HUP0302412A3 - Betha-carboline derivatives useful as inhibitors of phosphodiesterase and pharmaceutical compositions containing the same - Google Patents

Betha-carboline derivatives useful as inhibitors of phosphodiesterase and pharmaceutical compositions containing the same

Info

Publication number: HUP0302412A3
Authority: HU; Hungary
Prior art keywords: betha; phosphodiesterase; inhibitors; pharmaceutical compositions; same
Prior art date: 2000-05-17

Application number

HU0302412A

Other languages

English (en)

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-17

Filing date

2001-05-03

Publication date

2007-02-28

2001-05-03 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2003-11-28 Publication of HUP0302412A2 publication Critical patent/HUP0302412A2/hu

2007-02-28 Publication of HUP0302412A3 publication Critical patent/HUP0302412A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

HU0302412A 2000-05-17 2001-05-03 Betha-carboline derivatives useful as inhibitors of phosphodiesterase and pharmaceutical compositions containing the same HUP0302412A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20466700P	2000-05-17	2000-05-17
PCT/US2001/014357 WO2001087038A2 (en)	2000-05-17	2001-05-03	β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE

Publications (2)

Publication Number	Publication Date
HUP0302412A2 HUP0302412A2 (hu)	2003-11-28
HUP0302412A3 true HUP0302412A3 (en)	2007-02-28

Family

ID=22758909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0302412A HUP0302412A3 (en)	2000-05-17	2001-05-03	Betha-carboline derivatives useful as inhibitors of phosphodiesterase and pharmaceutical compositions containing the same

Country Status (31)

Country	Link
US (2)	US6492358B2 (hu)
EP (1)	EP1289985B1 (hu)
JP (1)	JP5014551B2 (hu)
KR (1)	KR20030031482A (hu)
CN (1)	CN1255403C (hu)
AR (1)	AR028576A1 (hu)
AT (1)	ATE256127T1 (hu)
AU (2)	AU2001261167B2 (hu)
BG (1)	BG66141B1 (hu)
CA (1)	CA2409715C (hu)
CZ (1)	CZ20023934A3 (hu)
DE (1)	DE60101479T2 (hu)
DK (1)	DK1289985T3 (hu)
ES (1)	ES2211806T3 (hu)
GE (1)	GEP20053511B (hu)
HR (1)	HRP20020910B1 (hu)
HU (1)	HUP0302412A3 (hu)
IL (2)	IL152873A0 (hu)
MX (1)	MXPA02011426A (hu)
MY (1)	MY128479A (hu)
NO (1)	NO324251B1 (hu)
NZ (1)	NZ522731A (hu)
PL (1)	PL205507B1 (hu)
PT (1)	PT1289985E (hu)
RU (1)	RU2271358C2 (hu)
SK (1)	SK16972002A3 (hu)
TR (1)	TR200302309T4 (hu)
TW (1)	TWI286553B (hu)
UA (1)	UA74826C2 (hu)
WO (1)	WO2001087038A2 (hu)
ZA (1)	ZA200210111B (hu)

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JP2004532816A (ja) *	2000-12-08	2004-10-28	スミスクライン・ビーチャム・コーポレイション	抗菌性化合物
US6900220B2 (en) *	2001-01-02	2005-05-31	Syntex (U.S.A.) Llc	Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
ES2248412T3 (es) *	2001-02-12	2006-03-16	Lilly Icos Llc	Derivados de carbolina.
ATE346067T1 (de) *	2001-02-12	2006-12-15	Lilly Icos Llc	Carbolinderivate
WO2002088123A1 (en) *	2001-04-25	2002-11-07	Lilly Icos Llc	Chemical compounds
WO2002098875A1 (en) *	2001-06-05	2002-12-12	Lilly Icos Llc	Carboline derivatives as pde-5 inhibitors
MXPA03011167A (es) *	2001-06-21	2004-02-26	Lilly Icos Llc	Derivados de carbolina utiles como ihibidores de pdev.
DE60221425T2 (de)	2001-11-14	2008-06-26	Ortho-Mcneil Pharmaceutical, Inc.	Substituierte tetrazyklische pyrrolochinolonderivate als phosphodiesterase-inhibitoren
HRP20100067A2 (hr) *	2002-02-07	2010-04-30	University Of Tennessee Research Foundation	Liječenje benigne hiperplazije prostate selektivnim modulatorima androgenih receptora
AU2003243640A1 (en) *	2002-06-19	2004-01-06	Janssen Pharmaceutica, N.V.	Substituted 2,4-dihydro-pyrrolo (3,4-b) -quinolin-9-one derivatives useful as phosphodiesterase inhibitors
US7872133B2 (en) *	2003-06-23	2011-01-18	Ono Pharmaceutical Co., Ltd.	Tricyclic heterocycle compound
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US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
DK1737461T3 (da) *	2004-03-15	2013-03-18	Ptc Therapeutics Inc	Carbolin-derivater til inhibering af angiogenese
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
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ES2459742T3 (es)	2004-12-22	2014-05-12	Ono Pharmaceutical Co., Ltd.	Compuesto tricíclico y uso del mismo
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JP2009536669A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	アンジオテンシン調節による神経新生
AU2007292848A1 (en) *	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US20100184758A1 (en) *	2007-07-19	2010-07-22	Dobbelaar Peter H	Beta carboline derivatives as antidiabetic compounds
US8124616B2 (en)	2007-11-30	2012-02-28	Biota Scientific Management Pty Ltd	Bicyclic PPAT inhibitors as antibacterial agents
CA2727055C (en)	2008-01-11	2016-12-20	Albany Molecular Research, Inc.	(1-azinone) -substituted pyridoindoles as mch antagonists
CN102083830B (zh)	2008-03-24	2014-11-12	梅迪维新技术公司	吡啶并[3,4-b]吲哚和应用方法
MD4009C2 (ro) *	2008-07-15	2010-08-31	Институт Химии Академии Наук Молдовы	Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
US20120135089A1 (en) *	2009-03-17	2012-05-31	Stockwell Brent R	E3 ligase inhibitors
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
JP2012532144A (ja)	2009-07-01	2012-12-13	アルバニーモレキュラーリサーチ，インコーポレイテッド	アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
WO2011003021A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US20130137705A1 (en) *	2009-09-23	2013-05-30	Sarvajit Chakravarty	Pyrido[3,4-b]indoles and methods of use
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US8993765B2 (en)	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
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2001
- 2001-03-05 UA UA2002119179A patent/UA74826C2/uk unknown
- 2001-05-02 US US09/847,767 patent/US6492358B2/en not_active Expired - Lifetime
- 2001-05-03 PL PL365445A patent/PL205507B1/pl unknown
- 2001-05-03 AU AU2001261167A patent/AU2001261167B2/en not_active Ceased
- 2001-05-03 WO PCT/US2001/014357 patent/WO2001087038A2/en active IP Right Grant
- 2001-05-03 RU RU2002133867/04A patent/RU2271358C2/ru not_active IP Right Cessation
- 2001-05-03 AU AU6116701A patent/AU6116701A/xx active Pending
- 2001-05-03 GE GE5003A patent/GEP20053511B/en unknown
- 2001-05-03 DK DK01935038T patent/DK1289985T3/da active
- 2001-05-03 KR KR1020027015581A patent/KR20030031482A/ko not_active Withdrawn
- 2001-05-03 JP JP2001583517A patent/JP5014551B2/ja not_active Expired - Fee Related
- 2001-05-03 NZ NZ522731A patent/NZ522731A/en not_active IP Right Cessation
- 2001-05-03 CN CNB018128432A patent/CN1255403C/zh not_active Expired - Fee Related
- 2001-05-03 EP EP01935038A patent/EP1289985B1/en not_active Expired - Lifetime
- 2001-05-03 IL IL15287301A patent/IL152873A0/xx unknown
- 2001-05-03 ES ES01935038T patent/ES2211806T3/es not_active Expired - Lifetime
- 2001-05-03 MX MXPA02011426A patent/MXPA02011426A/es active IP Right Grant
- 2001-05-03 CA CA2409715A patent/CA2409715C/en not_active Expired - Fee Related
- 2001-05-03 HU HU0302412A patent/HUP0302412A3/hu unknown
- 2001-05-03 CZ CZ20023934A patent/CZ20023934A3/cs unknown
- 2001-05-03 AT AT01935038T patent/ATE256127T1/de active
- 2001-05-03 PT PT01935038T patent/PT1289985E/pt unknown
- 2001-05-03 SK SK1697-2002A patent/SK16972002A3/sk unknown
- 2001-05-03 DE DE60101479T patent/DE60101479T2/de not_active Expired - Lifetime
- 2001-05-03 HR HR20020910A patent/HRP20020910B1/xx not_active IP Right Cessation
- 2001-05-03 TR TR2003/02309T patent/TR200302309T4/xx unknown
- 2001-05-16 AR ARP010102326A patent/AR028576A1/es unknown
- 2001-05-16 MY MYPI20012323A patent/MY128479A/en unknown
2002
- 2002-01-21 TW TW091100842A patent/TWI286553B/zh not_active IP Right Cessation
- 2002-10-01 US US10/261,861 patent/US6864253B2/en not_active Expired - Lifetime
- 2002-11-15 IL IL152873A patent/IL152873A/en not_active IP Right Cessation
- 2002-11-18 NO NO20025527A patent/NO324251B1/no not_active IP Right Cessation
- 2002-11-18 BG BG107285A patent/BG66141B1/bg unknown
- 2002-12-12 ZA ZA200210111A patent/ZA200210111B/en unknown

Also Published As

Publication number	Publication date
NO20025527L (no)	2003-01-16
HRP20020910A2 (en)	2004-12-31
PT1289985E (pt)	2004-03-31
TR200302309T4 (tr)	2004-02-23
ES2211806T3 (es)	2004-07-16
NO324251B1 (no)	2007-09-17
NZ522731A (en)	2004-09-24
WO2001087038A2 (en)	2001-11-22
KR20030031482A (ko)	2003-04-21
EP1289985B1 (en)	2003-12-10
PL365445A1 (en)	2005-01-10
MXPA02011426A (es)	2004-09-06
US6492358B2 (en)	2002-12-10
IL152873A (en)	2012-01-31
JP2003533453A (ja)	2003-11-11
WO2001087038A3 (en)	2002-05-16
IL152873A0 (en)	2003-06-24
NO20025527D0 (no)	2002-11-18
HRP20020910B1 (hr)	2011-02-28
RU2271358C2 (ru)	2006-03-10
JP5014551B2 (ja)	2012-08-29
AU6116701A (en)	2001-11-26
BG107285A (bg)	2003-07-31
PL205507B1 (pl)	2010-04-30
MY128479A (en)	2007-02-28
CZ20023934A3 (cs)	2003-10-15
SK16972002A3 (sk)	2003-11-04
ZA200210111B (en)	2004-03-12
CN1446217A (zh)	2003-10-01
CN1255403C (zh)	2006-05-10
AR028576A1 (es)	2003-05-14
US20030166641A1 (en)	2003-09-04
DE60101479D1 (en)	2004-01-22
HUP0302412A2 (hu)	2003-11-28
US20020010189A1 (en)	2002-01-24
AU2001261167B2 (en)	2006-10-05
HK1051368A1 (en)	2003-08-01
DE60101479T2 (de)	2005-04-28
UA74826C2 (en)	2006-02-15
US6864253B2 (en)	2005-03-08
TWI286553B (en)	2007-09-11
CA2409715A1 (en)	2001-11-22
ATE256127T1 (de)	2003-12-15
DK1289985T3 (da)	2004-04-05
BG66141B1 (bg)	2011-07-29
CA2409715C (en)	2010-09-14
GEP20053511B (en)	2005-05-10
EP1289985A2 (en)	2003-03-12

Publication	Publication Date	Title
HUP0302412A3 (en)	2007-02-28	Betha-carboline derivatives useful as inhibitors of phosphodiesterase and pharmaceutical compositions containing the same
HUP0302485A3 (en)	2007-09-28	Arylmethylamine derivatives for use as tryptase inhibitors and pharmaceutical compositions containing them
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HUP0201261A3 (en)	2003-12-29	Indole-type derivatives as inhibitors of p38 kinase and pharmaceutical compositions containing them
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HUP0301005A3 (en)	2006-05-29	Pirrolotriazine inhibitors of kinases pharmaceutical compositions containing them and their use
HUP0302922A3 (en)	2007-02-28	Imidazolo-5-yl-2-anilino-pyrimidines as agents for the inhibition of the cell proliferation and pharmaceutical compositions containing them
HUP0300318A3 (en)	2004-11-29	Pyrazolobenzodiazepines as cdk2 inhibitors and pharmaceutical compositions containing them and their use
HUP0401950A3 (en)	2010-06-28	Pyrimidine derivatives and pharmaceutical compositions containing that compounds
IL157131A0 (en)	2004-02-08	Nitrogen containing heterocyclic derivatives and pharmaceutical compositions containing the same
IL152451A0 (en)	2003-05-29	2-chloro-2-nitrophenylcarboxamide derivatives and pharmaceutical compositions containing the same
HUP0301178A3 (en)	2009-08-28	Glucopyranosyloxybenzylbenzene derivatives and pharmaceutical compositions containing the same
IL153123A0 (en)	2003-06-24	N-ureidoheterocycloalkyl-piperidine derivatives and pharmaceutical compositions containing the same
IL150734A0 (en)	2003-02-12	Azaindole derivatives and pharmaceutical compositions containing the same
AU2001244355A1 (en)	2001-10-15	Heterobiarylsulphonamides and their use as pde 7 inhibitors
HUP0400639A3 (en)	2010-03-29	Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them
IL164022A0 (en)	2005-12-18	Phosphate derivatives of fluoroxindole and pharmaceutical compositions containing the same
HUP0400011A3 (en)	2008-03-28	Dihydro isoquinoline derivatives as phosphodiesterase inhibitors and pharmaceutical compositions containing them
HUP0203245A3 (en)	2003-12-29	Imidazopyridine derivatives as phosphodiesterase vii inhibitors and pharmaceutical compositions containing them
HUP0203288A3 (en)	2003-12-29	Pyrrole derivatives as phosphodiesterase vii inhibitors, pharmaceutical compositions containing them and their use
IL157740A0 (en)	2004-03-28	Heterocyclic derivatives and pharmaceutical compositions containing the same
HUP0400654A3 (en)	2011-07-28	Substituted 8-arylquinoline phosphodiesterase 4 inhibitors and pharmaceutical compositions containing them
HUP0303184A3 (en)	2008-03-28	Substituted c-cyclohexylmethylamine derivatives and pharmaceutical compositions containing them

Legal Events

Date	Code	Title	Description
2016-03-29	FD9A	Lapse of provisional protection due to non-payment of fees