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HUP0103577A2 - Optikai lemez alapú eszközök és eljárások - Google Patents

Optikai lemez alapú eszközök és eljárások

Info

Publication number
HUP0103577A2
HUP0103577A2 HU0103577A HUP0103577A HUP0103577A2 HU P0103577 A2 HUP0103577 A2 HU P0103577A2 HU 0103577 A HU0103577 A HU 0103577A HU P0103577 A HUP0103577 A HU P0103577A HU P0103577 A2 HUP0103577 A2 HU P0103577A2
Authority
HU
Hungary
Prior art keywords
methods
signal
component
test
substrate
Prior art date
Application number
HU0103577A
Other languages
English (en)
Inventor
Jorma Virtanen
Original Assignee
Burstein Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Burstein Technologies, Inc. filed Critical Burstein Technologies, Inc.
Publication of HUP0103577A2 publication Critical patent/HUP0103577A2/hu

Links

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    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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  • Hematology (AREA)
  • Urology & Nephrology (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Optical Measuring Cells (AREA)

Abstract

A találmány tárgyát olyan optikai lemez alapú vizsgálati eszközökképezik, amelyekben egy optikai lemez szubsztrátjánkomponensspecifikus szignálelemek vannak elhelyezve, továbbá aszignálelemek, eljárások ezek előállítására és vizsgálandó komponensekvizsgálatára és mérésére, valamint mérőeszközök. A találmány előnyösmegvalósítási módjaiban a komponensspecifikus szignálelemek a lemezsávkövetési rendszerével leolvasható módon helyezkednek el. Előnyösen,amikor a kiválasztott vizsgálandó komponens egyidejűleg kötődik azelhasítható szignálelem első és második komponensspecifikusoldaltagjához, a szignálérzékeny csoport annak ellenére a szignálelemszubsztrátkapcsoló végéhez rögzül, hogy az első és második oldaltagközött elhelyezkedő hasítási hely elhasad. A szignálérzékeny csoportvisszaveri, elnyeli vagy megtöri a beeső lézerfényt. A leírás feltárnukleinsav-hibridizációs vizsgálati eljárásokat, nukleinsav-szekvenálást, immunvizsgálati eljárásokat, sejtszámlálási eljárásokatés kémiai detektálást is. A vizsgálati eszköz szubsztrát optikaihullámvezetőként történő működéshez való adaptálása folyamatos mérésrealkalmas vizsgálati geometriákat is lehetővé tesz. Ó
HU0103577A 1998-07-21 1999-07-20 Optikai lemez alapú eszközök és eljárások HUP0103577A2 (hu)

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US12004998A 1998-07-21 1998-07-21
PCT/US1999/012395 WO2000005582A2 (en) 1998-07-21 1999-07-20 Optical disc-based assay devices and methods

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