HRP20160379T1 - Stanično permeabilni peptidni inhibitori jnk signalnog transdukcijskog puta - Google Patents
Stanično permeabilni peptidni inhibitori jnk signalnog transdukcijskog puta Download PDFInfo
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- HRP20160379T1 HRP20160379T1 HRP20160379TT HRP20160379T HRP20160379T1 HR P20160379 T1 HRP20160379 T1 HR P20160379T1 HR P20160379T T HRP20160379T T HR P20160379TT HR P20160379 T HRP20160379 T HR P20160379T HR P20160379 T1 HRP20160379 T1 HR P20160379T1
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- Croatia
- Prior art keywords
- chimeric peptide
- peptide according
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- diseases
- cancer
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims 4
- 239000003112 inhibitor Substances 0.000 title 1
- 230000019491 signal transduction Effects 0.000 title 1
- 108091006116 chimeric peptides Proteins 0.000 claims 12
- 150000001413 amino acids Chemical group 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000011594 Autoinflammatory disease Diseases 0.000 claims 1
- 208000027496 Behcet disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 150000008574 D-amino acids Chemical class 0.000 claims 1
- 239000012623 DNA damaging agent Substances 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 208000016952 Ear injury Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020843 Hyperthermia Diseases 0.000 claims 1
- 206010021113 Hypothermia Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 150000008575 L-amino acids Chemical class 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 150000001408 amides Chemical group 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000004700 cellular uptake Effects 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 230000036031 hyperthermia Effects 0.000 claims 1
- 230000002631 hypothermal effect Effects 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000005865 ionizing radiation Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000001926 lymphatic effect Effects 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 230000030648 nucleus localization Effects 0.000 claims 1
- 230000006548 oncogenic transformation Effects 0.000 claims 1
- 230000007310 pathophysiology Effects 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000010410 reperfusion Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000009291 secondary effect Effects 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16371—Demonstrated in vivo effect
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Claims (12)
1. Kimerni peptid koji sadrži prvu domenu, drugu domenu i proizvoljno vezujuću sekvencu, te prva domena sadrži transportnu sekvencu i druga domena sadrži JNK inhibicijsku sekvencu, naznačen time da prva domena sadrži sve-D retro-inverzo sekvence amino kiseline u skladu sa SEQ ID NO:6 te time da druga domena sadrži sve-D retro-inverzo sekvence amino kiseline u skladu sa SEQ ID NO:2, pri čemu je prva domena vezana na C-terminalni kraj druge domene bilo izravno ili pomoću navedene vezujuće sekvence koja sadrži 1 do 10 amino kiselina.
2. Kimerni peptid prema zahtjevu 1, naznačen time da vezujuća sekvenca sadrži 1 do 5 amino kiselina.
3. Kimerni peptid prema zahtjevu 1 ili 2, naznačen time da je vezujuća sekvenca sastavljena od L amino kiselina, D amino kiselina ili od njihove kombinacije.
4. Kimerni peptid prema bilo kojem od zahtjeva od 1 do 3, naznačen time da transportna sekvenca povećava staničnu absorpciju peptida.
5. Kimerni peptid prema bilo kojem od zahtjeva od 1 do 4, naznačen time da transportna sekvenca usmjerava nuklearnu lokalizaciju peptida.
6. Kimerni peptid prema bilo kojem od zahtjeva od 1 do 5, naznačen time da kimerni peptid ima modifikaciju na C-terminalnom kraju.
7. Kimerni peptid peptide prema zahtjevu 6, naznačen time da je C-terminalni kraj izmijenjen sa amidnom modifikacijom.
8. Farmaceutski pripravak, naznačen time da sadrži kimerni peptid prema bilo kojem od zahtjeva od 1 do 7, te farmaceutski prihvatljiv nosač.
9. Uporaba kimernog peptida prema bilo kojem od zahtjeva od 1 do 8 naznačena time da je za pripremanje farmaceutskog pripravka za liječenje patofiziologije koja je odabrana iz skupine koja sadrži maligne bolesti pluća, dojki, limfnog, gastrointestinalnog i genitalno-urinarnog trakta kao i adenokarcinome, uključujući maligna stanja poput raka debelog crijeva, karcinoma bubrežnih stanica, raka prostate, karcinoma pluća ne-malih stanica, raka tankog crijeva i raka ezofagusa, kao i leukemije, karcinoma sa Bcr-Abl onkogenim transformacijama, psorijaze, pemphigus vulgaris, Behcetovog sindroma, akutnog respiratornog stresnog sindroma (ARDS), ishemijske bolesti srca, post-dijaliznog sindroma, reumatoidnog artritisa, sindroma stečene imuno deficijencije, vaskulitisa, septičkog šoka, restenoze, gubitka sluha, ozljede uha, ishemije, kapi; ozljeda zbog reperfuzije, hipoksije, autoimunih bolesti, neurodegenerativnih bolesti, kardiovaskularne bolesti, osteoporoze, sekundarnih učinaka zbog liječenja s proupalnim citokinima, dijabetes, srčanu i kardijalnu hipertrofije i arterioskleroznih lezija, patoloških stanja zbog ionizacijskog zračenja tijekom radioterapije i zračenja sa ultraljubičastim svijetlom (UV svijetlo), patoloških stanja prouzročenih sredstvima koja oštećuju DNK, uključujući lijekove za kemoterapiju, hipo- i hipertermiju, upalne bolesti, auto-upalne, imune i auto-imune bolesti, degenerativne bolesti, miopatije, kardiomiopatije i odbacivanje transplantata.
10. Uporaba kimernog peptida prema zahtjevu 9 naznačena time da je za pripremanje farmaceutskog pripravka za liječenje kapi, moždane traume, ozljede leđne moždine, amiotrofične lateralne skleroze, Huntingtonove bolesti, Alzheimerove bolesti i Parkinsonove bolesti.
11. Uporaba prema zahtjevu 9, naznačena time, da je farmaceutski pripravak namijenjen za davanje putem za davanje koji je odabran iz skupine koja sadrži intraperitonealno, nazalno, intravenozno, oralno davanje i davanje putem flastera.
12. Komplet (kit), naznačen time, da sadrži kimerni peptid prema bilo kojem od zahtjeva od 1 do 7.
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| EP11003985.6A EP2418217B1 (en) | 2005-09-12 | 2006-09-12 | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
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