
- <210> 1509 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1509
- <210> 1510 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1510
- <210> 1511 <211> 69 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1511
- <210> 1512 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1512
- <210> 1513 <211> 90 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1513
- <210> 1514 <211> 80 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1514
- <210> 1515 <211> 85 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1515
- <210> 1516 <211> 73 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1516
- <210> 1517 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1517
- <210> 1518 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1518
- <210> 1519 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1519
- <210> 1520 <211> 65 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1520
- <210> 1521 <211> 66 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1521
- <210> 1522 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1522
- <210> 1523 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1523
- <210> 1524 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1524
- <210> 1525 <211> 71 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1525
- <210> 1526 <211> 64 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1526
- <210> 1527 <211> 522 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1527
- <210> 1528 <211> 89 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1528
- <210> 1529 <211> 72 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1529
- <210> 1530 <211> 67 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1530
- <210> 1531 <211> 68 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1531
- <210> 1532 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1532
- <210> 1533 <211> 75 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1533
- <210> 1534 <211> 79 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1534
- <210> 1535 <211> 74 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1535
- <210> 1536 <211> 81 <212> DNA <213> Artificial Sequence
- <220> <223> Synthetic oligonucleotide
- <400> 1536
Claims (12)
- A method for predicting the clinical outcome of a patient diagnosed with cancer comprising:(a) obtaining an expression level of an expression product of at least one prognostic gene from a tissue sample obtained from a tumour of the patient, wherein the at least one prognostic gene is IL6ST;(b) normalizing the expression level of the expression product of the at least one prognostics gene to obtain a normalized expression level;(c) expressing the normalized expression level as an expression value compared to an expression level from a tumour reference set; and(d) calculating a risk score based on the normalized expression value, wherein increased expression of IL6ST is positively correlated with good prognosis.
- A method as claimed in claim 1, further comprising: generating a report based on the risk score.
- A method as claimed in claim 1, wherein the patient is a human patient.
- A method as claimed in claim 1, wherein the tumour is a breast cancer tumour.
- A method as claimed in claim 1, wherein the tissue sample is a fixed paraffin-embedded tissue.
- A method as claimed in claim 1, wherein the expression level is obtained using a PCR-based method.
- A method as claimed in claim 1, wherein an expression level is obtained from at least two genes in any of the stromal, metabolic, immune, proliferation, or metabolic groups, or their gene products.
- A method as claimed in claim 1, wherein an expression level is obtained from at least four genes in any two of the stromal, metabolic, immune, proliferation, or metabolic groups, or their gene products.
- A method as claimed in claim 1, further comprising obtaining an expression level of at least one co-expressed gene from those listed in Table 18.
- A method for classifying a cancer patient according to prognosis, comprising the steps of:(a) receiving a first data structure comprising the respective levels of an expression product of each of at least three different prognostic genes listed in any of Tables 1-12 in a tissue sample obtained from tumour in the patient, wherein one of the prognostic genes is IL6ST;(b) normalizing the at least three expression values to obtain normalized expression values;(c) determining the similarity of the normalized expression values of each of the at least three prognostic genes to respective control levels of expression of the at least three prognostic genes obtained from a second data structure to obtain a patient similarity value, wherein the second data structure is based on levels of expression from a plurality of cancer tumours;(d) comparing the patient similarity value to a selected threshold value of similarity of the respective normalized expression values of each of the at least three prognostic genes to the respective control levels of expression of the at least three prognostic genes; and(e) classifying the patient as having a first prognosis if the patient similarity value exceeds the threshold similarity value, and a second prognosis if the patient similarity value does not exceed the threshold similarity value.
- A computer program comprising computer code means for performing steps (b) to (d) of a method as claimed in any of claims 1 to 10, wherein the expression level of an expression product of at least one prognostic gene has been obtained from a tissue sample obtained from a tumour of the patient, wherein the at least one prognostic gene is IL6ST wherein said program is run on a computer.
- A computer program as claimed in claim 11 embodied on a computer-readable medium.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61/263,763 | 2009-11-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HK1175820A true HK1175820A (en) | 2013-07-12 |
| HK1175820B HK1175820B (en) | 2020-01-31 |
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