HRP20110907T1 - Supstituirani derivati sulfonamida - Google Patents

Supstituirani derivati sulfonamida Download PDF

Info

Publication number: HRP20110907T1
Authority: HR; Croatia
Prior art keywords: methyl; phenyl; benzenesulfonyl; acetamide; dichloro
Prior art date: 2007-04-30

Application number

HR20110907T

Other languages

English (en)

Croatian (hr)

Inventor

Merla Beatrix

Oberb�rsch Stefan

Reich Melanie

Sundermann Bernd

Englberger Werner

Str�nker Timo

Jostock Ruth

Hees Sabine

Bijsterveld Edward

Theil Fritz

Graubaum Heinz

Original Assignee

Grnenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-30

Filing date

2008-04-28

Publication date

2011-12-31

2008-04-28 Application filed by Grnenthal Gmbh filed Critical Grnenthal Gmbh

2011-12-31 Publication of HRP20110907T1 publication Critical patent/HRP20110907T1/hr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Addiction (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Obesity (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Immunology (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Child & Adolescent Psychology (AREA)

HR20110907T 2007-04-30 2008-04-28 Supstituirani derivati sulfonamida HRP20110907T1 (hr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102007020492A DE102007020492A1 (de)	2007-04-30	2007-04-30	Substituierte Sulfonamid-Derivate
PCT/EP2008/003417 WO2008131947A1 (fr)	2007-04-30	2008-04-28	Dérivés de sulfonamide substitués

Publications (1)

Publication Number	Publication Date
HRP20110907T1 true HRP20110907T1 (hr)	2011-12-31

Family

ID=39673041

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20110907T HRP20110907T1 (hr)	2007-04-30	2008-04-28	Supstituirani derivati sulfonamida

Country Status (14)

Country	Link
US (1)	US8119633B2 (fr)
EP (1)	EP2150530B1 (fr)
JP (1)	JP5355549B2 (fr)
AT (1)	ATE530524T1 (fr)
CA (1)	CA2685507A1 (fr)
CY (1)	CY1112429T1 (fr)
DE (1)	DE102007020492A1 (fr)
DK (1)	DK2150530T3 (fr)
ES (1)	ES2376505T3 (fr)
HR (1)	HRP20110907T1 (fr)
PL (1)	PL2150530T3 (fr)
PT (1)	PT2150530E (fr)
SI (1)	SI2150530T1 (fr)
WO (1)	WO2008131947A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102056919B (zh) *	2008-04-08	2014-03-12	格吕伦塔尔有限公司	取代的磺酰胺衍生物
MX337575B (es)	2009-10-09	2016-03-10	Zafgen Corp	Compuestos de sulfona y métodos para lafabricación y uso de éstos.
JP5187534B2 (ja) *	2010-02-12	2013-04-24	有機合成薬品工業株式会社	Ｎ−ｔｅｒｔ−ブトキシカルボニル−４−ホルミルピペリジンの製造方法
JP5913310B2 (ja)	2010-07-22	2016-04-27	ザフゲン，インコーポレイテッド	三環式化合物ならびにその作製および使用方法
WO2012014127A1 (fr)	2010-07-30	2012-02-02	Ranbaxy Laboratories Limited	Inhibiteurs de 5-lipoxygénase
EP2627632A1 (fr) *	2010-10-12	2013-08-21	Zafgen, Inc.	Composés sulfonamides et leurs procédés de fabrication et d'utilisation
EP2471363A1 (fr)	2010-12-30	2012-07-04	Bayer CropScience AG	Utilisation d'acides aryl-, hétéroaryl- et benzylsulfonaminés, d'esters d'acide aminé, d'amides d'acide aminé et carbonitrile ou leurs sels pour l'augmentation de la tolérance au stress dans des plantes
MX344238B (es)	2011-01-26	2016-12-07	Zafgen Inc	Compuestos de tetrazol y métodos para preparar y usar los mismos.
JP6062423B2 (ja)	2011-05-06	2017-01-18	ザフゲン，インコーポレイテッド	部分飽和三環式化合物ならびにその製造および使用方法
MX343687B (es)	2011-05-06	2016-11-16	Zafgen Inc	Compuestos sulfonamida tricíclica y métodos para su fabricación y uso.
AU2012253760B2 (en)	2011-05-06	2016-02-04	Zafgen, Inc.	Tricyclic pyrazole sulfonamide compounds and methods of making and using same
US9396311B2 (en)	2011-07-13	2016-07-19	Dell Products L.P.	Mini appliance ensuring software license compliance
KR20140112566A (ko)	2012-01-18	2014-09-23	자프겐 인크.	삼환식 설폰 화합물 그리고 그의 제조방법 및 그를 이용하는 방법
WO2013109739A1 (fr)	2012-01-18	2013-07-25	Zafgen, Inc.	Composés sulfonamides tricycliques, procédés de fabrication et d'utilisation de ceux-ci
JP2015536981A (ja)	2012-11-05	2015-12-24	ザフゲン，インコーポレイテッド	三環式化合物ならびにその製造および使用方法
CN104918928A (zh)	2012-11-05	2015-09-16	扎夫根股份有限公司	三环化合物及其制备方法和用途
WO2014071368A1 (fr)	2012-11-05	2014-05-08	Zafgen, Inc.	Méthodes de traitement de maladies hépatiques
JP2016505597A (ja)	2012-12-21	2016-02-25	エピザイム，インコーポレイティド	Ｐｒｍｔ５阻害剤およびその使用
US9365555B2 (en)	2012-12-21	2016-06-14	Epizyme, Inc.	PRMT5 inhibitors and uses thereof
US9745291B2 (en)	2012-12-21	2017-08-29	Epizyme, Inc.	PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
LT2935222T (lt)	2012-12-21	2018-12-27	Epizyme, Inc.	Prmt5 slopikliai ir jų panaudojimas
US8906900B2 (en)	2012-12-21	2014-12-09	Epizyme, Inc.	PRMT5 inhibitors and uses thereof
AU2015301196A1 (en)	2014-08-04	2017-01-12	Epizyme, Inc.	PRMT5 inhibitors and uses thereof
WO2018108627A1 (fr)	2016-12-12	2018-06-21	Bayer Cropscience Aktiengesellschaft	Utilisation d'indolinylméthylsulfonamides substitués ou de leurs sels pour accroître la tolérance au stress chez les plantes
WO2019025153A1 (fr)	2017-07-31	2019-02-07	Bayer Cropscience Aktiengesellschaft	Utilisation de n-sulfonyl-n'-aryldiaminoalcanes et de n-sulfonyl-n'-hétéroaryldiaminoalcanes substitués ou de leurs sels pour accroître la tolérance au stress chez les plantes
CN114276303B (zh) *	2021-12-29	2023-09-22	河南大学	脲基化合物或其药用盐及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6319920B1 (en) *	1998-02-27	2001-11-20	Syntex (U.S.A.) Llc	2-arylethyl-(piperidin-4-ylmethyl)amine derivatives
JP2001172257A (ja) *	1999-10-05	2001-06-26	Fujisawa Pharmaceut Co Ltd	有機スルホンアミド化合物
JP2006516132A (ja) *	2002-12-19	2006-06-22	エランファーマシューティカルズ，インコーポレイテッド	置換ｎ−フェニルスルホンアミドブラジキニン拮抗薬
MXPA05010883A (es) *	2003-04-10	2006-01-23	Amgen Inc	Derivados de amina ciclica y su uso en el tratamiento de trastornos inflamatorios relacionados mediados por bradiquinina.
BRPI0709961A2 (pt) *	2006-04-11	2011-08-02	Novartis Ag	compostos orgánicos

2007
- 2007-04-30 DE DE102007020492A patent/DE102007020492A1/de not_active Withdrawn
2008
- 2008-04-28 AT AT08749188T patent/ATE530524T1/de active
- 2008-04-28 HR HR20110907T patent/HRP20110907T1/hr unknown
- 2008-04-28 PT PT08749188T patent/PT2150530E/pt unknown
- 2008-04-28 SI SI200830518T patent/SI2150530T1/sl unknown
- 2008-04-28 PL PL08749188T patent/PL2150530T3/pl unknown
- 2008-04-28 JP JP2010504568A patent/JP5355549B2/ja not_active Expired - Fee Related
- 2008-04-28 DK DK08749188.2T patent/DK2150530T3/da active
- 2008-04-28 EP EP08749188A patent/EP2150530B1/fr not_active Not-in-force
- 2008-04-28 ES ES08749188T patent/ES2376505T3/es active Active
- 2008-04-28 CA CA002685507A patent/CA2685507A1/fr not_active Abandoned
- 2008-04-28 WO PCT/EP2008/003417 patent/WO2008131947A1/fr active Application Filing
- 2008-04-30 US US12/112,592 patent/US8119633B2/en not_active Expired - Fee Related
2011
- 2011-11-28 CY CY20111101172T patent/CY1112429T1/el unknown

Also Published As

Publication number	Publication date
DK2150530T3 (da)	2012-02-06
SI2150530T1 (sl)	2012-02-29
EP2150530B1 (fr)	2011-10-26
US20080312231A1 (en)	2008-12-18
DE102007020492A1 (de)	2008-11-06
PT2150530E (pt)	2012-01-17
ATE530524T1 (de)	2011-11-15
CA2685507A1 (fr)	2008-11-06
CY1112429T1 (el)	2015-12-09
JP2010525002A (ja)	2010-07-22
JP5355549B2 (ja)	2013-11-27
WO2008131947A1 (fr)	2008-11-06
EP2150530A1 (fr)	2010-02-10
US8119633B2 (en)	2012-02-21
PL2150530T3 (pl)	2012-03-30
ES2376505T3 (es)	2012-03-14

Publication	Publication Date	Title
HRP20110907T1 (hr)	2011-12-31	Supstituirani derivati sulfonamida
ES2373680T3 (es)	2012-02-07	Derivados de tiazol condensados como inhibidores de cinasa.
RU2401265C2 (ru)	2010-10-10	Соединения и композиции в качестве ингибиторов протеинкиназы
ES2609040T3 (es)	2017-04-18	Aminopirimidinas como inhibidores de Syk
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US20050256159A1 (en)	2005-11-17	1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors
AU2007316248A1 (en)	2008-05-08	Indazole derivatives useful as L-CPT1 inhibitors
RU2009115960A (ru)	2010-11-10	Замещенные сульфамидные производные
CN101146769A (zh)	2008-03-19	作为β-分泌酶抑制剂的唑基酰基胍
CA2583737A1 (fr)	2006-05-18	Composes et compositions utilises comme inhibiteurs de la proteine kinase
RU2008116313A (ru)	2009-11-10	Диарилминсодержащие соединения, композиции и их примеение в качестве модуляторов рецепторов с-кit
CA2589271A1 (fr)	2006-06-15	Inhibiteurs uree de map kinases
WO2009026197A1 (fr)	2009-02-26	Nouveaux inhibiteurs de la cathepsine c et leur utilisation
KR20090069333A (ko)	2009-06-30	히스타민 ｈ3-수용체 관련된 장애의 치료에 유용한 히스타민 ｈ3-수용체의 비페닐 술포닐 및 페닐-헤테로아릴 술포닐 조절제
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