HUE059925T2 - Módosított aminoacil-tRNS-szintetáz és alkalmazása - Google Patents
Módosított aminoacil-tRNS-szintetáz és alkalmazásaInfo
- Publication number
- HUE059925T2 HUE059925T2 HUE16764874A HUE16764874A HUE059925T2 HU E059925 T2 HUE059925 T2 HU E059925T2 HU E16764874 A HUE16764874 A HU E16764874A HU E16764874 A HUE16764874 A HU E16764874A HU E059925 T2 HUE059925 T2 HU E059925T2
- Authority
- HU
- Hungary
- Prior art keywords
- application
- trna synthetase
- modified aminoacyl
- aminoacyl
- modified
- Prior art date
Links
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 title 1
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015051202 | 2015-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE059925T2 true HUE059925T2 (hu) | 2023-01-28 |
Family
ID=56918843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE16764874A HUE059925T2 (hu) | 2015-03-13 | 2016-03-11 | Módosított aminoacil-tRNS-szintetáz és alkalmazása |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10815489B2 (hu) |
| EP (2) | EP4166664A1 (hu) |
| JP (3) | JP7020910B2 (hu) |
| DK (1) | DK3269809T3 (hu) |
| HU (1) | HUE059925T2 (hu) |
| WO (1) | WO2016148044A1 (hu) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9409952B2 (en) | 2011-12-28 | 2016-08-09 | Chugai Seiyaku Kabushiki Kaisha | Peptide-compound cyclization method |
| HUE059925T2 (hu) | 2015-03-13 | 2023-01-28 | Chugai Pharmaceutical Co Ltd | Módosított aminoacil-tRNS-szintetáz és alkalmazása |
| WO2018143145A1 (ja) | 2017-01-31 | 2018-08-09 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
| JP7232758B2 (ja) | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| US11492369B2 (en) | 2017-12-15 | 2022-11-08 | Chugai Seiyaku Kabushiki Kaisha | Method for producing peptide, and method for processing bases |
| EP3775216A4 (en) * | 2018-04-03 | 2022-04-13 | The University of Queensland | Oligonucleotide-mediated sense codon reassignment |
| JPWO2019235581A1 (ja) * | 2018-06-06 | 2021-07-08 | 国立大学法人大阪大学 | Ｒｅｇｎａｓｅ−１が関与する疾患の治療および／または予防方法 |
| KR102841441B1 (ko) | 2018-11-07 | 2025-07-31 | 추가이 세이야쿠 가부시키가이샤 | O-치환 세린 유도체의 제조 방법 |
| WO2020111238A1 (ja) | 2018-11-30 | 2020-06-04 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
| CN113454058B (zh) | 2018-12-12 | 2024-03-22 | 中外制药株式会社 | 具有能形成分子内氢键的官能团的氨基酸、包含该氨基酸的肽化合物、及其制备方法 |
| CN120518504A (zh) | 2019-03-15 | 2025-08-22 | 中外制药株式会社 | 芳香族氨基酸衍生物的制备方法 |
| JP2022545625A (ja) * | 2019-08-08 | 2022-10-28 | ブリックバイオ，インコーポレイテッド | 非天然アミノ酸の部位特異的組込みのためのアミノアシルｔｒｎａシンテターゼおよび細胞株 |
| WO2021090855A1 (ja) | 2019-11-07 | 2021-05-14 | 中外製薬株式会社 | Ｋｒａｓ阻害作用を有する環状ペプチド化合物 |
| KR20220113729A (ko) | 2019-12-12 | 2022-08-16 | 추가이 세이야쿠 가부시키가이샤 | 비천연 아미노산을 포함하는 펩타이드의 제조 방법 |
| EP4257978A4 (en) | 2020-12-25 | 2024-11-13 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR SCREENING CANDIDATE MOLECULES CAPABLE OF FORMING A COMPLEX IN CONJUNCTION WITH MULTIPLE TARGET MOLECULES |
| IL316253A (en) | 2022-05-06 | 2025-01-01 | Chugai Pharmaceutical Co Ltd | A cyclic compound with selective KRAS inhibitory effect on HRAS and NRAS |
| EP4594333A2 (en) * | 2022-09-28 | 2025-08-06 | President and Fellows of Harvard College | Evolution of fluorogenic sensors |
| JPWO2024128195A1 (hu) | 2022-12-12 | 2024-06-20 |
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| JP7232758B2 (ja) | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| US11492369B2 (en) | 2017-12-15 | 2022-11-08 | Chugai Seiyaku Kabushiki Kaisha | Method for producing peptide, and method for processing bases |
| KR102841441B1 (ko) | 2018-11-07 | 2025-07-31 | 추가이 세이야쿠 가부시키가이샤 | O-치환 세린 유도체의 제조 방법 |
| WO2020111238A1 (ja) | 2018-11-30 | 2020-06-04 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
| CN113454058B (zh) | 2018-12-12 | 2024-03-22 | 中外制药株式会社 | 具有能形成分子内氢键的官能团的氨基酸、包含该氨基酸的肽化合物、及其制备方法 |
| CN119080856A (zh) | 2018-12-26 | 2024-12-06 | 中外制药株式会社 | 用于密码子扩展的突变tRNA |
| CN120518504A (zh) | 2019-03-15 | 2025-08-22 | 中外制药株式会社 | 芳香族氨基酸衍生物的制备方法 |
| WO2021090855A1 (ja) | 2019-11-07 | 2021-05-14 | 中外製薬株式会社 | Ｋｒａｓ阻害作用を有する環状ペプチド化合物 |
| KR20220113729A (ko) | 2019-12-12 | 2022-08-16 | 추가이 세이야쿠 가부시키가이샤 | 비천연 아미노산을 포함하는 펩타이드의 제조 방법 |
| KR20220121831A (ko) | 2019-12-26 | 2022-09-01 | 추가이 세이야쿠 가부시키가이샤 | 번역용 조성물 및 펩타이드의 제조 방법 |
| CN115667539A (zh) | 2020-06-25 | 2023-01-31 | 中外制药株式会社 | 具有改变的遗传密码表的翻译系统 |
| CN117279933A (zh) | 2021-05-07 | 2023-12-22 | 中外制药株式会社 | 相对于hras和nras具有选择性kras抑制作用的环状化合物 |
-
2016
- 2016-03-11 HU HUE16764874A patent/HUE059925T2/hu unknown
- 2016-03-11 WO PCT/JP2016/057707 patent/WO2016148044A1/ja active Application Filing
- 2016-03-11 US US15/557,532 patent/US10815489B2/en active Active
- 2016-03-11 EP EP22186980.3A patent/EP4166664A1/en active Pending
- 2016-03-11 DK DK16764874.0T patent/DK3269809T3/da active
- 2016-03-11 JP JP2017506512A patent/JP7020910B2/ja active Active
- 2016-03-11 EP EP16764874.0A patent/EP3269809B1/en active Active
-
2020
- 2020-09-18 US US17/024,944 patent/US12163134B2/en active Active
-
2022
- 2022-01-05 JP JP2022000323A patent/JP7292442B2/ja active Active
-
2023
- 2023-06-06 JP JP2023093365A patent/JP7661399B2/ja active Active
-
2024
- 2024-10-25 US US18/926,665 patent/US20250051784A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20180127761A1 (en) | 2018-05-10 |
| US20210087572A1 (en) | 2021-03-25 |
| EP3269809A1 (en) | 2018-01-17 |
| EP3269809A4 (en) | 2018-12-05 |
| JP7292442B2 (ja) | 2023-06-16 |
| JP2022061999A (ja) | 2022-04-19 |
| US10815489B2 (en) | 2020-10-27 |
| JP2023116605A (ja) | 2023-08-22 |
| WO2016148044A1 (ja) | 2016-09-22 |
| JP7020910B2 (ja) | 2022-02-16 |
| US12163134B2 (en) | 2024-12-10 |
| US20250051784A1 (en) | 2025-02-13 |
| EP4166664A1 (en) | 2023-04-19 |
| DK3269809T3 (da) | 2022-09-12 |
| EP3269809B1 (en) | 2022-07-27 |
| JPWO2016148044A1 (ja) | 2017-12-28 |
| JP7661399B2 (ja) | 2025-04-14 |
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